Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 5 2023 05 07 950 959 EN Le Thi Vui Department of Population and Reproductive Health, Faculty of Social and Behavioral Sciences, Hanoi University of Public Health, Hanoi ,Vietnam Duong Minh Duc Department of Population and Reproductive Health, Faculty of Social and Behavioral Sciences, Hanoi University of Public Health, Hanoi ,Vietnam Chu Thi Thuy Quynh Department of Population and Reproductive Health, Faculty of Social and Behavioral Sciences, Hanoi University of Public Health, Hanoi ,Vietnam Duong Kim Tuan Department of Epidemiology, Faculty of Fundamental Sciences, Hanoi University of Public Health, Hanoi, Vietnam Nguyen Mai Huong Department of Psychiatry, National Hospital of Pediatrics, Hanoi, Vietnam Nguyen Thi Minh Thanh Department of Research Management and Cooperation, Hanoi University of Public Health, Hanoi, Vietnam Nguyen Minh Hung Department of Science and Technology for Economic Branches, Ministry of Science and Technology, Hanoi, Vietnam Hoang Van Minh Department of Health Policy and Economics, Health Management Training Institute, Hanoi University of Public Health, Hanoi, Vietnam Bui Thi Thu Ha Department of Population and Reproductive Health, Faculty of Social and Behavioral Sciences, Hanoi University of Public Health, Hanoi ,Vietnam 2021 06 25 2022 03 02 Background: Autism Spectrum Disorders (ASDs) are common behavioral syndromes but limited critical evidence in Vietnam. This study aimed to identify ante-, peri- and neonatal factors for ASDs amongst children in Vietnam. Methods: This population-based study applied the cross-sectional design with a multistage sampling in 21 urban and rural districts in seven cities/provinces in Vietnam during 2017-2018. Overall, 42,551 children age 18 to 30 months were enrolled in the study. Two phases of assessment using Modified Checklist for Autism in Toddlers (M-CHAT) for screening and diagnostic assessment using Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for confirmation. We employed univariate and binary logistic regression to identify. Results: Our study showed a fast-growing trend of ASDs amongst children age 18 and 30 months (75.8 per 10,000 individuals). Nine ante-, peri-, and neonatal factors were associated with ASDs: five factors of antenatal period (history of miscarriage/abortion or stillbirth, children conceived by assisted reproduction technologies, having cold, flu or acquiring virus during pregnancy, having gestational diabetes, toxemia, high blood pressure or pre-eclampsia during pregnancy, and having stress or mental disorders during pregnancy); one factors of perinatal period (mode of delivery); and three factors of neonatal period (jaundice, respiratory distress, and newborn seizures) Conclusion: This first large-scale survey in Vietnam confirms some prenatal, perinatal, and postnatal factors with ASDs amongst children age 18 and 30 months. Future interventions should focus on these factors to early diagnosis and intervention to improve functional outcomes for risky children. https://ijph.tums.ac.ir/index.php/ijph/article/view/25379 https://ijph.tums.ac.ir/index.php/ijph/article/download/25379/7929

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 5 2023 05 07 870 879 Milena Corbic Department of Neurology, Agnes Karll Laatzen Hospital, Laatzen, Germany Jasmina Sretenovic Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Vladimir Zivkovic 1. Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia 2. Department of Pharmacology, First Moscow State Medical University, University I.M. Sechenov, Moscow, Russia Vladimir Jakovljevic 1. Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia 2. Department of Human Pathology, First Moscow State Medical University, University I.M. Sechenov, Moscow, Russia Tamara Nikolic Turnic 1. Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia 2. Department of Public Health and Healthcare N. A. Semashko, F.F. Erismann Institute of Public Health, First Moscow State Medical University, University I.M. Sechenov, Moscow, Russia 2022 01 12 2023 01 22 Background: Three selective and most used inhibitors of PDE-5- sildenafil, vardenafil and tadalafil- have been successfully used for the treatment of erectile dysfunction. Erectile dysfunction and cardiovascular diseases might be considered as two dissimilar clinical signs of the identical systemic disease. PDE-5 inhibitors can through different models and mechanisms induce vasodilation, decrease apoptosis and cell proliferation, and they are widely present in various tissues that make them promising targets in a range of cardiovascular diseases. Methods: PubMed was explored to identify papers published from 1990-2019, presenting data for the most used PDE-5 inhibitors (sildenafil, tadalafil or vardenafil) in treatment of cardiovascular diseases. Results: This article analyses the therapeutic potentials of PDE-5 inhibitors in cardiovascular diseases and discusses mechanisms, possible risks and limitations. Comparable to earlier studies, newer studies suggest cardioprotective effects of PDE-5 inhibitors, which include different models and mechanisms and do not indicate an increased rate of significant cardiovascular adverse reactions. Dissimilarity in the pharmacokinetics and pharmacodynamics of PDE-5 inhibitors are significant to their risk- benefit profile and clinical use. Some of the studies suggesting infarct size reduction after PDE-5 inhibition described the especially close dose-effect relation, other studies dosage adaptation in drug- drug interactions. Conclusion: PDE-5 inhibitors indicate the encouraging useful effects by ischemia/reperfusion injury, myocardial infarction, cardiac hypertrophy, cardiomyopathy and systolic and diastolic congestive heart failure. Therefore, this and similar reviews can help for additional clinical targeting in the therapy of cardiovascular diseases.   https://ijph.tums.ac.ir/index.php/ijph/article/view/27461 https://ijph.tums.ac.ir/index.php/ijph/article/download/27461/7923

