Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 10 2024 09 30 2251 2259 Natalija Djurovic Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Snezana Radovanovic 1. Department of Social Medicine, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia 2. Institute for Public Health Kragujevac, Kragujevac, Serbia 3. Center for Research on Harmfull Effects of Biological and Chemical Hazards, Faculty of Medical Sciences, University of Kragu-jevac, Kragujevac, Serbia Olgica Mihaljevic Department of Pathophysiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Jovana Radovanovic Department of Epidemiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Milos Stepovic Department of Anatomy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Marija Kovacevic Department of Anatomy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Katarina Janicijevic Department of Social Medicine, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Gordana Djordjevic Department of Epidemiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Ognjen Djordjevic Department of Epidemiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Gordana Gajovic Health Center Arandjelovac, Arandjelovac, Serbia Nela Djonovic 1. Institute for Public Health Kragujevac, Kragujevac, Serbia 2. Department of Hygiene and Ecology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Tamara Dimovic Institute for Public Health Kragujevac, Kragujevac, Serbia Nikoleta Janicijevic Department of Hygiene and Ecology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Milena Maricic The College of Health Sciences, Academy of Applied Studies Belgrade, Belgrade, Serbia Dragan Vasiljevic Department of Hygiene and Ecology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Viktor Selakovic Department of Communication Skills, Ethics and Psychology, Faculty of Medical Sciences, University Kragujevac, Kragujevac, Saerbi 2024 07 10 2024 09 30 Background: Social networks and support have an independent and strong influence on health and quality of life at all stages of the life cycle, especially in the elderly. We aimed to determine the level of social support among the elderly population of the Republic of Serbia. Methods: The survey is part of the fourth Health survey of the population of Serbia, which was conducted in 2019  by the Republic Institute of Statistics with the Institute for Public Health of Serbia "Dr. Milan Jovanović Batut" and the Ministry of Health of the Republic of Serbia. The research instrument was standardized questionnaires constructed in accordance with the European Health Interview Survey (EHIS, wave3) and the social support score (Oslo-3 Social Support Scale). For the purposes of this research, data on the population aged 65 and over were used. Results: In terms of social support, 85.8% of respondents had bad , 13.9% moderate and 0.3% strong. Univariate regression analysis determined that respondents from the territory of Vojvodina had a 1.6 times higher chance of poor social support compared to respondents from southern and eastern Serbia.  The probability of bad social support was 1.5 times higher in persons who were never married/cohabiting, persons with secondary education were at 1.6 times higher risk of poor social support compared to persons with higher education. Inactive persons had poor social support 1.4 times more often than employed persons, as well as persons with comorbidities (OR=1.218). Conclusion: These researches are of great importance for public health because it provides valuable data for the creation of interventions that will intensify activities related to providing adequate social support to the elderly. https://ijph.tums.ac.ir/index.php/ijph/article/view/36040 https://ijph.tums.ac.ir/index.php/ijph/article/download/36040/8365

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 10 2024 09 29 2167 2179 Junhua Wang Department of Cardiovascular Medicine, Taixing People's Hospital, Taizhou, Jiangsu, China Hui Li Department of Medicine, Taixing People's Hospital, Taizhou, Jiangsu, China Wenjuan Yan Department of Cardiovascular Medicine, Taixing People's Hospital, Taizhou, Jiangsu, China Na Xue Department of Cardiovascular Medicine, Taixing People's Hospital, Taizhou, Jiangsu, China Jin Yin Department of Nursing, Taixing People's Hospital, Taizhou, Jiangsu, China Nawsherwan . Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China Sha Yin Department of Cardiovascular Medicine, Taixing People's Hospital, Taizhou, Jiangsu, China 2024 07 02 2024 09 29 . https://ijph.tums.ac.ir/index.php/ijph/article/view/35948 https://ijph.tums.ac.ir/index.php/ijph/article/download/35948/8358

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 10 2024 09 30 2380 2381 Sang-Hyuk Park Division of Sport Science, College of Arts & Physical Education, Incheon National University, Incheon, Republic of Korea Seung-Taek Lim 1. General Education, Kookmin University, Seoul, Republic of Korea 2. Waseda Institute for Sport Sciences, Waseda University, Saitama, Japan 2024 03 29 2024 09 30 No Abstract No Abstract No Abstract. https://ijph.tums.ac.ir/index.php/ijph/article/view/35011 https://ijph.tums.ac.ir/index.php/ijph/article/download/35011/8378

