Prevalence and Association of Human Papillomavirus with Esophageal Squamous Cell Carcinoma in Iran: A Systematic Review and Meta-Analysis
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Abstract
Background: Human papillomavirus (HPV) can infect the epithelium of the esophagus, but so far there is no reliable and comprehensive evidence about the prevalence and association of HPV with esophageal cancer in Iran, as high incidence region. This study aimed to evaluate the prevalence and association of HPV with esophageal squamous cell carcinoma (ESCC) in Iran.
Methods: Relevant English and Persian articles published up to Aug 2017 and indexed in databases were reviewed. Frequency of HPV genotypes in ESCC cases and controls was surveyed according to regions of Iran. Data were meta-analyzed with random effects models using Comprehensive Meta-Analysis software.
Results: Overall, 14 studies were eligible including 1444 samples (1062 ESCC cases and 382 controls). HPV was positive in 269 (25.32%) of 1062 ESCC cases and in 65 (17.01%) of 382 controls. Total prevalence of HPV in both groups was estimated 0.256 (95%CI, 0.208%-0.310%). The prevalence of HPV-16 and HPV-18 was estimated 0.121 (95%CI: 0.087-0.183) and 0.046 (95%CI; 0.023-0.088), respectively. The difference in HPV prevalence in different regions of Iran was statistically significant (Q=18.20, df =4, P=0.001). In 6 case-control studies, the pooled odds ratio was estimated 1.99 (95%CI; 0.916-4.315).
Conclusion: High-risk HPVs were observed in ESCC cases and controls from different regions of Iran. The odds ratio indicates that the HPV infection in ESCC cases was approximately 2 fold more than the controls. More case-control studies in other populations with larger sample size are necessary.
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15. Moradi A, Mokhtari-Azad T (2006). Detection of HPV in cancerous and non-cancerous esophageal tissues from Turkmen-Sahra, Iran. In J Cancer Research,2(2):113-8.
16. Yahyapour Y, Shamsi-Shahrabadi M, Mahmoudi M et al (2012). Evaluation of human papilloma virus infection in patients with esophageal squamous cell carcinoma from the Caspian Sea area, north of Iran. Asian Pac J Cancer Prev,13(4):1261-6.
17. Farhadi M, Tahmasebi Z, Merat S et al (2005). Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population. World J Gastroenterol,11(8):1200-3.
18. Far AE, Aghakhani A, Hamkar R et al (2007). Frequency of human papillomavirus infection in oesophageal squamous cell carcinoma in Iranian patients. Scand J Infect Dis,39(1):58-62.
19. Abdirad A, Eram N, Behzadi AH et al (2012). Human papillomavirus detected in esophageal squamous cell carcinoma in Iran. Eur J Intern Med, 23(2):e59-62.
20. Haeri H, Mardani O, Asadi-Amoli F, Shahsiah R (2014). Human papilloma virus and esophageal squamous cell carcinoma. Acta Med Iran, 52(3):197-200.
21. T Farhadi M1, Tahmasebi Z, Merat S et al (2005). Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population. World J Gastroenterol 9(1): 11(8):1200-3.
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23. Yahyapour Y, Shamsi-Shahrabadi M, Mahmoudi M et al (2013). High-risk and low-risk human papillomavirus in esophageal squamous cell carcinoma at Mazandaran, Northern Iran. Pathol Oncol Res,19(3):385-91.
24. Mohseni Mehran S (2010). Detection of human papilloma virus in esophageal squamous cell carcinoma in Guilan province. J Clin Diagnost Res,4:2373-7.
25. Emadian O, Naghshvar F, Rafiei A et al (2011). Correlation of human papillomavirus infection with esophageal squamous cell carcinoma. J Babol Univ Med Sci (JBUMS), 13(4):54-9.
26. Noori S, Monabati A, Ghaderi A (2012). The prevalence of human papilloma virus in esophageal squamous cell carcinoma. Iran J Med Sci, 37(2):126-33.
27. Zhang SK, Guo LW, Chen Q et al (2015). The association between human papillomavirus 16 and esophageal cancer in Chinese population: a meta-analysis. BMC Cancer,15:1096.