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 5 2023 05 08 1089 1091 Denis Niyazi Department of Microbiology and Virology, Medical University of Varna, Varna, Bulgaria Stephanie Radeva 1. Department of Microbiology and Virology, Medical University of Varna, Varna, Bulgaria 2. Microbiology Laboratory, MHAT “St. Anna” – Varna, Bulgaria Milena Bozhkova 1. Department of Microbiology and Virology, Medical University of Varna, Varna, Bulgaria 2. Laboratory of Clinical Microbiology, UMHAT “St. Marina”- Varna, Bulgaria Dobromira Savova 1. Department of Microbiology and Virology, Medical University of Varna, Varna, Bulgaria 2. Laboratory of Clinical Microbiology, UMHAT “St. Marina”- Varna, Bulgaria Temenuga Stoeva 1. Department of Microbiology and Virology, Medical University of Varna, Varna, Bulgaria 2. Laboratory of Clinical Microbiology, UMHAT “St. Marina”- Varna, Bulgaria 2021 10 27 2022 01 16 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/26700 https://ijph.tums.ac.ir/index.php/ijph/article/download/26700/7943

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 5 2023 05 08 960 968 Ling Zhang Center for Mental Health, Shaoxing University, Shaoxing, China Haibin Wang School of Educational Science, Huangshan University, Huangshan, China Junjie Zhang Center for Mental Health, Anhui University of Chinese Medicine, Hefei, China 2023 02 07 2023 05 08 Background: Middle and primary school teachers are experiencing considerable stress from their careers. However, previous studies on work stress among teachers focused on the influence of various types of stress on individuals but failed to explore the relationship among middle and primary school teachers’ work stress, psychache. We aimed to examine the basic conditions of the challenge-hindrance stress of middle and primary school teachers as well as its relationship with psychache and psychological resilience. Method: A total of 512 middle and primary school teachers from Zhejiang and Anhui in China were enrolled from May to October 2021. The subjects were evaluated with the challenge–hindrance stress questionnaire, psychache scale, and psychological resilience scale. t-test, ANOVA analysis, correlation analysis, and multivariate regression analysis were used to explore the relationship between challenge-hindrance stress and psychache Results: Middle and primary school teachers generally experience high challenge–hindrance stress and psychache. The challenge-hindrance stress had a significantly positive correlation with psychache (r=0.295, 0.439, P<0.01) and a significantly negative correlation with psychological resilience (r＝−0.320, −0.494, P<0.01). Challenge–hindrance stress could be used to significantly predict the psychache. Specifically, challenge stress and hindrance stress could significantly positively predicted the psychache (β=0.295 and β=0.439, respectively). In addition, psychological resilience exerted a partial mediating effect on the relationship between challenge–hindrance stress and psychache. Conclusion: The challenge–hindrance stress of middle and primary school teachers influences their psychache directly as well as indirectly through the mediating effect of psychological resilience.   https://ijph.tums.ac.ir/index.php/ijph/article/view/31163 https://ijph.tums.ac.ir/index.php/ijph/article/download/31163/7930

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 5 2023 05 07 880 891 Jiale Yu 1. Graduate School of Physical Education, Myongji University, Yongin 17058, Republic of Korea 2. School of Physical Education, Nanchang Normal University, Nanchang 330032, Jiangxi Province, China Buongo Chun Graduate School of Physical Education, Myongji University, Yongin 17058, Republic of Korea Dongjun Lee Graduate School of Physical Education, Myongji University, Yongin 17058, Republic of Korea Ladan Rokni Asia Contents Institute, Konkuk University, Seoul, Republic of Korea 2023 02 08 2023 04 18 Background: While people’s living standards are improving, the incidence of chronic diseases due to a lack of exercise is increasing. Complex health conditions (e.g., metabolic syndrome) are becoming common, and means to lower their incidence are essential. Methods: This study systematically reviewed the literature and performed a meta-analysis on the effects of Baduanjin exercise on metabolic syndrome-related factors. Using four English databases and three Chinese databases, randomized controlled trials on the effects of Baduanjin exercise on metabolic syndrome were identified. We analyzed whether Baduanjin could alleviate various metabolic syndrome indicators according to our selection guidelines. Results: We found that Baduanjin exercise had positive effects on blood pressure (systolic blood pressure: mean difference (MD)=-6.39; 95% confidence interval (CI): -9.86 to -2.92; I2=12%; diastolic blood pressure: MD=-2.86; 95% CI: -5.96 to -0.23; I2=35%; P=0.07) and total cholesterol (standardized mean (SMD)=-0.55; 95% CI: -1.11 to 0.02; I2=86%; P=0.06), triglyceride (SMD=-0.29; 95% CI: -1.13 to - 0.56; I2=94%; P<0.51), and low-density cholesterol (SMD =-0.33; 95% CI: -0.52 to -0.14; I2=0%; P<0.0007) levels. Conclusion: This evidence shows that Baduanjin exercise provides beneficial effects by improving metabolic syndrome and cardiovascular disease in adults. This suggests that Baduanjin exercise could be an effective alternative or complementary approach to conventional treatments for adults with metabolic problems. Additionally, these findings suggest that more rigorous randomized control trials are needed in the future.   https://ijph.tums.ac.ir/index.php/ijph/article/view/31176 https://ijph.tums.ac.ir/index.php/ijph/article/download/31176/7924

