Three Day Environmental Exposure May Trigger Oxidative Stress Development and Provoke Adaptive Response Resulting in Altered Antioxidant Activity

  • Zlatko ZIMET National Institute of Public Health, Ljubljana, Slovenia
  • Marjan BILBAN Department of Public Health, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
  • Joško OSREDKAR Institute of Clinical Chemistry and Biochemistry, University Medical Center Ljubljana, Ljubljana, Slovenia
  • Borut POLJŠAK Laboratory of Oxidative Stress Research, Faculty of Health Sciences, University of Ljubljana, Ljubljana, Slovenia
  • Teja FABJAN Institute of Clinical Chemistry and Biochemistry, University Medical Center Ljubljana, Ljubljana, Slovenia
  • Kristina SUHADOLC Institute of Clinical Chemistry and Biochemistry, University Medical Center Ljubljana, Ljubljana, Slovenia
Keywords: Polluted working environment, Oxidative stress, 8-isoprostane, Enzymatic antioxidant activity

Abstract

Background: We aimed to investigate the polluted working environment triggers oxidative stress and alter enzymatic antioxidant activity by a short-term interval. Methods: The experimental study, performed in 2014, involved 94 workers from the Velenje Coalmine in Slovenia, arranged into three groups according to a number of consecutive working days in a mineshaft, supported by a control group. Levels of the antioxidant enzymes (GPx, CAT, SOD) together with TAC (the combined effect of all antioxidants) and 8-isoprostane (a biological marker of oxidative stress/damage) were measured in human plasma. Results: Workers occupationally exposed for three consecutive working days had significantly increased 8-isoprostane biomarker, a parameter of oxidative stress (P<0.001). The antioxidant levels of TAC (P<0.001), CAT (P<0.001) and SOD (P<0.001) were all significantly decreased compared to a control group. Conclusion: Workers in polluted working environment had significantly increased oxidative stress and altered antioxidant activity already on a third consecutive working day.  

