Mucoromycosis and Wegner’s Granulomatosis: A Case Report
-
Nasrin SHAYANFAR
,
Abbas ZAMANIAN
,
Elham BEHRANGI
,
Nahid KIANMEHR
,
Faezeh FIROUZI
,
Zahra AZIZIAN
Abstract
Wegener's granulomatosis is a rare vasculitis affecting the upper and lower respiratory tracts and kidneys. The cornerstone of treatment in these patients is immunosuppressive therapy, which may predispose the patient to super-infections such as fungal diseases per se. However, the fungal infection mimics the clinical manifestations of Wegener's diseases would lead to neglected course of the infection and subsequent morbidity and mortality especially if unusual organs are involved. Here we report a 21-yr-old female patient referred to a hospital, Tehran, Iran in 2013 with a neglected skin mucormycosis and the course of the disease and outcome with Wegener's granulomatosis.
1. Vaezi A1, Moazeni M, Rahimi MT, et al (2016). Mucormycosis in Iran: a systemat-ic review. Mycoses, 59(7):402-15
2. Graves N (2006). Wegener granulomatosis. Proc (Bayl Univ Med Cent), 19(4):342-4.
3. Lamprecht P, Gross WL (2004). Wegener's granulomatosis. Herz, 29(1):47-56.
4. Gross WL, Trabandt A, Csernok E (1998). Pathogenesis of Wegener's granulomato-sis. Ann Med Interne (Paris), 149(5):280-6.
5. Kallenberg CG, Heeringa P, Stegeman CA (2006). Mechanisms of Disease: patho-genesis and treatment of ANCA-associated vasculitides. Nat Clin Pract Rheumatol, 2(12):661-70.
6. Lamprecht P (2004). New aspects in AN-CA-associated vasculitides. Med Klin (Mu-nich), 99(9):518-22.
7. Wung PK, Stone JH (2006). Therapeutics of Wegener's granulomatosis. Nat Clin Pract Rheumatol, 2(4):192-200.
8. Kondo Y, Matsuse H, Machida I, et al (2002). A case of Wegener's granulo-matosis complicated with cytomegalovi-rus pneumonia during the treatment with immunosuppressants. Nihon Kokyuki Gakkai Zasshi, 40(7):569-73.
9. Vinh DC, Freeman AF, Shea YR, et al (2009). Mucormycosis in chronic granu-lomatous disease: association with iatro-genic immunosuppression. J Allergy Clin Immunol, 123(6):1411-3.
10. Potenza L, Vallerini D, Barozzi P, et al (2011). Mucorales-specific T cells emerge in the course of invasive mucormycosis and may be used as a surrogate diagnos-tic marker in high-risk patients. Blood, 118(20):5416-9.
11. Li WF, He C, Liu XF, et al (2010). A diagno-sis neglected for 6 years: report of a mis-diagnosed case of pulmonary mu-cormycosis and review of the literature. Chin Med J (Engl), 123(17):2480-2.
12. Nogueira EL, Ind PW, Friedland JS, Salama AD (2010). Mucormycosis may mimic disease relapse in Wegener's granulo-matosis. J Rheumatol, 37(6):1364-5.
13. Abtahi SM, Omrani M, Karimifar M, et al (2012). Wegener's granulomatosis and mucoromycosis: A case study and review of literature. Adv Biomed Res, 1:23.
14. Piao YS, Tian C, Li X, et al (2012). Clinical and pathologic characteristics of 4 cases of Wegener's granulomatosis associated with specific pathogenic infections. Zhonghua Bing Li Xue Za Zhi, 41(2):123-4.
15. Zirak C, Brutus JP, De Mey A (2005). Atypi-cal cause of forearm skin ulceration in a leukemic child: mucormycosis. A case re-port. Acta Chir Belg, 105(5):551-3.
16. Francès C, Du LT, Piette JC, et al (1994). Wegener's granulomatosis. Dermatologi-cal manifestations in 75 cases with clini-copathologic correlation. Arch Dermatol, 130(7):861-7.
17. Comfere NI, Macaron NC, Gibson LE (2007). Cutaneous manifestations of We-gener's granulomatosis: a clinicopatho-logic study of 17 patients and correlation to antineutrophil cytoplasmic antibody status. J Cutan Pathol, 34(10):739-47.
18. 18.Spellberg B, Edwards J Jr, Ibrahim A (2005). Novel perspectives on mu-cormycosis: pathophysiology, presenta-tion, and management. Clin Microbiol Rev. 18(3):556-69.
19. Kerr OA, Bong C, Wallis C, Tidman MJ (2004). Primary cutaneous mucormycosis masquerading as pyoderma gangreno-sum. Br J Dermatol, 150(6):1212-3.
