Cytogenetic and Microdeletions of AZF Regions of Y Chromosome Studies in Infertile Males in Northwest of Iran

Maryam SABOUR TAKANLOU; Seyed Ali RAHMANI; Yadollah AHMADI ASR BADR; Mehrdad PASHAZADEH; Leila SABOUR TAKANLOU

doi:10.18502/ijph.v49i7.3595

Cytogenetic and Microdeletions of AZF Regions of Y Chromosome Studies in Infertile Males in Northwest of Iran

Maryam SABOUR TAKANLOU

Seyed Ali RAHMANI

Yadollah AHMADI ASR BADR

Mehrdad PASHAZADEH

Leila SABOUR TAKANLOU

Abstract

N A

Forti G, Krausz C. (1998). Clinical review 100: Evaluation and treatment of the infertile couple. J Clin Endocrinol Metab, 83, 4177-88.

De Kretser DM, Baker HW. (1999). Infertility in men: recent advances and continuing controversies. J Clin Endocrinol Metab, 84, 3443-50.

Jarow JP, Espeland MA, Lipshultz LI. (1989). Evaluation of the azoospermic patient. J Urol, 142, 62-5.

Khabour OF, Fararjeh AS, Alfaouri AA. (2014). Genetic screening for AZF Y chromosome microdeletions in Jordanian azoospermic infertile men. Int J Mol Epidemiol Genet, 5, 47-50.

Poongothai J, Gopenath TS & Manonayaki S. (2009). Genetics of human male infertility. Singapore Med J, 50, 336-47.

Paduch DA, Bolyakov A, Cohen P, Travis A. (2009). Reproduction in men with Klinefelter syndrome: the past, the present, and the future. Semin Reprod Med, 27, 137-48.

Elghezal H, Hidar S, Braham R, Denguezli W, Ajina M, Saâd A. (2006). Chromosome abnormalities in one thousand infertile males with nonobstructive sperm disorders. Fertil Steril, 86, 1792-5.

Castro A, Rodríguez F, Flórez M, López P, Curotto B, Martínez D, Maturana A, Lardone MC, Palma C, Mericq V, Ebensperger M, Cassorla F. (2017). Pseudoautosomal abnormalities in terminal AZFb+c deletions are associated with isochromosomes Yp and may lead to abnormal growth and neuropsychiatric function. Hum Reprod, 32, 465-475.

Vogt PH, Edelmann A, Kirsch S, Henegariu O, Hirschmann P, Kiesewetter F, Köhn FM, Schill WB, Farah S, Ramos C, Hartmann M, Hartschuh W, Meschede D, Behre HM, Castel A, Nieschlag E, Weidner W, Gröne HJ, Jung A, Engel W, Haidl G. (1996). Human Y chromosome azoospermia factors (AZF) mapped to different subregions in yq11. Hum Mol Genet, 5, 933–43.

Li Q1, Qiao D, Song NH, Ding Y, Wang ZJ, Yang J, Wang W, Yin CJ. (2013). Association of DAZ1/DAZ2 deletion with spermatogenic impairment and male infertility in the South Chinese population. World J Urol, 31, 1403-9.

Simoni M, Bakker E, Krausz C. (2004). EAA/EMQN best practice guidelines for molecular diagnosis of y-chromosomal microdeletions. State of the art 2004. Int J Androl. 2004, 27, 240-249.

Page DC, Silber S, Brown LG. (1999). Men with infertility caused by AZFc deletion can produce sons by intracytoplasmic sperm injection, but are likely to transmit the deletion and infertility. Hum Reprod, 14, 1722-6.

Totonchi M, Mohseni Meybodi A, Borjian Boroujeni P, Sedighi Gilani M, Almadani N, Gourabi H. (2012). Clinical data for 185 infertile Iranian men with Ychromosome microdeletion. J Assist Reprod Genet, 29, 847-53.

Foresta C, Moro E and Ferlin A. (2001). Y chromosome microdeletions and alterations of spermatogenesis. Endocrine Rev, 22, 226-239.

Gunduz G, Luleci G, Baykara M. (1998). Cytogenetic study in 102 infertile men. Urologia Internationalis, 6, 32–4.

Van Assche E, Bonduelle M, Tournaye H, Joris H, Verheyen G, Devroey P, Van Steirteghem, Liebaers I. (1996). Cytogenetics of infertile men. Hum Reprod, 4, 1-24.

Foresta C, Garolla A, Bartoloni L, Bettella A, Ferlin A. (2005). Genetic abnormalities among severely oligospermic men who are candidates for intracytoplasmic sperm injection. Journal of Clinical Endocrinology and Metabolism J Clin Endocrinol Metab, 90, 152-6.

De Braekeleer M, Dao TN. (1991). Cytogenetic studies in male infertility: a review. Hum Reprod. 6, 245–50.

Ananthapur V, Avvari S, Tella S, Nallari P, Akka J. (2010). A Robertsonian Translocation rob (14;15) (q10:q10) in a patient with recurrent abortions: A case report. J Reprod Infertil, 11, 197–200.

