Long Chain n-3 Fatty Acids Improve Depression Syndrome in Type 2 Diabetes Mellitus
-
Maryam MAZAHERIOUN
,
Ahmad SAEDISOMEOLIA
,
Mohammad Hassan JAVANBAKHT
,
Fariba KOOHDANI
,
Mahnaz ZAREI
,
Samaneh ANSARI
,
Fatemeh KHOSHKHOO BAZARGANI
,
Mahmoud DJALALI
Abstract
Background: Type 2 diabetes mellitus (T2DM) is commonly associated with depressive symptoms, which affect prognosis and quality of life. We investigated the antidepressant effects of n-3 fatty acids (n-3FAs) monotherapy (without conventional antidepressants) for T2DM patients with mild to moderate depressive symptoms.
Methods: A 10-wk, placebo-controlled, double-blind, parallel-group (1:1 ratio) randomized trial of n-3FAs (2700 mg/day EPA: DHA ratio=2) versus placebo in 88 Iranian diabetic patients with mild to moderate depression based on Beck Depression Inventory II (BDI-II-PERSIAN) was conducted. This study started from July 2014 to January 2015 in Tehran University of Medical Sciences, Tehran, Iran. The primary event was defined as worsened, non-changed, or inconsiderably improved depression (<5 unit decrease in BDI-II-PERSIAN depression scores after treatment) (ClinicalTrials.gov Identifier: NCT02261545).
Results: Randomly, 44 T2DM patients were treated with n-3FAs supplements and 44 cases received placebo (three patients discontinued). n-3FAs could significantly protect patients against the aforesaid event and exhibit satisfactory prevention (number needed to treat with 95% confidence interval: 2.52, 1.71-4.74). No serious adverse reactions were reported.
Conclusion: n-3FAs supplementation had significant antidepressant effects in T2DM patients with mild to moderate depressive symptoms, not confounded by metabolic factors and disease duration.
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| Files | ||
| Issue | Vol 47 No 4 (2018) | |
| Section | Original Article(s) | |
| Keywords | ||
| Depression n-3 fatty acids Type 2 diabetes mellitus Randomized controlled trial | ||
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