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 5 2023 05 08 1092 1094 Byeongmin Chae Department of Environmental Engineering, Incheon National University, Incheon 22012, South Korea Do Gyun Lee Department of Environmental Engineering, Incheon National University, Incheon 22012, South Korea 2021 10 12 2021 11 29 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/26554 https://ijph.tums.ac.ir/index.php/ijph/article/download/26554/7944

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 5 2023 05 08 969 977 Wiesław Chwała Department of Biomechanics of the University of Physical Education, 31-571 Cracow, Poland Katarzyna Burdacka Department of Recreology and Biological Regeneration of the University of Physical Education, 31-571 Cracow, Poland Robert Walaszek Department of Recreology and Biological Regeneration of the University of Physical Education, 31-571 Cracow, Poland Marcin Burdacki Med Coach, Non-Public Continuing Education Institution, 31-573 Cracow, Poland 2021 10 30 2022 02 23 Background: Dynamic balance monitoring involves the assessment of the muscular control during changes of the centre of gravity location in space above the supporting plane. We aimed to determine the structure of the Y-Balance Test and its accuracy based on measurements of strength and resistance to fatigue of muscles acting on the knee joint under static conditions, as well as joint motion ranges and static balance in girls aged 14 years. Methods: The study included 40 girls aged 14, who attended Gymnasium No. 2 in Cracow (Poland). The research was conducted in October 2020. Postural stability was examined with the use of the YBT. The measurements of muscle strength and knee joint extensor and flexor resistance to fatigue during an isometric contraction were performed in a standard position on the test bench. The measurements of lower extremity joint range of motion were performed in accordance with the SFTR methodology. Static balance was assessed with the use of the modified FBT. Results: The factor structure obtained for both lower extremities has satisfactorily explained the common variance (about 70%) and showed slight differences between the left and right extremities. Conclusion: The factor structure in the group of examined girls suggests a highly hybrid nature of the Y-Balance Test with a wide spectrum of biomechanical variables that have little influence on the measurement results.   https://ijph.tums.ac.ir/index.php/ijph/article/view/26718 https://ijph.tums.ac.ir/index.php/ijph/article/download/26718/7931

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 5 2023 05 07 892 902 Jae-hak Do Department of Korean Language and Literature, Kyonggi University, Suwon, Korea Sam-hun Park Asia Contents Institute, Konkuk University, Seoul, Korea 2023 02 03 2023 05 07 Background: Previous research dealt with the concept of ‘hygiene’ in Korea, mainly regarding the modern transition summarized as ‘from regimen to hygiene’, has been based on qualitative research methods. However, because modern Korean language material had been constructed as a corpus with a considerable size, a quantitative approach based on language material has become possible. Through this, the provision of a new implication point can be received. Methods: The Corpus of Modern Korean Magazines, which is a morph-tagged corpus constructed based on 20 kinds of original texts of modern magazines in Korea, was utilized. In this corpus, a list of the co-occurred words of ‘wisaeng [hygiene], yangsaeang [regimen], geongang [health], and cheonggyeol [cleanliness]’, importantly related to the concept of ‘modern hygiene’ and the strength of co-occurrence that was calculated with the t-score, were extracted and analyzed.  Results: Through a quantitative analysis of the corpus base, it was confirmed that the number of the co-occurred words of ‘wisaeng [hygiene]’ decreases and the strength of the co-occurrence gets low.  In contrast, the number of the co-occurred words of ‘geongang [health]’ increases and the strength of the co-occurred words becomes heightened.  Conclusion: Regarding the change after ‘from regimen to hygiene’, an analysis based on the corpus has been attempted. Through the quantitative data, the conversion into ‘from hygiene to health’ was confirmed. Research with such a method proves the need and the feasibility of quantitative research that supplements the previous qualitative analysis.   https://ijph.tums.ac.ir/index.php/ijph/article/view/31130 https://ijph.tums.ac.ir/index.php/ijph/article/download/31130/7947

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 5 2023 05 08 1095 1096 Sung-Bum Ju Department of Physical Education, Busan National University of Education, Busan, South Korea 2020 12 08 2021 01 11 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/23100 https://ijph.tums.ac.ir/index.php/ijph/article/download/23100/7945