Krausz C, Hoefsloot L, Simoni M, Tüttelmann F. (2014). EAA/EMQN best practice guidelines for molecular diagnosis of Y-chromosomal microdeletions: state-of-the-art 2013. Andrology, 2, 5-19.

Zhang HG, Zhang ZB, Wang RX, Yu Y, Yu XW, Fadlalla E, Liu RZ. (2013). Male infertility in Northeast China: molecular detection of Y chromosome microdeletions in azoospermic patients with Klinefelter’s syndrome. Genet Mol Res, 12, 4972–4980.

OA, Köksal IT, Karaüzüm SB, Cetin Z. (2015). A patient with azoospermia and 45,X/ 46,X,r(Y)(p11.2q11.2) mosaicism without AZF deletions. Genet Couns, 26, 347–351.

Alves C, Carvalho F, Cremades N, Sousa M, Barros A. (2002). Unique (Y;13) translocation in a male with oligozoospermia: cytogenetic and molecular studies. Eur J Hum Genet, 10, 467–474.

Yousefi-Razin E, Nasiri MJ, Omrani MD. (2016). Frequency of Y chromosome microdeletions among Iranian infertile men with Azoospermia and Severe Oligozoospermia: a meta-analysis. J Reprod Infertil, 17, 208–212.

Zhang YS, Dai RL, Wang RX, Zhang HG, Chen S, Liu RZ. (2013). Analysis of Y chromosome microdeletion in 1738 infertile men from northeastern China. Urology, 82, 584–588.

Liu XG, Hu HY, Guo YH, Sun YP. (2016). Correlation between Y chromosome microdeletion and male infertility. Genet Mol Res. Jun 3, 15, gmr.15028426.

Tse JY, Yeung WS, Ng EH, Cheng LN, Zhu HB, Teng XM, Liu YK, Ho PC. (2002). A comparative study of Y chromosome microdeletions in infertile males from two Chinese populations. J Assist Reprod Genet, 19, 376-83.

Song NH1, Wu HF, Zhang W, Zhuo ZM, Qian LX, Hua LX, Guo L, Feng NH. (2005). Screening for Y chromosome microdeletions in idiopathic and nonidiopathic infertile men with varicocele and cryptorchidism. Chin Med J (Engl), 118, 1462-7.

Naasse Y, Charoute H, El Houate B, Elbekkay C, Razoki L, Malki A, Barakat A, Rouba H. (2015). Chromosomal abnormalities and Y chromosome microdeletions in infertile men from Morocco. BMC Urol, 15, 95.

Al-Achkar W, Wafa A, Moassass F. (2013). Cytogenetic abnormalities and Y-chromosome microdeletions in infertile Syrian males. Biomed Rep, 1, 275-279.

Luddi A, Margollicci M, Gambera L, Serafini F, Cioni M, De Leo V, Balestri P, Piomboni P. (2009). Spermatogenesis in a man with complete deletion of USP9Y. N Engl J Med, 360, 881-5.

Yang Y, Ma MY, Xiao CY, Li L, Li SW, Zhang SZ. (2008). Massive deletion in AZFb/b+c and azoospermia with sertoli cell only and/or maturation arrest. Int J Androl, 31, 573-8.

Brandell RA, Mielnik A, Liotta D, Ye Z, Veeck LL, Palermo GD, Schlegel PN. (1998). AZFb deletions predict the absence of spermatozoa with testicular sperm extraction: preliminary report of a prognostic genetic test. Hum Reprod, 13, 2812-5.

Choi JM, Chung P, Veeck L, Mielnik A, Palermo GD, Schlegel PN. (2004). AZF microdeletions of the Y chromosome and in vitro fertilization outcome. Fertil Steril, 81, 337–341.

Shi YC, Cui YX, Zhou YC, Wei L, Jiang HT, Xia XY, Lu HY, Wang HY, Shang XJ, Zhu WM, Li XJ, Huang YF. (2011). A rare Y chromosome constitutional rearrangement: a partial AZFb deletion and duplication within chromosome Yp in an infertile man with severe oligoasthenoteratozoospermia. Int J Androl, 34, 461–469.

Lahn BT, Page DC. (1997). Functional coherence of the human Y chromosome. Science, 278, 675-80.

Vogt P. (1998). Human chromosome deletions in Yq11, AZF candidate genes and male infertility: history and update. Mol hum reprod, 4, 739–744.

Ferlin A, Arredi B, Speltra E, Cazzadore C, Selice R, Garolla A, Lenzi A, Foresta C. (2007). Molecular and clinical characterization of Y chromosome microdeletions in infertile men: a 10-year experience in Italy. J Clin Endocrinol Metab, 92, 762–770.

Hopps CV, Mielnik A, Goldstein M, Palermo GD, Rosenwaks Z, Schlegel PN. (2003). Detection of sperm in men with Y chromosome microdeletions of the AZFa, AZFb and AZFc regions. Hum Reprod, 18, 1660–1665.