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 10 2024 09 30 2260 2270 Yan Gu Department of Cardiothoracic Surgery, The Sixth Affiliated Hospital of Nantong University, Yancheng Third People's Hos-pital, Yancheng, Jiangsu 224000, China Rongjin Chen Department of Cardiothoracic Surgery, The Sixth Affiliated Hospital of Nantong University, Yancheng Third People's Hos-pital, Yancheng, Jiangsu 224000, China Jianxiang Song Department of Cardiothoracic Surgery, The Sixth Affiliated Hospital of Nantong University, Yancheng Third People's Hos-pital, Yancheng, Jiangsu 224000, China Zhan Shi Department of Cardiothoracic Surgery, The Sixth Affiliated Hospital of Nantong University, Yancheng Third People's Hos-pital, Yancheng, Jiangsu 224000, China Jixiang Wu Department of Cardiothoracic Surgery, The Sixth Affiliated Hospital of Nantong University, Yancheng Third People's Hos-pital, Yancheng, Jiangsu 224000, China Huiwen Chang Department of Cardiothoracic Surgery, The Sixth Affiliated Hospital of Nantong University, Yancheng Third People's Hos-pital, Yancheng, Jiangsu 224000, China Conghu Yuan Department of Anesthesiology, The Sixth Affiliated Hospital of Nantong University, Yancheng Third People's Hospital, Yan-cheng, Jiangsu 224000, China Woda Shi Department of Cardiothoracic Surgery, The Sixth Affiliated Hospital of Nantong University, Yancheng Third People's Hos-pital, Yancheng, Jiangsu 224000, China Yajun Zhang Department of Cardiothoracic Surgery, The Sixth Affiliated Hospital of Nantong University, Yancheng Third People's Hos-pital, Yancheng, Jiangsu 224000, China 2023 11 23 2024 09 30 Background: Calcific aortic valve disease (CAVD) is the most common heart relating disease with high morbidity and mortality, especially in elderly population. While extensive investigations have been devoted to the study of mechanistic pathways related to CAVD, the key factors and mechanisms mediating valve mineralization remain unclear. The aim of this study is to investigate the role of mirnas and their downstream targets in CAVD disease progression. A previous recent multi-omics study suggested a novel CAVD molecular interaction network contained miR-21-5p. Methods: CAV and their pair-matched adjacent normal tissues were obtained from 15 patients pathologically diagnosed as CAVD and admitted in Yancheng Third People's Hospital (The Sixth Affiliated Hospital of Nantong University) from 2019-2021. RT-qPCR was utilized for detection of miR-21-5p and related protein expression levels to confirm the related factors in CAVD progression. Western blotting was applied to strengthen the results of RT-qPCR and confirm osteogenic differentiation of VICs via biomarker detection. The staining of alkaline phosphatase (ALP) and alizarin red was performed to assess the degree of VIC mineralization. Results: We found that miR-21-5p was remarkably increased (P<0.0001) in calcified aortic valves (AVs) whereas TGFBI was diminished (P<0.01) in CAVD samples compared to the paired normal tissues from CAVD patients. Additionally, TGFBI was targeted by miR-21-5p. Furthermore, overexpressing TGFBI could block VIC osteogenic differentiation mediated by miR-21-5p. To sum up, miR-21-5p promotes VIC osteogenic differentiation and calcification via TGFBI in CAVD progression. Conclusion:  Our work might bring a sight on underlying mechanisms of CAVD progression and provide a possible therapeutic target for diagnosis and treatment. https://ijph.tums.ac.ir/index.php/ijph/article/view/33840 https://ijph.tums.ac.ir/index.php/ijph/article/download/33840/8366

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 10 2024 09 30 2180 2190 EN Nurgul Sikhayeva National Center for Biotechnology, Astana, 010000, Kazakhstan Akmaral Nursafina Faculty of Natural Science, Eurasian National University Named After L.N. Gumilyov, Astana, 010000, Kazakhstan Aidana Satayeva Faculty of Natural Science, Eurasian National University Named After L.N. Gumilyov, Astana, 010000, Kazakhstan Talgat Utupov National Center for Biotechnology, Astana, 010000, Kazakhstan 2023 08 16 2024 01 15 Background: Thirty-two single nucleotide polymorphisms (SNPs) are commonly found in ADIPOQ. APN levels are decreased in obesity, and SNPs of the ADIPOQ gene affecting APN have varying associations with the development of obesity in different populations. This systematic review and meta-analysis aimed to investigate the association of SNPs in ADIPOQ with the risk of obesity development in various populations. Methods: A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist date up to Feb 2023. We used the Newcastle–Ottawa scale to find out if a study fit the main criteria for submission and to assess the data quality of the articles included in the systematic review and meta-analysis. Odds ratios (OR) and 95% confidence intervals (CI) were calculated via Review Manager (RM) V.5.4 to estimate the connection between ADIPOQ polymorphic qualities of a gene and the risk of developing obesity. Results: The present study analysed the association between ADIPOQ polymorphisms (rs1501299, rs2241766, rs266729, rs822393, and rs822396) and obesity risk and suggested that APN is partially responsible for the emergence of obesity and increases its risk. Conclusion: It is important to take into account several limitations of this meta-analysis when evaluating the findings. First off, even though we looked through numerous databases for all relevant papers, there is a chance we overlooked some. Our capacity to arrive at more firm conclusions was further hampered by the small number of papers that made up our meta-analysis. The most current data, however, are presented in this study since it used newly published data to perform a meta-analysis and evaluate the relationship between ADIPOQ polymorphisms and obesity. https://ijph.tums.ac.ir/index.php/ijph/article/view/32922 https://ijph.tums.ac.ir/index.php/ijph/article/download/32922/8359

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 10 2024 09 30 2382 2384 Masoumeh Roohaninasab Department of Dermatology, Rasool Akram Medical Complex, Iran University of Medical Sciences, Tehran, Iran Safoura Shakoei Department of Dermatology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Azadeh Goodarzi Department of Dermatology, Rasool Akram Medical Complex, Iran University of Medical Sciences, Tehran, Iran Parvin Mansouri Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran Farahnaz Nikkhah Department of Rasool Akram Medical Complex Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran 2021 05 27 2022 02 23 No Abstract No Abstract No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/25092 https://ijph.tums.ac.ir/index.php/ijph/article/download/25092/8379

