Association of MMP-2 -753C>T and MMP-9 -1562C>T Polymorphisms with Chronic/Aggressive Periodontitis Risk: A Systematic Review and Meta-Analysis

  • Fatemeh MASHHADIABBAS Department of Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Hossein NEAMATZADEH Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran AND Mother and Newborn Health Research Center, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Elnaz FOROUGHI Department of Pediatric Dentistry, School of Dentistry, Arak university of Medical Sciences, Arak, Iran
  • Seyed Alireza DASTGHEIB Mail Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  • Soudabeh FARAHNAK Department of Endodontics, School of Dentistry, Arak University of Medical Sciences, Arak, Iran
  • Rezvan NASIRI Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  • Shima AHMADI Department of Prosthodontics, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Periodontitis, MMP gene, Polymorphism, Meta-analysis


Background: Two functional polymorphisms in the matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9) genes may contribute to periodontitis pathogenesis. However, the results were inconsistent and inconclusive. Therefore, to clarify precise associations of MMP-2 -753 C>T and MMP-9 -1562C>T polymorphisms with chronic (CP) and aggressive (AgP) periodontitis, we performed a systematic review and meta-analysis.

Methods: A literature search was conducted using PubMed, Google Scholar, Embase, and Web of Science databases until 5 July 2017. The data were analyzed with CMA software, and risk estimates are expressed as odds ratios (ORs) and 95% confidence intervals (95% CIs).

Results: Nineteen case-control studies in ten publications with 2089 periodontitis cases and 2345 controls met the criteria. The pooled ORs indicated that MMP-2 -753C>T and MMP-9 -1562C>T polymorphisms were not significantly associated with risk of periodontitis in overall analysis. Stratified analyses by ethnicity and periodontitis type indicated that the MMP-9 -1562C>T polymorphism showed a significant association with the risk of periodontitis among Caucasians and CP/AgP subgroup, whereas MMP-2 -753C>T polymorphism was significantly associated with periodontitis risk only among Asians.

Conclusion: MMP-2 -753C>T and MMP-9 -1562C>T polymorphisms may not be associated with risk of periodontitis in overall population. However, MMP-2 -753C>T and MMP-9 -1562C>T polymorphisms might have influence on the susceptibility of periodontitis by ethnicity.




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How to Cite
MASHHADIABBAS F, NEAMATZADEH H, FOROUGHI E, DASTGHEIB SA, FARAHNAK S, NASIRI R, AHMADI S. Association of MMP-2 -753C>T and MMP-9 -1562C>T Polymorphisms with Chronic/Aggressive Periodontitis Risk: A Systematic Review and Meta-Analysis. Iran J Public Health. 48(7):1227-1238.
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