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 5 2023 05 08 978 985 Berta Schulz-Bañares Department of Pharmacy, School of Pharmacy, University of Concepcion, Concepcion, Chile Carla González-Norambuena Central Pharmacy, Hospital Las Higueras, Talcahuano, Chile Claudio Muller-Ramirez Department of Pharmacy, School of Pharmacy, University of Concepcion, Concepcion, Chile 2022 09 01 2023 01 09 Background: Poisonings is a preventable public health problem that globally affects the population. We aimed to characterize drug-related acute poisonings occurred in Chile between the years of 2016 and 2020. Methods: A retrospective study of poisonings among hospitalized patients was carried out. Data were obtained from the Medical Outcome Statistical Report database. Inclusion criteria were cases of patients admitted into either public or private healthcare settings with diagnosis of drug-related poisoning according to the WHO ICD-10 codes T30-T50. Statistical analyses were run to establish either significant associations or differences between variables selected in the study. Results: Overall, 12,975 poisonings were identified during the 2016-2020 period. These events corresponded to 0.16% of all national hospital admissions in the study period. Women represented 71.1% of the cases. 76.7% of events were related to intentional poisonings while 7.3% and 16% were accidental and undetermined poisonings respectively. 44.6% of accidental and intentional poisonings occurred at the age of 18-29 yr old. Benzodiazepines (22.8%), antidepressants (11.2%), and acetaminophen (5.1) were the most common drugs associated with poisonings. Average length of hospitalization was between 3.3 and 8.2 days. 0.6% of poisonings resulted in deaths.     Conclusion: Poisonings were characterized by patients’ sex and age, circumstance of exposure, length of hospitalization, and outcome. Poisoning rates were stable along the years with a slight decrease in 2020. Intentional poisonings among young women and men were more common. Most of the cases had favorable outcome for patients.   https://ijph.tums.ac.ir/index.php/ijph/article/view/29695 https://ijph.tums.ac.ir/index.php/ijph/article/download/29695/7932

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 5 2023 05 07 903 912 Liming Zhao Department of Vascular Surgery, Liu Zhou People’s Hospital, Guangxi, 545006, China Ying Liu Department of Endocrinology, Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi, China Ziting Cao Department of Vascular Surgery, Liu Zhou People’s Hospital, Guangxi, 545006, China Jun Wang Department of Vascular Surgery, Liu Zhou People’s Hospital, Guangxi, 545006, China Xin Huo Department of Vascular Surgery, Liu Zhou People’s Hospital, Guangxi, 545006, China 2022 11 07 2023 01 22 Background: Proprotein convertase subtilisin / Kexin type 9 (PCSK9) inhibitors are efficacious lipid-lowering agents. This drug is related to improving the prognosis of patients with cardiovascular disease (CVD). The purpose of this meta-analysis was to systematically analyze the safety and efficacy of PCSK9 inhibitors in all published randomized controlled trials (RCTs). Methods: As of October 25, 2021, we searched PubMed, EMBASE, MEDLINE, Cochrane Library and web of science. Results: From 684 articles, we included 11 trials for meta-analysis, including 52511 participants (26938 in the PCSK9 inhibitor group and 25573 in the control group). In terms of effectiveness, PCSK9 inhibitors reduced the risk of major adverse cardiovascular events(MACE) (OR=0.89, 95% Cl: 0.83-0.95, P=0.0009), but did not significantly reduce the risk of cardiovascular death (OR=0.95, 95% Cl: 0.84-1.07, P=0.38) or all-cause death (OR=0.93, 95% Cl: 0.85-1.03, P=0.18); In terms of safety, PCSK9 did not increase the risk of treatment-emergent adverse events (TEAE)(OR=0.98, 95% Cl: 0.94-1.02, P=0.28). Conclusion: PCSK9 inhibitors can significantly reduce the risk of MACE in patients with high cardiovascular risk, which is well tolerated, but the impact on the risk of death is unclear.   https://ijph.tums.ac.ir/index.php/ijph/article/view/30305 https://ijph.tums.ac.ir/index.php/ijph/article/download/30305/7925

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 5 2023 05 08 1097 1098 Mahdi Mohammadian Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran Abdollah Mohammadian-Hafshejani Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran 2021 12 10 2022 01 16 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/27135 https://ijph.tums.ac.ir/index.php/ijph/article/download/27135/7946

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 5 2023 05 08 986 994 EN Xiuli Hu Department of Epidemiology and Health Statistics, School of Public Health, Zunyi Medical University, Zunyi, Guizhou, China Miao Qi Department of Epidemiology and Health Statistics, School of Public Health, Zunyi Medical University, Zunyi, Guizhou, China Ping Yuan Department of Epidemiology and Health Statistics, School of Public Health, Zunyi Medical University, Zunyi, Guizhou, China Guojia Qi Department of Epidemiology and Health Statistics, School of Public Health, Zunyi Medical University, Zunyi, Guizhou, China Xiahong Li Department of Epidemiology and Health Statistics, School of Public Health, Zunyi Medical University, Zunyi, Guizhou, China Yanna Zhou Department of Epidemiology and Health Statistics, School of Public Health, Zunyi Medical University, Zunyi, Guizhou, China Xiuquan Shi Department of Epidemiology and Health Statistics, School of Public Health, Zunyi Medical University, Zunyi, Guizhou, China 2021 09 27 2022 02 23 Background: We aimed to analyze the differences and changing trends of mortality of Injury and Poisoning (IP) between urban and rural areas and gender in China to find out the influencing factors and to propose improvement measures. Methods: IP mortality, population, economy, medical and health information data came from the official website of the National Bureau of Statistics, and basic data on education level came from the Chinese Ministry of Education. Then the differences of the mortality of IP were compared between different areas and gender in China from 2009 to 2019, and the relationships between the mortality changes of IP and education level, GDP per capita, the numbers of practicing physicians, health institutions and urbanization rate were also explored by establishing a ridge regression model. Results: The mortality of IP in rural areas was significantly higher than that of urban areas, and in male was higher than that of female (both P<0.001). Primary school graduates, GDP per capita, the number of practicing physicians, health institutions and urbanization rate had strong correlations (rmin=-0.622) with the mortality of IP. Ridge regression model showed that there was a quantitative relationship between primary school graduates, GDP per capita, the number of practising physicians, health institutions, urbanization rate and the mortality of IP in China. Conclusion: As the difference of working nature, economic development imbalance, psychological and gender, the mortality of IP was significantly different, so the state should take more effective measures to develop the urban and rural areas balanced, and reduce the IP risk in some particular occupations.   https://ijph.tums.ac.ir/index.php/ijph/article/view/26408 https://ijph.tums.ac.ir/index.php/ijph/article/download/26408/7933

