The Expression Level of BRCA2 and Its Changes during Chemo-therapy in Patients with Different Pathological Types of Mam-mary Cancer

  • Yu HUANG Department of Medical Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, P.R. China
  • Min LUO Department of Medical Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, P.R. China
  • Junqing HUANG Department of Medical Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, P.R. China
  • Shaoxin HUANG Department of Medical Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, P.R. China
  • Liuxia WEI Department of Medical Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, P.R. China
  • Yumei ZHANG Department of Medical Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, P.R. China
  • Zhiming ZHANG Department of Medical Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, P.R. China
Keywords: Noninvasive mammary cancer; Invasive mammary cancer; BRCA2; Chemotherapy

Abstract

Abstract Background: We aimed to investigate the expression level of breast cancer susceptibility gene 2 (BRCA2) and its changes during chemotherapy in patients with different pathological types of mammary cancer (MC). Methods: Overall, 102 patients treated in Affiliated Tumor Hospital of Guangxi Medical University, China from April 2013 to August 2017 were enrolled as experimental group, including 58 patients with noninvasive MC (group A) and 44 with invasive MC (group B). Fifty healthy volunteers at the same time were enrolled as control group. The relative expression of BRCA2 in the blood of MC patients was detected by real-time fluorescence quantitative PCR (FQ-PCR). Results: In the experimental group, the expression level of BRCA2 in group A was higher than that in group B before chemotherapy (P<0.001); the expression level in group A and group B 1 month after chemotherapy was higher than that before chemotherapy (P<0.001); the expression level in the both groups 3 months after chemotherapy was higher than that 1 month after chemotherapy (P<0.001); the expression level of BRCA2 in blood of group A increased gradually before, 1 month and 3 months after chemotherapy (P<0.001). The expression level of BRCA2 in blood of group B increased gradually at the same time points (P<0.001). Conclusion: BRCA2 is over-expressed in noninvasive MC patient and under-expressed in invasive MC patient. And it can be used as an index for monitoring the condition of MC patients with different pathological types during chemotherapy.    

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Published
2019-09-03
How to Cite
1.
HUANG Y, LUO M, HUANG J, HUANG S, WEI L, ZHANG Y, ZHANG Z. The Expression Level of BRCA2 and Its Changes during Chemo-therapy in Patients with Different Pathological Types of Mam-mary Cancer. Iran J Public Health. 48(9):1654-1662.
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Original Article(s)