Antioxidant and Bone; Protect Your Future: A Brief Review
Abstract
The global campaign of osteoporosis has been organized by the International Osteoporosis Foundation (IOF) and them introducing World Osteoporosis Day (WOD) in 1997. The day is celebrated on October 20th each year and aimed to improve the awareness of the population about disease prevention. We present some aspects of bone health and the prevention of osteoporosis related to the use of vitamins. The presenting mini-review covers a variety of sources including PubMed, Embase, Scopus, and directory of open access journals (DOAJ) from 10 years ago (Oct 2009 to Oct 2019) for recent developments in the prevention of bone loss. The search was performed by using combinations of the following keywords and or their equivalents; osteoporosis, bones health, bone loss, and vitamin to find related articles about the prevention of osteoporosis by nutritional factors. The factors affecting bone are various and could begin from fetal periods to the end of life. Some of them are not changeable including age, and genetic; however, it is possible to modify some others such as poor nutrition and vitamin deficiency. Beyond vitamin D deficiency, consumption of other vitamins also is beneficial to maintain bone health. By considering the nutritional factors especially vitamins that affect bones, it is possible to have stronger bones to enjoy life in the elderly and protect your future.
1. Cooper C, Dawson-Hughes B, Gordon CM, et al (2015). Healthy nutrition, healthy bones: How nutritional factors affect musculoskeletal health throughout life. In: Jagait CK, Misteli L, editors. World Osteoporosis Day Thematic Report. Nyon: International Osteoporosis Foundation.
2. Ahmed SF, Elmantaser M (2009). Secondary osteoporosis. Endocr Dev; 16:170-90.
3. Khodadadi S, Khodadadi S (2016). Estimation of annual per capita treatment in osteoporosis. J parathyr dis. 2016,4:17-19.
4. Nasouti MA, Nasouti A. On the occasion of world osteoporosis day 2018(2018); osteoporosis in young individuals. J Ren Endocrinol, 4:e10.
5. Chavan SN, More U, Mulgund S, Saxena V, Sontakke AN (2007). Effect of supplementation of vitamin C and E on oxidative stress in osteoporosis. Indian J Clin Biochem, 22(2):101-5.
6. International Osteoporosis Foundation: https://www.iofbonehealth.org/osteoporosis-musculoskeletal-disorders. Accessed October 2016. In
7. Mlakar SJ, Osredkar J, Prezelj J, et al (2010). The antioxidant enzyme GPX1 gene polymorphisms are associated with low BMD and increased bone turnover markers. Dis Markers,29(2):71-80.
8. Baucom K, Pizzorno L, Pizzorno J(2014). Osteoporosis: The Need for Prevention and Treatment. J Restorative Med,3:1-28.
9. Gullberg B, Johnell O, Kanis JA(1997). World-wide projections for hip fracture. Osteoporos Int, 7(5):407-13.
10. Chan GK, Duque G(2002). Age-related bone loss: old bone, new facts. Gerontology,48(2):62-71.
11. Eisman JA, Kelly PJ, Morrison NA, et al (1993). Peak Bone Mass and Osteoporosis Prevention. Osteoporos Int,3:56-60.
12. National Osteoporosis Society: What is Osteoporosis https://nos.org.uk/about-osteoporosis/what-is-osteoporosis/. Accessed October 2016. In.
13. Zeng H, Cao JJ, Combs GF (2013). Selenium in bone health: roles in antioxidant protection and cell proliferation. Nutrients,5(1):97-110.
14. Sheweita SA, Khoshhal KI (2007). Calcium metabolism and oxidative stress in bone fractures: role of antioxidants. Curr Drug Metab,8(5):519-25.
15. Jahanian E, Karimifar M, Rafieian-Kopaei M (2016). Antioxidants as a novel way to alleviate the adverse effects of oxidative stress in osteoporosis. J Parathyr Dis,4(2):60-65.
16. Azma K, Mottaghi P, Hosseini A, et al (2014). Benign joint hypermobility syndrome in soldiers; what is the effect of military training courses on associated joint instabilities? J Res Med Sci,19(7):639-43.
17. Sanchez-Rodriguez MA, Ruiz-Ramos M, Correa-Munoz E, et al (2007). Oxidative stress as a risk factor for osteoporosis in elderly Mexicans as characterized by antioxidant enzymes. BMC Musculoskelet Disord,8:124.
18. Karimifar M, Pasha MA, Salari A, et al (2021). Evaluation of bone loss in diabetic postmenopausal women. J Res Med Sci,17(11):1033-8.
