Review Article

Next Generation Sequencing in Clinical Oncology: Applications, Challenges and Promises: A Review Article



Background: The aim of this mini-review is to highlight the potential applications of next-generation sequencing technology to the field of clinical oncology with respect to genetic diagnosis, cancer classification, predictive biomarkers and personalized medicine.

Methods: Scientific databases were searched to collect relative data.

Results: Effective systematic analysis of whole-genome sequence and whole-exome sequence of tumors, targeted genome profiling, transcriptome sequencing and tumor- normal comparisons can be performed using NGS in order to diagnosis of several types of cancer.

Conclusion: NGS technology can be powerful enough to discover new and infrequent gene alterations, identify hereditary cancer mutation carriers and provide a reliable molecular portrait of wide range of cancers in a quick and cost-effective manner.


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IssueVol 47 No 10 (2018) QRcode
SectionReview Article(s)
Next generation sequencing, Cancer, Genetic diagnosis, Biomarkers, Personalized medicines

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How to Cite
SHABANI AZIM F, HOURI H, GHALAVAND Z, NIKMANESH B. Next Generation Sequencing in Clinical Oncology: Applications, Challenges and Promises: A Review Article. Iran J Public Health. 2018;47(10):1453-1457.