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 10 2024 09 30 2049 2058 Junfeng Zhang Department of Thoracic Surgery, Zhongkegengjiu Hospital of Anhui/Gengjiu Clinical Medical College, Anhui Medical University, Hefei, 230001, China Weiyi Gong Department of Thoracic Surgery, Zhongkegengjiu Hospital of Anhui/Gengjiu Clinical Medical College, Anhui Medical University, Hefei, 230001, China Xinle Wang Department of Thoracic Surgery, Zhongkegengjiu Hospital of Anhui/Gengjiu Clinical Medical College, Anhui Medical University, Hefei, 230001, China Longbo Yang Department of Thoracic Surgery, Zhongkegengjiu Hospital of Anhui/Gengjiu Clinical Medical College, Anhui Medical University, Hefei, 230001, China 2023 09 21 2024 09 03 Background: Long non-coding RN (lncRNAs) have been implicated in lung cancer, but the mechanisms stay unclear. We investigated the theatrical role and mechanism of lncRNA Lung cancer associated transcript 1 LUCAT1 in the malignant progress of lung cancer. Methods: From May 2022 to March 2023, a total of thirty normal and cancerous tissues were collected from patients diagnosed with non-small cell lung cancer at Zhongke Gengjiu Hospital in Anhui Province, China. The human SPC-A1 and A549 cell lines were chosen as the subjects for the relevant cellular experiments in this study. LncRNAs were expressed in a different manner identified by bioinformatics methods, and the expression levels in lung cancer tissues as well as cells were verified by the qRT-PCR assay. The biological role of LUCAT1 in NSCLC was determined by CCK-8, EdU, and transwell assay. Results: The regulation of ubiquitin of P53 by LUCAT1 was studied, which showed that LUCAT1 was significantly elevated in NSCLC cell lines and patients’ tissues (P<0.05). High levels of LUCAT1 promoted the proliferation, invasion, and migration of NSCLC cells. Mechanism studies showed that LUCAT1 was mainly located in the nucleus, which bound to P53 and mediated the ubiquitinated degradation of P53. Meanwhile, LUCAT1 knockdown attenuated the ubiquitination process of P53. In addition, rescue experiments illustrated that LUCAT1 induced the proliferation and invasion of NSCLC cells, and played a key role in the survival and tumorigenicity of NSCLC cells by mediating the ubiquitination of P53. Conclusion: Collectively, LUCAT1 activated the malignant phenotypes of NSCLC cells via regulating P53 ubiquitination, which provided a new idea for the diagnosis and treatment of NSCLC. https://ijph.tums.ac.ir/index.php/ijph/article/view/33259 https://ijph.tums.ac.ir/index.php/ijph/article/download/33259/8344

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 9 2024 09 03 1935 1950 EN Yang He 1. Department of Urology, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China 2. Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China Abai Xu Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China Li Xiao Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China Ying Yang Department of Hematology, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China Boping Li Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China Zhe Liu Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China Peng Rao Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China Yicheng Wang Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China Li Ruan Department of Urology, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China Tao Zhang Department of Urology, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China 2023 07 29 2024 02 05 Background: Phosphorus metabolism might be associated with tumor initiation and progression. We aimed to screen out the phosphorus metabolism genes related to bladder cancer and construct a clinical prognosis model. Methods: The dataset used for the analysis was obtained from TCGA database. GO and KEGG enrichment analyses were subsequently applied to differentially expressed genes. Consensus clustering was utilized, and different clusters of the tumor immune microenvironment and other features were compared. The phosphorus metabolism-related genes involved in prognosis were screened out by univariate Cox regression, LASSO regression and multivariate Cox regression analysis, and a nomogram was constructed. The performance of the nomogram was validated using TCGA dataset and the GEO dataset, respectively. Results: Overall, 405 phosphorus metabolism-related differentially expressed genes from TCGA database were identified, which were associated with phosphorylation, cell proliferation, leukocyte activation, and signaling pathways. Two clusters were obtained by consistent clustering. After tumor immune microenvironment analysis, significant differences in immune cell infiltration between cluster 1 and cluster 2 were found. Four phosphorus metabolism-related genes (LIME1, LRP8, SPDYA, and MST1R) were associated with the prognosis of bladder cancer (BLCA) patients. We built a prognostic model and visualized the model as a nomogram. Calibration curves demonstrated the performance of this nomogram, in agreement with that shown by the ROC curves. Conclusion: We successfully identified four phosphorus metabolism-related genes associated with prognosis, providing potential targets for biomarkers and therapeutics. A nomogram based on these genes was developed. Nevertheless, this study is based on bioinformatics, and experimental validation remains essential. https://ijph.tums.ac.ir/index.php/ijph/article/view/32707 https://ijph.tums.ac.ir/index.php/ijph/article/download/32707/8335

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 9 2024 09 03 2165 2166 Dong-Il Kim 1. Division of Health and Kinesiology, Incheon National University, Incheon, Republic of Korea 2. Sport Science Institute, Incheon National University, Incheon, Republic of Korea 3. Sports Functional Disability Institute, Incheon National University, Incheon, Republic of Korea 2024 07 03 2024 09 01 No Abstract. No Abstract. No Abstract. https://ijph.tums.ac.ir/index.php/ijph/article/view/35961 https://ijph.tums.ac.ir/index.php/ijph/article/download/35961/8357