19. Kafeshani M(2015). Diet and immune system. Immunopathol Persa,1(1):e04.
20. Mottaghi P, Karimifar M, Salesi M, et al (2010). Osteoporosis Screening tools in Iranian postmenopausal women . IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ),12:122-126.
21. Domazetovic V, Marcucci G, Iantomasi T, et al (2017). Oxidative stress in bone remodeling: role of antioxidants. Clin Cases Miner Bone Metab,14(2):209-216.
22. Birben E, Sahiner UM, Sackesen C, et al (2012). Oxidative stress and antioxidant defense. World Allergy Organ J,5(1):9-19.
23. Sendur OF, Turan Y, Tastaban E, et al (2009). Antioxidant status in patients with osteoporosis: a controlled study. Joint Bone Spine,76(5):514-8.
24. Yalin S, Bagis S, Polat G, et al(2005). Is there a role of free oxygen radicals in primary male osteoporosis? Clin Exp Rheumatol,23(5):689-92.
25. Abdollahi M, Larijani B, Rahimi R, et al (2005). Role of oxidative stress in osteoporosis. Therapy, 2(5), 787-796.
26. Momenzadeh M, Khosravian M, Lakkakula BVKS (2021). Potential of renin-angiotensin system inhibition to improve metabolic bone disorders. J Nephropharmacol,10(2):e16.
27. Hasanpour Dehkordi A (2018). Vitamin D and population health; a nephrology viewpoint. J Nephropathol. 7(3):117-119.
28. Bahadoram S, Davoodi M , Keikhaei B, et al (2021). An update on the mechanism and therapeutic implications of, pregnancy and lactation-associated osteoporosis; a narrative review. J Parathyr Dis,9: e01.
29. Maggio D, Barabani M, Pierandrei M, et al (2003). Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study. J Clin Endocrinol Metab, 88(4):1523-7.
30. Karimifar M, Botlani N, Salari A(2020). A randomized clinical trial on improving osteopenia in postmenopausal women after two years of preventive treatment with alendronate; a dose of 35 mg per week is more effective or a dose of 70 mg? J Prev Epidemiol,5(1):e16.
31. Mottaghi P(2010). Intravenous bisphosphonates for postmenopausal osteoporosis. J Res Med Sci,15(3):175-84.
32. Goronzy JJ, Weyand CM (1997). Rheumatoid arthritis: Epidemiology, pathology and pathogenesis. . In: Klippel JH, Weyand CM, Wortmann R, editors. Primer on the rheumatic diseases. 11th ed. Atlanta: : Arthritis Foundation,p. 155-61.
33. Sahni S, Hannan MT, Gagnon D, et al (2009). Protective effect of total and supplemental vitamin C intake on the risk of hip fracture--a 17-year follow-up from the Framingham Osteoporosis Study. Osteoporos Int,20(11):1853-61.
34. Kim J, Choi YH(2016). Physical activity, dietary vitamin C, and metabolic syndrome in the Korean adults: the Korea National Health and Nutrition Examination Survey 2008 to 2012. Public Health,135:30-7.
35. Martínez-Ramírez, Pérez P, Delgado-Martínez, et al (2007). Vitamin C, vitamin B12, folate and the risk of osteoporotic fractures. A case-control study. Int J Vitam Nutr Res,77(6):359-68.
36. Frei B, Birlouez-Aragon I, Lykkesfeldt J(2012). Authors' perspective: what is the optimum intake of vitamin C in humans? Crit Rev Food Sci Nutr,52(9):815-29.
37. Langi P, Kiokias S, Varzakas T, (2018). Carotenoids: From plants to food and feed industries. Methods Mol Biol, 1852:57-71.
38. Przybylska S (2020). Lycopene–a bioactive carotenoid offering multiple health benefits: a review. Int J Food Sci Technol, 55(1):11-32.
39. Iimura Y, Agata U, Takeda S, et al (2015). The protective effect of lycopene intake on bone loss in ovariectomized rats. J Bone Miner Metab,33(3):270-8.
40. Abbas M, Saeed F, Anjum FM, et al (2017). Natural polyphenols: An overview. International Journal of Food Properties, 20(8):1689-99.
41. Durazzo A, Lucarini M, Souto EB, et al (2019). Polyphenols: A concise overview on the chemistry, occurrence, and human health. Phytotherapy Research,33(9):2221-2243.
42. Wang Y, Alkhalidy H, Liu D(2021). The Emerging Role of Polyphenols in the Management of Type 2 Diabetes. Molecules,26(3):703.
43. Briguglio G, Costa C, Pollicino M, et al (2020). Polyphenols in cancer prevention: New insights. International Journal of Functional Nutrition, DOI:10.3892/IJFN.2020.9.
