Population Attributable Risk of Hyperuricemia in Hypertension Incidence in 20-74-Year-Old Population during a 10-Year Longitudinal Cohort: Yazd Healthy Heart Cohort

  • Mojtaba MOHAMMADHOSEINI Research Center of Prevention and Epidemiology of Non-Communicable Disease, Department Biostatics & Epidemiology, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Seyedeh Mahdieh NAMAYANDEH Mail Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical sciences, Yazd, Iran
  • Hosein FALLAHZADEH Research Center of Prevention and Epidemiology of Non-Communicable Disease, Department Biostatics & Epidemiology, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Fatemeh MAJIDPOUR Research Center of Prevention and Epidemiology of Non-Communicable Disease, Department Biostatics & Epidemiology, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Seyed Mahmoud SADR-BAFGHI Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical sciences, Yazd, Iran
  • Mohammadhosein SOLTANI Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical sciences, Yazd, Iran
  • Leila HADIANI Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical sciences, Yazd, Iran
  • Mohammadtaghi SAREBANHASSANABADI Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical sciences, Yazd, Iran
  • Hossein NOUGH Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical sciences, Yazd, Iran
  • Ahmad KARIMI Research Center of Prevention and Epidemiology of Non-Communicable Disease, Department Biostatics & Epidemiology, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Maryam ASKARI Research Center of Prevention and Epidemiology of Non-Communicable Disease, Department Biostatics & Epidemiology, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Keywords:
Population attributable risk percentage (PAR%), Hypertension, Hyperuricemia, Uric acid, Iran

Abstract

Background: The population attributable risk (PAR) percent has used widely in public health policy. We aimed to calculate the attribute risk of hypertension due to hyperuricemia by Levin's formulas compare to direct PAR calculation method.

Methods: This was a sub-study of Yazd Healthy Heart Cohort (YHHC). Overall, 1256 normotensive individuals were enrolled through multistage randomized cluster sampling and followed up for mean 9.8 years, from 2005-2015. The threshold cutoff point of the hyperuricemia was considered equal and more than 75th percentile that equal to 5.5 mg/dl for men and 4.3mg/dl for women. To calculate the attributable risk of hyperuricemia in developing hypertension, two methods were applied. Levin's formulas and direct PAR estimation by population risk calculation via exposure prevalence weighted formula. Multiple logistic regression was used for estimate of odds ratio (OR) of hyperuricemia in developing hypertension. We calculated Relative Risk (RR) from OR. The data were analyzed using SPSS software version 16. A significant level of 0.05 was considered.

Results: Hypertension developed in 44.7% of individuals with uric acid level ≥ 75th percentile vs. 35.6% of other individuals (P=0.024). Attributable risk (AR) of hyperuricemia in hypertension incidence was 9.1%. PAR of hyperuricemia for hypertension incidence by using two methods mentioned before was 6%, 5.8% respectively.

Conclusion: The results of the study confirmed the noticeable contribution of hyperuricemia as an independent other risk factor for the occurrence of hypertension. PAR of hyperuricemia for hypertension incidence by using two methods almost near was 6%, 5.8% respectively.

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Published
2020-10-01
How to Cite
1.
MOHAMMADHOSEINI M, NAMAYANDEH SM, FALLAHZADEH H, MAJIDPOUR F, SADR-BAFGHI SM, SOLTANI M, HADIANI L, SAREBANHASSANABADI M, NOUGH H, KARIMI A, ASKARI M. Population Attributable Risk of Hyperuricemia in Hypertension Incidence in 20-74-Year-Old Population during a 10-Year Longitudinal Cohort: Yazd Healthy Heart Cohort. Iran J Public Health. 49(10):1977-1982.
Section
Original Article(s)