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 9 2024 09 03 2059 2068 Eun Jung Lee Department of Social Welfare, School of Social Science, Yonsei University, Seoul, Korea Jee Young Kwak Department of Social Welfare, Korea Soongsil Cyber University, Seoul, Korea Hye Jin Kim Graduate School of Social Welfare, Yonsei University, Seoul, Korea 2023 03 10 2023 11 07 Background: As a health vulnerable group, people with disabilities require more health-promoting behavior than non-disabled people. We aimed to identify the types of health behavior of disabled people and to track the trajectories of stress by the type of health behaviors. Methods: Data came from the Panel Survey of Employment for the Disabled Second Wave by the Employment Development Institute (EDI) in Korea. We used dataset from the first 6 years of the 2nd wave of PSEDSW (2016-2021). The current study analyzed 3,991 subjects. The types of health behavior were identified through latent class analysis (LCA) and the trajectories of stress were estimated through multi-group latent growth modeling using Mplus 8.0. Results: Two types of groups in health behaviors, smoking-drinking group (SD), nonsmoking-less drinking group (NLSD) were derived. Depending on the types of health behavior, the trajectories of stress appeared significantly different: the NLSD had significantly lower stress than the SD in the first year, and this low-level stress trajectory was maintained continuously for 6 years. Conclusion: Health behaviors could be suitable as a stress coping method for people with disabilities. This study suggests that it is necessary to make efforts to create an environment that supports people with disabilities to learn healthier ways to cope with stress. https://ijph.tums.ac.ir/index.php/ijph/article/view/31437 https://ijph.tums.ac.ir/index.php/ijph/article/download/31437/8345

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 9 2024 09 03 1951 1963 Haisheng Luo Department of Traditional Chinese Medicine, Baisha Li Autonomous County People's Hospital, Baisha, 572800, Hainan, China Chunying Jing College of Traditional Chinese Medicine, Hainan Medical University (Hainan Academy of Medical Sciences), Haikou, 571199, Hainan, China Hongbo Liu College of Traditional Chinese Medicine, Hainan Medical University (Hainan Academy of Medical Sciences), Haikou, 571199, Hainan, China 2024 04 16 2024 06 27 Background: We aimed to examine how electroacupuncture and manual acupuncture affect treatment results, pain levels, and joint function in individuals with knee osteoarthritis. Methods: Research was carried out in various databases including PubMed, Medline, Embase, CENTRAL, and CNKI. Following the "Cochrane manual", the risk of bias of included RCTs was assessed. A funnel plot was utilized to evaluate any potential bias in the publications. The impact size was indicated by the average discrepancy along with its 95% confidence interval. Results: The EA group showed a higher effectiveness rate (P = 0.001) and a lower WOMAC pain score (P < 0.00001) compared to the control group. The EA group had a lower WOMAC pain score compared to the SA/exercise group and the group that received manual acupuncture. The WOMAC pain score was significantly lower in the EA group compared to the manual acupuncture group under intense electroacupuncture stimulation (P < 0.0001). The WOMAC pain score was significantly lower in the EA group compared to the manual acupuncture group when weak current acupuncture was applied (P = 0.0001). However, no significant difference in WOMAC function score between EA and control group. Conclusion: Comparison to manual acupuncture, placebo acupuncture, and exercise training, electroacupuncture enhanced the effectiveness of treating KOA and decreased the WOMAC pain score in patients with KOA. The level of pain relief achieved may be linked to the strength of the current stimulation. However, electroacupuncture had no significant effect on WOMAC function score. https://ijph.tums.ac.ir/index.php/ijph/article/view/35185 https://ijph.tums.ac.ir/index.php/ijph/article/download/35185/8336

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 9 2024 09 03 2069 2078 EN Izzet Ulker Department of Nutrition and Dietetics, Faculty of Health Sciences, Erzurum Technical University, Erzurum, Turkey Nihal Gordes Aydogdu Department of Public Health Nursing, Faculty of Health Sciences, Erzurum Technical University, Erzurum, Turkey 2023 10 11 2024 04 04 Background: Dietary habits are influenced by environmental factors. Among these environmental factors are the place of residence, cultural characteristics, food accessibility, and economic status, which can all contribute to changes in the dietary pattern. Migration is another factor that can influence changes in the aspects mentioned above. We aimed to assess the dietary habits of individuals who have migrated from Turkey to Germany in comparison to those living in Turkey. Methods: In this descriptive and cross-sectional study, 254 individuals were enrolled with 102 individuals in Germany and 152 individuals in Turkey between April 2022 and July 2023. The data collection tools included Socio-demographic Characteristics Forms, Dietary Habits and Health Status Forms, and Food Consumption Frequency Forms. The data was collected online via Google Forms. Results: There were statistically significant differences in the consumption frequency of processed meats, meat and poultry, sweetened beverages, sugar, desserts and pastries, vegetables, fruits, eggs and grains, olive oil, sunflower oil, hazelnut oil, grains, dairy products, coffee, starch, and carbonated beverages between the two groups (P<0.05). Statistically significant differences were not found in terms of butter and tea consumption frequency. Conclusion: Overall, the study results have revealed significant differences in dietary habits between Turks living in Germany and those living in Turkey. The most noteworthy dimension of these differences is that individuals living in Turkey exhibit a stronger adherence to the Mediterranean dietary pattern, while those living in Germany tend to follow a Western dietary pattern. https://ijph.tums.ac.ir/index.php/ijph/article/view/33436 https://ijph.tums.ac.ir/index.php/ijph/article/download/33436/8346

