Original Article

Association between Probiotic Yogurt Intake and Gestational Diabetes Mellitus: A Case-Control Study

Abstract

Background: Gestational diabetes mellitus is one of the most frequent metabolic complications of pregnancy. Previous studies have reported that using either probiotic yogurt or a probiotic supplement reduces the incidence of gestational diabetes. However, the results were inconsistent. Thus, the aim of the present study was to investigate the association between gestational diabetes mellitus and probiotic yogurt intake during pregnancy and pre-pregnancy in Chinese women.

Methods: This was a case-control study involving 123 cases with gestational diabetes mellitus and 126 controls matched for age and pre-pregnancy body mass index. Each participant was interviewed face-to-face using a structured questionnaire to collect socio-demographic characteristics, diet and exercise habits, as well as probiotic yogurt consumption (containing Lactobacillus acidophilus and Bifidobacterium) during pregnancy and pre-pregnancy. An unconditional logistic regression analysis was used to analyze the data.

Results: Mothers in both groups had similar socio-demographic backgrounds. Probiotic yogurt intake during pregnancy was significantly higher in normal pregnant women than that in women with gestational diabetes mellitus (adjusted odds ratio: 0.292, 95% confidence interval: 0.148 - 0.577, P < 0.05). There were no significant differences in probiotic yogurt consumption before pregnancy between cases and controls.

Conclusion: Probiotic yogurt intake before pregnancy was not associated with gestational diabetes mellitus, but probiotic yogurt consumption during pregnancy was effective in reducing the risk of gestational diabetes mellitus in Chinese women. The findings from the present study may have implications for the future care of pregnant Chinese women with gestational diabetes mellitus.

 

 

1. Radha V, Kanthimathi S, Anjana RM, Mohan V (2016). Genetics of Gestational Diabetes Mellitus. J Pak Med Assoc, 66(9 Suppl 1):S11-4.
2. Cho GJ, Kim LY, Sung YN et al. (2015). Secular Trends of Gestational Diabetes Mellitus and Changes in Its Risk Factors. PLOS One, 10 (8): e0136017.
3. Pagan A, Sabater-Molina M, Olza J et al. (2014). A gene variant in the transcription factor 7-like 2 (TCF7L2) is associated with an increased risk of gestational diabetes mellitus. Eur J Obstet Gynecol Reprod Biol, 180: 77-82.
4. Beltcheva O, Boyadzhieva M, Angelova O et al. (2014). The rs266729 single-nucleotide polymorphism in the adiponectin gene shows association with gestational diabetes. Arch Gynecol Obstet, 289 (4): 743-8.
5. Ruiz-Gracia T, Duran A, Fuentes M et al. (2016). Lifestyle patterns in early pregnancy linked to gestational diabetes mellitus diagnoses when using IADPSG criteria. The St Carlos gestational study. Clin Nutr, 35 (3): 699-705.
6. Schwartz N, Nachum Z, Green MS (2015). The prevalence of gestational diabetes mellitus recurrence--effect of ethnicity and parity: a metaanalysis. Am J Obstet Gynecol, 213 (3): 310-7.
7. Chiefari E, Arcidiacono B, Foti D et al (2017). Gestational diabetes mellitus: an updated overview. J Endocrinol Invest, 40(9):899-909.
8. Rosenstein MG, Cheng YW, Snowden JM et al (2012). The risk of stillbirth and infant death stratified by gestational age in women with gestational diabetes. Am J Obstet Gynecol, 206 (4): 309 e1-7.
9. Allalou A, Nalla A, Prentice K et al (2016). A Predictive Metabolic Signature for the Transition From Gestational Diabetes Mellitus to Type 2 Diabetes. Diabetes, 65 (9): 2529-39.
10. NaRen RQG, Li DM, Mi LX et al (2018). Prevalence rate of gestational diabetes mellitus in China: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 18 (3): 280-5.
11. Hill C, Guarner F, Reid G et al (2014). Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol, 11 (8): 506-14.
12. Ley RE (2010). Obesity and the human microbiome. Curr Opin Gastroenterol, 26(1):5-11.
13. Koren O, Goodrich JK, Cullender TC et al (2012). Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell, 150 (3): 470-80.
14. Gohir W, Whelan FJ, Surette MG et al (2015). Pregnancy-related changes in the maternal gut microbiota are dependent upon the mother's periconceptional diet. Gut Microbes, 6 (5): 310-20.
15. Asemi Z, Samimi M, Tabassi Z et al (2013). Effect of daily consumption of probiotic yogurt on insulin resistance in pregnant women: a randomized controlled trial. Eur J Clin Nutr, 67 (1): 71-4.
16. Wickens KL, Barthow CA, Murphy R et al (2017). Early pregnancy probiotic supplementation with Lactobacillus rhamnosus HN001 may reduce the prevalence of gestational diabetes mellitus: a randomised controlled trial. Br J Nutr, 117 (6): 804-13.
17. Lindsay KL, Brennan L, Kennelly MA et al (2015). Impact of probiotics in women with gestational diabetes mellitus on metabolic health: a randomized controlled trial. Am J Obstet Gynecol, 212 (4): 496 e1-11.
18. Badehnoosh B, Karamali M, Zarrati M et al (2018). The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med, 31 (9): 1128-36.
19. Wei XH, Wang YF (2016). Interpretation of FIGO guideline for gestational diabetes mellitus in 2015. Chinese Journal of Endocrine Metabolism, 32 (11): 895-9.
20. Luoto R, Laitinen K, Nermes M et al (2010). Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: a double-blind, placebo-controlled study. Br J Nutr, 103 (12): 1792-9.
21. Lau CS, Ward A, Chamberlain RS (2016). Probiotics improve the efficacy of standard triple therapy in the eradication of Helicobacter pylori: a meta-analysis. Infect Drug Resist, 9: 275-89.
22. Roberfroid M, Gibson G, Hoyles L et al (2010). Prebiotic effects: metabolic and health benefits. Br J Nutr, 104 Suppl 2: S1-S63.
23. Turnbaugh PJ, Ley RE, Mahowald MA et al (2006). An obesity-associated gut microbiome with increased capacity for energy harvest. Nature, 444 (7122): 1027-31.
24. Tremaroli V, Backhed F (2012). Functional interactions between the gut microbiota and host metabolism. Nature, 489 (7415): 242-9.
25. Zhang CY, Wang WR, He QM et al (2017). Characteristics of important intestinal flora and its correlation with inflammatory factors in gestational. Chin J Diabetes, 25 (4): 320-4.
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IssueVol 48 No 7 (2019) QRcode
SectionOriginal Article(s)
DOI https://doi.org/10.18502/ijph.v48i7.2946
Keywords
Case-control study Chinese Gestational diabetes mellitus Probiotic yogurt
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
CHEN X, JIANG X, HUANG X, HE H, ZHENG J. Association between Probiotic Yogurt Intake and Gestational Diabetes Mellitus: A Case-Control Study. Iran J Public Health. 2019;48(7):1248-1256.