Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 5 2019 05 14 825 833 Wenjuan WANG Department of Human Resources, The First Hospital Affiliated of Harbin Medical University, Harbin, P.R. China Hui REN Department of Infection Control, The First Hospital Affiliated of Harbin Medical University, Harbin, P.R. China Qiuye TIAN Commission for Discipline, The First Hospital Affiliated of Harbin Medical University, Harbin, P.R. China Chunling TANG Mental Health Center, The First Hospital Affiliated of Harbin Medical University, P.R. China Wenjuan MENG Department of Comprehensive Archives, The First Hospital Affiliated of Harbin Medical University, Harbin, P.R. China 2019 05 14 Background: We aimed to investigate the effects of occupational stress on blood lipids, blood glucose and immune function of doctors. Methods: In 2017, 1291 doctors (565 males, 726 females) in The First Hospital Affiliated with Harbin Medical University (Harbin, China) were enrolled based on the principle of convenience of sampling and cluster sampling. Questionnaires were used to investigate demographic characteristics and occupational stress related factors. Level of glycated hemoglobin was detected by immunoturbidimetric method. Concentration of triglyceride was determined by glycerol phosphate oxidase end point method. Total cholesterol concentration in serum    was determined by total cholesterol oxidase end point method. Concentration of serum immunoglobulin was detected by immunoturbidimetry. Results: Levels of glycated hemoglobin and triglyceride in high tension group were higher than those in the low tension group. Levels of IgG and IgM in high tension group were lower than those in low tension group. The risk of elevated glycated hemoglobin levels in > 50-yr-old age group was higher than that of the =<35-yr-old age group. Those in the high coping strategy group was higher in the low coping strategy group. The risk of elevated total cholesterol levels in drinkers is 1.158 times that of non-drinkers. The risk of IgG concentration reduction in smokers was 0.428 times that of non-smokers. The risk of a decrease in IgA concentration in doctors with good sleep quality is 1.527 times that of those with poor sleep quality. Conclusion: Occupational stress can lead to increased blood lipids and sugar levels as well suppression of immune function in doctors.   https://ijph.tums.ac.ir/index.php/ijph/article/view/17108 https://ijph.tums.ac.ir/index.php/ijph/article/download/17108/6377

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 5 2019 05 14 784 795 Zhaofang LI Institute of Endemic Diseases and Key Laboratory of Trace Elements and Endemic Diseases, National Health Commission of the People’s Republic of China, School of Public Health, Xi′an Jiaotong University Health Science Center, Xi′an, Shaanxi 710061, P.R. China Xiaoli YANG Institute of Endemic Diseases and Key Laboratory of Trace Elements and Endemic Diseases, National Health Commission of the People’s Republic of China, School of Public Health, Xi′an Jiaotong University Health Science Center, Xi′an, Shaanxi 710061, P.R. China Rongqiang ZHANG Institute of Endemic Diseases and Key Laboratory of Trace Elements and Endemic Diseases, National Health Commission of the People’s Republic of China, School of Public Health, Xi′an Jiaotong University Health Science Center, Xi′an, Shaanxi 710061, P.R. China Baorong LI Institute of Endemic Diseases and Key Laboratory of Trace Elements and Endemic Diseases, National Health Commission of the People’s Republic of China, School of Public Health, Xi′an Jiaotong University Health Science Center, Xi′an, Shaanxi 710061, P.R. China Di ZHANG Institute of Endemic Diseases and Key Laboratory of Trace Elements and Endemic Diseases, National Health Commission of the People’s Republic of China, School of Public Health, Xi′an Jiaotong University Health Science Center, Xi′an, Shaanxi 710061, P.R. China Qiang LI Institute of Endemic Diseases and Key Laboratory of Trace Elements and Endemic Diseases, National Health Commission of the People’s Republic of China, School of Public Health, Xi′an Jiaotong University Health Science Center, Xi′an, Shaanxi 710061, P.R. China Yongmin XIONG Institute of Endemic Diseases and Key Laboratory of Trace Elements and Endemic Diseases, National Health Commission of the People’s Republic of China, School of Public Health, Xi′an Jiaotong University Health Science Center, Xi′an, Shaanxi 710061, P.R. China 2019 05 14 Background: The association between estrogen receptor-β (ESR2) rs4986938 polymorphism and the risk of various types of cancer have been investigated in previous studies. However, the results remained disputable. Here, we conducted a meta-analysis to investigate the association between ESR2 rs4986938 polymorphism and the risk of cancer. Methods: We searched for relevant articles collected by the PubMed, EMBASE, and Cochrane library up to March 30, 2018. The association was assessed using Odds ratios (ORs) and 95% confidence intervals (CIs). Results: The meta-analysis involved a total of 23 studies in 20 papers, including 24,334 cases and 31,707 controls. No significant association was detected between the rs4986938 polymorphism and cancer risk in the additive model (A compared with G: OR=0.97, 95% CI=0.92-1.02, P=0.20), dominant model (AA+AG compared with GG: OR=0.96, 95% CI=0.93-1.03, P=1.00), recessive model (AA compared with AG + GG: OR=0.94, 95% CI=0.86-1.03, P=0.18), heterozygous model (AG compared with GG: OR=0.97, 95% CI=0.94-1.01, P=0.14), and homozygous model (AA compared with GG: OR=0.96, 95% CI=0.87-1.06, P=0.39). Results of subgroup analysis stratified by ethnicity and cancer types further validated the results. Conclusion: We found no evidence of an association between rs4986938 and the risk of overall cancer.     https://ijph.tums.ac.ir/index.php/ijph/article/view/17104 https://ijph.tums.ac.ir/index.php/ijph/article/download/17104/6373