28. Li X, Gao C, Yang Y et al (2014). Systematic review with meta-analysis: the association between human papillomavirus infection and oesophageal cancer. Aliment Pharmacol Ther.39(3):270-81.
29. Hardefeldt HA, Cox MR, Eslick GD (2014). Association between human papillomavirus (HPV) and oesophageal squamous cell carcinoma: a meta-analysis. Epidemiol Infect 142(6):1119-37.
30. Yong F, Xudong N, Lijie T (2013). Human papillomavirus types 16 and 18 in esophagus squamous cell carcinoma: a meta-analysis. Ann Epidemiol, 23(11):726-34.
31. Sitas F, Egger S, Urban MI et al (2012). InterSCOPE study: Associations between esophageal squamous cell carcinoma and human papillomavirus serological markers. J Natl Cancer Inst, 104(2):147-58.
32. Seifi S, Asvadi Kermani I, Dolatkhah R et al (2013). Prevalence of oral human papilloma virus in healthy individuals in East azerbaijan province of iran. Iran J Public Health, 42(1):79-85.
2. Gholipour M, Islami F, Roshandel G et al (2016). Esophageal Cancer in Golestan Province, Iran: A Review of Genetic Susceptibility and Environmental Risk Factors. Middle East J Dig Dis,8(4):249-66.
3. Liyanage SS, Rahman B, Ridda I et al (2013). The aetiological role of human papillomavirus in oesophageal squamous cell carcinoma: a meta-analysis. PLoS One,8(7):e69238.
4. Yahyapour Y, Sadeghi F, Alizadeh A et al (2016). Detection of Merkel Cell Polyomavirus and Human Papillomavirus in Esophageal Squamous Cell Carcinomas and Non-Cancerous Esophageal Samples in Northern Iran. Pathol Oncol Res, 22(4):667-72.
5. Petrick JL, Wyss AB, Butler AM et al (2014). Prevalence of human papillomavirus among oesophageal squamous cell carcinoma cases: systematic review and meta-analysis. Br J Cancer,110(9):2369-77.
6. Kolahdoozan S, Sadjadi A, Radmard AR, Khademi H (2010). Five common cancers in Iran. Arch Iran Med, 13(2):143-6.
7. Farhood B, Geraily G, Alizadeh A (2018). Incidence and mortality of various cancers in Iran and compare to other countries: A review article. Iran J Public Health, 47(3):309-16.
8. Jalilvand S, Shoja Z, Hamkar R (2014). Human papillomavirus burden in different cancers in Iran: a systematic assessment. Asian Pac J Cancer Prev,15(17):7029-35.
9. Soheili F, Heidary N, Rahbar M et al (2016). Human papillomavirus and its clinical relevance in oesophageal squamous cell carcinoma in a Kurdish population in the west of Iran. Infect Dis (Lond), 48(4):270-273.
10. Carroll KC, Butel J, Morse S. Jawetz Melnick & Adelbergs Medical Microbiology 27 E: McGraw Hill Professional; 2016.
11. Syrjänen K (2013). Geographic origin is a significant determinant of human papillomavirus prevalence in oesophageal squamous cell carcinoma: Systematic review and meta-analysis. Scand J Infect Dis, 45(1):1-18.
12. Zhang SK, Guo LW, Chen Q et al (2014). Prevalence of human papillomavirus 16 in esophageal cancer among the Chinese population: a systematic review and meta-analysis. Asian Pac J Cancer Prev,15(23):10143-9.
13. Omrani-Navai V, Alizadeh-Navaei R, Yah-yapour Y et al (2017). Human papillomavirus and gastrointestinal cancer in Iranian population: A systematic review and meta-analysis. Caspian J Intern Med, 8(2):67-85.
14. Moradi A, Villiers E-Md, Mokhtari-Azad T et al (2002). Detection of human papillomavirus DNA by PCR in esophageal squamous cell carcinoma from Turkmen Sahra, north-east of Iran. Iranian Biomedical Journal,6(1):19-23.
15. Moradi A, Mokhtari-Azad T (2006). Detection of HPV in cancerous and non-cancerous esophageal tissues from Turkmen-Sahra, Iran. In J Cancer Research,2(2):113-8.
