Effect of Selenium on Thyroid Disorders: Scientometric Analysis

  • Farzad PAKDEL Department of Oculofacial, Eye Research Center, Farabi Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Roghayeh GHAZAVI Vice Chancellery of Research and Technology, Isfahan University of Medical Sciences, Isfahan, Iran
  • Roghayeh HEIDARY International Virtual Ophthalmic Research Center, Tehran, Iran
  • Athena NEZAMABADI Department of Oculofacial, Eye Research Center, Farabi Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Maryam PARVIZI Department of Pathology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Mahsa HAJI SAFAR ALI MEMAR Department of Oculofacial, Eye Research Center, Farabi Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Reza GHAREBAGHI International Virtual Ophthalmic Research Center, Tehran, Iran
  • Fatemeh HEIDARY Mail Immunoregulation Research Center, Shahed University, Tehran, Iran AND Department of Ophthalmology, Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Selenium, Thyroid disorders, Scientometric analysis, Field maps, International collaborations


Background: Association of Selenium (Se) deficiency, an essential trace element, has been found with human diseases. Identifying literature trends on the effects of Se on the thyroid may guide in planning future studies.

Methods: A literature search was conducted using the Web of Science database to identify studies on Se and the thyroid published over the 20 years duration (1995-Dec 2014). Scientometric indices were used to draw field maps. The scientific processes, structure, evidence history, and international collaborations were included in the map. The most influential authors, journals, institutions, and countries were also examined.

Results: Our search identified 184 research and review papers. The number of scientific studies on Se and the thyroid has been irregular, but interest in this topic has increased in recent years. The highest number of studies was published in 2014 (16 papers) and overall growth factor of publication was 3.78. Overall, 744 authors from 282 institutions in 43 countries published in this field. The author J. Kohrle (828 citations, 14 publications), and German scientists (1272 citations, 30 publications) were most influential.

Conclusion: This study reveals the interrelationships between different publications on the effects of Se on the thyroid. Leading scientific issues and their extent of impact were successfully determined by examining citations. The results of systematic citations and mapping fields can be used to assist in policy and management contexts.


1. Köhrle J, Gärtner R (2009). Selenium and thyroid. Best Pract Res Clin Endocrinol Metab, 23(6):815-27.
2. Petricca D, Nacamulli D, Mian C et al (2012). Effects of selenium supplementa-tion on the natural course of autoim-munethyroiditis: a short review. J Endo-crinol Invest, 35(4):419-24.
3. Köhrle J, Jakob F, Contempré B et al (2005). Selenium, the thyroid, and the endocrine system. Endocr Rev, 26(7):944-84.
4. Köhrle J (2005). Selenium and the control of thyroid hormone metabolism. Thyroid, 15(8):841-53.
5. Köhrle J (2013). Selenium and the thyroid. Curr Opin Endocrinol Diabetes Obes, 20(5):441-8.
6. Mazokopakis EE, Chatzipavlidou V (2007). Hashimoto's thyroiditis and the role of selenium. Current concepts. Hell J Nucl Med, 10(1):6-8.
7. Schomburg L, Köhrle J (2008). On the im-portance of selenium and iodine metabo-lism for thyroid hormone biosynthesis and human health. Mol Nutr Food Res, 52(11):1235-46.
8. Duntas LH (2010). Selenium and the thy-roid: a close-knit connection. J Clin Endo-crinol Metab, 95(12):5180-8.
9. Ventura M, Melo M, Carrilho F (2017). Sele-nium and Thyroid Disease: From Patho-physiology to Treatment. Int J Endocrinol, 2017:1297658.
10. Zheng H, Wei J, Wang L et al (2018). Ef-fects of Selenium Supplementation on Graves' Disease: A Systematic Review and Meta-Analysis. Evidence-Based Comple-mentary and Alternative Medicine, 2018:3763565.
11. Li Z, Cestari DM, Fortin E (2018). Thyroid eye disease: what is new to know? Curr Opin Ophthalmol, 29(6):528-534.
12. Stuss M, Michalska-Kasiczak M, Sewerynek E (2017). The role of selenium in thyroid gland pathophysiology. Endokrynol Pol, 68(4):440-465.
13. Raja S, Ramkumar P, Viji P (2011). Scien-tometric dimension on gender in world-wide thyroid cancer: A study based on web of science database. Indian Journal of Science and Technology, 4:425-8.
14. Qin Z (2012). Bibliometric Analysis of Anti-oxidant Effect of Selenium Based on SCI. Journal of Anhui Agricultural Sciences, 40:13164-6.
15. Kumar KV, Misra A (2013). Endocrine and diabetes research from SAARC (South AsianAssociation for Regional Coopera-tion) countries. Indian J Endocrinol Metab, 17(5):950-1.
16. Bhutani G, Verma P, Kalra S (2014). Biblio-metric analysis of thyroid research and practice. Thyroid Research and Practice, 11:17-21.
17. Winther KH, Bonnema SJ, Hegedüs L (2017). Is selenium supplementation in autoimmune thyroid diseases justified? Curr Opin Endocrinol Diabetes Obes, 24(5):348-355.
18. Negro R, Greco G, Mangieri T et al (2007). The influence of selenium supplementa-tion on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies. J Clin Endocrinol Metab, 92(4):1263-8.
19. Mao J, Pop VJ, Bath SC et al (2016). Effect of low-dose selenium on thyroid auto-immunity and thyroid function in UK pregnant women with mild-to-moderate iodine deficiency. Eur J Nutr, 55(1):55-61.
20. Falagas ME, Pitsouni EI, Malietzis GA et al (2007). Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknesses. FASEB J, 22(2):338-42.
How to Cite
PAKDEL F, GHAZAVI R, HEIDARY R, NEZAMABADI A, PARVIZI M, HAJI SAFAR ALI MEMAR M, GHAREBAGHI R, HEIDARY F. Effect of Selenium on Thyroid Disorders: Scientometric Analysis. Iran J Public Health. 48(3):410-420.
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