Nutritional Intake and Chronicity Associated with the Old World Cutaneous Leishmaniasis: Role of Vitamin A
-
Vahid MASHAYEKHI GOYONLO
,
Abdolreza NOROUZY
,
Mohsen NEMATI
,
Pouran LAYEGH
,
Saeed AKHLAGHI
,
Ahmad Reza TAHERI
,
Bita KIAFAR
Abstract
Background: Old world cutaneous leishmaniasis (CL) is known as a self-healing cutaneous parasitic infection. Host immunity has a fundamental role in the course of this infection. This study was designed to investigate the relationship between nutritional status and vitamin A intake with the clinical course of CL.
Methods: Overall, 250 patients with CL attending a dermatology clinic in Imam Reza Hospital Mashhad, Iran, were enrolled from Apr 2011 to Aug 2012. For data gathering, a semi-quantitative 302-item food frequency questionnaire was utilized. They received routine treatment protocols for leishmaniasis and 1 year of follow-up
Results: As for the 149 patients who completed the study, a deficiency of macro and micronutrients, particularly vitamin A, was significantly related to a chronic clinical disease course.
Conclusion: Imbalanced or insufficient nutritional intake including vitamin A deficiency, may influence the clinical course of CL.
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2. Tashakori M, Ajdary S, Kariminia A et al (2003). Characterization of Leishmania species and L. major strains in different endemic areas of cutaneous leishmaniasis in Iran. Iran Biomed J,7(2):43-50.
3. Burnett MW (2015). Cutaneous leishmania-sis. J Spec Oper Med,15(1):128-9.
4. McGwire BS, Satoskar AR (2014). Leish-maniasis: clinical syndromes and treat-ment. QJM,107(1):7-14.
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6. Murray HW, Berman JD, Davies CR, Saravia NG (2005). Advances in leishmaniasis. Lancet,366(9496):1561-77.
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9. Revillard J, Cozon G (1990). Experimental models and mechanisms of immune de-ficiencies of nutritional origin. Food Addit Contam, 7 Suppl 1:S82-6.
10. Sacks DL, Melby PC (2015). Animal models for the analysis of immune responses to leishmaniasis. Curr Protoc Immunol, 108:19.2.1-19.2.24.
11. Anstead GM, Chandrasekar B, Zhao W et al (2001). Malnutrition alters the innate im-mune response and increases early vis-ceralization following Leishmania donovani infection. Infect Immun,69(8):4709-18.
12. Carrillo E, Jimenez MA, Sanchez C et al (2014). Protein malnutrition impairs the immune response and influences the se-verity of infection in a hamster model of chronic visceral leishmaniasis. PLoS One,9(2):e89412.
13. Mashayekhi Goyonlo V, Elnour H, Nord-lind K (2014). Interleukin-2 expression in lupoid and usual types of old world cuta-neous leishmaniasis. Iran Red Crescent Med J, 16(11):e5410.
14. Mashayekhi-Ghoyonlo V, Kiafar B, Rohani M et al (2015). Correlation between Soci-oeconomic Status and Clinical Course in Patients with Cutaneous Leishmaniasis. J Cutan Med Surg,19(1):40-4.
15. Mirmiran P, Hosseini Esfahani F, Mehrabi Y et al (2010). Reliability and relative valid-ity of an FFQ for nutrients in the Tehran Lipid and Glucose Study. Public Health Nutr,13(5):654-62.
16. Ghazizadeh S, Noori M, Norouzy A et al (2014). Scientific: validity and reproduci-bility of Iranian food frequency question-naire. Nutrition and Food Sciences Research, 1(Supple 1):16.
17. Malekshah A, Kimiagar M, Saadatian-Elahi M et al (2006). Validity and reliability of a new food frequency questionnaire com-pared to 24 h recalls and biochemical measurements: pilot phase of Golestan cohort study of esophageal cancer. Eur J Clin Nutr,60(8):971-7.
18. França T, Ishikawa L, Zorzella-Pezavento S et al (2009). Impact of malnutrition on immunity and infection. J Venom Anim Toxins Incl Trop Dis,15(3):374-90.
19. Schaible UE, Kaufmann SH (2007). Malnu-trition and infection: complex mecha-nisms and global impacts. PLoS Med,4(5):e115.
20. Dayakar A, Chandrasekaran S, Veronica J, Maurya R (2011). Role of leptin in human visceral leishmaniasis? Med Hypotheses, 77(3):416-8.