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 9 2024 09 03 1964 1975 Shiva Khaleghparast Cardiovascular Nursing Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran Majid Maleki Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran Fereidoun Noohi Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran Mahmood Sheikh Fathollahi Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran Yasaman Khalili Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran Yeganeh Pasebani Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran Farnaz Rafiee Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran Fahimeh Farrokhzadeh Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran Sajjad Biglari Maastricht University Medical Center MUMC+, Department of Clinical Genetics, Maastricht, The Nederland Saeideh Mazloomzadeh Cardiovascular Nursing Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran 2023 10 13 2024 06 01 Background: The global SARS-CoV-2 pandemic has disrupted health systems and put a huge strain on hospitals and healthcare workers. Prioritizing COVID-19 patients in hospitals caused irreversible harm to cardiac patients. Although multiple studies have shown that ST-segment elevation myocardial infarction (STEMI) patients have worse admission circumstances than before the pandemic, the hospital outcomes of these patients have remained limited. This systematic review and meta-analysis examined STEMI patient outcomes during the COVID-19 epidemic. Methods: We conducted systematic searches of MEDLINE (through PubMed), Web of Science, Scopus, and Embase through Jan 10, 2021. All studies with reporting in-hospital mortality, length of stay, and door-to-balloon time with over twenty participants were included. Articles without clear definitions or results were excluded. The study followed PRISMA guidelines. The outcomes of interest were door-to-balloon time, death, and hospital stay during COVID-19 pandemic compared prior. Results: Our meta-analysis included 12 studies and 21170 people (115-6609). The pooled analysis showed significantly more pandemic mortality (OR=1.24; 95% CI: 1.07-1.43). Ten studies (13,091) recorded door-to-balloon times. Door-to-balloon time (in minutes) significantly increased during the pandemic (Standardized Mean Difference [SMD]= 0.46; 95% CI: 0.03-0.89). The length of hospital stay was reported by five studies (n=9448). Length of hospital stay (in days) was not significantly longer during the pandemic than before the outbreak (SMD= 0.04; 95% CI: -0.19-0.26). Conclusion: The COVID-19 pandemic is associated with increased mortality and door-to-balloon delay that might be attributable to the strict infection control measures in outbreak. Studies with a longer follow-up time are needed to investigate the outcomes of STEMI patients. https://ijph.tums.ac.ir/index.php/ijph/article/view/33475 https://ijph.tums.ac.ir/index.php/ijph/article/download/33475/8337

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 9 2024 09 03 2079 2089 Wuzhen Dong Department of Proctology, Jinhua Central Hospital, Jinhua, Zhejiang, China Wen Lin Department of Nursing, Ziyang College of Dental Technology, Ziyang, Sichuan, China Chong Li Department of General Surgery, The Third Affiliated Hospital of Chongqing Medical University, Shuanghu Branch Road No. 1, Yubei District, Chongqing, China 2023 10 12 2024 04 04 Background: We aimed to explore the role of C-X-C motif chemokine ligand 12 (CXCL12) and cytokine-cytokine receptor interaction signaling pathway in the radiotherapy and chemotherapy resistance as well as cell stemness in colorectal cancer (CRC). Methods: Bioinformatics analysis was used to identify the differentially expressed mRNAs and signal pathways closely related to differentially expressed mRNAs have also been analyzed in March 2022 at the Jinhua Central Hospital, China. Then, the expression of CXCL12 was detected by qRT-PCR in colorectal cancer cells and testing the effects of transfecting CXCL12 into different CRC-derived cell lines. The effects of CXCL12 on cell proliferation were evaluated by chemosensitivity assay and radiation sensitivity assay. Results: Bioinformatics analysis of DEGs found a total of 2429 differentially expressed genes, THBS3 and CXCL12 genes are two abnormally highly expressed genes in the CRC. KEGG analysis showed the correlative signaling pathway, cytokine-cytokine receptor interaction, which is related to cell stemness. Furthermore, the expression of CXCL12 in CRC cells was detected and an increasing trend was obtained in CRC cells. In addition, the chemosensitivity and radiotherapy tolerance were elevated after transfected with CXCL12. Conclusion: CXCL12 could be a potential promote biomarkers in CRC and also promote the chemosensitivity and radiotherapy tolerance. https://ijph.tums.ac.ir/index.php/ijph/article/view/33462 https://ijph.tums.ac.ir/index.php/ijph/article/download/33462/8347

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 9 2024 09 03 1976 1991 Fatemeh Ebrahimi Department of Epidemiology & Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran Samaneh Torkian Department of Epidemiology, School of Health, Iran University of Medical Sciences, Tehran, Iran Elahe Zare-Farashbandi Clinical Informationist Research Group, Health Information Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Babak Tamizifar Isfahan Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran 2023 06 23 2024 02 02 Background: Inflammatory bowel disease (IBD) patients who cease anti-tumor necrosis factor (TNF) therapy are at risk of relapse, which is a matter of concern for the medical community. This study aimed to determine the relapse rate of IBD in patients who cease anti- TNF therapy. Methods: A systematic search of international databases (Medline, Web of Sciences, Scopus, and EMBASE) was conducted until Mar 9th, 2022. The random effects model was used to calculate the IBD relapse rate, accompanied by a 95% confidence interval. Results: The IBD relapse rate in patients who discontinued anti-TNF therapy was 44%. The pooled IBD-UC and IBD-CD relapse rate in patients who stopped anti-TNF therapy were 43% and 46%, respectively. The studies using infliximab (IFX) showed a pooled IBD relapse rate of 45%, and the IBD relapse rate in the IFX/ADA (Adalimumab) group was 42%. The IBD relapse rate for papers with treatment durations of less than or equal to 12 months was 51%, while for articles with treatment durations of more than 12 months, it was 30%. Conclusion: This study emphasizes the need for careful evaluation and monitoring of IBD patients who cease anti-TNF therapy, as well as further investigation of alternative treatments for those who exhibit intolerance or inadequate response to anti-TNF therapy. https://ijph.tums.ac.ir/index.php/ijph/article/view/32427 https://ijph.tums.ac.ir/index.php/ijph/article/download/32427/8338