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 5 2019 05 15 971 973 Hyun-Min CHOI Department of Sports Sciences, GwangJu University, Gwangju, Korea Tai-Hyung KIM Graduate School of Technology Management, KyungHee University, Yongin, Korea 2019 05 15 No Abstract### https://ijph.tums.ac.ir/index.php/ijph/article/view/17136 https://ijph.tums.ac.ir/index.php/ijph/article/download/17136/6395

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 5 2019 05 14 834 840 Shynar ABDRAKHMANOVA National Center of Public Health, Nur-Sultan, Kazakhstan Zarina KERUYENOVA National Center of Public Health, Nur-Sultan, Kazakhstan 2019 05 14 Background: The Global Adult Tobacco Survey (GATS) is a global study to monitor tobacco use, and evaluate current measures and requisite policies on tobacco control. In this study, the key indicators from GATS Kazakhstan that address six tobacco control policies are assessed. Methods: GATS Kazakhstan was a nationally representative household survey of the adult population aged 15 yr or older (n=4425, 52.8% females) implemented in 2014, in all regions of Kazakhstan. A multi-stage, geographically clustered sample design was used to obtain the key indicators of tobacco use and tobacco measures in the country. The sampling weights were employed to ensure real national representation. A household and individual questionnaire were administered through electronic devices. Results: The majority of current tobacco users were cigarette smokers 22.2%. Overall, 19.0% of adults were exposed to secondhand smoke while at work. One third of smokers made a quit attempt in the last 12 months. Only, 74.0% of adults believed that breathing other people’s smoke causes serious illness in non-smokers. Almost all current smokers (97.6%) noticed pictorial health warnings on cigarette packages. Over half (58.0%) of the current smokers had thought about quitting, having seen pictorial warning labels. Exposure to any cigarette advertisement, sponsorship or promotion had been experienced by 25.7% of adults, with the highest rate of noticing cigarette advertisements being found in stores where cigarettes are sold (14.0%). Cigarettes were largely affordable for the population. Conclusion: The GATS Kazakhstan results identified tobacco use indicators, as well as existing gaps in tobacco control measures.     https://ijph.tums.ac.ir/index.php/ijph/article/view/17109 https://ijph.tums.ac.ir/index.php/ijph/article/download/17109/6378

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 5 2019 05 14 796 807 Hou-Xing WANG Department of Emergency Intensive Care Unit, Yinzhou Second Hospital, Ningbo, China Shu-Yuan XIE Department of Emergency Intensive Care Unit, Yinzhou Second Hospital, Ningbo, China Hao WANG Department of Emergency Intensive Care Unit, Yinzhou Second Hospital, Ningbo, China Hao-Kai CHU Department of Emergency Intensive Care Unit, Yinzhou Second Hospital, Ningbo, China 2019 05 14 Background: To assess the effects of chlorhexidine dressing on health care-associated infection in hospitalized patients. Methods: We searched for English-language published randomized controlled trials (RCTs) in Cochrane Library, EMBASE and PubMed between January 1998 and January 2018. We used meta-analysis to calculate the risk ratios (RRs) and 95% confidence intervals (CIs) of the data, and using the I2 assessment to summarize the heterogeneity of RCTs and the funnel plot and Egger regression test to evaluate publication bias. Results: A total of 13 RCTs were included in our meta-analysis, including 7555 patients and 11,931 catheters. The effects of chlorhexidine dressing on the incidence of catheter-related bloodstream infections (CRBSIs) were reported in 13 RCTs, and the incidence of CRBSIs were 1.3% (80/6160) in the chlorhexidine group and 2.5% (145/5771) in the control group. We used a forest plot to determine the risk ratio (RR) of chlorhexidine dressing on the incidence of CRBSIs, and our results showed that chlorhexidine dressing significantly reduced the incidence of CRBSIs (RR 0.55, 95% CI 0.39-0.77, P<0.001). Moreover, we also analyzed the effects of chlorhexidine dressing on the incidence of catheter colonization and catheter-related infections (CRIs), and our forest plot results showed that chlorhexidine dressing significantly reduced the incidence of catheter colonization (RR 0.52, 95% CI 0.40-0.67, P<0.001) and the incidence of CRIs (RR 0.43, 95% CI 0.28-0.66, P<0.001) in hospitalized patients. Conclusion: The use of chlorhexidine dressings for hospitalized patients significantly reduce the incidence of CRBSIs, catheter colonization and CRIs.   https://ijph.tums.ac.ir/index.php/ijph/article/view/17105 https://ijph.tums.ac.ir/index.php/ijph/article/download/17105/6374

