Original Article

Guiding Effect of Serum Procalcitonin (PCT) on the Antibiotic Application to Patients with Sepsis


Background: This study aimed to investigate the guiding effect of serum procalcitonin (PCT) on the antibiotic application to patients with sepsis.

Methods: Ninety-eight patients with sepsis treated in Renmin Hospital of Wuhan University, China from 2015-2017 were enrolled. They were divided into two equal groups of control group and the observation group. Patients in the observation group received the antibiotic therapy guided by PCT while patients in the control group received the regular antibiotic therapy. The conventional indexes, prognosis and clinical effects of the two groups were compared.

Results: There were no statistical significance in the differences of the Acute Physiology and Chronic Health Evaluation II (APACHE-II) scores C-reactive protein (CRP) and white blood cell count (WBC) levels between the two groups. The duration of the antibiotic application to patients in the observation group was (7.74±0.61) d which was (10.22±0.78) d shorter than that to patients in the control group. The difference was statistically significant (P<0.05). The Intensive Care Unit (ICU) stay time and the hospital stays of patients in the observation group were shorter than those of patients in the control group. The difference had statistical significance (P<0.05). The difference in 30-day-recurrence rate and 30 day-mortality of the patients in the two groups had no statistical significance. There was statistically significant difference in the comparison of the clinical effects between the two groups.

Conclusion: Guiding effects of the serum PCT on the application of antibiotics to patients with sepsis shorten the usage time of the antibiotics, ICU stay time and hospital stays.



Cvetkovic M, Lutman D, Ramnarayan P, Pathan N, Inwald DP and Peters MJ (2015). Timing of death in children referred for intensive care with severe sepsis: implications for interventional studies. Pediatr Crit Care Med, 16: 410-417.

Casserly B, Phillips GS, Schorr C et al (2015). Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database. Crit Care Med, 43: 567-573.

Drey M, Behnes M, Kob R et al (2015). C-terminal agrin fragment (CAF) reflects renal function in patients suffering from severe sepsis or septic shock. Clin Lab, 61: 69-76.

Angeletti S, Spoto S, Fogolari M et al (2015). Diagnostic and prognostic role of procalcitonin (PCT) and MR-pro-Adrenomedullin (MR-proADM) in bacterial infections. APMIS, 123: 740-748.

Janz DR, Bastarache JA, Rice TW et al (2015). Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial. Crit Care Med, 43: 534-541.

Hancock C (2015). A national quality improvement initiative for reducing harm and death from sepsis in Wales. Intensive Crit Care Nurs, 31: 100-105.

Takehara K, Murakami T, Kuwahara-Arai K, Iba T, Nagaoka I and Sakamoto K (2017). Evaluation of the effect of recombinant thrombomodulin on a lipopolysaccharide-induced murine sepsis model. Exp Ther Med, 13: 2969-2974.

Rascher D, Geerlof A, Kremmer E et al (2014). Total internal reflection (TIRF)-based quantification of procalcitonin for sepsis diagnosis--a point-of-care testing application. Biosens Bioelectron, 59: 251-258.

Bishop BM, Bon JJ, Trienski TL, Pasquale TR, Martin BR and File TJ (2014). Effect of introducing procalcitonin on antimicrobial therapy duration in patients with sepsis and/or pneumonia in the intensive care unit. Ann Pharmacother, 48: 577-583.

Naffaa M, Makhoul BF, Tobia A et al (2014). Procalcitonin and interleukin 6 for predicting blood culture positivity in sepsis. Am J Emerg Med, 32: 448-451.

Zhu F, Jiang Z, Li WH, Wei HY and Su GD (2015). Clinical significance of serum procalcitonin level monitoring on early diagnosis of severe pneumonia on children. Eur Rev Med Pharmacol Sci, 19: 4300-4303.

Endo S, Suzuki Y, Takahashi G et al (2014). Presepsin as a powerful monitoring tool for the prognosis and treatment of sepsis: a multicenter prospective study. J Infect Chemother, 20: 30-34.

IssueVol 46 No 11 (2017) QRcode
SectionOriginal Article(s)
Sepsis Serum Procalcitonin Antibiotic

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
LIU Y, YANG W, WEI J. Guiding Effect of Serum Procalcitonin (PCT) on the Antibiotic Application to Patients with Sepsis. Iran J Public Health. 2017;46(11):1535-1539.