Correlation Analysis of Erectile Dysfunction with Lower Urinary Tract Symptoms (LUTS) Degree and Clinical Features in LUTS Patients
Abstract
Background: We aimed to investigate the prevalence of erectile dysfunction (ED) in patients with lower urinary tract symptoms (LUTS) and to explore the correlation of ED with LUTS and its clinical features.
Methods: Overall, 400 outpatients and inpatients with LUTS diagnosed in Zhengzhou Central Hospital, Zhengzhou University, Zhengzhou, Henan Province, China from June 2015 to June 2017 were collected. LUTS degree was assessed by the International Prostate Symptom Score (IPSS), and ED degree was assessed by the International Index of Erectile Function (IIEF-5). The correlation of ED with LUTS degree, age, blood lipids, homocysteine (Hcy) and other factors was analyzed.
Results: The prevalence of ED in patients with LUTS was 82.25%. With the increase in age, the prevalence of ED was significantly elevated, and ED degree gradually became higher (P<0.01). The higher the degree of LUTS was, the higher the prevalence of ED would be. The degree of ED was highly correlated with the combination with hypertension, diabetes mellitus and coronary heart disease (P<0.05). The prevalence of ED was positively correlated with LUTS degree and the levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and Hcy (P<0.05 or P<0.01).
Conclusion: ED prevalence of patients with LUTS is high, and ED is significantly related to LUTS degree, age and the levels of TC, LDL-C and Hcy in patients with LUTS.
Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, Van Kerrebroeck P, Victor A, Wein A, Standardisation Sub-Committee of the International Conti-nence Society (2003). The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International Con-tinence Society. Urology, 61: 37-49.
Lu SH, Chen CS (2014). Natural history and epidemiology of benign prostatic hyper-plasia. Form J Surg, 47: 207-10.
Seim A, Hoyo C, Ostbye T, Vatten L (2005). The prevalence and correlates of urinary tract symptoms in Norwegian men: The HUNT Study. BJU Int, 96: 88-92.
Hatzimouratidis K, Amar E, Eardley I, Giu-liano F, Hatzichristou D, Montorsi F, Vardi Y, Wespes E, European Associa-tion of Urology (2010). Guidelines on Male Sexual Dysfunction: Erectile Dys-function and Premature Ejaculation. Eur Urol, 57: 804-14.
Green JS, Holden ST, Ingram P, Bose P, St George DP, Bowsher WG (2001). An in-vestigation of erectile dysfunction in Gwent, Wales. BJU Int, 88: 551-3.
Ichikawa T, Takao A, Nakayama Y, Saegusa M, Aramaki K (2001). Sexual function in men with lower urinary tract symptoms. Nihon Hinyokika Gakkai Zasshi, 92: 464-9.
Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB (1994). Im-potence and Its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging Study. J Urol, 151: 54-61.
Seidman SN, Roose SP, Menza MA, Shabsigh R, Rosen RC (2001). Treatment of erectile dysfunction in men with de-pressive symptoms: results of a placebo-controlled trial with sildenafil citrate. Am J Psychiatry, 158: 1623-30.
Feldman HA, Johannes CB, Derby CA, Kleinman KP, Mckinlay JB (2000). Erec-tile dysfunction and cardiovascular risk factors: Prospective results from the Massachusetts male aging study. Prev Med, 30(4):328-38.
Fung MM, Bettencourt R, Barrett-Connor E (2004). Heart disease risk factors predict erectile dysfunction 25 years later: the Rancho Bernardo Study. J Am Coll Cardiol 43: 1405-11.
Wu C, Zhang H, Gao Y et al (2012). The as-sociation of smoking and erectile dys-function: results from the Fangcheng-gang Area Male Health and Examination Survey (FAMHES). J Androl, 33: 59-65.
Martin-Morales A, Sanchez-Cruz JJ, Saenz de Tejada I, Rodriguez-Vela L, Jimenez-Cruz JF, Burgos-Rodriguez R (2001). Prevalence and independent risk factors for erectile dysfunction in Spain: results of the epidemiologia de la disfuncion erectil masculina study. J Urol, 166: 574-75.
Madersbacher S, Alivizatos G, Nordling J, Sanz CR, Emberton M, de la Rosette JJ (2004). EAU 2004 guidelines on assess-ment, therapy and follow-up of men with lower urinary tract symptoms suggestive of benign prostatic obstruction (BPH guidelines). Eur Urol, 46: 547-54.
Moyad MA, Park K (2012). What do most erectile dysfunction guidelines have in common? No evidence-based discussion or recommendation of heart-healthy life-style changes and/or Panax ginseng. Asian J Androl, 14: 830-41.