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 9 2024 09 03 2090 2102 Arash Poursheikhani 1. Department of Genetics and Advanced Medical Technology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran 2. Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran Meysam Mosallaei Student Research Committee, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Mehrdad Nasrollahzadeh Sabet Department of Laboratory Sciences, School of Allied Health Medicine, AJA University of Medical Sciences, Tehran, Iran Mohammad Foad Heidari Department of Laboratory Sciences, School of Allied Health Medicine, AJA University of Medical Sciences, Tehran, Iran. Mohsen Rajaeinejad AJA Cancer Epidemiology Research and Treatment Center (AJA‐ CERTC), AJA University of Medical Sciences, Tehran, Iran Mohsen Chamanara 1. Toxicology Research Center, AJA University of Medical Sciences, Tehran, Iran 2. Department of Pharmacology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran Mojtaba Yousefi zoshk 1. Trauma Research Center, AJA University of Medical Sciences, Tehran, Iran 2. Department of Pediatrics, School of Medicine, AJA University of Medical Sciences, Tehran, Iran Peyman Aslani 1. Department of Parasitology and Mycology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran 2. Infectious Research Center, AJA University of Medical Sciences, Tehran, Iran Ebrahim Hazrati Department of Anesthesiology and Critical Care, AJA University of Medical Sciences, Tehran, Iran Mojgan Mohammadimehr Department of Laboratory Sciences, School of Allied Health Medicine, AJA University of Medical Sciences, Tehran, Iran Javad Behroozi 1. Department of Genetics and Advanced Medical Technology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran 2. Research Center for Cancer Screening and Epidemiology, AJA University of Medical Sciences, Tehran, Iran 2022 05 17 2022 11 19 Background: Glioblastoma multiforme (GBM) is one of the most invasive types of brain cancer. LncRNAs can be considered a new prognostic and diagnostic biomarker in GBM. This study comprehensively explored the interaction of lncRNAs with mRNAs in the TCGA database and proposed a novel promising biomarker with favorable diagnostic and prognostic values. Methods: The public data of RNA-seq and related clinical data were downloaded from the TCGA database. Differential expression analysis was conducted in R. GO and KEGG signaling pathways were used for enrichment. The STRING database was used for PPI analysis. CE-network was constructed by STAR database. Kaplan-Meier survival analysis and ROC curve analysis to indicate the biomarkers' diagnostic and prognostic values. Results: Differentially expressed data illustrated that 4428 mRNAs were differentially expressed in GBM. The GO and KEGG pathway analysis showed that the differentially expressed mRNAs were enriched in critical biological processes. The PPI showed that WEE1, BARD1, and CDK6 were the important PPI hubs. The ceRNA network data demonstrated critical lncRNAs. The data revealed that the lncRNA CRNDE, LINC00957, AC072061.1, AC068888.1, and DBH-AS1 are potential diagnostic prognostic biomarkers in the GBM patients. Conclusion: Altogether, we demonstrated lncRNA, and mRNA interaction and mentioned regulatory networks, considered a therapeutic option in GBM. In addition, we proposed potential diagnostic and prognostic biomarkers for the patients. https://ijph.tums.ac.ir/index.php/ijph/article/view/28777 https://ijph.tums.ac.ir/index.php/ijph/article/download/28777/8348

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 9 2024 09 03 1992 2005 EN Nooshin Mohtasham 1. Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran 2. Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran Mahtab Tarrah Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Fatemeh Arab Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Masoumeh Sadeghi Department of Epidemiology, Faculty of Health, Mashhad University of Medical Sciences, Mashhad, Iran Farnaz Mohajertehran Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran 2023 08 12 2024 01 15 Background: MicroRNAs (miRNAs) are implicated in several biological processes, such as control of tissue homeostasis, cell signaling, differentiation, proliferation, neoplastic transformation, and activation/inhibition of apoptotic mechanisms. In this systematic review, we evaluated the changes in the expression pattern of miRNAs in salivary gland tumors (SGTs). Methods: A comprehensive search was conducted in PubMed, and Scopus with no language and date restrictions in Feb 2023. All the studies on SGTs that evaluated miRNA profiling were included. Relevant data regarding the overexpression and down-regulation of the miRNAs were extracted. The quality of the included studies was evaluated with Newcastle–Ottawa checklist. The altered expression of miRNAs was evaluated between SGTs and normal cases, benign and malignant tumors, and primary and high-grade tumors. Results: Thirteen studies were included in this systematic review. There were considerable differences between malignant and benign tumors regarding the miRNAs expression level. In the five studies, the miRNA profile of the primary tumors was compared with metastatic tumors to reveal the involvement of the miRNA in the prognosis of the salivary tumors. The miRNAs expression changes were correlated with tumor size, stage, recurrence, and occurrence of solid components. Perineural invasion and lymph node metastasis were also reported in ACC-LM cell line and recurrence of adenoid cystic carcinoma (ACC) tissues. Conclusion: The miRNA profiling confirms their prognostic value in salivary gland tumors. Significant alternations of the miRNAs expression are useful for distinguishing different types of salivary tumors and malignant tumors from benign types. The miRNA expression changes also affect the prognosis of salivary tumors. https://ijph.tums.ac.ir/index.php/ijph/article/view/32842 https://ijph.tums.ac.ir/index.php/ijph/article/download/32842/8339