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 5 2023 05 07 913 923 Niloofar Mohammadzadeh Department of Health Information Management, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran Meysam Rahmani Katigari Department of Health Information Management, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran Rahil Hosseini Department of Health Information Management, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran Shahrbanoo PahlevanyNejad Health Information Technology Department, School of Allied Medical Sciences, Semnan University of Medical Sciences, Semnan, Iran 2022 01 19 2022 09 10 Background: This study was conducted to classify the types of evaluation methods in clinical health technologies based on a systematic review method. Methods: An electronic search was conducted in three scientific databases including Scopus, PubMed and ISI. The search strategy was performed in Jul to Nov 2021 and based on the three main concepts of "evaluation", "technology", "health. This search has been restricted to 10 years (2011-2021). Moreover, it only was limited to English and papers published in journals and conferences proceeding. Results: Overall, 8149 references were identified for title and abstract screening. Full text screening was performed for 2674 articles, with 174 meeting the criteria for study inclusion. Conclusion: Most of the technologies evaluated in these articles were associated with PC-based systems (N=107), and there have been fewer mobile apps (N=67). Most of used technologies were with goals of treatment (43%, N=74) and education (26%, N=45). Among all the methods, the most and the least used methods were usability (66%, N=115) and qualitative (1%, N=2) method, respectively. The most method for health clinical technologies is usability method especially in telemedicine field.   https://ijph.tums.ac.ir/index.php/ijph/article/view/27551 https://ijph.tums.ac.ir/index.php/ijph/article/download/27551/7926

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 5 2023 05 08 995 1007 EN Yunying Cai Department of Endocrinology and Metabolism, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, China Ben Niu Department of Endocrinology and Metabolism, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 65003h.tums.ac.ir/index.php/ijph/article/view/19361 https://ijph.tums.ac.ir/index.php/ijph/article/download/19361/6631

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 1 2020 01 08 201 202 Ammar N.H. ALBUJEER Nab’a Al-Hayat Foundation for Medical Sciences and Health Care, Najaf, Iraq AND School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain AND School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Mohammad Reza KHAMI School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran AND Research Center for Caries Prevention, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran Alya ALMAHAFDHA School of Medicine, International Campus, Tehran University of Medical Sciences, Tehran, Iran 2020 01 08 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/19387 https://ijph.tums.ac.ir/index.php/ijph/article/download/19387/6651

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 1 2020 01 07 77 85 Mehdi BAGHERI Clinical Research Development Unit, Imam Hossein Hospital, Shahroud University of Medical Sciences, Shahroud, Iran Mozhgan FAZLI School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran Sara SAEEDNIA School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran Majid GHOLAMI KHARANAGH Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran Naghmeh AHMADIANKIA School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran AND Cancer Prevention Research Center, Shahroud University of Medical Sciences, Shahroud, Iran 2020 01 07 Background: We aimed to assess the effect of sulforaphane (SFN) on breast cancer cell migration and also its effect on the expression of epithelial mesenchymal transition (EMT) markers and β-catenin. Methods: This study was performed in Shahroud University of Medical Sciences, Shahroud, Iran from 2017- 2018. In this experimental study, MDA-MB-231 cells were treated with different concentrations of SFN (5, 10, 20, 30 and 40 μM) at different time points of 24, 48, and 72 h. The control group was untreated cells. The inhibitory effects of different concentrations of SFN on cell migration at different time points were evaluated using scratch assay. Moreover, apoptosis was assessed by using flow cytometric analysis. The expression of βcatenin and EMT markers of ZEB1, fibronectin, and claudin-1 were determined by real-time PCR. Western blotting analysis of β-catenin was applied to determine its changes after SFN treatment Results: SFN markedly inhibited the migration of cells at concentrations of 10, 20, 30, and 40µM after 24, 48, and 72 h. At relatively, high concentrations (30, 40µM), SFN induced apoptosis. Moreover, SFN reduced the gene expression of ZEB1, fibronectin, and claudin-1 after 72 h. The expression of β-catenin revealed a time-dependent decrease at the concentration of 40 µM SFN. Conclusion: Downregulation of EMT markers and β-catenin showed accordance with the inhibition of migration. SFN could be a promising drug candidate to reduce metastasis in breast cancer. https://ijph.tums.ac.ir/index.php/ijph/article/view/19363 https://ijph.tums.ac.ir/index.php/ijph/article/download/19363/6632