20. Alsuwaida K (2002). Primary cutaneous mu-cormycosis complicating the use of adhe-sive tape to secure the endotracheal tube. Can J Anaesth, 49(8):880-2.
2. Graves N (2006). Wegener granulomatosis. Proc (Bayl Univ Med Cent), 19(4):342-4.
3. Lamprecht P, Gross WL (2004). Wegener's granulomatosis. Herz, 29(1):47-56.
4. Gross WL, Trabandt A, Csernok E (1998). Pathogenesis of Wegener's granulomato-sis. Ann Med Interne (Paris), 149(5):280-6.
5. Kallenberg CG, Heeringa P, Stegeman CA (2006). Mechanisms of Disease: patho-genesis and treatment of ANCA-associated vasculitides. Nat Clin Pract Rheumatol, 2(12):661-70.
6. Lamprecht P (2004). New aspects in AN-CA-associated vasculitides. Med Klin (Mu-nich), 99(9):518-22.
7. Wung PK, Stone JH (2006). Therapeutics of Wegener's granulomatosis. Nat Clin Pract Rheumatol, 2(4):192-200.
8. Kondo Y, Matsuse H, Machida I, et al (2002). A case of Wegener's granulo-matosis complicated with cytomegalovi-rus pneumonia during the treatment with immunosuppressants. Nihon Kokyuki Gakkai Zasshi, 40(7):569-73.
9. Vinh DC, Freeman AF, Shea YR, et al (2009). Mucormycosis in chronic granu-lomatous disease: association with iatro-genic immunosuppression. J Allergy Clin Immunol, 123(6):1411-3.
10. Potenza L, Vallerini D, Barozzi P, et al (2011). Mucorales-specific T cells emerge in the course of invasive mucormycosis and may be used as a surrogate diagnos-tic marker in high-risk patients. Blood, 118(20):5416-9.
11. Li WF, He C, Liu XF, et al (2010). A diagno-sis neglected for 6 years: report of a mis-diagnosed case of pulmonary mu-cormycosis and review of the literature. Chin Med J (Engl), 123(17):2480-2.
12. Nogueira EL, Ind PW, Friedland JS, Salama AD (2010). Mucormycosis may mimic disease relapse in Wegener's granulo-matosis. J Rheumatol, 37(6):1364-5.
13. Abtahi SM, Omrani M, Karimifar M, et al (2012). Wegener's granulomatosis and mucoromycosis: A case study and review of literature. Adv Biomed Res, 1:23.
14. Piao YS, Tian C, Li X, et al (2012). Clinical and pathologic characteristics of 4 cases of Wegener's granulomatosis associated with specific pathogenic infections. Zhonghua Bing Li Xue Za Zhi, 41(2):123-4.
15. Zirak C, Brutus JP, De Mey A (2005). Atypi-cal cause of forearm skin ulceration in a leukemic child: mucormycosis. A case re-port. Acta Chir Belg, 105(5):551-3.
16. Francès C, Du LT, Piette JC, et al (1994). Wegener's granulomatosis. Dermatologi-cal manifestations in 75 cases with clini-copathologic correlation. Arch Dermatol, 130(7):861-7.
17. Comfere NI, Macaron NC, Gibson LE (2007). Cutaneous manifestations of We-gener's granulomatosis: a clinicopatho-logic study of 17 patients and correlation to antineutrophil cytoplasmic antibody status. J Cutan Pathol, 34(10):739-47.
18. 18.Spellberg B, Edwards J Jr, Ibrahim A (2005). Novel perspectives on mu-cormycosis: pathophysiology, presenta-tion, and management. Clin Microbiol Rev. 18(3):556-69.
19. Kerr OA, Bong C, Wallis C, Tidman MJ (2004). Primary cutaneous mucormycosis masquerading as pyoderma gangreno-sum. Br J Dermatol, 150(6):1212-3.
20. Alsuwaida K (2002). Primary cutaneous mu-cormycosis complicating the use of adhe-sive tape to secure the endotracheal tube. Can J Anaesth, 49(8):880-2.
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| Issue | Vol 47 No 11 (2018) | |
| Section | Case Report(s) | |
| Keywords | ||
| Mucoromycosis Wegner’s granulomatosis Case report Iran | ||
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How to Cite
1.
SHAYANFAR N, ZAMANIAN A, BEHRANGI E, KIANMEHR N, FIROUZI F, AZIZIAN Z. Mucoromycosis and Wegner’s Granulomatosis: A Case Report. Iran J Public Health. 2018;47(11):1763-1766.
