TRAIAL OF PHENYLEN DI-ISOTHIOCYANATE (JOINT) IN THE MASS – TREATMET OF INTESTNAL HELMINTHIASIS

Abstract

The effect of Phenylen di-isothiocyanate (Jonit) in the mass treatment of various intestinal helminthiases was evaluated among the inhabitants of a village in Dezful, southwest Iran. Stool samples collected and examined from 17 persons showed infection rates of 80% for Ancylostoma duodenale, 57.3% for Ascaris, 46.7% for Trichostronylus spp. and 22.8% for H. nana.Seventy- one persons (41 children and 30 adults), 92.9% of whom were infected with Ancylostoma, 63.3% with Ascaris, 61.9% with Trichostrongylus spp. and 28.1% with H. nana, were treated with doses of 100 to 300 mg of the drug according to their age. A stool examination of these patiennts undertaken 30 days after treatment showed cure rates of 50 % for H. Nana, 39.3% for Ancylostoma, 38.6% for Trichostrongylus spp, and 6.6% for Ascaris. The side effects observed, in order of severity, were nausea,