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 1 2020 01 08 203 205 Arlin ADAM Department of Health Education and Behavioral Science, Faculty of Public Health, Pejuang Republic of Indonesia University, Makassar, Indonesia Andi ALIM Department of Health Policy Administration, Faculty of Public Health, Pejuang Republic of Indonesia University, Makassar, Indonesia Dedy MAULANA Department of Health Promotion, Faculty of Public Health, Pejuang Republic of Indonesia University, Makassar, Indonesia 2020 01 08 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/19388 https://ijph.tums.ac.ir/index.php/ijph/article/download/19388/6652

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 1 2020 01 07 86 95 Hossein MIRZAEI HIV/STI Surveillance Research Center, WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran Zhaleh ABDI National Institute for Health Research (NIHR), Tehran University of Medical Sciences, Tehran, Iran Elham AHMADNEZHAD National Institute for Health Research (NIHR), Tehran University of Medical Sciences, Tehran, Iran Mahshad GOHRIMEHR National Institute for Health Research (NIHR), Tehran University of Medical Sciences, Tehran, Iran Elham ABDALMALEKI National Institute for Health Research (NIHR), Tehran University of Medical Sciences, Tehran, Iran Rezvaneh ALVANDI National Institute for Health Research (NIHR), Tehran University of Medical Sciences, Tehran, Iran Iraj HARIRCHI School of Medicine, Tehran University of Medical Sciences, Tehran, Iran 2020 01 07 Background: The aim of this study was to evaluate the health status of the Iranians following the sustainable development goals’ (SDGs) introduction and the recent health reform implementation in Iran and to compare with those of the Middle East and North Africa region (MENA) and global average. Methods: This comparative study used secondary data to investigate socio-demographic and health status indicators. The sources included census, population-based surveys and death registries. Global and regional health status indicators were obtained from international databases including WHO, the World Bank and the Institute for Health Metric and Evaluation (IHME). Results: Life expectancy and human development index improved following the reform implementation. Among causes of death, 74.6% were attributed to non-communicable diseases (NCDs). There was an increasing trend in risk factors for NCDs in Iran, while at the same time neonatal, infant and under-5 mortality rates reduced. Compared to the MENA, Iran has a lower maternal mortality ratio, neonatal, infant, and under-5 mortality rates, and a higher life expectancy. NCDs and road traffic injuries accounted for a larger portion of disability-adjusted life years in Iran compared to the MENA and worldwide. Conclusion: Actions against communicable diseases and road traffic injuries are required together with continued efforts to address NCDs. Although based on the results, Iran has relatively high rankings, there is a need ‎to develop a roadmap to accelerate achieving global health goals and SDGs targets.  https://ijph.tums.ac.ir/index.php/ijph/article/view/19365 https://ijph.tums.ac.ir/index.php/ijph/article/download/19365/6633

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 1 2020 01 08 206 208 Ensiyeh JENABI Autism Spectrum Disorders Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Salman KHAZAEI Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran 2020 01 08 NO Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/19389 https://ijph.tums.ac.ir/index.php/ijph/article/download/19389/6653

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 1 2020 01 07 96 103 Laleh HOVEIDA Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran Behrooz ATAEI Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Nour AMIRMOZAFARI Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Zahra NOORMOHAMMADI Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran 2020 01 07 Background: The presence and diversity of Staphylococcus species and their enterotoxin-encoding genes in foodstuffs have not been comprehensively studied in some developing countries. This study aimed to assess the frequency of Staphylococcus spp. and their related virulence factors in foodstuffs in Isfahan, Iran. Methods: Overall, 139 foodstuff samples, collected from Isfahan City (center of Iran) from Sep 2015 to Oct 2016, were processed for the presence of Staphylococcus spp. using standard bacteriological procedures and sequence analysis of 16S rRNA gene. Antimicrobial susceptibilities and prevalence of mecA and toxin-encoded genes (sea, seb, sed, see and tsst1) were tested for all of the Staphylococcal isolates. Results: Forty-four Gram-positive cocci were recovered from 139 dairy and meat samples. The most prevalent species were S. vitulinus 25.0% (11/44) and S. aureus 20.5% (9/44); respectively. The most prevalent antimicrobial resistance was noted towards penicillin, cefoxitin and tetracycline. The sec, sea, see and tsst1 genes were found in 19%, 9.5%, 3.5%, and 3.5% of the isolates, respectively. Conclusion: Numerous virulence factors were detected in different Staphylococcus spp. isolated from foodstuffs, more attention should be paid to the presence of the bacteria. Proper hygienic and management practices should be considered in order to increase food safety and prevent extra treatment costs. https://ijph.tums.ac.ir/index.php/ijph/article/view/19366 https://ijph.tums.ac.ir/index.php/ijph/article/download/19366/6634

