Efficacy of Pumpkin Ointment in Treatment of Chronic Hand Eczema: A Randomized, Active-Controlled, Double Blind Clini-cal Trial

  • Alemeh Khademi Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Parvin Mansouri Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Daryoush Pahlevan Research Center for Social Determinants of Health, Semnan University of Medical Sciences, Semnan, Iran
  • Mahbubeh Bozorgi Department of Traditional Pharmacy, School of Iranian Traditional Medicine, Tehran University of Medical Science, Tehran, Iran
  • Malihe Nasiri Department of Biostatistics, School of Paramedical, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Somayeh Hejazi Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Zahra Azizian Department of Dermatology, Iran University of Medical Sciences, Tehran, Iran
  • Laila Shirbeigi Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
Keywords:
Hand Eczema, Traditional medicine, Pumpkin, Almond, Betamethasone

Abstract

Background: Hand Eczema (HE) is chronic skin disease with a high prevalence in population. It has negative impact on the quality of life. Due to the public interest in herbal remedies, we attempt to assess the efficacy of pumpkin ointment in treatment of chronic HE in this research.

Methods:  This study was conducted in an outpatient clinic at Imam-Khomeini Hospital in Tehran (Iran) from May 2015 to Nov 2016. We performed a double-blind trial on 60 patients with chronic HE randomized to four groups included pumpkin, betamethasone, eucerin and almond ointment (n=15 for each group) for 28 days. Patients were ordered to apply ointments twice a day. Hand Eczema Severity Index (HECSI) and Dermatology Life Quality Index (DLQI) of the patients were evaluated by a dermatologist on the 1st, 14th and 28th d after the start of treatment.

Results: Patients’ DLQI scores in pumpkin and betamethasone group was significant and pumpkin group showed a better response in quality of life (P=0.001). Betamethasone and pumpkin ointment were effective and showed significant improvement compared with almond and eucerin and reduce HECSI scores (P=0.002 and P=0.012 respectively). Betamethasone ointment outcome on HECSI scores in comparison with topical pumpkin was significant (P<0.001). No clinically adverse effects were observed.

Conclusion: Although pumpkin ointment showed a better response in patients’ DLQI in HE but it was less effective than betamethasone in decreasing HECSI.

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Published
2020-06-30
How to Cite
1.
Khademi A, Mansouri P, Pahlevan D, Bozorgi M, Nasiri M, Hejazi S, Azizian Z, Shirbeigi L. Efficacy of Pumpkin Ointment in Treatment of Chronic Hand Eczema: A Randomized, Active-Controlled, Double Blind Clini-cal Trial. Iran J Public Health. 49(7):1339-1347.
Section
Original Article(s)