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 9 2024 09 03 2103 2112 EN Dariush D. Farhud 1. School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2. Research Center for Paleogenomics, Tehran University of Medical Sciences, Tehran, Iran 3. Dr. Farhud Genetics Clinic, Tehran, Iran Mahsa Azari 1. Research Center for Paleogenomics, Tehran University of Medical Sciences, Tehran, Iran 2. Dr. Farhud Genetics Clinic, Tehran, Iran 3. Department of Archeology, Faculty of Literature and Humanities, Tehran University, Tehran, Iran Mehdi Rahbar Organization of Cultural Heritage, Handicrafts and Tourism, Tehran, Iran 2023 05 28 2024 09 03 Background: Tuberculosis is caused by a bacterium called Mycobacterium tuberculosis, which is a contagious and infectious disease; in the first stage, it destroys the lungs and in the next stage other body organs, such as the spine and long bones. This disease is transmitted through an infected person and due to the weakness of the immune system, the infection intensifies. Tuberculosis has two stages: low activity and high activity. In this article, we have discussed the signs of tuberculosis destruction with high intensity on the bones of prehistory human remains. Methods: The examples of our research are related to human remains from the ancient cemetery of 4000 years ago from Sagezabad region of Qazvin Province of Iran. That period of history coincides with the Iron Age 2 and 3 in the region. People inside the Sagezabad cemetery were very near to early urban (the late rural) society. Results: By matching the form of bone destruction with international atlases for tuberculosis, we have reached a satisfactory result in this article. Due to the strong penetration of the infection into the bones, destruction in the remains was high, so it has simplified the diagnosis for us. Conclusion: We found tuberculosis among the bones. This common ancient disease existed even among Neanderthals. https://ijph.tums.ac.ir/index.php/ijph/article/view/32140 https://ijph.tums.ac.ir/index.php/ijph/article/download/32140/8349

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 9 2024 09 03 2006 2019 Ali Ghaffarian Department of Health Services Management, School of Management and Medical Information Sciences, Isfahan University of Medical Sciences, Isfahan, Iran Azam Cheraghi Department of Hospitals Supervision and Accreditation, Vice-Chancellery for Clinical Affairs, Isfahan University of Medical Sciences, Isfahan, Iran Masoud Ferdosi Health Management and Economics Research Center, School of Management and Medical Information Sciences, Isfahan Uni-versity of Medical Sciences, Isfahan, Iran 2023 08 23 2024 02 12 Background: One of the upcoming challenges in hospital accreditation is using the same and similar standards for all types of hospitals in size and type of activity. We aimed to identify the accreditation modules for all types of hospitals in size (small hospitals) and type of activity (special hospitals). Methods: This research was conducted as a scoping review from Mar to May 2023. "Arsky and O'Malley" six-step protocol was used to conduct this study. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses" (PRISMA) was used to identify, evaluate, and select research articles. The "framework analysis" method was used to analyze the data. Results: Of 14 articles, 64% have been published in peer-reviewed scientific journals. Moreover, 36% of them were accreditation organizations' standards at the national level. The accreditation modules of small hospitals are Responsibilities of Management, Care of Patients, Management of Medication, Patient Safety, Infection Control, Continuous Quality Improvement, Patient Rights and Education, Blood and Blood Products, and Partnering with Consumers. The accreditation modules of special hospitals are Governing Body and Administration, Clinical Management, Prevention and Health, Care and Treatment, Diagnostic Services, Patient Rights, and Quality Improvement. Conclusion: Identifying the main modules of accreditation for small and special hospitals can help policymakers and hospital managers improve the quality and safety of their hospitals by using appropriate standards and help improve the services provided to patients and increase their satisfaction. https://ijph.tums.ac.ir/index.php/ijph/article/view/32987 https://ijph.tums.ac.ir/index.php/ijph/article/download/32987/8340