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 5 2019 05 15 974 976 Chunsong HU Department of Cardiovascular Medicine, Nanchang University, Nanchang 330006, China Tengiz TKEBUCHAVA Boston TransTec, LLC, Boston, MA 02459, USA Qinghua WU Department of Cardiovascular Medicine, Nanchang University, Nanchang 330006, China Dayi HU Cardiovascular Center, Peking University People’s Hospital, Beijing 100044, China 2019 05 15 No Abstract### https://ijph.tums.ac.ir/index.php/ijph/article/view/17137 https://ijph.tums.ac.ir/index.php/ijph/article/download/17137/6396

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 5 2019 05 14 841 848 Rong GUI The Third Xiangya Hospital, Central South University, Changsha, Hunan, China Xueyuan HUANG The Third Xiangya Hospital, Central South University, Changsha, Hunan, China Ming ZHOU Department of Hematology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China Shujuan OUYANG The Hunan Cancer Hospital, Changsha, Hunan , China Yunfeng FU The Third Xiangya Hospital, Central South University, Changsha, Hunan, China Hao TANG The Third Xiangya Hospital, Central South University, Changsha, Hunan, China Fengxia LIU The Third Xiangya Hospital, Central South University, Changsha, Hunan, China Rong HUANG The Third Xiangya Hospital, Central South University, Changsha, Hunan, China Meng GAO The Third Xiangya Hospital, Central South University, Changsha, Hunan, China Hang DONG The Third Xiangya Hospital, Central South University, Changsha, Hunan, China Yongjun WANG The Second Xiangya Hospital, Central South University, Changsha, Hunan, China 2019 05 14 Background: We aimed to establish the reference range of thrombelastogram (TEG) for Chinese healthy volunteers and pregnant women and analyze the influence factors. Methods: Blood samples were collected from healthy volunteers and pregnant women at five tertiary hospitals (the Third Xiangya Hospital of Central South University, the Second Xiangya Hospital of Central South University, Hunan Provincial People's Hospital, Hunan Cancer Hospital and Changsha Central Hospital) in 2016. The effects of age, gender, blood type, and full-term pregnancy on the reference range of normal TEG for healthy volunteers and pregnant women were studied. The specificity of TEG in detecting coagulation disorder. Results: For healthy volunteers, the normal ranges of TEG parameters were as follows: R, 4.3-9.3 min; K, 1.2-3.2 min; α, 50.2-71.2°; MA, 54.1-71.3 mm; LY30: 0%-2.2%; CI, -3.8-2.4. At least one parameter exceeded the normal range specified by the manufacturer in 20.3% of the healthy volunteers; about 7.6% healthy volunteers were diagnosed as coagulation disorder by the above standards; the specificity of detection was 79.7%. There were significant differences in R, K, α, MA and CI between males and females (P<0.01). For pregnant women, the normal ranges of TEG were as follows: R, 3.9-7.5 min; K, 1.0-2.4 min; α, 57.e, non-suicidal self-injury scale, aggression scale, and resilience scale. Results: Depression, non-suicidal self-injury, and aggression are significantly higher among the members of the depression group compared with the members of the healthy control group (P<0.001), and the resilience of the members of the former group is remarkably lower than that of the members of the latter group (P<0.001). Aggression among the depressed youths exhibits a significant positive correlation with non-suicidal self-injury (r= 0.43, P<0.01), whereas aggression (r= –0.18, P<0.05) and non-suicidal self-injury (r= –0.20, P<0.05) demonstrates significant negative correlations with resilience. The resilience of the youths in the depression group plays a partial mediating role in the relationship between aggression and non-suicidal self-injury. Conclusion: The more aggressive the behaviors of the depressed youths, the more serious their non-suicidal self-injurious symptoms. Furthermore, resilience plays a partial mediating role in the relationship between aggression and non-suicidal self-injury. https://ijph.tums.ac.ir/index.php/ijph/article/view/23443 https://ijph.tums.ac.ir/index.php/ijph/article/download/23443/7128

