Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 8 2021 07 22 1586 1594 Zhenjiang Zhang Department of Infectious Diseases, The Affiliated Suqian First People‘s Hospital of Nanjing Medical University, Suqian, JiangSu 223800, China Jing Su Department of Hematology, The Affiliated Suqian First People‘s Hospital of Nanjing Medical University, Suqian, JiangSu 223800, China Xin Shen Department of Clinical Laboratory, The Affiliated Suqian First People‘s Hospital of Nanjing Medical University, Suqian, Jiang-Su 223800, China Bing Pei Department of Clinical Laboratory, The Affiliated Suqian First People‘s Hospital of Nanjing Medical University, Suqian, Jiang-Su 223800, China Fang Zhu Department of Infectious Diseases, The Affiliated Suqian First People‘s Hospital of Nanjing Medical University, Suqian, JiangSu 223800, China Huichun Ji Department of Infectious Diseases, The Affiliated Suqian First People‘s Hospital of Nanjing Medical University, Suqian, JiangSu 223800, China Tingting Shi Department of Ophthalmology, The Affiliated Suqian First People‘s Hospital of Nanjing Medical University, Suqian, JiangSu 223800, China Youde Yan Department of Infectious Diseases, The Affiliated Suqian First People‘s Hospital of Nanjing Medical University, Suqian, JiangSu 223800, China 2021 01 20 2021 03 06 Background: To evaluate the condition of antiviral therapy (ART) for individuals infected HIV-1 in Suqian district of Jiangsu Province, China. Methods: Altogether, 561 HIV-positive patients who received antiviral therapy in Suqian district in 2019 were recruited. EDTA anticoagulated blood was collected and separated to obtain the plasma samples. Viral load (VL) were tested for evaluating the outcome of ART. Then samples with VL beyond 1000IU/mL were used to conduct the molecular test in order to master the characters of HIV-1 and the prevalence of resistance strains. Results: VL results showed that the virus in 91.1% of the patients who received continuous antiviral treatment for more than 6 months were effectively inhibited (VL ≤ 1000 IU / ml). Among the 50 patients who failed in the treatment, 46 HIV-1 pol gene sequences were obtained, and the positive rate was 92.0%. The most prevalent strain was CRF_ 07bc (32.6%), and new epidemic strains, such as 67_01B、79_0107、87_cpx, were popular in this district. Drug resistance test results showed that 56.5% of the patients failed in antiviral treatment due to drug resistance, mainly resistant to the national first-line antiviral drug 3TC. Drug-resistant strains were not found in 43.5% of the patients. Conclusion: ART achieved a satisfied result in Suqian district, but the main cause resulting in ART-failure was resistant, so it is very necessary to enhance the education of adherence prior to the initiation of ART. https://ijph.tums.ac.ir/index.php/ijph/article/view/23551 https://ijph.tums.ac.ir/index.php/ijph/article/download/23551/7316

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 8 2021 07 21 1517 1525 EN Juan Xu Department of Internal Medicine, The People’s Hospital of Guandu District, 63 Yingfeng Road, Kunming 650200, China Yang Li Department of Clinical Laboratory, The Third Affiliated Hospital of Kunming Medical University, 519 Kunzhou Road, Kun-ming 650118, China Quansong Xia Department of Clinical Laboratory, The Third Affiliated Hospital of Kunming Medical University, 519 Kunzhou Road, Kun-ming 650118, China Qiong Shi Department of Clinical Laboratory, The Third Affiliated Hospital of Kunming Medical University, 519 Kunzhou Road, Kun-ming 650118, China 2021 04 16 2021 05 06 Background: COVID-19 has resulted in an emerging respiratory infection with a pandemical diffusion since December 2019. We aimed to elucidate whether the presence of thyroid disease might increase the risk of severe COVID-19 infection. Methods: Studies reporting seriously ill in COVID-19 patients with and without thyroid disease combined were searched and 11 relevant studies were subjected to our analysis, and pooled odds ratios (ORs) together with 95% confidence intervals (CIs) were calculated by using STATA and Review Manager Software. Results: In total, 2,995 COVID-19 patients were included in this study. The pooled ORs were calculated using a fixed-effects model according to the heterogeneity. The pooled results revealed that thyroid disease was associated with severe COVID-19 infection in patients (OR = 2.14, 95 % CI: 1.23–3.72, P = 0.007). In the subgroup analysis by type of thyroid disease, hypothyroidism was positively associated with risks of severe COVID-19 infection (OR = 4.78, 95 % CI: 1.59–14.36, P = 0.005), however, no obvious difference was found in the risk regarding the severe COVID-19 infection amongst hyperthyroidism or unclassified thyroid disease. In addition, subgroup analysis stratified by ethnic groups demonstrated that thyroid disease was linked to the risks of severe COVID-19 infection in Asian patients (OR = 2.41, 95 % CI: 1.30–4.48, P = 0.005) rather than non-Asian (OR = 1.31, 95 % CI: 0.35–4.87, P = 0.684). Conclusion: This study indicates a correlation between thyroid disease and severe COVID-19 infection. https://ijph.tums.ac.ir/index.php/ijph/article/view/24594 https://ijph.tums.ac.ir/index.php/ijph/article/download/24594/7309

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 8 2021 07 22 1722 1723 Lu Chen Division of Prevention and Community Health, Fuwai Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 102308, China Zengwu Wang Division of Prevention and Community Health, Fuwai Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 102308, China 2021 04 27 2021 06 21 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/24729 https://ijph.tums.ac.ir/index.php/ijph/article/download/24729/7331