21. Malafaia G, Serafim TD, Silva ME et al (2009). Protein-energy malnutrition de-creases immune response to Leishmania chagasi vaccine in BALB/c mice. Parasite Immunol, 31(1):41-9.
22. Corware K, Yardley V, Mack C et al (2014). Protein energy malnutrition increases ar-ginase activity in monocytes and macro-phages. Nutr Metab (Lond), 11(1):51.
23. Maciel BLL, Lacerda HG, Queiroz JW et al (2008). Association of nutritional status with the response to infection with Leishmania chagasi. Am J Trop Med Hyg, 79(4):591-8.
24. Pourfallah F, Javadian S, Zamani Z et al (2009). Evaluation of serum levels of zinc, copper, iron, and zinc/copper ratio in cu-taneous leishmaniasis. Iran J Arthropod Borne Dis, 3(2):7-11.
25. Guzman-Rivero M, Rojas E, Verduguez-Orellana A et al (2014). Nutritional status in patients with cutaneous leishmaniasis and a study of the effects of zinc sup-plementation together with antimony treatment. Food Nutr Res,58:23353.
26. Oliveira A, Brito P, Schubach Aet al (2013). Influence of the nutritional status in the clinical and therapeutical evolution in adults and elderly with American Tegu-mentary Leishmaniasis. Acta Trop,128(1):36-40.
27. Stephensen CB, Jiang X, Freytag T (2004). Vitamin A Deficiency Increases the In Vivo Development of IL-10–Positive Th2 Cells and Decreases Development of Th1 Cells in Mice. J Nutr, 134(10):2660-6.
28. Anstead G, Zhang Q, Melby P (2009). Mal-nutrition promotes prostaglandin over leukotriene production and dysregulates eicosanoid-cytokine crosstalk in activated resident macrophages. Prostaglandins Leu-kot Essent Fatty Acids, 81(1):41-51
29. Wintergerst ES, Maggini S, Hornig DH (2007). Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab,51(4):301-23.
30. Hughes DA, Darlington LG, Bendich A (2003). Diet and human immune func-tion: Springer Science & Business Media.
2. Tashakori M, Ajdary S, Kariminia A et al (2003). Characterization of Leishmania species and L. major strains in different endemic areas of cutaneous leishmaniasis in Iran. Iran Biomed J,7(2):43-50.
3. Burnett MW (2015). Cutaneous leishmania-sis. J Spec Oper Med,15(1):128-9.
4. McGwire BS, Satoskar AR (2014). Leish-maniasis: clinical syndromes and treat-ment. QJM,107(1):7-14.
5. Pazoki H, Fakhar M, Rasooli A et al (2016). Lupoid leishmaniasis among the known cases of cutaneous leishmaniasis in Herat Province, western Afghanistan. J Infect Public Health, 9(5):557-563.
6. Murray HW, Berman JD, Davies CR, Saravia NG (2005). Advances in leishmaniasis. Lancet,366(9496):1561-77.
7. Louzir H, Melby PC, Salah AB et al (1998). Immunologic determinants of disease evolution in localized cutaneous leish-maniasis due to Leishmania major. J Infect Dis,177(6):1687-95.
8. Reithinger R, Dujardin J-C, Louzir H et al (2007). Cutaneous leishmaniasis. Lancet Infect Dis,7(9):581-96.
9. Revillard J, Cozon G (1990). Experimental models and mechanisms of immune de-ficiencies of nutritional origin. Food Addit Contam, 7 Suppl 1:S82-6.
10. Sacks DL, Melby PC (2015). Animal models for the analysis of immune responses to leishmaniasis. Curr Protoc Immunol, 108:19.2.1-19.2.24.
11. Anstead GM, Chandrasekar B, Zhao W et al (2001). Malnutrition alters the innate im-mune response and increases early vis-ceralization following Leishmania donovani infection. Infect Immun,69(8):4709-18.
12. Carrillo E, Jimenez MA, Sanchez C et al (2014). Protein malnutrition impairs the immune response and influences the se-verity of infection in a hamster model of chronic visceral leishmaniasis. PLoS One,9(2):e89412.
13. Mashayekhi Goyonlo V, Elnour H, Nord-lind K (2014). Interleukin-2 expression in lupoid and usual types of old world cuta-neous leishmaniasis. Iran Red Crescent Med J, 16(11):e5410.