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 245 256 Mahtab TABATABAIE Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Sepideh SOLTANI Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Hassan MOZAFFARI-KHOSRAVI Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Amin SALEHI-ABARGOUEI 1. Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 2. Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 2019 09 14 2020 05 29 Background: Zinc as one of the important trace elements in human health has been suggested to be a supplement for modifying the level of adipokines, whereas findings from studies have been inconsistent. This study aimed to systematically review the evidence provided by randomized controlled trials (RCTs) regarding the effect of zinc supplementation on serum adipokines levels. Methods: PubMed, Google Scholar, Web of Science, and Scopus were systematically searched up to June 2019. The mean differences and their corresponding standard deviations (SDs) of changes in serum adipokines levels were used as effect size. Results: Eight eligible RCTs (leptin n=6, adiponectin n=3) were included in the current study. There were no significant changes in serum leptin levels [weighted mean difference (WMD) =0.60 ng/ml, 95% confidence interval (CI): -1.78, 2.99; I-squared (I2) = 64.3%] and adiponectin levels (WMD = 1.09 ng/ml, 95% CI: -0.76, 3.18, I2 = 78.8%) following zinc supplementation compared to placebo group. These findings did not change after considering several subgroups including gender, study duration, health status, body weight and the type of zinc used for supplementation. Conclusion: No evidence was found to support the efficacy of dietary zinc supplements on serum levels of adipokines. Further, high-quality, long-term controlled clinical trials are warranted to confirm these findings. https://ijph.tums.ac.ir/index.php/ijph/article/view/18361 https://ijph.tums.ac.ir/index.php/ijph/article/download/18361/7124

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 413 414 EN Jupil KO Division of Health and Kinesiology, Incheon National University, Incheon, Republic of Korea Young-Min PARK Division of Health and Kinesiology, Incheon National University, Incheon, Republic of Korea 2020 11 17 2020 12 16 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/22650 https://ijph.tums.ac.ir/index.php/ijph/article/download/22650/7144

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 297 305 EN Hsin-Yi YANG Department of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi City, Taiwan Cheng-Ren CHEN Department of Internal Medicine, Ditmansion Medical Foundation Chia-Yi Christian Hospital, Chia-Yi City, Taiwan Shih-Yu LEE Department of Internal Medicine, Ditmansion Medical Foundation Chia-Yi Christian Hospital, Chia-Yi City, Taiwan Wen-Chen TSAI Department of Health Services Administration, China Medical University, Taichung City, Taiwan Yueh-Han HSU 1. Department of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi City, Taiwan 2. Department of Internal Medicine, Ditmansion Medical Foundation Chia-Yi Christian Hospital, Chia-Yi City, Taiwan 3. Department of Medical Research, China Medical University Hospital, Taichung City, Taiwan 4. Department of Nursing, Min-Hwei College of Health Care Management, Tainan City, Taiwan 2019 02 14 2019 05 22 Background: The field of physician health is gaining increasing attention; however, most research and interventions have concentrated on factors such as job stress, mental health, and substance abuse. The risks of major cancers in physicians remain unclear. We used a propensity score-matched analysis to investigate the risk of cancer in physicians relative to the general population who had no healthcare-related professional background. Methods: Data were obtained from the National Health Insurance system in Taiwan. The physician cohort contained 29,713 physicians, and each physician was propensity score-matched with a person from the general population. Results: The physicians demonstrated a 0.90-fold lower risk of all-cancers (95% confidence interval [CI] = 0.83 – 0.96) when compared with the general population. Female physicians had a higher risk of cancer than male physicians (adjusted hazard ratio [HR] = 1.59; 95% CI = 1.28 – 1.96). Physicians had higher risks of prostate (HR = 1.26; 95% CI = 1.00 – 1.59) and thyroid cancers (HR = 3.16; 95% CI = 1.69 – 5.90) when compared with the general population. Conclusion: Physicians have lower rates of overall cancer risk than the general population. Female physicians have higher cancer risks than male physicians. Male physicians have higher risks of thyroid and prostate cancer relative to the general population. https://ijph.tums.ac.ir/index.php/ijph/article/view/16242 https://ijph.tums.ac.ir/index.php/ijph/article/download/16242/7129

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 257 270 Mahdi MALAKOUTIKHAH Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran Hadiseh RABIEI Department of Occupational Health Engineering, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran Soheil HASSANIPOUR Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sci-ences, Rasht, Iran Mehdi JAHANGIRI Department of Occupational Health Engineering, Research Center for Health Sciences, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran 2020 01 24 2020 06 24 Background: Unsafe behaviors are the cause of 80% of accidents. However, there has also been no worldwide review and meta-analysis of the prevalence of workers’ unsafe behaviors. Therefore, the present study aimed to investigate and estimate the prevalence of unsafe behaviors among Iranian workers using a systematic review and meta-analysis study. Methods: This systematic review and meta-analysis were conducted from Nov to Dec 2018. The researchers searched Medline/PubMed, Scopus, Embase, Science Direct, and Google Scholar for international articles and four Iranian databases (Scientific Information Database, MagIran, IranMedex, and IranDoc) for Persian articles. The method of reporting this study was based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) checklist. Results: Overall, 235 articles from databases were imported to EndNote library. Final screening of the included studies produced a total of 38 studies. Based on the random-effect model, the prevalence of total unsafe behaviors, non-use or inappropriate use of personal protective equipment, and inappropriate work posture was 40.37% (CI 95% = 35.8-44.9), 27.79% (CI 95% = 21.2-34.3), and 14.87% (CI 95% = 10.7-18.9). There was no statistically significant relationship between unsafe behaviors and mean age, mean of work experiences, and year of study. Conclusion: The prevalence of unsafe behaviors among Iranian workers was relatively high and the most common behaviors were non-use or inappropriate use of PPE; one of the most important causes for this behavior is lack of training, inappropriate working conditions, and lack of positive attitude towards safety. Therefore, further studied are required to investigate the causes of these unsafe behaviors. https://ijph.tums.ac.ir/index.php/ijph/article/view/19535 https://ijph.tums.ac.ir/index.php/ijph/article/download/19535/7125