44. Bellavia D, Caradonna F, Dimarco E, et al (2021). Non-flavonoid polyphenols in osteoporosis: preclinical evidence. Trends Endocrinol Metab,32(7):515-529.
45. Corey RM, Cannada LK(2021). Nutritional Supplementation of Fracture Healing. Hoppenfeld's Treatment and Rehabilitation of Fractures.
46. Chisari E, Shivappa N, Vyas S(2019). Polyphenol-rich foods and osteoporosis. Curr Pharm Des,(22):2459-2466.
2. Ahmed SF, Elmantaser M (2009). Secondary osteoporosis. Endocr Dev; 16:170-90.
3. Khodadadi S, Khodadadi S (2016). Estimation of annual per capita treatment in osteoporosis. J parathyr dis. 2016,4:17-19.
4. Nasouti MA, Nasouti A. On the occasion of world osteoporosis day 2018(2018); osteoporosis in young individuals. J Ren Endocrinol, 4:e10.
5. Chavan SN, More U, Mulgund S, Saxena V, Sontakke AN (2007). Effect of supplementation of vitamin C and E on oxidative stress in osteoporosis. Indian J Clin Biochem, 22(2):101-5.
6. International Osteoporosis Foundation: https://www.iofbonehealth.org/osteoporosis-musculoskeletal-disorders. Accessed October 2016. In
7. Mlakar SJ, Osredkar J, Prezelj J, et al (2010). The antioxidant enzyme GPX1 gene polymorphisms are associated with low BMD and increased bone turnover markers. Dis Markers,29(2):71-80.
8. Baucom K, Pizzorno L, Pizzorno J(2014). Osteoporosis: The Need for Prevention and Treatment. J Restorative Med,3:1-28.
9. Gullberg B, Johnell O, Kanis JA(1997). World-wide projections for hip fracture. Osteoporos Int, 7(5):407-13.
10. Chan GK, Duque G(2002). Age-related bone loss: old bone, new facts. Gerontology,48(2):62-71.
11. Eisman JA, Kelly PJ, Morrison NA, et al (1993). Peak Bone Mass and Osteoporosis Prevention. Osteoporos Int,3:56-60.
12. National Osteoporosis Society: What is Osteoporosis https://nos.org.uk/about-osteoporosis/what-is-osteoporosis/. Accessed October 2016. In.
13. Zeng H, Cao JJ, Combs GF (2013). Selenium in bone health: roles in antioxidant protection and cell proliferation. Nutrients,5(1):97-110.
14. Sheweita SA, Khoshhal KI (2007). Calcium metabolism and oxidative stress in bone fractures: role of antioxidants. Curr Drug Metab,8(5):519-25.
15. Jahanian E, Karimifar M, Rafieian-Kopaei M (2016). Antioxidants as a novel way to alleviate the adverse effects of oxidative stress in osteoporosis. J Parathyr Dis,4(2):60-65.
16. Azma K, Mottaghi P, Hosseini A, et al (2014). Benign joint hypermobility syndrome in soldiers; what is the effect of military training courses on associated joint instabilities? J Res Med Sci,19(7):639-43.
17. Sanchez-Rodriguez MA, Ruiz-Ramos M, Correa-Munoz E, et al (2007). Oxidative stress as a risk factor for osteoporosis in elderly Mexicans as characterized by antioxidant enzymes. BMC Musculoskelet Disord,8:124.
18. Karimifar M, Pasha MA, Salari A, et al (2021). Evaluation of bone loss in diabetic postmenopausal women. J Res Med Sci,17(11):1033-8.
19. Kafeshani M(2015). Diet and immune system. Immunopathol Persa,1(1):e04.
20. Mottaghi P, Karimifar M, Salesi M, et al (2010). Osteoporosis Screening tools in Iranian postmenopausal women . IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ),12:122-126.
21. Domazetovic V, Marcucci G, Iantomasi T, et al (2017). Oxidative stress in bone remodeling: role of antioxidants. Clin Cases Miner Bone Metab,14(2):209-216.
22. Birben E, Sahiner UM, Sackesen C, et al (2012). Oxidative stress and antioxidant defense. World Allergy Organ J,5(1):9-19.
23. Sendur OF, Turan Y, Tastaban E, et al (2009). Antioxidant status in patients with osteoporosis: a controlled study. Joint Bone Spine,76(5):514-8.
24. Yalin S, Bagis S, Polat G, et al(2005). Is there a role of free oxygen radicals in primary male osteoporosis? Clin Exp Rheumatol,23(5):689-92.
25. Abdollahi M, Larijani B, Rahimi R, et al (2005). Role of oxidative stress in osteoporosis. Therapy, 2(5), 787-796.
26. Momenzadeh M, Khosravian M, Lakkakula BVKS (2021). Potential of renin-angiotensin system inhibition to improve metabolic bone disorders. J Nephropharmacol,10(2):e16.
27. Hasanpour Dehkordi A (2018). Vitamin D and population health; a nephrology viewpoint. J Nephropathol. 7(3):117-119.
28. Bahadoram S, Davoodi M , Keikhaei B, et al (2021). An update on the mechanism and therapeutic implications of, pregnancy and lactation-associated osteoporosis; a narrative review. J Parathyr Dis,9: e01.
29. Maggio D, Barabani M, Pierandrei M, et al (2003). Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study. J Clin Endocrinol Metab, 88(4):1523-7.
30. Karimifar M, Botlani N, Salari A(2020). A randomized clinical trial on improving osteopenia in postmenopausal women after two years of preventive treatment with alendronate; a dose of 35 mg per week is more effective or a dose of 70 mg? J Prev Epidemiol,5(1):e16.
31. Mottaghi P(2010). Intravenous bisphosphonates for postmenopausal osteoporosis. J Res Med Sci,15(3):175-84.
32. Goronzy JJ, Weyand CM (1997). Rheumatoid arthritis: Epidemiology, pathology and pathogenesis. . In: Klippel JH, Weyand CM, Wortmann R, editors. Primer on the rheumatic diseases. 11th ed. Atlanta: : Arthritis Foundation,p. 155-61.
33. Sahni S, Hannan MT, Gagnon D, et al (2009). Protective effect of total and supplemental vitamin C intake on the risk of hip fracture--a 17-year follow-up from the Framingham Osteoporosis Study. Osteoporos Int,20(11):1853-61.
34. Kim J, Choi YH(2016). Physical activity, dietary vitamin C, and metabolic syndrome in the Korean adults: the Korea National Health and Nutrition Examination Survey 2008 to 2012. Public Health,135:30-7.
35. Martínez-Ramírez, Pérez P, Delgado-Martínez, et al (2007). Vitamin C, vitamin B12, folate and the risk of osteoporotic fractures. A case-control study. Int J Vitam Nutr Res,77(6):359-68.
36. Frei B, Birlouez-Aragon I, Lykkesfeldt J(2012). Authors' perspective: what is the optimum intake of vitamin C in humans? Crit Rev Food Sci Nutr,52(9):815-29.
37. Langi P, Kiokias S, Varzakas T, (2018). Carotenoids: From plants to food and feed industries. Methods Mol Biol, 1852:57-71.
38. Przybylska S (2020). Lycopene–a bioactive carotenoid offering multiple health benefits: a review. Int J Food Sci Technol, 55(1):11-32.
39. Iimura Y, Agata U, Takeda S, et al (2015). The protective effect of lycopene intake on bone loss in ovariectomized rats. J Bone Miner Metab,33(3):270-8.
40. Abbas M, Saeed F, Anjum FM, et al (2017). Natural polyphenols: An overview. International Journal of Food Properties, 20(8):1689-99.
41. Durazzo A, Lucarini M, Souto EB, et al (2019). Polyphenols: A concise overview on the chemistry, occurrence, and human health. Phytotherapy Research,33(9):2221-2243.
42. Wang Y, Alkhalidy H, Liu D(2021). The Emerging Role of Polyphenols in the Management of Type 2 Diabetes. Molecules,26(3):703.
43. Briguglio G, Costa C, Pollicino M, et al (2020). Polyphenols in cancer prevention: New insights. International Journal of Functional Nutrition, DOI:10.3892/IJFN.2020.9.
44. Bellavia D, Caradonna F, Dimarco E, et al (2021). Non-flavonoid polyphenols in osteoporosis: preclinical evidence. Trends Endocrinol Metab,32(7):515-529.
45. Corey RM, Cannada LK(2021). Nutritional Supplementation of Fracture Healing. Hoppenfeld's Treatment and Rehabilitation of Fractures.
46. Chisari E, Shivappa N, Vyas S(2019). Polyphenol-rich foods and osteoporosis. Curr Pharm Des,(22):2459-2466.
| Files | ||
| Issue | Vol 50 No 9 (2021) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v50i9.7049 | |
| Keywords | ||
| Osteoporosis Bones health Bone loss Vitamin | ||
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How to Cite
1.
Motaghi P, Nasri P. Antioxidant and Bone; Protect Your Future: A Brief Review. Iran J Public Health. 2021;50(9):1783-1788.
