Significant Association between Microrna Gene Polymorphisms and Type 2 Diabetes Mellitus Susceptibility in Asian Population: A Meta-Analysis
Background: The gene polymorphisms in microRNA might relate to susceptibility of type 2 diabetes mellitus (T2DM). However, the results of existing studies were inconsistent and obscure. To investigate the precise associations between microRNA gene polymorphisms and T2DM risk, the present meta-analysis was performed.
Methods: The literatures were searched from four electronic databases, PubMed, Embase, CNKI and Wanfang. Subsequently, odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were both used to evaluate the associations between two single nucleotide polymorphisms (SNPs) (microRNA146a rs2910164 (G>C), microRNA124a rs531564 (C>G)) and risk of T2DM in Asian population.
Results: Totally, there were 4 studies included in our present analysis in the language of English and Chinese. There were partly significant associations between susceptibility of T2DM and SNPs (microRNA146a rs2910164 (G>C), microRNA124a rs531564 (C>G)). The G allele in microRNA146a rs2910164 (G>C) and C allele in microRNA124a rs531564 (C>G) both presented remarkably reduced risk of T2DM when compared with the healthy population.
Conclusion: The microRNA146a rs2910164 (G allele) and microRNA124a rs531564 (C allele) might function as protective factors in the pathogenetic process of T2DM in Asian population.
2. Stadler L, Farooqi IS (2017). A New Drug Target for Type 2 Diabetes. Cell, 170:12-14.
3. Sanghera DK, Blackett PR (2012). Type 2 Diabetes Genetics: Beyond GWAS. J Di-abetes Metab, 3(198): 6948.
4. Shaw JE, Sicree RA, Zimmet PZ (2010). Global Estimates of the Prevalence of Diabetes for 2010 and 2030. Diabetes Res Clin Pract, 87:4-14.
5. Castanotto D, Rossi JJ (2009). The Promises and Pitfalls of RNA-interference-based Therapeutics. Nature, 457:426-433.
6. Muhonen P, Holthofer H (2009). Epigenetic and microRNA-mediated Regulation in Diabetes. Nephrol Dial Transplant, 24:1088-1096.
7. Cruz K, de Oliveira A, Morais J et al (2017). Role of microRNAs On Adipogenesis, Chronic Low-Grade Inflammation, and Insulin Resistance in Obesity. Nutrition, 35:28-35.
8. Guay C, Roggli E, Nesca V et al (2011). Di-abetes Mellitus, a microRNA-related Dis-ease? Transl Res, 157:253-264.
9. Kadamkode V, Banerjee G (2014). Micro RNA: An Epigenetic Regulator of Type 2 Diabetes. Microrna, 3:86-97.
10. Butkiewicz M, Bush WS (2016). In Silico Functional Annotation of Genomic Vari-ation. Curr Protoc Hum Genet, 88:6-15.
11. Fernandez N, Cordiner RA, Young RS et al (2017). Genetic Variation and RNA Struc-ture Regulate microRNA Biogenesis. Nat Commun, 8:15114.
12. Wang J, Wang ML, Wang CH et al (2018). A Novel Functional Polymorphism of GFAP Decrease Glioblastoma Suscepti-bility through Inhibiting the Binding of miR-139. Aging (Albany NY), 10(5):988-999.
13. Guo Y, Yu J, Wang C, et al (2017). MiR-212-5p Suppresses Lipid Accumulation by Targeting FAS and SCD1. J Mol Endo-crinol, 59:205-217.
14. Valentino A, Calarco A, Di Salle A et al (2017). Deregulation of MicroRNAs Me-diated Control of Carnitine Cycle in Prostate Cancer: Molecular Basis and Pathophysiological Consequences. Onco-gene, 36:6030-6040
15. Wang SS, Li YQ, Liang YZ et al (2017). Ex-pression of miR-18a and miR-34c in Cir-culating Monocytes Associated with Vul-nerability to Type 2 Diabetes Mellitus and Insulin Resistance. J Cell Mol Med, 21:3372-3380.
16. Alam KJ, Mo JS, Han SH et al (2017). Mi-croRNA 375 Regulates Proliferation and Migration of Colon Cancer Cells by Sup-pressing the CTGF-EGFR Signaling Pathway. Int J Cancer, 141:1614-1629.
17. Xu Y, Wang L, He J et al (2013). Prevalence and Control of Diabetes in Chinese Adults. JAMA, 310:948-959.
18. Ghaedi H, Tabasinezhad M, Alipoor B et al (2016). The Pre-Mir-27a Variant Rs895819 May Contribute to Type 2 Di-abetes Mellitus Susceptibility in an Iranian Cohort. J Endocrinol Invest, 39:1187-1193.
19. Li Y, Zhang Y, Li X, Shi L et al (2015). As-sociation Study of Polymorphisms in miRNAs with T2DM in Chinese Popula-tion. Int J Med Sci, 12:875-880.
20. Wang TT, Chen YJ, Sun LL et al (2015). Af-fection of Single-Nucleotide Polymor-phisms in miR-27a, miR-124a, and miR-146a On Susceptibility to Type 2 Diabetes Mellitus in Chinese Han People. Chin Med J (Engl), 128:533-539.
|Issue||Vol 49 No 5 (2020)|
|microRNAs; Gene polymorphism; Type 2 diabetes mellitus; Susceptibility|
|Rights and permissions|
|This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.|