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 1 2020 01 08 209 210 Fatemeh RAZAVI Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran AND Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran Sara SHEIKHOLESLAMI Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medi-cal Sciences, Tehran, Iran Marjan ZARIF YEGANEH Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medi-cal Sciences, Tehran, Iran Tahereh NAJI Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran Mehdi HEDAYATI Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medi-cal Sciences, Tehran, Iran 2020 01 08 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/19390 https://ijph.tums.ac.ir/index.php/ijph/article/download/19390/6654

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 1 2020 01 07 104 113 Shirin DJALALINIA Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran AND Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Mohammad Bagher TALEI Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran Abbas NAJJARI Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran Mohammad Reza BAGHERI Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran Shahin AKHONDZADEH Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran AND Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran Reza MALEKZADEH Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran AND Digestive Diseases Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Asghar EBADIFAR Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran AND Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2020 01 07 Background: Health research networks (HRNs) are critical components of large-scale systems of production and validation of scientific evidence. As evaluation of research systems is a reliable process to measure efficiency and effectiveness of their activities, we aimed to report the processes of development of evaluation indicators’ for Iranian health research networks and the results of conducted assessment. Methods: In 2017, for the first time, aim to develop the evaluation framework for national HRNs, following the qualitative approach to assess the quality of research we designed the peer review method as one of the most important tools. This qualitative method was conducted according to experts’ views in specific fields. Key policy makers and stakeholders collaboratively developed a number of criteria for evaluation of research performance of Iranian HRNs. Following the review of conducted studies, benefitting from published guide line, these indicators were defined under 4 main axes of governance and leadership; infrastructures; research products and research impact. Results: Based on requirements of developed protocol for evaluation of HRNs in Iran, 18 HRNs completed the processes of evaluation. Results show a progressive need for more attention to precise planning of HRNs for achieving to goals. Another point to consider is the attention to documenting processes. The observational system for researches for detection of latest research priority was the most important issues that need to be more addressed by all of networks. Conclusion: Research evaluation of Iranian HRNs more over creating of constructive positive competition provide an overview of the shortcomings and research challenges could be used for better planning and promotion of the health research system. https://ijph.tums.ac.ir/index.php/ijph/article/view/19367 https://ijph.tums.ac.ir/index.php/ijph/article/download/19367/6635

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 1 2020 01 07 114 124 Soraya FATHOLLAHI Department of Emergencies and Disaster Health, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran AND Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Sahar SAEEDI MOGHADDAM Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran AND Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Mohammad Ali MANSOURNIA Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mahmoud RAHIMI Department of Urban Planning, Faculty of Architecture and Urban Planning, Islamic Azad University, Central Tehran Branch, Tehran, Iran Mehdi ZARE International Institute of Earthquake Engineering and Seismology, Tehran, Iran Ali ARDALAN Department of Emergencies and Disaster Health, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran AND Harvard Humanitarian Initiative, Harvard University, Cambridge, USA Ali SHEIDAEI Department of Biostatistics, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran Niloofar PEYKARI Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran AND Development of Research and Technology Center, Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran Shohreh NADERIMAGHAM Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran AND Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Farshad FARZADFAR Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran AND Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 2020 01 07 Background: Constructions in informal settlements not respected any applying rules, regulations of urban planning, and building codes with high population density, are the municipality challenge. We aimed to identify level of buildings seismic vulnerability and population at risk in Tehran’s Farahzad informal settlement in 2017. Methods: In this observational cross-sectional study, residential buildings were assessed for seismic performance of constructions. We screened 160 buildings according to Iranian national guidelines by Rapid Seismic Visual Screening Method as a tool to calculate and determine Level of Retrofitting (LR) scores of buildings. We also interviewed residents of the buildings to collect data regarding socio-demographic data, individual disability status, Disaster Assessment of Readiness and Training (DART) regarding household disaster preparedness, and time occupancy in the buildings. Results: Overall, 160 buildings with 209 households and 957 individuals were surveyed. 97.5% of buildings were formed of heavy construction materials. None of them were categorized as engineered buildings and LR of residential buildings ranged from 82.4% to 163.8% with a mean 117.9%. LR scores of more than 100% were capped as 100%. Vulnerable groups of the sample population include under-five years old (8.7%), 60 yr old and above (6.7%), and 9.1% of households had at least one disabled member. 16.7% of households were living in homes with dense area. The DART score for 94.3% of surveyed households was zero. Conclusion: Disaster managers in Tehran municipality must design and implement a comprehensive risk reduction plan in poor urban areas as vulnerable regions for earthquake hazard. https://ijph.tums.ac.ir/index.php/ijph/article/view/19368 https://ijph.tums.ac.ir/index.php/ijph/article/download/19368/6636