Braun MH, Sommer F, Haupt G, Mathers MJ, Reifenrath B, Engelmann UH (2003). Lower urinary tract symptoms and erec-tile dysfunction: co-morbidity or typical "Aging Male" symptoms? Results of the "Cologne Male Survey". Eur Urol, 44: 588-94.
Meuleman EJ, Hatzichristou D, Rosen RC, Sadovsky R (2010). Diagnostic tests for male erectile dysfunction revisited. Com-mittee Consensus Report of the Interna-tional Consultation in Sexual Medicine. J Sex Med, 7: 2375-81.
Coyne KS, Sexton CC, Thompson CL et al (2009). The prevalence of lower urinary tract symptoms (LUTS) in the USA, the UK and Sweden: results from the Epi-demiology of LUTS (EpiLUTS) study. BJU Int, 104: 352-60.
Holden CA, McLachlan RI, Pitts M, Cum-ming R, Wittert G, Agius PA, Handels-man DJ, de Kretser DM (2005). Men in Australia Telephone Survey (MATeS): a national survey of the reproductive health and concerns of middle-aged and older Australian men. Lancet, 366: 218-24.
Vallancien G, Emberton M, Harving N, van Moorselaar RJ, Alf-One Study Group (2003). Sexual dysfunction in 1,274 Euro-pean men suffering from lower urinary tract symptoms. J Urol, 169: 2257-61.
Chung WS, Nehra A, Jacobson DJ, Roberts RO, Rhodes T, Girman CJ, Lieber MM, Jacobsen SJ (2004). Lower urinary tract symptoms and sexual dysfunction in community-dwelling men. Mayo Clin Proc, 79: 745-49.
Corona G, Mannucci E, Lotti F, Fisher AD, Bandini E, Balercia G, Forti G, Maggi M (2009). Pulse pressure, an index of arterial stiffness, is associated with androgen de-ficiency and impaired penile blood flow in men with ED. J Sex Med, 6: 285-93.
McVary K (2006). Lower urinary tract symp-toms and sexual dysfunction: epidemiol-ogy and pathophysiology. BJU Int, 97: 23-8.
Costabile RA, Steers WD (2006). How can we best characterize the relationship be-tween erectile dysfunction and benign prostatic hyperplasia. J Sex Med, 3: 676-81.
Ponholzer A, Temml C, Mock K, Marszalek M, Obermayr R, Madersbachera S (2005). Prevalence and Risk Factors for Erectile Dysfunction in 2869 Men Using a Vali-dated Questionnaire. Eur Urol, 47: 80-5.
Aldemir M, Okulu E, Neşelioğlu S, Erel O, Ener K, Kayıgil Ö (2012). Evaluation of serum oxidative and antioxidative status in patients with erectile dysfunction. An-drologia, 44: 266-71.
Vlachopoulos C, Ioakeimidis N, Stefanadis C (2008). Erectile dysfunction and coro-nary artery disease: a relationship for dis-closure. Hellenic J Cardiol, 49: 1-6.
Shah NP, Cainzos-Achirica M, Feldman DI, Blumenthal RS, Nasir K, Miner MM, Billups KL, Blaha MJ (2016). Cardiovas-cular Disease Prevention in Men with Vascular Erectile Dysfunction: The View of the Preventive Cardiologist. Am J Med, 129: 251-9.
Billups KL, Bank AJ, Padma-Nathan H, Katz S, Williams R (2005). Erectile dys-function is a marker for cardiovascular disease: results of the minority health in-stitute expert advisory panel. J Sex Med, 2: 40-50.
Yeşilli C, Yaman O, Anafarta K (2001). Ef-fect of experimental hypercholesterolemia on cavernosal structures. Urology, 57: 1184-8.
Kanth VV, Golla JP, Sastry BK, Naik S, Kabra N, Sujatha M (2011). Genetic in-teractions between MTHFR (C677T), me-thionine synthase (A2756G, C2758G) variants with vitamin B12 and folic acid deter-mine susceptibility to premature coronary artery disease in Indian population. J Cardiovasc Dis Res, 2: 156-63.
Demir T, Comlekçi A, Demir O, Gülcü A, Calýpkan S, Argun L, Seçil M, Yepil S, Esen A (2006). Hyperhomocysteinemia: a novel risk factor for erectile dysfunction. Metabolism, 55: 1564-8.
Files | ||
Issue | Vol 47 No 5 (2018) | |
Section | Original Article(s) | |
Keywords | ||
Lower urinary tract symptoms Erectile dysfunction Clinical features |
Rights and permissions | |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |