Original Article

Seasonal Variations of Serum Zinc Concentration in Adult Population: Tehran Lipid and Glucose Study

Abstract

Background: Zinc, an essential trace element, plays a key role in many biological human body functions. Serum zinc concentration is the most widely used indicator of zinc status for general populations. Considering the limited data available on seasonal fluctuation of serum zinc concentration, we aimed at determining seasonal variations in serum zinc concentrations of Tehranian adults.

Methods: The current study was conducted within the framework of the Tehran Lipid and Glucose Study, on 4698 subjects, aged ≥20 years. Serum zinc samples of subjects were obtained from all four seasons over three years (from 2009 to 2011); samples of similar seasons over three years were placed in one group and the geometric means of serum zinc concentration of four seasons were compared to determine possible seasonal variations.

Results: Participants with mean age 46.3 yr and geometric mean of serum zinc concentration 116.3 µg/dl, were studied for almost three years through four seasons. Serum zinc concentrations in spring and summer were significantly higher than those in autumn and winter (112.2 and 114.4 vs. 106.7 and 104.8 µg/dl; P<0.001, respectively). Moreover, monthly serum zinc concentration of all subjects differed, with the lowest and highest levels found in October and August (98.5 vs. 122.7; P<0.001).

Conclusion: This study demonstrates the difference in serum zinc concentration in Iranian adults of both genders in different months and seasons during the year.

 

1. Prasad AS (1991). Discovery of human zinc deficiency and studies in an experimental human model. Am J Clin Nutr, 53(2):403-12.
2. Saper RB, Rash R (2009). Zinc: an essential micronutrient. Am Fam Physician, 79(9):768-72.
3. Ghasemi A, Zahediasl S, Hosseini-Esfahani F, Azizi F (2012). Reference values for serum zinc concentration and prevalence of zinc deficiency in adult Iranian subjects. Biol Trace Elem Res, 149(3):307-14.
4. World Health Organization. The World Health Report, 2002: Reducing Risks, Promoting Healthy Life. Geneva, Switzerland: World Health Organization; 2002.
5. Haghollahi F, Ramezanzadeh F, Norouzi M et al (2008). Zinc deficiency in first year female students of Tehran university of medical sciences. Journal of Family and Reproductive Health, 2(2):81-6.
6. Hotz C, Peerson JM, Brown KH (2003). Suggested lower cutoffs of serum zinc concentrations for assessing zinc status: reanalysis of the second National Health and Nutrition Examination Survey data (1976-1980). Am J Clin Nutr, 78(4):756-64.
7. Hess SY, Peerson JM, King JC, Brown KH (2007). Use of Serum Zinc Concentration as an Indicator of Population Zinc Status. Food Nutr Bull, 28(3 suppl3):S403-S29.
8. Galan P, Viteri FE, Bertrais S et al (2005). Serum concentrations of beta-carotene, vitamins C and E, zinc and selenium are influenced by sex, age, diet, smoking status, alcohol consumption and corpulence in a general French adult population. Eur J Clin Nutr, 59(10):1181-90.
9. Ghayour-Mobarhan M, Taylor A, New SA, Lamb DJ, Ferns GA (2005). Determinants of serum copper, zinc and selenium in healthy subjects. Ann Clin Biochem, 42(Pt 5):364-75.
10. Banks SD, Thomas P, Baer KN (1999). Seasonal variations in hepatic and ovarian zinc concentrations during the annual reproductive cycle in female channel catfish (Ictalurus punctatus). Comp Biochem Physiol C Pharmacol Toxicol Endocrinol, 124(1):65-72.
11. Dar A, Jadhav R, Dimri U, Khan A, Khan H, Sharm M (2014). Effects of physiological status and seasonal variation on plasma mineral profile of sheep in Kashmir valley. Scientific Research and Essays, 9(4):69-76.
12. Keen CL, Lonnerdal B, Fisher GL (1981). Seasonal variations and the effects of age on serum copper and zinc values in the dog. Am J Vet Res, 42(2):347-50.
13. Gibson RS, Ferguson EF, Vanderkooy PD, MacDonald AC (1989). Seasonal variations in hair zinc concentrations in Canadian and African children. Science of the Total Environment, 84:291-8.
14. Rush E, Li L, Chandu V, Whiting R (2003). Hair zinc concentrations not subject to seasonal variation in adults in New Zealand. Biol Trace Elem Res, 95(3):193-202.
15. Azizi F, Ghanbarian A, Momenan AA et al (2009). Prevention of non-communicable disease in a population in nutrition transition: Tehran Lipid and Glucose Study phase II. Trials, 10:5.
16. He L, Zhao W, Zhang X, You Y, Chen J (2004). [Trend of seasonal change on intake of nutrients in a year of the residents in both northern and southern China]. Wei sheng yan jiu = Journal of hygiene research, 33(6):694-7.
17. Watson PE, McDonald BW (2007). Seasonal variation of nutrient intake in pregnancy: effects on infant measures and possible influence on diseases related to season of birth. EJCN, 61(11):1271-80.
18. Arnaud J, Fleites P, Chassagne M et al (2001). Seasonal variations of antioxidant imbalance in Cuban healthy men. Eur J Clin Nutr, 55(1):29-38.
19. Mitchikpe CE, Dossa RA, Ategbo EA et al (2009). Seasonal variation in food pattern but not in energy and nutrient intakes of rural Beninese school-aged children. Public health nutr, 12(3):414-22.
20. Shahar DR, Froom P, Harari G et al (1999). Changes in dietary intake account for seasonal changes in cardiovascular disease risk factors. Eur J Clin Nutr, 53(5):395-400.
21. Al-Timimi DJ, Al-Sharbatti SS, Al-Najjar F (2005). Zinc deficiency among a healthy population in Baghdad, Iraq. Saudi med J, 26(11):1777-81.
22. Amani R, Saeidi S, Nazari Z, Nematpour S (2010). Correlation Between Dietary Zinc Intakes and Its Serum Levels with Depression Scales in Young Female Students. Biol Trace Elem Res, 137(2):150-8.
23. Salgueiro MJ, Zubillaga M, Lysionek A et al (2000). Zinc as an essential micronutrient: A review. Nutrition Research, 20(5):737-55.
24. Singh RB, Niaz MA, Rastogi SS et al (1998). Current zinc intake and risk of diabetes and coronary artery disease and factors associated with insulin resistance in rural and urban populations of North India. J Am Coll Nutr, 17(6):564-70.
25. Diaz Romero C, Lopez Blanco F, Henriquez Sanchez P et al (2001). Serum selenium concentration in a representative sample of the Canarian population. Sci Total Environ, 269(1-3):65-73.
26. Crook MA (2011). Zinc deficiency. Nutrition (Burbank, Los Angeles County, Calif), 27(10):1085-6.
27. Hyun TH, Barrett-Connor E, Milne DB (2004). Zinc intakes and plasma concentrations in men with osteoporosis: the Rancho Bernardo Study. Am J Clin Nutr, 80(3):715-21.
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IssueVol 48 No 8 (2019) QRcode
SectionOriginal Article(s)
DOI https://doi.org/10.18502/ijph.v48i8.2990
Keywords
Adult Serum zinc Trace elements Seasonal variation

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How to Cite
1.
ASKARI S, ASGHARI G, FARHADNEJAD H, GHANBARIAN A, MIRMIRAN P, AZIZI F. Seasonal Variations of Serum Zinc Concentration in Adult Population: Tehran Lipid and Glucose Study. Iran J Public Health. 2019;48(8):1496-1502.