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 1 2020 01 07 125 133 Amir JAVADI Department of Health Information Management, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran AND Department of Medical Social Sciences, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran Ali KHAMESIPOUR Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran Farshid MONAJEMI Ministry of Health and Medical Education, Tehran, Iran Marjan GHAZISAEEDI Department of Health Information Management, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran 2020 01 07 Background: In a new approach, computational methods are used to design and evaluate the vaccine. The aim of the current study was to develop a computational tool to predict epitope candidate vaccines to be tested in experimental models. Methods: This study was conducted in the School of Allied Medical Sciences, and Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran in 2018. The random forest which is a classifier method was used to design computer-based tool to predict immunogenic peptides. Data was used to check the collected information from the IEDB, UniProt, and AAindex database. Overall, 1,264 collected data were used and divided into three parts; 70% of the data was used to train, 15% to validate and 15% to test the model. Five-fold cross-validation was used to find optimal hyper parameters of the model. Common performance metrics were used to evaluate the developed model. Results: Twenty seven features were identified as more important using RF predictor model and were used to predict the class of peptides. The RF model improves the performance of predictor model in comparison with the other predictor models (AUC±SE: 0.925±0.029). Using the developed RF model helps to identify the most likely epitopes for further experimental studies. Conclusion: The current developed random forest model is able to more accurately predict the immunogenic peptides of intracellular parasites. https://ijph.tums.ac.ir/index.php/ijph/article/view/19369 https://ijph.tums.ac.ir/index.php/ijph/article/download/19369/6637

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 1 2020 01 07 134 144 Marjan KHOSRAVANI Department of Microbiology, Fars Science and Research Branch, Islamic Azad University, Shiraz, Iran AND Department of Microbiology, Shiraz Branch, Islamic Azad University, Shiraz, Iran Mohammad Mehdi SOLTAN DALLAL Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Divison of Microbiology, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mehdi NOROUZI Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2020 01 07 Background: The AcrB efflux pump in Salmonella species plays a significant role in the development of antibiotic resistance in ciprofloxacin-resistant Salmonella enteritidis. This study aimed to investigate the anti-efflux pump activity of Artemisia tournefortiana extracts among S. Enteritidis strains. Methods: The hydroalcoholic, aqueous, and hexanolic extracts of A. tournefortiana were prepared and phytochemical composition of extract was determined using gas chromatography/mass spectrometry (GC/MS) method. After antibiogram, the AcrB efflux pump was detected in ciprofloxacin intermediate and resistant S. enteritidis strains using cartwheel and Polymerase chain reaction (PCR) methods. Finally, minimum inhibitory concentrations (MIC) of extracts against S. enteritidis strains were evaluated. After treatment of S. enteritidis strains with sub-MIC concentrations of extracts, the expression level of AcrB efflux pump gene was evaluated using Real-Time PCR. Results: Phytochemical analysis of extracts using GC/MS method showed that hexadecanoic acid, ethyl ester (30.7%), and cyclopropane,1-(1-hydroxy-1-heptyl)-2-methylene-3-pentyl (17.8%) were the most dominant volatile components volatile compounds in the extract. The results of antibiogram, cartwheel and PCR methods showed that among 20 strains of S. enteritidis that were resistant and intermediate to ciprofloxacin, 16 strains had AcrB efflux pumps. Finally, Real-Time PCR results showed a significant down-regulation of acrB gene in S. enteritidis strains. Conclusion: A. tournefortiana had anti-efflux activity and this plant can potentially be used as a natural efflux inhibitor for S. enteritidis strains. https://ijph.tums.ac.ir/index.php/ijph/article/view/19371 https://ijph.tums.ac.ir/index.php/ijph/article/download/19371/6639

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 1 2020 01 07 145 156 Zahra VEISI Department of Electrical and Computer Engineering, Razi University, Kermanshah, Iran Heydar KHADEM Department of Electrical and Computer Engineering, Razi University, Kermanshah, Iran Samin RAVANSHADI Department of Electronic and Electrical Engineering, University of Sheffield, Sheffield, United Kingdom 2020 01 07 Background: Immunotherapy is a recently developed method of cancer therapy, aiming to strengthen a patient’s immune system in different ways to fight cancer. One of these ways is to add stem cells into the patient’s body. Methods: The study was conducted in Kermanshah, western Iran, 2016-2017. We first modeled the interaction between cancerous and healthy cells using the concept of evolutionary game theory. System dynamics were analyzed employing replicator equations and control theory notions. We categorized the system into separate cases based on the value of the parameters. For cases in which the system converged to undesired equilibrium points, “stem-cell injection” was employed as a therapeutic suggestion. The effect of stem cells on the model was considered by reforming the replicator equations as well as adding some new parameters to the system. Results: By adjusting stem cell-related parameters, the system converged to desired equilibrium points, i.e., points with no or a scanty level of cancerous cells. In addition to the theoretical analysis, our simulation results suggested solutions were effective in eliminating cancerous cells. Conclusion: This model could be applicable to different types of cancer, so we did not restrict it to a specific type of cancer. In fact, we were seeking a flexible mathematical framework that could cover different types of cancer by adjusting the system parameters. https://ijph.tums.ac.ir/index.php/ijph/article/view/19372 https://ijph.tums.ac.ir/index.php/ijph/article/download/19372/6640

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 1 2020 01 07 157 166 Hamid HASANPOUR Department of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran AND Department of Parasitology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Reza FALAK Immunology ‎Research Center, Iran University of Medical Sciences, Tehran, Iran Saied Reza NADDAF Department of Parasitology, Pasteur Institute of Iran, Tehran, Iran Santiago MAS-COMA Department of Parasitology, Faculty of Pharmacy, University of Valencia, Valencia, Spain Mohammad Bagher ROKNI Department of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Alireza BADIRZADEH Department of Pa