Original Article

Effect of Comprehensive Cerebral Protection Program on Cerebral Oxygen Metabolism and Vascular Endothelial Function in Elderly Patients with Acute Cerebral Infarction

Abstract

Background: We aimed to explore the effect of comprehensive cerebral protection on cerebral oxygen metabolism and vascular endothelial function in elderly patients with acute cerebral infarction.

Methods: A total of 168 elderly patients with acute cerebral infarction treated in The First Affiliated Hospital of Nanchang University, China from January 2016 to January 2018 were selected. The patients were divided into a control group and an observation group using random number method, n=84. Patients in the observation group were given comprehensive cerebral protection treatment, and patients in the control group were treated with conventional standardized treatments. The changes of cerebral oxygen metabolism, hemorheology and vascular endothelial function before and after treatment were compared between the two groups.

Results: After treatment, oxygen content in arteries and internal jugular veins (Da-vO2), ofoxygen uptake fraction (OEF), Oxygen saturation (SpO2), nitric oxide (NO) were increased in both groups in comparison to before treatment, jugular venous oxygen saturation (SjvO2), brain oxygen uptake rate (ERO2), endothelin (ET), intracranial pressure (ICP), whole blood viscosity, plasma viscosity, reduced viscosity of whole blood, and hematocrit were decreased. However, the changes in the observation group were larger than those in the control group, the difference was statistically significant (P<0.05).

Conclusion: The treatment of cerebral infarction in elderly patients with acute cerebral infarction can effectively improve the cerebral oxygen metabolism and vascular endothelial function and improve the blood rheology, which has important clinical value.

 

1.Sun Y, Xu Y, Geng L (2015). Caspase-3 inhibitor prevents the apoptosis of brain tissue in rats with acute cerebral infarc-tion. Exp Ther Med, 10(1): 133-138.
2. Barrese V, Taglialatela M, Greenwood IA, Davidson C (2015). Protective role of Kv7 channels in oxygen and glucose deprivation-induced damage in rat cau-date brain slices. J Cereb Blood Flow Metab, 35(10): 1593-600.
3. Liu XT, Wang W, Wang LJ et al (2011). [Cor-relation of collateral circulation and prog-nosis in patients with acute cerebral in-farction]. Z honghua Yi Xue Za Zhi 91(11):766-8.
4. Hu SL, Huang YX, Hu R, Li F, Feng H (2015). Osteopontin Mediates Hyperbaric Oxygen Preconditioning-Induced Neu-roprotection Against Ischemic Stroke. Mol Neurobiol, 52(1): 236-43.
5. Deng Q, Zhang Y, Ding H, Dong Q, Fu J (2015). Calcific emboli originating from the brachiocephalic trunk causing acute cerebral infarction and worm-like calcifi-cation in the right middle cerebral artery. J Clin Neurosci, 22(5): 889-90.
6. Ishihara M, Fujino M, Ogawa H et al (2015). Clinical Presentation, Management and Outcome of Japanese Patients With Acute Myocardial Infarction in the Tro-ponin Era - Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET). Circ J, 79(6): 1255-62.
7. Fan AP, Govindarajan ST, Kinkel RP et al (2015). Quantitative oxygen extraction fraction from 7-Tesla MRI phase: repro-ducibility and application in multiple scle-rosis. J Cereb Blood Flow Metab, 35(1): 131-9.
8. Talley Watts L, Long JA, Manga VH, Huang S, Shen Q, Duong TQ (2015). Normo-baric oxygen worsens outcome after a moderate traumatic brain injury. J Cereb Blood Flow Metab, 35(7): 1137-44.
9. Johansen FF, Hasseldam H, Rasmussen RS, Bisgaard AS, Bonfils PK, Poulsen SS, Hansen-Schwartz J (2014). Drug-induced hypothermia as beneficial treatment be-fore and after cerebral ischemia. Pathobiol-ogy, 81(1): 42-52.
10. Sakurai T, Kudo M, Watanabe T et al (2013). Hypothermia protects against fulminant hepatitis in mice by reducing reactive ox-ygen species production. Dig Dis, 31(5-6): 440-6.
11. Hadanny A, Golan H, Fishlev G, Bechor Y, Volkov O, Suzin G, Ben-Jacob E, Efrati S (2015). Hyperbaric oxygen can induce neuroplasticity and improve cognitive functions of patients suffering from an-oxic brain damage. Restor Neurol Neuros, 33(4):471-486.
12. Zhu M, Lu M, Li QJ, Zhang Z, Wu ZZ, Li J, Qian L, Xu Y, Wang ZY (2015). Hy-perbaric oxygen suppresses hypoxic-ischemic brain damage in newborn rats. J Child Neurol, 30(1): 75-82.
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IssueVol 48 No 2 (2019) QRcode
SectionOriginal Article(s)
DOI https://doi.org/10.18502/ijph.v48i2.828
Keywords
Acute cerebral infarction Senile Comprehensive cerebral protection Cerebral oxygen metabolism Endothelial function
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
ZHOU M, HUANG Z. Effect of Comprehensive Cerebral Protection Program on Cerebral Oxygen Metabolism and Vascular Endothelial Function in Elderly Patients with Acute Cerebral Infarction. Iran J Public Health. 2019;48(2):299-304.