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 8 2021 07 22 1595 1602 EN In Cheol Hwang Department of Family Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea Hong Yup Ahn Department of Statistics, Dongguk University, Seoul, South Korea 2020 02 03 2020 05 05 Background: The relationship between cadmium (Cd) exposure and depression remains unclear. This nationwide study aimed to compare the levels of blood Cd with the presence of depressive mood in Korean adults. Methods: From the 2008–2013 Korea National Health and Nutrition Examination Survey, 10,968 individuals over 20 yr old were identified. Data on demographics, health behaviors, depressive mood, and blood Cd (B-Cd) levels were used in the analysis. Estimated levels of B-Cd were drawn from multivariate regression models. Results: Higher age-adjusted B-Cd levels were noted among women, rural residents, people who have a low economic or educational status, smoke currently, drink frequently, or have depressive mood than the counterpart groups. In fully adjusted models, men with depressive mood exhibited significantly higher B-Cd levels than those without depressive mood, and these levels were strongly mediated by smoking status. Conclusion: Our results suggest a need for Cd accumulation screening among individuals with depressive mood. https://ijph.tums.ac.ir/index.php/ijph/article/view/19643 https://ijph.tums.ac.ir/index.php/ijph/article/download/19643/7317

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 8 2021 07 21 1526 1535 EN Nam Young Kim Department of Nursing, Jungwon University, Goesan, Korea Se Ang Ryu Department of Nursing, Mokpo National University, Muan, Korea Yun Hee Kim Department of Nursing, Mokpo National University, Muan, Korea 2020 01 16 2020 05 29 Background: The delirium in Intensive Care Untints (ICU) patients is a major cause of unplanned extubation, increased length of hospital day. This study aimed to review systematically risk factors associated with the occurrence of delirium among ICU patients in South Korea. Methods: Data collection was done with domestic literature search databases including KMbase, KoreaMed, KISS, and KisTi and also with hand searching, from February 17 to May 19, 2019. Two researchers independently selected research literatures, and three researchers summarized and identified related variables based on data extraction methods. Results: Overall, 140 articles identified, 18 articles met the inclusion criteria for review. According to the results of the methodological quality, one article was found to have a high level of quality, while the remaining 17 articles belonged to the medium level. Those factors found to be highly associated with delirium by more than 9 out of the 18 selected studies were listed as follows; age, the application of ventilator, APACHE II score, comorbidity, the application of restraint, and educational level. In addition, catheter insertion and the application of artificial airway were also found to have significant relevance with the occurrence of delirium. Conclusion: For management of delirium among ICU patients, it is necessary to eliminate and prevent delirium-associated risk factors, and also to detect and treat the delirium early through regular monitoring using an appropriate screening tool for delirium. https://ijph.tums.ac.ir/index.php/ijph/article/view/19459 https://ijph.tums.ac.ir/index.php/ijph/article/download/19459/7310

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 8 2021 07 22 1724 1725 In-Dong Kim Changduk Girls’ High School, Seoul, Republic of Korea Ji-Hoon Cho Department of Sport and Leisure Studies, Shingyeong University, Hwaseong, Republic of Korea Seung-Taek Lim Olympic Studies Center, Kangwon National University, Gangwon-do, Republic of Korea 2021 05 22 2021 06 21 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/25024 https://ijph.tums.ac.ir/index.php/ijph/article/download/25024/7332

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 8 2021 07 22 1603 1612 Xiaolan Zhao Department of Ultrasound, Yantaishan Hospital, Yantai 264000, China Yifang Xia Department of Imaging, Zhangqiu District People’s Hospital, Jinan 250200, China Chunjing Li Department of Imaging, Zhangqiu District People’s Hospital, Jinan 250200, China Dapeng Wang Department of Imaging, the Affiliated Hospital of China University of Petroleum (East China), Qingdao 266580, China 2020 12 23 2021 02 06 Background: The efficacy of color Doppler ultrasound, multislice spiral CT combined with serum alpha-fetoprotein (AFP) and alpha-fetoprotein heterogeneity (AFP-L3) in the diagnosis of primary hepatic carcinoma was evaluated. Methods: Seventy-nine patients with primary hepatic carcinoma (PHC group) and 50 patients with benign liver lesions (benign control group) admitted in Yantaishan Hospital (Yantai, China) from January 2016 to December 2018 were selected. The liver was scanned by color Doppler ultrasound and multiple multislice spiral CT. The serum AFP and AFP-L3 levels were detected by electrochemiluminescence. The value of color Doppler ultrasound, multislice spiral CT combined with serum AFP and AFP-L3 in diagnosis of primary liver cancer was retrospectively analyzed. Results: The color Doppler flow imaging (CDFI) showed a high-speed and high-resistance spectrum. The serum AFP and AFP-L3 levels of patients with primary hepatic carcinoma were significantly higher than those of the benign control group were (U=138.000 and 155.500, P=0.000 and 0.000), P<0.01. The sensitivity, accuracy and negative predictive value of color Doppler ultrasound, multislice spiral CT combined with serum AFP and AFP-L3 examinations for diagnosis of primary hepatic carcinoma were 96.20, 90.70 and 93.18%, which was significantly improved compared with each single examination (X2=27.888, 17.511 and 16.202, P=0.000, 0.002 and 0.003), P<0.01. Conclusion: Color Doppler ultrasound, multislice spiral CT combined with AFP and AFP-L3 examination could significantly improve the diagnosis efficiency of primary hepatic carcinoma, which was beneficial to early clinical diagnosis and early treatment. https://ijph.tums.ac.ir/index.php/ijph/article/view/23283 https://ijph.tums.ac.ir/index.php/ijph/article/download/23283/7318