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 415 417 Nurul Izzah IBRAHIM Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur, Malaysia Mohd Sharkawi AHMAD Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur, Malaysia Mohamed ZULFARINA Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur, Malaysia Sharifah Nurul Aqilah SAYED MOHD ZARIS Department of Orthopedics and Traumatology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaa-cob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur, Malaysia Nor Azlin ZAINAL ABIDIN Department of Orthopedics & Traumatology, Hospital Kuala Lumpur, Jalan Pahang, Kuala Lumpur, Malaysia Isa Naina MOHAMED Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur, Malaysia Norazlina MOHAMED Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur, Malaysia Sabarul Afian MOKHTAR Department of Orthopedics and Traumatology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaa-cob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur, Malaysia Ahmad Nazrun SHUID Department of Pharmacology, Faculty of Medicine UiTM, Sg Buloh Campus, Selangor, Malaysia 2018 10 25 2018 12 02 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/15101 https://ijph.tums.ac.ir/index.php/ijph/article/download/15101/7145

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 306 314 Feifei LI Two Areas of Galactophore Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P.R. China Wei LIU One Areas of Galactophore Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P.R. China Fei HUO Two Areas of Galactophore Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P.R. China Weifang HE Two Areas of Galactophore Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P.R. China Fan YANG Department of Pathology, Shaoxing Second Hospital, Shaoxing 312000, P.R. China Jiabin WEI Department of Pathology, Zhoukou Central Hospital, Zhoukou 466000, P.R. China Jing WANG Two Areas of Galactophore Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P.R. China 2020 06 29 2020 08 20 Background: We aimed to investigate the effect of self-controlled exercise on the antioxidant activity of red blood cells and the recovery of limb function in patients with breast cancer after rehabilitation. Methods: Overall 130 breast cancer patients admitted to the First Affiliated Hospital of Zhengzhou University, China from Feb 2018 to Jan 2019 were divided into intervention group and control group. The control group received perioperative care and chemotherapy, the intervention group implemented a self-controlled exercise program. Indexes were compared between the two groups before intervention, 3 months and 6 months after intervention. Results: The activity of erythrocyte superoxide dismutase (SOD in the intervention group was significantly increased in the first 3 months (P=0.030), and decreased from 3rd to 6th month (P=0.033). The glutathione peroxidase (GSH-Px) activity in the intervention group increased through the whole intervention period. The plasma malondialdehyde (MDA) in the intervention group was significantly decreased (P=0.029, 0.012). After intervention for 3 months and 6 months, the 6MND distances in the intervention group were significantly longer (P=0.001, 0.045). The average exercise time in the intervention group were significantly increased (P=0.004, 0.000). Conclusion: Self-controlled exercise can effectively improve the antioxidant ability of red blood cells in patients with breast cancer, improve the mobility of shoulder joints of the affected side and increase their exercise capacity, with good sustainability. It has positive effect on postoperative rehabilitation, could be used in long-term regular clinical work. https://ijph.tums.ac.ir/index.php/ijph/article/view/21299 https://ijph.tums.ac.ir/index.php/ijph/article/download/21299/7130

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 418 420 Shenghui YAO Department of Gynecology, Xuzhou No.1 People's Hospital, Xuzhou 221002, P.R. China Huili SUN Department of TCM Physiotherapy, Xuzhou No.1 People's Hospital, Xuzhou 221002, P.R. China 2020 08 26 2020 10 14 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/21988 https://ijph.tums.ac.ir/index.php/ijph/article/download/21988/7146

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 315 324 Haewon BYEON Department of Medical Big Data, College of AI Convergence, Inje University, Gimhae 50834, Republic of Korea 2019 05 19 2019 06 25 Background: We aimed to develop a model predicting the participation of the elderly in a cognitive health program using the random forest algorithm and presented baseline information for enhancing cognitive health. Methods: This study analyzed the raw data of Seoul Welfare Panel Study (SWPS) (20), which was surveyed by Seoul Welfare Foundation for the residents of Seoul from Jun 1st to Aug 31st, 2015. Subjects were 2,111 (879 men and 1232 women) persons aged 60 yr and older living in the community who were not diagnosed with dementia. The outcome variable was the intention to participate in a cognitive health promotion program. A prediction model was developed by the use of a Random forests and the results of the developed model were compared with those of a decision tree analysis based on classification and regression tree (CART). Results: The random forests model predicted education level, subjective health, subjective friendship, subjective family bond, mean monthly family income, age, smoking, living with a spouse or not, depression history, drinking, and regular exercise as the major variables. The analysis results of test data showed that the accuracy of the random forests was 72.3% and that of the CART model was 70.9%. Conclusion: It is necessary to develop a customized health promotion program considering the characteristics of subjects in order to implement a program effectively based on the developed model to predict participation in a cognitive health promotion program.       https://ijph.tums.ac.ir/index.php/ijph/article/view/17222 https://ijph.tums.ac.ir/index.php/ijph/article/download/17222/7131

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 421 422 Ibrahim TOTIC Faculty of Law, State University of Novi Pazar, Novi Pazar, Republic of Serbia Mirza TOTIC Faculty of Law, State University of Novi Pazar, Novi Pazar, Republic of Serbia 2018 11 03 2018 11 10 No abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/15227 https://ijph.tums.ac.ir/index.php/ijph/article/download/15227/7147

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 325 332 Dahong SUN Department of Pediatrics, The Third People’s Hospital of Qingdao, Qingdao266041, China Qing WANG Department of Imaging, The People’s Hospital of Zhangqiu Area, Jinan250200, China Xiaoyan ZHANG Picu, Qingdao Women and Children's Hospital, Qingdao266000, China Xiuzhen ZHAO ZHAO Department of Pediatrics, The People’s Hospital of Zhangqiu Area, Jinan250200, China Haiyan ZHANG Department of Pediatrics, The People’s Hospital of Zhangqiu Area, Jinan250200, China Aimei LIU Outpatient Department, Weifang People’s Hospital, Weifang 261041, China 2020 08 18 2020 10 14 Background: To investigate the clinical application value of the combination of the inflammatory factors and dynamic detection in the diagnosis and treatment of neonatal sepsis by detecting serum inflammatory factor C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) levels before and after treatment of neonatal infection.  Methods: A total of 138 neonates with different degrees of infection were randomly enrolled, including 88 cases in the sepsis group and 50 cases in the virus infection group. Another 50 non-infected newborns in the same period were enrolled as the normal control group. Venous blood of all subjects for CRP, PCT, IL-6 detection, and send bacterial blood culture for sepsis and virus infection groups were collected at the same time. In the recovery period, venous blood of children in sepsis group was collected again to review CRP, PCT, IL-6, and differences in each test index of each group were compared. Results: The serum CRP, PCT, IL-6 levels in the sepsis group were significantly higher than those in the virus infection group (all P <0.05); serum CRP, PCT, IL-6 levels in the sepsis group were significantly lower than before treatment (P <0.05); the sensitivity and accuracy of the combined detection of indicators for the diagnosis of neonatal sepsis were significantly improved. Conclusion: The inflammatory factors CRP, PCT, and IL-6 are closely related to the occurrence and development of neonatal sepsis. Combined detection can effectively improve the diagnostic accordance rate, which is beneficial to the early diagnosis and early clinical intervention of neonatal sepsis. https://ijph.tums.ac.ir/index.php/ijph/article/view/21864 https://ijph.tums.ac.ir/index.php/ijph/article/download/21864/7132

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 423 424 EN Raja ZAKARIA Laboratory of Human Ecology, Faculty of Science Semlalia, University of Cadi Ayyad, Marrakesh, Morocco Hakima AMOR Laboratory of Human Ecology, Faculty of Science Semlalia, University of Cadi Ayyad, Marrakesh, Morocco Abdellatif BAALI Laboratory of Human Ecology, Faculty of Science Semlalia, University of Cadi Ayyad, Marrakesh, Morocco 2018 07 20 2018 08 27 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/14119 https://ijph.tums.ac.ir/index.php/ijph/article/download/14119/7148

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 333 340 Yanli LIU Department of Pediatrics, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao 266000, China Xiuhua SUN Property Management Section, Zhangqiu District People’s Hospital, Jinan 250200, China Yaqiong WANG Department of Infectious Diseases, Qingdao Central Hospital, Qingdao University, Qingdao 266000, China Cuihong XING Nursing Department, Zhangqiu District People’s Hospital, Jinan 250200, China Li LI Department of Neurosurgery, Zhangqiu District People’s Hospital, Jinan 250200, China Shiying ZHOU Department of Pediatrics, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao 266000, China 2020 06 19 2020 10 14 Background: To evaluate changes of associated markers in neonatal pathological jaundice due to bacterial infection in newborns, to provide an experimental basis for early diagnosis and treatment of neonatal pathological jaundice. Methods: A total of 126 newborns with neonatal pathological jaundice in the Pediatrics Department of Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University from Jan 2016 to Jun 2018 were enrolled. The patients were divided into bacterial infection group (76 cases with combined bacterial infection) and non-infection group (50 cases without bacterial infection). Peripheral blood was drawn from patients, and levels of inflammatory factors, levels of indexes of liver function and levels of cardiac markers were detected. Correlation between inflammatory factors and neonatal pathological jaundice was assessed. Results: The levels of WBC, hs-CRP and PCT in the bacterial infection group were significantly higher than those in the non-infected group (P<0.05). The level of TRF in the bacterial infection group was significantly lower than that in the non-infection group (P<0.01). In the bacterial infection group, the levels of WBC, hs-CRP, PCT, and TRF were positively correlated with the levels of CK, CKMB, LDH, and α-HBDB, respectively (all P<0.05). The TRF level after treatment was significantly higher than that before treatment (P<0.01). Conclusion: Markers such as WBC, hs-CRP, PCT, and TRF can be used as effective indicators in diagnosis of pathological jaundice due to bacterial infection in newborns. The combined testing of WBC, hs-CRP, PCT, and TRF was helpful for early diagnosis and early clinical intervention of neonatal pathological jaundice, which can lower the risk of clinical complications. https://ijph.tums.ac.ir/index.php/ijph/article/view/21188 https://ijph.tums.ac.ir/index.php/ijph/article/download/21188/7133