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 9 2024 09 03 2113 2120 EN Abbas Bahrampour Department of Biostatistics and Epidemiology, Faculty of Health, Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran Mohammad Reza Baneshi Australian Women and Girls’ Health Research Centre, School of Public Health, The University of Queensland, Herston, Queensland, Australia Ali Karamoozian Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran Navisa Sadat Seyedghasemi Department of Biostatistics and Epidemiology, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran Abbas Etminan Physiology Research Center, Departments of Nephrology, Urology and Renal Transplantation, Kerman University of Medical Sciences, Kerman, Iran Mostafa Eghbalian Department of Biostatistics and Epidemiology, School of Public Health, Kerman University of Medical Sciences, Kerman, Iran 2023 10 23 2024 01 13 Background: Along with the increasing prevalence of ESRD in developing countries, the use of more up-to-date statistical models is highly recommended. It is crucial to control potential cure pattern and heterogenicity among patients. Methods: In this longitudinal study, the data of 170 hemodialysis patients who visited the dialysis department of Shafa Hospital in Kerman from 2006 to 2016 were collected. To provides robust estimates the time to event data (death) were analyzed with a gamma frailty mixed cure Weibull model (MC-WG) using Bayesian inference. Results: About 49% of patients experienced the death and median survival time was 37.5 months. Older patients (0.264), female patients (0.269), and patients with higher mean serum urea levels (0.186) had a higher risk of death. Moreover, we observe a decrease in death with increase in Creatine (Cr). Conclusion: In the MC-WG Bayesian model, the diabetes, AST, calcium, phosphorus and uric acid variables had a significant effect on the survival of hemodialysis patients, while they were not significant in the Cox PH model. The results of MC-WG Bayesian model are more consistent with other studies. https://ijph.tums.ac.ir/index.php/ijph/article/view/33553 https://ijph.tums.ac.ir/index.php/ijph/article/download/33553/8350

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 9 2024 09 03 2020 2029 Nader Salari Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran Mehrab Ahmadi Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran Hooman Ghasemi Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran Reza Yarani Interventional Regenerative Medicine and Imaging Laboratory, Department of Radiology, School of Medicine, Stanford Uni-versity, Palo Alto, CA 94304, USA Masoud Mohammadi Research Center for Noncommunicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran 2023 10 09 2024 01 13 Background: We aimed to determine the prevalence of sedentary time in diabetes and metabolic syndrome worldwide via a systematic review and meta-analysis study. Methods: This study was conducted using the systematic review method following PRISMA 2020 criteria. Searches were conducted in PubMed, Scopus, ScienceDirect, Web of Science, and Google Scholar from January 2000 to December 2022. The heterogeneity of studies was measured using the I2 test. Results: The prevalence of sedentary time in diabetic patients was 52.3% (CI 95 %:46.2-58.2) and the prevalence of sedentary time in metabolic syndrome was 43.3% (95% CI: 31- 56.5).  Also, the results of subgroup analysis show that the prevalence of inactivity in diabetic women was 60.3% higher than that of diabetic men. The prevalence of inactivity in patients with metabolic syndrome was 28.6% in men and women, respectively. Conclusion: Sedentary time has a very high prevalence in metabolic syndrome and diabetic patients. In other words, almost half of these patients experience their life patterns. Therefore, effective and efficient efforts to improve activity and exercise in patients with diabetes and metabolic syndrome will have a more effective therapeutic effect and improve their quality of life. https://ijph.tums.ac.ir/index.php/ijph/article/view/33423 https://ijph.tums.ac.ir/index.php/ijph/article/download/33423/8341

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 9 2024 09 03 2121 2129 Shohreh SeyyedHosseini Deapartment of Medical Library and Information Science, School of Paramedicine, Bushehr University of Medical Sciences, Bushehr, Iran Mohammadreza Yazdankhahfard Department of Nursing, School of Nursing and Midwifery, Bushehr University of Medical Sciences, Bushehr, Iran Maryam Azargoon Department of Knowledge and Information Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran Reza BasirianJahromi Department of Medical Library and Information Science, School of Paramedicine, Bushehr University of Medical Sciences, Bushehr, Iran 2023 09 07 2024 02 12 Background: Nowadays, blended learning in medicine (BLM) has gained the attention of most experts as an invaluable approach to improving the quality of medical education. The level of attention to articles in this field on social networks is substantial. This study aimed to study the effectiveness of published articles in blended learning, indexed in Scopus and Web of Science databases between 2013 and 2022, from an altmetrics perspective. Methods: The research is descriptive-analytical, with a scientometrics approach (using the Altmetrics index). The population includes all the articles on blended learning in medicine, indexed in Scopus and Web of Science databases, two well-known citation databases worldwide. Data were extracted using the Altmetrics bookmarklet tool and analyzed with descriptive statistics methods in Excel software. Results: Out of 1327 articles, 136 articles (10.25%) did not have a digital object identifier (DOI) or PMID number. Mendeley, X (previously Twitter), and Dimensions were the most widely used social networks in blended learning. The United States, the United Kingdom, and Australia had the highest number of tweets in blended learning in medicine. Conclusion: The number of articles with altmetrics indicators, categorized by publication year, demonstrates an improvement in the familiarity and use of social media by blended learning researchers in medicine. Blended learning researchers are advised to carefully select reputable journals - preferably with DOI - to increase the visibility and attention to their articles on social media. https://ijph.tums.ac.ir/index.php/ijph/article/view/33155 https://ijph.tums.ac.ir/index.php/ijph/article/download/33155/8351

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 9 2024 09 03 2130 2139 Riaz Alaei Kalajahi Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mohammad Ghorbani Department of Mathematics and Mathematical Statistics, Umeå University, Umeå, Sweden Mohammad Arab Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Ebrahim Jaafaripooyan Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mehdi Yaseri Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2022 09 09 2023 02 02 Background: We aimed to investigate Tehran’s University of Medical Sciences (TUMS) affiliated hospitals organizational readiness toward implementing the ‘Autonomous Hospitals’ program as a change initiative from a managerial perspective in 2020. Methods: A census covering all eligible managers working in TUMS affiliated hospitals, Tehran, Iran (350 individuals) was carried out. Overall, 281 questionnaires were returned (a 30% non-responsi