14. Mashayekhi-Ghoyonlo V, Kiafar B, Rohani M et al (2015). Correlation between Soci-oeconomic Status and Clinical Course in Patients with Cutaneous Leishmaniasis. J Cutan Med Surg,19(1):40-4.
15. Mirmiran P, Hosseini Esfahani F, Mehrabi Y et al (2010). Reliability and relative valid-ity of an FFQ for nutrients in the Tehran Lipid and Glucose Study. Public Health Nutr,13(5):654-62.
16. Ghazizadeh S, Noori M, Norouzy A et al (2014). Scientific: validity and reproduci-bility of Iranian food frequency question-naire. Nutrition and Food Sciences Research, 1(Supple 1):16.
17. Malekshah A, Kimiagar M, Saadatian-Elahi M et al (2006). Validity and reliability of a new food frequency questionnaire com-pared to 24 h recalls and biochemical measurements: pilot phase of Golestan cohort study of esophageal cancer. Eur J Clin Nutr,60(8):971-7.
18. França T, Ishikawa L, Zorzella-Pezavento S et al (2009). Impact of malnutrition on immunity and infection. J Venom Anim Toxins Incl Trop Dis,15(3):374-90.
19. Schaible UE, Kaufmann SH (2007). Malnu-trition and infection: complex mecha-nisms and global impacts. PLoS Med,4(5):e115.
20. Dayakar A, Chandrasekaran S, Veronica J, Maurya R (2011). Role of leptin in human visceral leishmaniasis? Med Hypotheses, 77(3):416-8.
21. Malafaia G, Serafim TD, Silva ME et al (2009). Protein-energy malnutrition de-creases immune response to Leishmania chagasi vaccine in BALB/c mice. Parasite Immunol, 31(1):41-9.
22. Corware K, Yardley V, Mack C et al (2014). Protein energy malnutrition increases ar-ginase activity in monocytes and macro-phages. Nutr Metab (Lond), 11(1):51.
23. Maciel BLL, Lacerda HG, Queiroz JW et al (2008). Association of nutritional status with the response to infection with Leishmania chagasi. Am J Trop Med Hyg, 79(4):591-8.
24. Pourfallah F, Javadian S, Zamani Z et al (2009). Evaluation of serum levels of zinc, copper, iron, and zinc/copper ratio in cu-taneous leishmaniasis. Iran J Arthropod Borne Dis, 3(2):7-11.
25. Guzman-Rivero M, Rojas E, Verduguez-Orellana A et al (2014). Nutritional status in patients with cutaneous leishmaniasis and a study of the effects of zinc sup-plementation together with antimony treatment. Food Nutr Res,58:23353.
26. Oliveira A, Brito P, Schubach Aet al (2013). Influence of the nutritional status in the clinical and therapeutical evolution in adults and elderly with American Tegu-mentary Leishmaniasis. Acta Trop,128(1):36-40.
27. Stephensen CB, Jiang X, Freytag T (2004). Vitamin A Deficiency Increases the In Vivo Development of IL-10–Positive Th2 Cells and Decreases Development of Th1 Cells in Mice. J Nutr, 134(10):2660-6.
28. Anstead G, Zhang Q, Melby P (2009). Mal-nutrition promotes prostaglandin over leukotriene production and dysregulates eicosanoid-cytokine crosstalk in activated resident macrophages. Prostaglandins Leu-kot Essent Fatty Acids, 81(1):41-51
29. Wintergerst ES, Maggini S, Hornig DH (2007). Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab,51(4):301-23.
30. Hughes DA, Darlington LG, Bendich A (2003). Diet and human immune func-tion: Springer Science & Business Media.
| Files | ||
| Issue | Vol 49 No 1 (2020) | |
| Section | Short Communication(s) | |
| DOI | https://doi.org/10.18502/ijph.v49i1.3063 | |
| Keywords | ||
| Cutaneous leishmaniasis Nutrition Vitamin A | ||
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How to Cite
1.
MASHAYEKHI GOYONLO V, NOROUZY A, NEMATI M, LAYEGH P, AKHLAGHI S, TAHERI AR, KIAFAR B. Nutritional Intake and Chronicity Associated with the Old World Cutaneous Leishmaniasis: Role of Vitamin A. Iran J Public Health. 2020;49(1):167-172.