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 425 427 Farbod ALINEZHAD Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Mahin AHANGAR OSKOUEE 1. Infectious and Tropical Diseases Research Center, Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran 2. Department of Microbiology & Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Hossein BANNAZADEH BAGHI 1. Infectious and Tropical Diseases Research Center, Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran 2. Department of Microbiology & Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Siamak TAMIRI OSKOUEE Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran Heidar-Ali ESMAEILI Department of Pathobiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran 2018 12 23 2019 01 05 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/15684 https://ijph.tums.ac.ir/index.php/ijph/article/download/15684/7149

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 341 349 Fateme DAVARZANI Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran Navid SAIDI Molecular Microbiology Research Center (MMRC), Faculty of Medicine, Shahed University, Tehran, Iran Saeed BESHARATI Molecular Microbiology Research Center (MMRC), Faculty of Medicine, Shahed University, Tehran, Iran Horieh SADERI Molecular Microbiology Research Center (MMRC), Faculty of Medicine, Shahed University, Tehran, Iran Iraj RASOOLI Department of Biology, Faculty of Science, Shahed University, Tehran, Iran Parviz OWLIA Molecular Microbiology Research Center (MMRC), Faculty of Medicine, Shahed University, Tehran, Iran 2020 05 22 2020 09 23 Background: Pseudomonas aeruginosa is one of the most common opportunistic bacteria causing nosocomial infections, which has significant resistance to antimicrobial agents. This bacterium is a biofilm and alginate producer. Biofilm increases the bacterial resistance to antibiotics and the immune system. Therefore, the present study was conducted to investigate the biofilm formation, alginate production and antimicrobial resistance patterns in the clinical isolates of P. aeruginosa. Methods:  One hundred isolates of P. aeruginosa were collected during the study period (from Dec 2017 to Jul 2018) from different clinical samples of the patients admitted to Milad and Pars Hospitals at Tehran, Iran. Isolates were identified and confirmed by phenotypic and genotypic methods. Antimicrobial susceptibility was specified by the disk diffusion method. Biofilm formation and alginate production were measured by microtiter plate and carbazole assay, respectively. Results: Sixteen isolates were resistant to all the 12 studied antibiotics. Moreover, 31 isolates were Multidrug-Resistant (MDR). The highest resistance rate was related to ofloxacin (36 isolates) and the least resistance was related to piperacillin-tazobactam (21 isolates). All the isolates could produce the biofilm and alginate. The number of isolates producing strong, medium and weak biofilms was equal to 34, 52, and 14, respectively. Alginate production was more than 400 μg/ml in 39 isolates, 250-400 μg/ml in 51 isolates and less than 250 μg/ml in 10 isolates. Conclusion: High prevalence of MDR, biofilm formation, and alginate production were observed among the clinical isolates of P. aeruginosa. The results also showed a significant relationship between the amount of alginate production and the level of biofilm formation. https://ijph.tums.ac.ir/index.php/ijph/article/view/20881 https://ijph.tums.ac.ir/index.php/ijph/article/download/20881/7134

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 15540 15540 Mohammad SAADATI Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Ramin REZAPOUR Iranian Center of Excellence in Health Management, School of Health Management and Medical Informatics, Tabriz University of Medical Sci-ences, Tabriz, Iran 2018 12 06 2018 12 15 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/15540 https://ijph.tums.ac.ir/index.php/ijph/article/download/15540/7150

