Use of Malondialdehyde as a Biomarker for Assessing Oxidative Stress in Different Disease Pathologies: a Review

Abstract

Malondialdehyde (MDA) is widely used as a biomarker for assessing oxidative stress in biomedical fields. Lipid peroxidation is a chain phenomenon resulting in the formation of various active compounds that result in cellular damage. Biomonitoring of MDA has been used in both in-vivo and in-vitro studies as a key biomarker for various disease patterns including hypertension, diabetes, atherosclerosis, heart failure and cancer. Higher levels of MDA are reported in patients of various categories including lung cancer patients, complex regional pain syndrome patients and glaucoma patients. The findings suggest the validity of the MDA assay as a reliable tool in finding out the oxidative stress in different disease pathologies. The present review emphasizes on the reliability and efficacy of MDA estimation in various health disorders.

Keywords: Malondialdehyde, Lipid peroxidation, Free radicals, Oxidative stress