The Association between Human Papillomavirus Infection and Smoking, Age, Gender in Lung Cancer Patients: A Meta-Analysis
-
Rui ZHANG
,
Ling CHEN
,
Ya-Deng CUI
,
Ge LI
Abstract
Background: The aim of our study was to identify the association between Human papillomavirus (HPV) positive rate and smoking in lung cancer (LC) patients. Meanwhile, to analyze differences among gender, age differences on HPV infection rate in LC patients.
Methods: We performed a systematic literature search through PubMed, Wan Fang, China National Knowledge Infrastructure (CNKI), MEDLINE, EMBASE (OVID), and Web of Science databases from 1991-2017, and we searched these keywords such as “lung cancer”, “HPV”, “smoking”, and “human papillomavirus”. Review Manager 5.3 software was used to analyze. An estimate of the odds ratio (OR) with 95% confidence intervals (CI) was calculated.
Results: In China, a statistical significance was observed between HPV positive rate and smoking in LC patients (OR=2.34, 95%CI: 1.76–3.09, P<0.001; I2 =25%). However, after stratified by region, no significance was observed in other regions, gender, and age.
Conclusion: HPV infections are associated with smoking in LC patients. The association between HPV infection and smoking in LC patients may relate to different regions. There were no differences between gender and age among HPV infection rates in LC patients. To identify the etiology of smoking, HPV, and LC, a further experimental research needs to be conducted.
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26. Argyri E, Tsimplaki E, Marketos C et al (2017). Investigating the role of human papillomavirus in lung cancer. Papilloma-virus Res, 3: 7-10.
27. Burger MP, Hollema H, Gouw AS et al (1993). Cigarette smoking and human papillomavirus in patients with reported cervical cytological abnormality. BMJ, 306(6880):749-52.
28. Kinoshita I, Dosaka Akita H, S hindoh M et al (1995). Human papillomavirus type 18 DNA and E6-E7 mRNA are detected in squamous cell carcinoma and adenocar-cinoma of the lung. Br J Cancer, 7(12): 344-9.
29. Ragin C, Obikoya-Malomo M, Kim S et al (2014). HPV-associated lung cancers: an international pooled analysis. Carcinogenesis, 35(6):1267-75.
30. Hasegawa Y, Ando M, Kubo A et al (2014). Human papilloma virus in non-small cell lung cancer in never smokers: A system-atic review of the literature. Lung Cancer, 83(1):8-13.
31. Boyle P, Leon ME, Maisonneuve P et al (2003). Cancer control in women. Update 2003. Int J Gynecol Obstet, 83(Suppl 1): 179-202.
2. Grulich AE, Jin F, Conway EL et al (2010). Cancers attributable to human papilloma-virus infection. Sex Health, 7(3):244-252.
3. Syrjanen KJ (1980). Epithelial lesions sug-gestive of a condylomatous origin found closely associated with invasive bronchial squamous cell carcinomas. Respiration, 40(3):150-160.
4. Zhai K, Ding J, Shi H (2015). HPV and lung cancer risk: a meta-analysis. J Clin Virol, 63:84-90.
5. Moher D, Liberati A, Tetzlaff J et al (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med, 6(7):e1000097.
6. Liberati A, Altman DG, Tetzlaff J,et al (2009). The PRISMA statement for re-porting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elabo-ration. BMJ, 339:b2700.
7. Higgins JP, Thompson SG (2002). Quanti-fying heterogeneity in a meta-analysis. Stat Med, 21(11):1539-58.
8. Nadji SA, Mokhtari-Azad T, Mahmoodi M et al (2007). Relationship between lung cancer and human papillomavirus in north of Iran, Mazandaran province. Can-cer Lett, 248(1) 41-46.
9. Sarchianaki E, Derdas SP, Ntaoukakis M et al (2014). Detection and genotype analysis of human papillomavirus in non-small cell lung cancer patients. Tumour Biol, 35(4):3203-9.
10. Fei Y, Yang J, Hsieh WC et al (2006). Dif-ferent Human Papillomavirus 16/18 In-fection in Chinese Non-Small Cell Lung Cancer Patients Living in Wuhan, China. Jpn J Clin Oncol, 36(5)274-279.
11. Liu J, Wu CH, Lu Y et al (2007). The corre-lation of HPV infection with the expres-sion of epidermal growth factor receptor and vascular endothelial growth factor in non- small cell lung cancer. Tumor, 27(10):821-824.
12. Chen WQ, Qi HW, Wu CG et al (2005). The Studies on Human Papillomavirus Infec-tion in Squamous Cancer of the Lung. Chin J Clin Oncol, 32(17):966-968.