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 8 2021 07 21 1536 1546 EN Dumilah Ayuningtyas Faculty of Public Health, Universitas Indonesia, Depok, Indonesia Sri Windiarti Regional Public Hospital in Bima City, Bima, Indonesia M Hadi Faculty of Public Health, Universitas Indonesia, Depok, Indonesia Ulya Fasrini Faculty of Medicine, Universitas Andalas, Padang, Indonesia Sandra Barinda Faculty of Public Health, Universitas Indonesia, Depok, Indonesia 2021 03 31 2021 07 10 Afshin ZARGHI Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran Saeed SAFARI Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran AND Emergency Department, Shohadye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Teh-ran, Iran Behrooz HASHEMI Emergency Department, Shohadye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Mehdi FOROUZANFAR Emergency Department, Shohadye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mostafa HOSSEINI Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2020 06 29 2020 07 14 Background: We aimed to examine the available evidence regarding the efficacy and safety of corticosteroids on the management of coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome (SARS-CoV) and Middle East respiratory syndrome (MERS-CoV). Method: An extensive search was conducted in Medline, Embase, and Central databases until the end of March 2020, using keywords related to corticosteroids, COVID-19, SARS-CoV and MERS-CoV. The main outcome was considered to be the mortality rate, length of stay, virus clearance time, symptom improvement, and lung function improvement. The findings are presented as odds ratio (OR) with 95% confidence interval (95% CI). Results: Fifteen paper compromising 5 studies on COVID-19, 8 studies on SARS-CoV and 2 studies on MERS-CoV were included. One study was clinical trial and the rest were cohort. The analyses showed that corticosteroids were not reduce the mortality rate of COVID-19 (OR=1.08; 95% CI: 0.34 to 3.50) and SARS-CoV (OR=0.77; 95% CI: 0.34 to 1.3) patients, while they were associated with higher mortality rate of patients with MERS-CoV (OR = 2.52; 95% CI: 1.41 to 4.50). Moreover, it appears that corticosteroids administration would not be effective in shortening viral clearance time, length of hospitalization, and duration of relief symptoms following viral severe acute respiratory infections. Conclusion: There is no evidences that corticosteroids are safe and effective on the treatment of severe acute respiratory infection when COVID-19 disease is suspected. Therefore, corticosteroids prescription in COVID-19 patients should be avoided. https://ijph.tums.ac.ir/index.php/ijph/article/view/21297 https://ijph.tums.ac.ir/index.php/ijph/article/download/21297/6934

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1571 1572 Moon-Hyon HWANG Division of Health & Kinesiology, Incheon National University, Incheon, South Korea AND Sport Science Institute, Incheon National University, Incheon, South Korea 2019 04 23 2019 05 29 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/16934 https://ijph.tums.ac.ir/index.php/ijph/article/download/16934/6953

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1455 1466 ChunHuan HUANG College of Landscape Architecture, Nanjing Forestry University, Nanjing, China Xin DENG College of Landscape Architecture, Nanjing Forestry University, Nanjing, China Hailin YANG College of Landscape Architecture, Nanjing Forestry University, Nanjing, China Xinhui ZHOU College of Landscape Architecture, Nanjing Forestry University, Nanjing, China Qi JIA College of Arts and Design, Zhengzhou University of Light Industry, Zhengzhou, China 2020 06 14 2020 07 11 Background: We explored the spatio-temporal characteristics of urban heat island (UHI) effect on cardiovascular diseases (CVDs). Methods: The land surface temperatures (LST) were retrieved from four Landsat remote-sensing images’ data, the temperature data from 95 meteorological stations, and analysis data on CVDs mortality. Based on these data, landscape pattern indexes were used to analyze the pattern-process-function and the mechanism. Results: During 1984–2017, the effects of UHI on CVDs increased, thereby increased the mortality by 28.8%. The affected areas gradually expand from the central area of the city and undergo three evolution stages; the highly affected areas are mainly distributed in central and southern regions, and patches increase in number. The areas and ratio of high-level patches also show an upward tendency, increasing dominance in the overall landscape. Patches of the overall landscape become more complicated in shape, whereas those of high-level ones become less complicated. Concentration degree of the overall landscape decreases gradually with the types of landscapes patches increasing, reaching a rather even space distribution. Conclusion: Increased temperatures exacerbated by UHI lead to increased CVD mortality. As cities expand, the effects of UHI on CVDs increase in terms of both intensity and areas, with the overall landscape in uneven distribution, high-level affected areas in point distribution, and low-level ones in large-area concentration. https://ijph.tums.ac.ir/index.php/ijph/article/view/21122 https://ijph.tums.ac.ir/index.php/ijph/article/download/21122/6939

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1422 1431 Abbas HOMAUNI Department of Health Economics and Management, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Sanaz ZARGAR BALAYE JAME Department of Health Management and Economics, School of Medicine, AJA University of Medical Sciences, Tehran, Iran Ebrahim HAZRATI Department of Anesthesiology, AJA University of Medical Sciences, Tehran, Iran Nader MARKAZI-MOGHADDAM Department of Health Management and Economics, School of Medicine, AJA University of Medical Sciences, Tehran, Iran 2019 12 23 2020 05 29 Background: It is of paramount importance to reduce the probability of clinical risks to improve the quality of health care services, make the relationship between service providers and patients more effective, enhance patient satisfaction, and decrease the rate of complaints regarding medical errors in hospitals. This study aimed at detecting potential and unacceptable risks occurring in the hospital ICUs. Methods: In this systematic review, all studies examining the risk assessment of ICUs in hospitals using Failure Mode and Effect Analysis method were reviewed. Google scholar, PubMed, Scopus, SID, Magiran and Web of Science databases were searched to find relevant articles published from 1980 to 2019. Results: The most frequent failures detected in the reviewed articles consisted of high risk of infection inwards for medical and nursing operations, high infection rates inwards for medical devices’ operation within the unit, and early discharge. Moreover, the processes through which potential high-risk Failures were examined in these studies were injection or prescription process, suction process, the process of inserting or removing endotracheal tubes, the process of transferring patients from the operation room to the unit or vice versa, pressure ulcers, and processes related to the medical devices’ operation. Conclusion: There are many possible reasons for failure occurring throughout these processes, and the failure modes occurring in these processes are more probable to cause serious damages to patients, have high repeatability with low probability of failure detection as the failures cannot be discovered by the personnel. https://ijph.tums.ac.ir/index.php/ijph/article/view/19259 https://ijph.tums.ac.ir/index.php/ijph/article/download/19259/6935