16. Yahyapour Y, Shamsi-Shahrabadi M, Mahmoudi M et al (2012). Evaluation of human papilloma virus infection in patients with esophageal squamous cell carcinoma from the Caspian Sea area, north of Iran. Asian Pac J Cancer Prev,13(4):1261-6.
17. Farhadi M, Tahmasebi Z, Merat S et al (2005). Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population. World J Gastroenterol,11(8):1200-3.
18. Far AE, Aghakhani A, Hamkar R et al (2007). Frequency of human papillomavirus infection in oesophageal squamous cell carcinoma in Iranian patients. Scand J Infect Dis,39(1):58-62.
19. Abdirad A, Eram N, Behzadi AH et al (2012). Human papillomavirus detected in esophageal squamous cell carcinoma in Iran. Eur J Intern Med, 23(2):e59-62.
20. Haeri H, Mardani O, Asadi-Amoli F, Shahsiah R (2014). Human papilloma virus and esophageal squamous cell carcinoma. Acta Med Iran, 52(3):197-200.
21. T Farhadi M1, Tahmasebi Z, Merat S et al (2005). Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population. World J Gastroenterol 9(1): 11(8):1200-3.
22. Abbaszadegan M, Omidi A, Niyazi A et al (2003). Prevalence of human papillomavirus type 16 and 18 and p53 mutant protein expression in esophageal squamous cell carcinomas. Iran J Basic Med Sci, 6(1):38-42. (in Persian)
23. Yahyapour Y, Shamsi-Shahrabadi M, Mahmoudi M et al (2013). High-risk and low-risk human papillomavirus in esophageal squamous cell carcinoma at Mazandaran, Northern Iran. Pathol Oncol Res,19(3):385-91.
24. Mohseni Mehran S (2010). Detection of human papilloma virus in esophageal squamous cell carcinoma in Guilan province. J Clin Diagnost Res,4:2373-7.
25. Emadian O, Naghshvar F, Rafiei A et al (2011). Correlation of human papillomavirus infection with esophageal squamous cell carcinoma. J Babol Univ Med Sci (JBUMS), 13(4):54-9.
26. Noori S, Monabati A, Ghaderi A (2012). The prevalence of human papilloma virus in esophageal squamous cell carcinoma. Iran J Med Sci, 37(2):126-33.
27. Zhang SK, Guo LW, Chen Q et al (2015). The association between human papillomavirus 16 and esophageal cancer in Chinese population: a meta-analysis. BMC Cancer,15:1096.
28. Li X, Gao C, Yang Y et al (2014). Systematic review with meta-analysis: the association between human papillomavirus infection and oesophageal cancer. Aliment Pharmacol Ther.39(3):270-81.
29. Hardefeldt HA, Cox MR, Eslick GD (2014). Association between human papillomavirus (HPV) and oesophageal squamous cell carcinoma: a meta-analysis. Epidemiol Infect 142(6):1119-37.
30. Yong F, Xudong N, Lijie T (2013). Human papillomavirus types 16 and 18 in esophagus squamous cell carcinoma: a meta-analysis. Ann Epidemiol, 23(11):726-34.
31. Sitas F, Egger S, Urban MI et al (2012). InterSCOPE study: Associations between esophageal squamous cell carcinoma and human papillomavirus serological markers. J Natl Cancer Inst, 104(2):147-58.
32. Seifi S, Asvadi Kermani I, Dolatkhah R et al (2013). Prevalence of oral human papilloma virus in healthy individuals in East azerbaijan province of iran. Iran J Public Health, 42(1):79-85.
| Files | ||
| Issue | Vol 48 No 7 (2019) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v48i7.2943 | |
| Keywords | ||
| Human papillomavirus (HPV); Esophageal cancer Esophageal squamous cell carcinoma (ESCC) | ||
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How to Cite
1.
MOHAMMADPOUR B, ROUHI S, KHODABANDEHLOO M, MORADI M. Prevalence and Association of Human Papillomavirus with Esophageal Squamous Cell Carcinoma in Iran: A Systematic Review and Meta-Analysis. Iran J Public Health. 2019;48(7):1215-1226.