13. Zhang JF, Yang QL, Huang L et al (2012). The relationship between human papil-lomavirus type 16 infection and nonsmall cell lung cancer. Chin Clin Oncol, 17(3):233-236.
14. Xiong WM, He F, Xiao RD et al (2016). As-sociation between human papillomavirus an lung cancer. Chin J Epidemiology, 37(12):1658-1661.
15. Zhou Y, Zhang H. Xie YH et al(2015). Ex-pression of P53 and hypoxia-inducible factor-1α in human papillomavirus infec-tion and its correlation with non-small cell lung cancer. Chin J Gerontology, 35(2): 335-337.
16. Zhou J , You J , Hong ZP et al (2015). Anal-ysis on the HPV16/18 infection and gene polymorphism of p53codon72 in hospi-talized patients with lung cancer in Yun-nan Province. Chin J Cancer Prevention Treatment, 22(1):19-22.
17. Yan Y, Yang AM, Hu SK et al (2009). Cor-relation of HPV-16/18 infection of hu-man papillomavirus with lung squamous cell carcinomas in Western China. Oncol Rep, 21(6):1627-32.
18. Wang XH, Wu CH, Huang BX et al (2005). Relationship among HPV infection, FHIT protein expression and non-small cell lung cancer. Chin J Histochemistry and Cytochemistry, 14(4):375-380.
19. Yuan CY, Wu CH, Guo JL et al (2006). In-fection of HPV and Its Relationship with Expression of P53 and Survivin in NSCLC. Acta Med Univ Sci Technol Huazhong, 35(6): 740-743.
20. Huang BX , Wu CH, Wang XH et al (2006). Detection of High Risk Papillomavirus Infection in Non-small Cell Lung Can-cers. Acta Med Univ Sci Technol Huazhong, 35(4):436-439.
21. Zhen ZW, Wu J, Yang HL (2015). Significance of the expression of human papilloma virus proto-oncogene proteins E6E7 in non-small-cell lung cancer in Hakka region. Chin J Diagnostics (Electronic Edition), 3(1): 7-11.
22. Jiang R, Wu CH, Zheng LD et al (2005). Re-lationship between HPV Infection and Non-small Cell Lung Cancer. Acta Med Univ Sci Technol Huazhong, 34(2): 141-144.
23. Zhou J, Hong ZP, Sun XH, et al(2014). Study on relationship between human papillomavirus infection and non- small cell lung cancer in Yunan area. Chin J Nos-ocomiol, 24(22): 5470-5472.
24. Zhang R. Infection of high risk HPV and its relationship with the expression of P53 protein primary lung cancer [master the-sis]. Third Affiliated hospital, Xinjiang Medical University, China; 2016.
25. Kong HL. A study on the correlation be-tween expression of E2F-1, Survivin pro-tein and HPV infection in NSCLC [mas-ter thesis]. Huazhong University of Sci-ence and Technology, China; 2009.
26. Argyri E, Tsimplaki E, Marketos C et al (2017). Investigating the role of human papillomavirus in lung cancer. Papilloma-virus Res, 3: 7-10.
27. Burger MP, Hollema H, Gouw AS et al (1993). Cigarette smoking and human papillomavirus in patients with reported cervical cytological abnormality. BMJ, 306(6880):749-52.
28. Kinoshita I, Dosaka Akita H, S hindoh M et al (1995). Human papillomavirus type 18 DNA and E6-E7 mRNA are detected in squamous cell carcinoma and adenocar-cinoma of the lung. Br J Cancer, 7(12): 344-9.
29. Ragin C, Obikoya-Malomo M, Kim S et al (2014). HPV-associated lung cancers: an international pooled analysis. Carcinogenesis, 35(6):1267-75.
30. Hasegawa Y, Ando M, Kubo A et al (2014). Human papilloma virus in non-small cell lung cancer in never smokers: A system-atic review of the literature. Lung Cancer, 83(1):8-13.
31. Boyle P, Leon ME, Maisonneuve P et al (2003). Cancer control in women. Update 2003. Int J Gynecol Obstet, 83(Suppl 1): 179-202.
| Files | ||
| Issue | Vol 48 No 1 (2019) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/ijph.v48i1.777 | |
| Keywords | ||
| Human papillomavirus Smoking Meta-analysis Gender Age | ||
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How to Cite
1.
ZHANG R, CHEN L, CUI Y-D, LI G. The Association between Human Papillomavirus Infection and Smoking, Age, Gender in Lung Cancer Patients: A Meta-Analysis. Iran J Public Health. 2019;48(1):1-8.