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1573 1575 EN Miroslava IVANOVA Department of Informatics and Mathematics, Trakia University, 6000 Stara Zagora, Bulgaria Lilko DOSPATLIEV Department of Pharmacology, Animal Physiology and Physiological Chemistry, Trakia University, 6000 Stara Zagora, Bulgaria Denitsa GRIGOROVA Department of Probability, Operations Research and Statistics, Sofia University "St. Kliment Ohridski", 1164 Sofia, Bulgaria Penko PAPAZOV Department of Organic Chemistry and Inorganic Chemistry, University of Food Technology, 4000 Plovdiv, Bulgaria 2018 09 19 2018 09 30 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/14755 https://ijph.tums.ac.ir/index.php/ijph/article/download/14755/6954

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1467 1475 Jin Ho YOON Department of Sports Rehabilitation, Korea Nazarene University, Cheonan, Korea Ki-Jae SONG Department of Sports Medicine, Korea National Sport University, Seoul, Korea Mu-Yeop JI Department of Sports Medicine, Korea National Sport University, Seoul, Korea Bang-Sub LEE Department of Sports Science, Korea Institute of Sport Science, Chungcheongbok-do, Korea Jae-Keun OH Department of Sports Medicine, Korea National Sport University, Seoul, Korea 2020 06 08 2020 07 30 Background: The shoulder joint has a wide range of motion, but is vulnerable to sport-related injuries. We aimed to evaluate the differences in the proprioception of the shoulder should instability, and shoulder pain in high school baseball players with shoulder instability following a 12-week rehabilitation exercise program. Methods: We enrolled 13 baseball players with shoulder instability who visited the Orthopedics Department at Konkook University Hospital in Seoul, South Korea and 12 controls without shoulder instability. We examined the dominant shoulder and the non-dominant shoulder for both groups. We restricted participation to individuals who had no other orthomechanical disease in the past six months, except for instability of the shoulder, and no physical limitation to participate in the exercise. We measured the proprioception of the shoulder and shoulder instability, and we also evaluated pain with the Visual Analog Scale before and after the rehabilitation program. To verify the differences between groups, we used a two-way analysis of variance, and a two-way analysis of covariance was used when a significant difference was found at the pretest (baseline between groups). Results: Proprioception was associated with shoulder instability. The Visual Analog Scale rating improved in the dominant shoulder with instability; and a positive change was found in the dominant shoulder without instability after the rehabilitation program (P < 0.05). Conclusion: The 12-week rehabilitation exercise program might improve the proprioception and pain of patients with shoulder instability. However, further studies with more participants and a rehabilitation exercise program should be undertaken. https://ijph.tums.ac.ir/index.php/ijph/article/view/21057 https://ijph.tums.ac.ir/index.php/ijph/article/download/21057/6940

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1432 1438 Sanaz MUSAVI Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Hossein MASHHADI ABDOLAHI Tabriz Health Services Management Research Center, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran Morteza GHOJAZADEH Research Center for Evidence-Based Medicine, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran Mahdieh ABBASALIZAD FARHANGI Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Zeinab NIKNIAZ Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Leila NIKNIAZ Tabriz Health Services Management Research Center, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran 2019 06 08 2019 10 20 Background: This systematic review and meta-analysis of the observational studies aimed at evaluating the infertile women’s attitude toward gestational surrogacy. Methods: Published studies until Jan 2019 were searched using PubMed/MEDLINE, Scopus, EMBASE, Cochrane Library, ISI Web of Science, Proquest and Google scholar, MagIran, SID and IranMedex. Studies in English or Persian language surveyed attitudes toward surrogacy for infertile women published until Jan 2019. Animal studies and studies with poor methodological quality were excluded from the review. Results: Six eligible studies including 1359 infertile women were identified. Of these, 559 and 742 women agreed and disagreed with surrogacy respectively. The overall event rate of positive attitude for surrogacy in infertile women was %39.7 (%95 CI=24.5 to 57.1, P=0.245). Conclusion: The infertile women’s attitude toward surrogacy is not strongly positive. We believe, more studies should be conducted among different socioeconomic, religious and cultural groups. https://ijph.tums.ac.ir/index.php/ijph/article/view/17403 https://ijph.tums.ac.ir/index.php/ijph/article/download/17403/6936

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1576 1578 Cosmin VESA Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania AND Clinical County Emergency, Hospital of Oradea, Oradea, Romania Carmen RADU Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania AND Clinical County Emergency, Hospital of Oradea, Oradea, Romania Loredana POPA Clinical County Emergency, Hospital of Oradea, Oradea, Romania Claudia JURCA Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania Lucia DAINA Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania AND Clinical County Emergency, Hospital of Oradea, Oradea, Romania Cornelia BALA Faculty of Medicine, University of Medicine and Pharmacy “Iuliu Hațieganu”, Cluj-Napoca, Romania Gabriela ROMAN Faculty of Medicine, University of Medicine and Pharmacy “Iuliu Hațieganu”, Cluj-Napoca, Romania Mădălina MOISI Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania AND Clinical County Emergency, Hospital of Oradea, Oradea, Romania Amorin POPA Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania AND Faculty of Medicine, University of Medicine and Pharmacy “Iuliu Hațieganu”, Cluj-Napoca, Romania Mihaela POPOVICIU Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania AND Clinical County Emergency, Hospital of Oradea, Oradea, Romania Anca FERICIAN Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania AND Clinical County Emergency, Hospital of Oradea, Oradea, Romania Dana ZAHA Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania AND Clinical County Emergency, Hospital of Oradea, Oradea, Romania 2018 09 11 2020 07 30 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/14693 https://ijph.tums.ac.ir/index.php/ijph/article/download/14693/6955