Zhang F, Li L, Wang L, Yang L, Liang Z, Li J, Jin F, Tian Y. (2013). Clinical characteristics and treatment of azoospermia and severe oligospermia patients with Y-chromosome microdeletions. Mol Reprod Dev, 80, 908–915.

Yang Y, Ma MY, Xiao CY, Li L, Li SW, Zhang SZ. (2008). Massive deletion in AZFb/bþc and azoospermia with Sertoli cell only and/or maturation arrest. Int J Androl, 31, 573–578.

Longepied G, Saut N, Aknin-Seifer I, Levy R, Frances AM, Metzler-Guillemain C, Guichaoua MR, Mitchell MJ. (2010). Complete deletion of the AZFb interval from the Y chromosome in an oligozoospermic man. Hum Reprod, 25, 2655–2663.

Kent-First M, Muallem A, Shultz J, Pryor J, Roberts K, Nolten W, Meisner L, Chandley A, Gouchy G, Jorgensen L, Havighurst T, Grosch J. (1999). Defining regions of the Y chromosome responsible for male infertility and identification of a fourth AZF region (AZFd) by Y chromosome microdeletion detection. Mol Reprod Dev, 53, 27– 41.

Foresta C, Ferlin A, Garolla A, Moro E, Pistorello M, Barbaux S, Rossato M. (1998). High frequency of well-defined Y-chromosome deletions in idiopathic Sertoli cell-only syndrome. Hum Reprod, 13, 302–307.

Liow SL, Ghadessy FJ, Ng SC, Yong EL. (1998). Y chromosome microdeletions, in azoospermic or near-azoospermic subjects, are located in the AZFc (DAZ) subregion. Mol Hum Reprod, 4, 763–768.

Omrani MD, Samadzadae S, Bagheri M, Attar K. (2006). Y chromosome microdeletions in idiopathic infertile men from West Azarbaijan. Urol J, 3(1), 38-43.

Malekasgar AM, Mombaini H. (2008). Screening of 'Y' chromosome microdeletions in Iranian infertile males. J Hum Reprod Sci, 1, 2-9.

Mirfakhraie R, Mirzajani F, Kalantar SM, Montazeri M, Salsabili N, Pourmand GR, Houshmand M. (2010). High prevalence of AZFb microdeletion in Iranian patients with idiopathic non-obstructive azoospermia. Indian J Med Res, 132, 265-70.

Zaimy MA, Kalantar SM, Sheikhha MH, Jahaninejad T, Pashaiefar H, Ghasemzadeh J, Zahraei M. (2013). The frequency of Yq microdeletion in azoospermic and oligospermic Iranian infertile men. Iran J Reprod Med, 11, 453-8.

Masoudi R, Mazaheri-Asadi L, Khorasani K. (2016). Partial and complete microdeletions of Y chromosome in infertile males from South of Iran. Mol Biol Res Commun, 5, 247–255.

Motovali-Bashi M, Rezaei Z, Dehghanian F, Rezaei H. (2015). Multiplex PCR based screening for micro/partial deletions in the AZF region of Y-chromosome in severe oligozoospermic and azoospermic infertile men in Iran. Iran J Reprod Med, 13, 563–570.

Ambulkar P, Chuadhary A, Waghmare J, Tarnekar A, Pal A. (2015). Prevalence of Y Chromosome Microdeletions in Idiopathic Azoospermia Cases in Central Indian Men. J Clin Diagn Res, 9, GC01–GC04.

Kim MJ1, Choi HW, Park SY, Song IO, Seo JT, Lee HS. (2012). Molecular and cytogenetic studies of 101 infertile men with microdeletions of Y chromosome in 1,306 infertile Korean men. J Assist Reprod Genet, 29, 539-46.

Akin H, Onay H, Turker E, Ozkinay F. (2011). Primary male infertility in Izmir/Turkey: a cytogenetic and molecular study of 187 infertile Turkish patients. J Assist Reprod Genet, 28, 419-23.

Elfateh F, Rulin D, Xin Y, Linlin L, Haibo Z, Liu RZ. (2014). Prevalence and patterns of Y chromosome microdeletion in infertile men with azoospermia and oligzoospermia in Northeast China. Iran J Reprod Med. 12(6):383-8.

Files	XML PDF (583KB)
Issue	Vol 49 No 7 (2020)
Section	Letter to the Editor
DOI	https://doi.org/10.18502/ijph.v49i7.3595
PMCID	PMC7548496
PMID	33083308

Rights and permissions
	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

SABOUR TAKANLOU M, RAHMANI SA, AHMADI ASR BADR Y, PASHAZADEH M, SABOUR TAKANLOU L. Cytogenetic and Microdeletions of AZF Regions of Y Chromosome Studies in Infertile Males in Northwest of Iran. Iran J Public Health. 2020;49(7):1380-1381.

Vancouver

Download Citation