References

1. Valko M, Leibfritz D, Moncol J et al (2007). Free radicals and antioxidants in normal physiological functions and human dis-ease. Int J Biochem Cell Biol, 39:44–84.
2. Pelclová D, Fenclová Z, Kačer P et al (2008). Increased 8-isoprostane, a marker of ox-idative stress in exhaled breath conden-sate in subjects with asbestos exposure. Ind Health, 46:484–489.
3. Auten RL, Davis JM (2009). Oxygen toxicity and reactive oxygen species: the devil is in the details. Pediatr Res, 66:121–127.
4. Rendón-Ramírez AL, Maldonado-Vega M, Quintanar-Escorza MA et al (2014). Ef-fect of vitamin E and C supplementation on oxidative damage and total antioxi-dant capacity in lead-exposed workers. Environ Toxicol Pharmacol, 37:45–54.
5. Omidianidost A, Ghasemkhani M, Kakooei H et al (2016). Risk Assessment of occu-pational exposure to crystalline silica in small foundries in Pakdasht, Iran. Iran J Public Health, 45:70–75.
6. Domej W, Oettl K, Renner W (2014). Oxi-dative stress and free radicals in COPD-implications and relevance for treatment. Int J Chron Obstruct Pulmon Dis, 9:1207–1224.
7. National Institute of Public Health (2015). The lost work days statistics in Slovenia; https://podatki.nijz.si/pxweb/sl/NIJZ%20podatkovni%20portal/
8. Genestra M (2007). Oxyl radicals, redox-sensitive signalling cascades and antioxi-dants. Cell Signal, 19:1807–1819.
9. Halliwell B (2007). Biochemistry of oxidative stress. Biochem Soc Trans, 35:1147–1150.
10. Valavanidis A, Vlahogianni T, Dassenakis M, Scoullos M (2006). Molecular bi-omarkers of oxidative stress in aquatic organisms in relation to toxic environ-mental pollutants. Ecotoxicol Environ Saf, 64:178–189.
11. Osuji FN, Onyenekwe CC, Ifeanyichukwu M et al (2012). Antioxidant activity in HIV and malaria co-infected subjects in Anambra State, southeastern Nigeria. Asian Pac J Trop Med, 5:841–847.
12. Cornelli U, Lu C, Sun X et al (2017) Humoral factors in the skin. In: Practical Immuno-dermatology, Gao X-H, Chen H-D, eds. Springer, Dordrecht, NL, pp. 115-142.
13. Kuipers I, Guala AS, Aesif SW et al (2011). Cigarette smoke targets glutaredoxin 1, increasing s-glutationylation and epithelial cell death. Am J Respir Cell Mol Biol, 45:931-937.
14. Janicka M, Kot-Wasik A, Kot J et al (2010). Isoprostanes-biomarkers of lipid peroxi-dation: their utility in evaluating oxidative stress and analysis. Int J Mol Sci, 11:4631–4659.
15. Elango N, Kasi V, Vembhu B, Poornima JG (2013). Chronic exposure to emis-sions from photocopiers in copy shops causes oxidative stress and systematic in-flammation among photocopier opera-tors in India. Environ Health, 12:78.
16. Pelclová D, Fenclová Z, Vlčková S et al (2014). Occupational asthma follow-up--which markers are elevated in exhaled breath condensate and plasma? Int J Oc-cup Med Environ Health, 27:206–215.
17. Flaherty NL, Chandrasekaran A, del Pilar Sosa Peña M et al (2015). Comparative analysis of redox and inflammatory properties of pristine nanomaterials and commonly used semiconductor manufac-turing nano-abrasives. Toxicol Lett, 239:205–215.
18. Wilhelm Filho D, Avila S Jr, Possamai FP et al (2010). Antioxidant therapy attenuates oxidative stress in the blood of subjects exposed to occupational airborne con-tamination from coal mining extraction and incineration of hospital residues. Eco-toxicology, 19:1193–1200.
19. Oliveras-López M-J, Berná G, Jurado-Ruiz E et al (2014). Consumption of extra-virgin olive oil rich in phenolic com-pounds has beneficial antioxidant effects in healthy human adults. J Funct Foods, 10:475–484.
20. Fraile-Bermúdez AB, Kortajarena M, Zar-razquina I et al (2015). Relationship be-tween physical activity and markers of oxidative stress in independent commu-nity-living elderly individuals. Exp Geron-tol, 70:26–31.
21. Dimitrov DM, Rumrill PD Jr. (2003). Pre-test-posttest designs and measurement of change. Work, 20:159–165.
22. Goodman GVR, Karacan CÖ, Schatzel SJ et al (2008). NIOSH research for monitor-ing and controlling methane at U.S. un-derground coal mining operations. Pitts-burgh (USA): National Institute for Oc-cupational Safety and Health, Pittsburgh Research Laboratory; https://www.cdc.gov/niosh/mining/UserFiles/works/pdfs/nrfma.pdf
23. MSHA (2003). Effects of blasting on air quality. Arlington: Mine Safety and Health Administration.
24. Pournourmohammadi S, Khazaeli P, Eslam-izad S et al (2008). Study on the oxidative stress status among cement plant work-ers. Hum Exp Toxicol, 27:463–469.
25. Suryakar AN, Katkam RV, Dhadke VN et al (2010). A study of oxidative stress in cot-ton industry workers from Solapur city. Biomed Res, 21:260–264.
26. Permpongpaiboon T, Nagila A, Pidetcha P et al (2011). Decreased paraoxonase 1 ac-tivity and increased oxidative stress in low lead-exposed workers. Hum Exp Toxicol, 30:1196–1203.
27. Elis A, Froom P, Ninio A et al (2001). Em-ployee exposure to chromium and plas-ma lipid oxidation. Int J Occup Environ Health, 7:206–208.
28. Poljšak B, Fink R (2014). The protective role of antioxidants in the defence against ROS/RNS-mediated environmental pol-lution. Oxid Med Cell Longev, 2014:671539.
Published
2019-07-01
How to Cite
1.
ZIMET Z, BILBAN M, OSREDKAR J, POLJŠAK B, FABJAN T, SUHADOLC K. Three Day Environmental Exposure May Trigger Oxidative Stress Development and Provoke Adaptive Response Resulting in Altered Antioxidant Activity. Iran J Public Health. 48(7):1284-1291.
Section
Original Article(s)