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1476 1484 Qingquan REN Department of Labor and Environmental Hygiene, Shenyang Medical College, Liaoning 110034, P.R. China AND Key Laboratory of Environmental Pollution and Microecology of Liaoning Province, Shenyang Medical College, Shenyang, Liaoning 110034, P.R. China Shuyin LI Key Laboratory of Environmental Pollution and Microecology of Liaoning Province, Shenyang Medical College, Shenyang, Liaoning 110034, P.R. China AND Department of Pathogenic Biology, Shenyang Medical College, Shenyang, Liaoning 110034, P.R. China Chunling XIAO Key Laboratory of Environmental Pollution and Microecology of Liaoning Province, Shenyang Medical College, Shenyang, Liaoning 110034, P.R. China AND Department of Pathogenic Biology, Shenyang Medical College, Shenyang, Liaoning 110034, P.R. China Jiazhi ZHANG Shenyang Environmental Monitoring Center Station, Shenyang, Liaoning 110016, P.R. China Hong LIN Shenyang Environmental Monitoring Center Station, Shenyang, Liaoning 110016, P.R. China Shuai WANG Shenyang Environmental Monitoring Center Station, Shenyang, Liaoning 110016, P.R. China 2020 04 17 2020 05 29 Background: The aim of this study was to investigate the overall impact of PM2.5, PM10, NO2, SO2, CO, and O3 on the admission of cardiovascular and cerebrovascular disease. Methods: We collected data on cardiovascular and cerebrovascular disease admissions from two hospitals in Shenyang Liaoning, China from Jan 2014 to Dec 2017, as well as daily measurements of six pollutants at 11 sites in Shenyang. The generalized additive model was used to assess the association between daily contaminants and admission to cardiovascular and cerebrovascular disease. Results: The single-contamination model showed a significant correlation between NO2, O3, PM10 and cardiovascular and cerebrovascular diseases at lag0 day. Air pollutants had lag effects on different gender groups. Excess relative risks (ERs) associated with a 10 μg/m3 increase were 1.522(1.057, 1.988) on lag02 for NO2, 0.547% (0.367%, 0.728%), 0.133% (0.061%, 0.205%) on lag3 for O3 and PM10. The dual pollutant model showed that the effects of NO2, O3, and PM10 after adjusting the influence of other pollutants were still statistically significant. Conclusion: Short-term exposure to ambient air pollution (NO2, O3, and PM10) may be associated with an increased risk of daily cardiovascular and cerebrovascular admission, which may provide reliable evidence for further understanding of the potential adverse effects of air pollution on cardiovascular and cerebrovascular diseases. https://ijph.tums.ac.ir/index.php/ijph/article/view/20390 https://ijph.tums.ac.ir/index.php/ijph/article/download/20390/6941

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 14777 14777 Muhammad SOHAIL AFZAL Department of Life Sciences, School of Science, University of Management and Technology (UMT), Lahore, Pakistan 2018 09 22 2018 09 30 No Abstract. https://ijph.tums.ac.ir/index.php/ijph/article/view/14777 https://ijph.tums.ac.ir/index.php/ijph/article/download/14777/6956

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1485 1493 EN Siti Rohana AHMAD Department of Community Medicine, Universiti Sains Malaysia, Kelantan, Malaysia Nor YAACOB Department of Community Medicine, Universiti Sains Malaysia, Kelantan, Malaysia Mat JAEB Respiratory Clinic, Hospital Raja Perempuan Zainab, Kelantan, Malaysia Zalmizy HUSSIN School of Applied Psychology, Social Work, and Policy, Universiti Utara Malaysia, Kedah, Malaysia Wan Mohd WAN MOHAMMAD Department of Community Medicine, Universiti Sains Malaysia, Kelantan, Malaysia 2018 07 16 2018 12 30 Background: There is growing evidence that DM may play an important role in the occurrence of unsuccessful TB treatment outcomes. This study was undertaken to examine the prevalence of  DM among TB population, compare the profile of TB patients with and without DM and determine the effect of DM on unsuccessful treatment outcomes among TB patients in Kelantan state, Malaysia from 2012 to 2016. Methods: A cross sectional study was conducted in Sep 2017 using data from registered TB cases in Kelantan state, Malaysia from 2012 to 2016. The profile of TB patients with and without DM were compared in univariable analysis. Multiple logistic regression was used to determine association between DM and unsuccessful treatment outcomes. Results: A total of 1854 TB patients were diagnosed with DM. The annual proportion was ranging from 26 to 29%. TB patients with DM had an older age, live single, low educational status, poor chest x ray finding and diagnosed with smear positive sputum compared to TB patients without DM. TB patients with DM had three times higher risk to develop unsuccessful TB treatment outcomes compared to TB patients without DM (95% CI 2.47-3.58; P = 0.012) in multivariable analysis. Conclusion: Those with DM had the worst prognosis of TB outcomes among the significant risk factors. TB control program in Malaysia will need to expand efforts to focus on treatment of TB-DM patients to improve their cure rates in order to achieve the goals of tuberculosis elimination.  https://ijph.tums.ac.ir/index.php/ijph/article/view/14038 https://ijph.tums.ac.ir/index.php/ijph/article/download/14038/6942

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1580 1581 EN Abraham ASSAN Department of Health Economics and Management, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran AND Global Policy and Advocacy Network (GLOOPLAN), Accra, Ghana Ali AKBARI SARI Department of Health Economics and Management, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran AND Global Policy and Advocacy Network (GLOOPLAN), Accra, Ghana Amirhossein TAKIAN Department of Health Economics and Management, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran AND Department of Global Health and Public Policy, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran AND Health Equity Research Centre (HERC), Tehran University of Medical Sciences, Tehran, Iran 2018 08 01 2018 08 11 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/14323 https://ijph.tums.ac.ir/index.php/ijph/article/download/14323/6957

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1494 1501 Liwu ZHOU Department of Orthopedics, Jinling Hospital, Nanjing University, Nanjing 210004, P.R. China Yang WAN Department of Orthopedics, Jinling Hospital, Nanjing University, Nanjing 210004, P.R. China Qiang CHENG Department of Orthopedics, Jinling Hospital, Nanjing University, Nanjing 210004, P.R. China Ben SHI Department of Orthopedics, Jinling Hospital, Nanjing University, Nanjing 210004, P.R. China Lei ZHANG Department of Orthopedics, Jinling Hospital, Nanjing University, Nanjing 210004, P.R. China Shuo CHEN Department of Orthopedics, Jinling Hospital, Nanjing University, Nanjing 210004, P.R. China 2020 03 02 2020 06 24 Background: To investigate the expression and diagnostic value of LncRNA H19 in the blood of patients with osteoarthritis. Methods: A total of 130 cases of patients with osteoarthritis admitted to Jinling Hospital, Nanjing, China from Jun 2016 to Jul 2017 were elected as the study group, and 100 patients who underwent physical examination in Jinling Hospital during the same period were selected as the control group. The differences in expression levels of LncRNA H19 between the two groups were compared, the diagnostic value of LncRNA H19 in osteoarthritis and its relationship with clinical characteristics of patients with osteoarthritis were analyzed. Results: The expression level of LncRNA H19 increased in peripheral blood of patients with osteoarthritis (P<0.05). The AUC, critical value, sensitivity and specificity of the diagnosis of osteoarthritis were 0.891, 1.879, 96.00% and 85.73%, respectively. The expression level of LncRNA H19 was related to K-L grading, and the expression level of LncRNA H19 increased with K-L grading. Pearson correlation analysis showed that LncRNA H19 was negatively correlated with bone metabolism indexes PINP, N-MID, BGP, BALP and Lysholm score (P<0.05), and positively correlated with bone metabolism indexes β-CTX, VAS score and WOMAC score (P<0.05). Conclusion: LncRNA H19 is highly expressed in peripheral blood of patients with osteoarthritis, which is closely related to the occurrence and development of osteoarthritis and has a good diagnostic value for osteoarthritis. https://ijph.tums.ac.ir/index.php/ijph/article/view/19907 https://ijph.tums.ac.ir/index.php/ijph/article/download/19907/6943

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1582 1584 Hamid CHEGNI Department of Immunology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran Nafiseh PAKRAVAN Department of Immunology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran Mojtaba SAADATI Department of Biology, Imam Hossein University, Tehran, Iran Ali GHAFFARI Department of Parasitology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran Hadi SHIRZAD Institute of Policy Research and Social Studies, Tehran, Iran Zuhair HASSAN Department of Immunology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran 2020 05 17 2020 07 11 - https://ijph.tums.ac.ir/index.php/ijph/article/view/20835 https://ijph.tums.ac.ir/index.php/ijph/article/download/20835/6958

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1502 1509 EN Lyazzat SHINETOVA Department of General Biology and Genomics, L.N. Gumilyov Eurasian National University, Astana, 010008, Kazakhstan Almira AKPAROVA Department of General Biology and Genomics, L.N. Gumilyov Eurasian National University, Astana, 010008, Kazakhstan Saulemai BEKEYEVA Department of General Biology and Genomics, L.N. Gumilyov Eurasian National University, Astana, 010008, Kazakhstan 2018 07 22 2018 11 10 Background: Mercury is a common environmental contaminant and it is also harmful to human health. Among reported toxicities, its harmful effect on hypertension is poorly documented. In Kazakhstan, Temirtau city has been reported to have a high level of mercury contamination from an acetaldehyde production factory. Therefore, we aimed to investigate the association between serum profile of cytokines and the development of hypertension among the exposed citizens. Methods: We selected 81 individuals for study, out of them, 41 exposed ones suffered hypertension and 40 – unexposed healthy controls in villages Chkalovo, Samarkand, Gagarinskoye, Tegiszhol, Rostovka in 2016. Mercury content in urine was studied by inversion voltammetry. Cytokine levels of IL-2, IL-6, IL-10 and TNF-α were determined by ELISA. Results: Mercury-exposed citizens, especially those with hypertension, had significantly higher concentrations of inflammatory cytokines TNF-α, IL-2, IL-6 and anti-inflammatory cytokine IL-10 as compared to the unexposed population. The dependence of the mercury level in urine on IL-2 content was also detected. Therefore, chronic low doses of exposure to mercury were associated with an increase in serum levels of immune markers and with the increased risk of hypertension. https://ijph.tums.ac.ir/index.php/ijph/article/view/14133 https://ijph.tums.ac.ir/index.php/ijph/article/download/14133/6944

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1585 1587 EN Zahra BAHROLOLOOMI Oral Health Research Center, Department of Pediatric Dentistry, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Narjes AMROLLAHI Dental Research Center, Department of Pediatric Dentistry, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran Nasrin MOSTAFALOO Department of Pediatric Dentistry, School of Dentistry, Semnan University of Medical Sciences, Semnan, Iran 2018 10 01 2018 10 14 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/14860 https://ijph.tums.ac.ir/index.php/ijph/article/download/14860/6959

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1510 1519 EN Mohsen VIGEH Maternal, Fetal, and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Department of Epidemiology and Environmental Health, Faculty of Medicine, Juntendo University, Tokyo, Japan Kazuhito YOKOYAMA Department of Epidemiology and Environmental Health, Faculty of Medicine, Juntendo University, Tokyo, Japan Takehisa MATSUKAWA Department of Epidemiology and Environmental Health, Faculty of Medicine, Juntendo University, Tokyo, Japan Atsuko SHINOHARA Department of Epidemiology and Environmental Health, Faculty of Medicine, Juntendo University, Tokyo, Japan Katsumi OHTANI Occupational Epidemiology Research Group, National Institute of Occupational Safety and Health, Kawasaki, Japan Mamak SHARIAT Maternal, Fetal, and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran 2018 08 04 2018 12 15 Background: Exposure to toxic metals remains a public health problem with lifelong impacts on childhood growth and development. We aimed to investigate metals effects on preschool children’s anthropometric variables. Methods: The study was conducted in Tehran, Iran, from Jul 2013 to Mar 2016. We measured scalp hair metal concentrations (lead, cadmium, arsenic, zinc, manganese, and cobalt), using inductively coupled plasma mass spectrometry, in 207 preschool children’s (36 to 72 months old). Results: A significant negative correlation between children's hair lead levels and children's weight was found (r= −0.178, P<0.05). Linear regression analysis confirmed the relationship when adjusted for the confounders, including children's age, sex, height, family income, and maternal education (β= −0.191; t= −3.426, P< 0.01). The ANOVA analysis showed a significant (P<0.01) difference between hair lead level and children's weight-for-age percentiles. Totally and separately, in almost all weight percentiles, hair lead levels were higher in girls than boys. Conclusion: The present study on Iranian children showed the current levels of lead exposure might negatively influence on children growth, with higher risk for girls than boys. https://ijph.tums.ac.ir/index.php/ijph/article/view/14347 https://ijph.tums.ac.ir/index.php/ijph/article/download/14347/6945

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1588 1589 Mehdi HASSANIAZAD Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Marjan GHAZISAEEDI Department of Health Information Management, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran Tayebeh BANIASADI Department of Health Information Management, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran 2020 05 25 2020 06 24 No abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/20913 https://ijph.tums.ac.ir/index.php/ijph/article/download/20913/6960

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1520 1529 Soheila SHAGHAGHIAN Department of Medical Journalism, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran Behrooz ASTANEH Department of Medical Journalism, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran 2018 12 31 2019 04 23 Background: Although much medical knowledge comes from observational research, such studies are more prone to confounding and bias than others. This study was conducted to evaluate the adherence of the observational studies published in Iranian medical journals to the STROBE (strengthening the reporting of observational studies in epidemiology) statement. Methods: In this cross-sectional study, we selected 150 articles of Iranian medical journals, using multistage sampling from Aug 2016 to Jun 2017. The reported items of the STROBE statement in the articles was determined and considered as the adherence of the articles to the statement. The adherence of the articles with different characteristics was compared. Results: The adherence of the articles to the statement varied from 24% to 68% with a mean score of 48%±9%. The lowest mean scores were found in the Result (36%) and Method (49%) sections. The adherence was significantly better in the articles published in the journals indexed in PubMed or Web of Knowledge (ISI) databases (P<0.001) and those written by cooperation of the authors from other countries (P=0.044). Conclusion: The evaluated articles in our study had not adequately reported the items recommended by the STROBE statement. This indicates deficiency in key elements for readers to assess the validity and applicability of a study. https://ijph.tums.ac.ir/index.php/ijph/article/view/15763 https://ijph.tums.ac.ir/index.php/ijph/article/download/15763/6946

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1590 1591 Behzad HEYDARPOUR Cardiac Rehabilitation Center, Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran Sahar NAJAFI Lifestyle Modification Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran Maryam JANATMAKAN Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran Saeid KOMASI Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran 2018 09 30 2018 10 08 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/14851 https://ijph.tums.ac.ir/index.php/ijph/article/download/14851/6961

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1530 1538 EN Mohammad Esmaeil MOTLAGH Department of Pediatrics, School of Medicine, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran Seiyed Davoud NASROLLAHPOUR SHIRVANI Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Science, Babol, Iran Zahra HASSANZADEH-ROSTAMI Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran Farahnaz TORKESTANI Department of Obstetrics and Gynecology, School of Medicine, Shahed University, Tehran, Iran Seyed-Mozaffar RABIEE Department of Anesthesiology and Intensive Care, Babol University of Medical Sciences, Babol, Iran Hassan ASHRAFIAN AMIRI Babol University of Medical Sciences, Babol, Iran Laleh RADPOOYAN Department of Health, Ministry of Health and Medical Education, Tehran, Iran 2018 07 27 2018 12 15 Background: Unwanted pregnancy is a type of unplanned pregnancy that can endanger health of mother and child. This study aimed to determine the prevalence of unwanted pregnancy and its associated factors and consequences in Iran. Methods: This cross-sectional study was conducted in regions with low, moderate and high risk of maternal death. Two provinces were randomly selected in each region and 24 public health centers in each province during 2007-2012. Thereafter, 15-20 mothers, received at least one session of pregnancy care, were selected from each healthcare center. Data were gathered from both health records and interview with the mothers. Results: Of 2714 participants, 86.4% and 13.6% had respectively wanted and unwanted pregnancies. The underlying factors of unwanted pregnancy were determined as low distance with previous and next pregnancy, economic problems and have enough children. Moreover, there were significant relationships between unwanted pregnancy and place of residence, mother’s age and education, father’s education, pre-pregnancy care and number of previous pregnancies and children. There were also significant association between unwanted pregnancy and pregnancy care, anemia, exposure to risk factors and disease, intake of folic acid and iron, domestic violence, bitter memories and men’s participation. Conclusion: Although the prevalence of unwanted pregnancy has had a significant decrease in Iran, these mothers still require a higher level of educational, counseling and supportive services due to their low access to pregnancy care services and high exposure to associated risk factors. https://ijph.tums.ac.ir/index.php/ijph/article/view/14186 https://ijph.tums.ac.ir/index.php/ijph/article/download/14186/6947

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1592 1593 EN Mehran ROSTAMI Deputy of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran Shahab REZAEIAN Infectious Diseases Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran AND Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran 2018 05 21 2018 06 02 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/13446 https://ijph.tums.ac.ir/index.php/ijph/article/download/13446/6962

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1539 1545 EN Reza RANJBAR Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran Shahin ZAYERI Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran Davoud AFSHAR Department of Microbiology and Virology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran 2018 07 30 2018 12 15 Background: Efflux pumps are involved in resistance of Acinetobacter baumannii isolates to antimicrobial agents. AdeABC efflux pump is one of the RND superfamily efflux pump and consists of adeA (membrane fusion), adeB (multidrug transporter) and adeC (outer membrane) genes. In this study, the frequency of adeA, adeB and adeC genes among A. baumannii isolates with resistance to erythromycin, trimethoprim, meropenem and imipenem was investigated.  Methods: Overall, 79 strains of A. baumannii were isolated from patients admitted to two major hospitals in Tehran during 2016. Antibiotic susceptibility testing was determined by disc diffusion and microdilution methods according to Clinical and Laboratory Standards Institute (CLSI) guideline. The presence of adeA, adeB and adeC genes was also determined using Multiplex PCR assay. Results: The highest and the lowest resistance among A. baumannii isolates were to trimethoprim (93%) and erythromycin (53%), respectively. The frequency of adeA, adeB and adeC genes was 96.2%, 96.2% and 91.1 % respectively. There was a significant relationship between imipenem resistance and presence of efflux pump genes (P<0.05). Conclusion: According to the high prevalence of the AdeABC efflux system genes, it may involve in resistance of clinical isolates of A. baumannii to imipenem, especially.  https://ijph.tums.ac.ir/index.php/ijph/article/view/14244 https://ijph.tums.ac.ir/index.php/ijph/article/download/14244/6948

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1594 1596 Ke FENG Department of Emergency, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China Zhongwei CHEN Department of Emergency, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China Bin MEI Department of Neurology, Wuhan University Zhongnan Hospital, Wuhan, Hubei, China Xing DU Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical Univer-sity, Yinchuan, Ningxia, China Xufeng FU Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical Univer-sity, Yinchuan, Ningxia, China 2020 06 17 2020 07 11 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/21158 https://ijph.tums.ac.ir/index.php/ijph/article/download/21158/6963

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30 1546 1554 EN Roya KOLAHDOUZ-MOHAMMADI Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran Ali-Akbar DELBANDI Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran AND Immunology Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sci-ences, Tehran, Iran Sepideh KHODAVERDI Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran Soheila AREFI Bahman Hospital Infertility Center, Tehran, Iran AND Genetics and In Vitro Assisted Reproductive (GIVAR) Center, Erfan Hospital, Tehran, Iran Tahereh ARABLOU Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran Farzad SHIDFAR Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran 2018 10 20 2018 12 02 Background: We aimed to examine resveratrol effects on gene expression of Bcl-2, Bax and Bcl-2/Bax ratio in endometrial stromal cells derived from women with and without endometriosis. Methods: Endometrial tissues were obtained from 40 endometriotic patients and 15 non-endometriotic controls undergoing laparoscopic surgery or hysterectomy in the gynecology ward of Rassoul Akram Hospital, Tehran, Iran from 2015 to 2017. After the enzymatic digestion, eutopic (EuESCs) and ectopic (EESCs) endometrial stromal cells from patients with endometriosis as well as endometrial stromal cells from non-endometriotic controls (CESCs) were treated with or without resveratrol (100 µM) and the levels of Bcl-2, Bax and Bcl-2/Bax gene expression ratio in the cells from all origins were examined at 6, 24 and 48 h post-treatment by real-time PCR. Results: Resveratrol treatment increased Bcl-2 expression in CESCs at 24 and 48 h and in EuESCs at 48 h (P<0.05), but had no significant effects on the expression of this gene in EESCs. On the other hand, resveratrol treatment increased Bax expression in EuESCs at 6 h and decreased its expression in EESCs at 48 h (P<0.05). Regarding the Bcl-2/Bax gene expression ratio, resveratrol treatment increased Bcl-2/Bax gene expression ratio in CESCs and EuESCs at 48 h (P<0.01). However, this treatment had no significant differential effect on Bcl-2 and Bcl-2/Bax gene expression ratio between CESCs and EuESCs at 48 h. Conclusion: Resveratrol treatment significantly increased Bcl-2/Bax gene expression ratio in EuESCs and CESCs but had no significant effect in EESCs. https://ijph.tums.ac.ir/index.php/ijph/article/view/15052 https://ijph.tums.ac.ir/index.php/ijph/article/download/15052/6949

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 49 8 2020 07 30