Comparative Analysis of Clinical Effects of Mineral Trioxide Aggregate in the Treatment of Endodontic Diseases
Abstract
Background: We aimed to evaluate the efficacy of mineral trioxide aggregate (MTA) in the treatment of endodontic disease.
Methods: Oversell, 384 patients with endodontic disease treated in Xuzhou Stomatological Hospital, Xuzhou, China, from June 2015 to June 2017 were selected, and randomly divided into four groups with 96 cases per group. The repair effects of MTA, zinc phosphate cement (ZPC), silver amalgam and light-curing calcium hydroxide (LCH) on the teeth and dental pulp of patients in the four groups were compared. Meanwhile, the ill symptoms of the patients were observed to confirm whether they could be alleviated. Besides, whether the repair effects were related to ages of patients, perforation diameters of diseased teeth and repair materials was discussed.
Results: The success rates of MTA group, ZPC group, LCH group and silver amalgam group were 90.6%, 68.7%, 70.8% and 52.1%, respectively. The success rate of MTA group was significantly higher than that of ZPC group, silver amalgam group and LCH group. When the success rates of four groups were compared, the differences were statistically significant (P=0.0072). The patient's age, repair material and perforation diameter were positively correlated with MTA repair effect (P=0.003, P=0.002, P=0.01). The patients' teeth in each group were repaired with different materials, and the reexamination was conducted 4 weeks later. Three patients in the silver amalgam group were found to have gingival swelling.
Conclusion: The therapeutic effect of MTA was significant in the treatment of endodontic disease, and it is worthy of clinical application.
2. Pontius V, Pontius O, Braun A, Franken-berger R, Roggendorf MJ (2013). Retro-spective evaluation of perforation repairs in 6 private practices. J Endod, 39(11): 1346-58.
3. Versiani MA, Sousa-Neto MD, Pecora JD (2011). Pulp pathosis in inlayed teeth of the ancient Mayas: A microcomputed tomography study. Int Endod J, 44(11): 1000-4.
4. Moller MH, Vester-Andersen M, Thomsen RW (2013). Long-term mortality follow-ing peptic ulcer perforation in the PULP trial. A nationwide follow-up study. Scand J Gastroenterol, 48(2): 168-75.
5. Mente J, Hage N, Pfefferle T et al (2010). Treatment outcome of mineral trioxide aggregate: Repair of root perforations. J Endod, 36(2): 208-13.
6. Darvell BW, Wu RC (2011). "MTA"-an Hy-draulic Silicate Cement: Review update and setting reaction. Dent Mater, 27(5): 407-22.
7. Paranjpe A, Zhang H, Johnson JD (2010). Effects of mineral trioxide aggregate on human dental pulp cells after pulp-capping procedures. J Endod, 36(6): 1042-7.
8. Huang TH, Ding SJ, Hsu TC, Kao CT (2003). Effects of mineral trioxide aggre-gate (MTA) extracts on mitogen-activated protein kinase activity in human osteosar-coma cell line (U2OS). Biomaterials, 24(22): 3909-13.
9. Sarkar NK, Caicedo R, Ritwik P, Moiseyeva R, Kawashima I (2005). Physicochemical basis of the biologic properties of miner-al trioxide aggregate. J Endod, 31(2): 97-100.
10. Karabucak B, Li D, Lim J, Iqbal M (2005). Vital pulp therapy with mineral trioxide aggregate. Dent Traumatol, 21(4): 240-3.
11. Shayegan A, Petein M, Vanden AA (2009). The use of beta-tricalcium phosphate, white MTA, white Portland cement and calcium hydroxide for direct pulp capping of primary pig teeth. Dent Traumatol, 25(4): 413-9.
12. Leye BF, Gaye NF, Kane AW, Benoist HM, Farge P (2012). Evaluation of mineral tri-oxide aggregate (MTA) versus calcium hydroxide cement (Dycal((R))) in the formation of a dentine bridge: A ran-domised controlled trial. Int Dent J, 62(1): 33-9.
13. Ortiz A, Torres PE, Orellana GE (2016). First evidence of pre-Hispanic dentistry in South America - Insights from Cusco, Peru. Homo, 67(2): 100-9.
14. Asrari M, Lobner D (2003). In vitro neuro-toxic evaluation of root-end-filling mate-rials. J Endod, 29(11): 743-6.
15. Masuda YM, Wang X, Hossain M, Unno A, Jayawardena JA, Saito K, Nakamura Y, Matsumoto K (2005). Evaluation of bio-compatibility of mineral trioxide aggregate with an improved rabbit ear chamber. J Oral Rehabil, 32(2): 145-50.
16. Mehrvarzfar P, Dahi-Taleghani A, Saghiri MA, Karamifar K, Shababi B, Behnia A (2010). The comparison of MTA, Ger-istore(R) and Amalgam with or without Bioglass as a matrix in sealing the furcal perforations (in vitro study). Saudi Dent J, 22(3): 119-24.
17. Nazari MK, Aghili H, Rashed MA, Zahed-pasha S, Moghadamnia AA (2014). A comparative study on sealing ability of mineral trioxide aggregate, calcium en-riched cement and bone cement in furcal perforations. Minerva Stomatol, 63(6): 203-10.
18. Fuss Z, Abramovitz I, Metzger Z (2000). Sealing furcation perforations with silver glass ionomer cement: An in vitro evalua-tion. J Endod, 26(8): 466-8.
19. Moller MH, Engebjerg MC, Adamsen S, Bendix J, Thomsen RW (2012). The Pep-tic Ulcer Perforation (PULP) score: A predictor of mortality following peptic ul-cer perforation. A cohort study. Acta Anaes-thesiol Scand, 56(5): 655-62.
20. Krupp C, Bargholz C, Brusehaber M, Hulsmann M (2013). Treatment outcome after repair of root perforations with mineral trioxide aggregate: A retrospective evaluation of 90 teeth. J Endod, 39(11): 1364-8.
21. Unal GC, Maden M, Isidan T (2010). Repair of furcal iatrogenic perforation with min-eral trioxide aggregate: Two years follow-up of two cases. Eur J Dent, 4(4): 475-81.
22. Post LK, Lima FG, Xavier CB, Demarco FF, Gerhardt-Oliveira M (2010). Sealing ability of MTA and amalgam in different root-end preparations and resection bev-el angles: An in vitro evaluation using marginal dye leakage. Braz Dent J, 21(5): 416-9.
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Issue | Vol 48 No 4 (2019) | |
Section | Original Article(s) | |
DOI | https://doi.org/10.18502/ijph.v48i4.1003 | |
Keywords | ||
Oral biomaterials Mineral trioxide aggregate (MTA) Root canals Endodontic disease |
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