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 350 359 Hossein NEZAMZADEH-EZHIYEH Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Hossein MIRHENDI Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Reza JAFARI Isfahan Health Research Station, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Arshad VEYSI Zoonoses Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran Yavar RASSI Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mohammad Ali OSHAGHI Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mohammad Hossein ARANDIAN Isfahan Health Research Station, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Hamid ABDOLI Isfahan Health Research Station, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Samad BAHRAMI Isfahan Health Center, Isfahan University of Medical Sciences, Isfahan, Iran Ali Reza ZAHRAEI RAMAZANI Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Reza FADAEI Isfahan Health Center, Isfahan University of Medical Sciences, Isfahan, Iran Javad RAMAZANPOOR Isfahan Health Center, Isfahan University of Medical Sciences, Isfahan, Iran Mehdi FARSI Isfahan Health Center, Isfahan University of Medical Sciences, Isfahan, Iran Kurosh AMINIAN Isfahan Health Center, Isfahan University of Medical Sciences, Isfahan, Iran Zahra SAEIDI Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mohammad Reza YAGHOOBI–ERSHADI Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Amir Ahmad AKHAVAN Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2020 06 05 2020 08 21 Background: Leishmaniasis is an expanding neglected tropical disease in the world reporting from 98 countries including Iran. This study focused on eco-epidemiological determinants of the disease following a rapid and unexpected increase of leishmaniasis incidence in a strategic residential district in North-East of Isfahan County, Iran. Methods: This study was accomplished from Apr 2012 to Jan 2014 in a strategic residential zone in North-East of Isfahan County, Esfahan, Iran. Monthly activity, parity, Leishmania infection and susceptibility tests, were determined on sand flies. Some portion of inhabitants and school children were surveyed to find active or passive cases of leishmaniasis and also wild rodents were collected to determine reservoir host. Results: Totally 5223 sand flies belonging to Phlebotomus and Sergentomyia genus were collected and identified; Ph. papatasi was the dominant species and started to appear in May and disappeared in Oct. The majority of living dissected sand flies were unfed and parous. Ph. papatasi showed 4.6% Leishmania infection through direct examination and 39.54% by nested-PCR respectively. Phlebotomus papatasi was susceptible against deltametrin 0.05%. Totally 2149 people were surveyed and incidence and prevalence of zoonotic cutaneous leishmaniasis estimated as 45.39 and 314.40 per 1000 population. Rodents showed 73.91% and 80% Leishmania infection by direct examination and nested-PCR respectively. Conclusion: Cutaneous leishmaniasis due to L. major has been established in this area. Rodent control operation and personal protection are highly recommended to control the disease in this focus. https://ijph.tums.ac.ir/index.php/ijph/article/view/21027 https://ijph.tums.ac.ir/index.php/ijph/article/download/21027/7135

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 429 430 Zeinab ALIBEIGI 1. Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran 2. School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran Mojgan TANSAZ Department of Persian Medicine, School of Persian Medicine, Sahid Beheshti University of Medical Sciences, Tehran, Iran Jale ALIASL Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran Efat JAFARI-DEHKORDI 1. Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran 2. School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran 2018 11 05 2018 12 02 No Abstract https://ijph.tums.ac.ir/index.php/ijph/article/view/15233 https://ijph.tums.ac.ir/index.php/ijph/article/download/15233/7151

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 360 368 EN Mohammad BIDKHORI Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mehdi YASERI Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Ali AKBARI SARI Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Reza MAJDZADEH 1. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2. Knowledge Utilization Research Center, Tehran University of Medical Sciences, Tehran, Iran 2018 05 22 2019 05 15 Background: Cosmetic surgery accompanied with high economic cost is increasing in Iran. It is necessary to be aware about factors affecting cosmetic surgery in order to control its increasing trend. Therefore, we aimed to determine the factors affecting the incidence of cosmetic surgery in Tehran, Iran. Methods: This survey was conducted on 2002 subjects between the ages of 15 to 60 yr using random digit dialing in Tehran, Iran 2015. Demographic data was collected from all of participants and in the presence of cosmetic surgery, the related cosmetic questions were asked in details. Cosmetic surgery was considered as an event and the incidence rate ratio for variables were estimated. For univariate analysis, Poisson regression was used as well as multi-level Poisson regression was used for multivariate analysis. Results: Totally, 224 participants (11%) undergone cosmetic surgery. There was a significant relationship between the age at surgery of participants with the incidence of cosmetic surgery (P<0.001). Cosmetic surgery in women was 1.9 times greater than in men (P <0.001). Incidence Rate Ratio (IRR) for the average and wealthy economic status in comparison to poor level was estimated (IRR=5.6, CI%95: 3.64,8.63) and (IRR=3.14, CI%95: 1.93,5.11), respectively.  In addition, according to multivariate analysis all variables except the level of education and occupation, had significant relationship with the incidence of cosmetic surgery (P<0.001). Conclusion: Cosmetic surgery was related to socioeconomic and demographic factors. Given the high economic burden of this unnecessary surgery, it can be effective to emphasize on awareness-raising programs for those are more likely to undergo cosmetic surgery. https://ijph.tums.ac.ir/index.php/ijph/article/view/13462 https://ijph.tums.ac.ir/index.php/ijph/article/download/13462/7136

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 369 375 Reyhaneh SEFIDKAR Department of Biostatistics, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran Farid ZAYERI 1. Department of Biostatistics, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2. Proteomics Research Center and Department of Biostatistics, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran Elaheh KAZEMI Department of Biostatistics, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran Masoud SALEHI Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran Afsaneh DEHNAD Department of Foreign Languages, School of Management and Informatics Health, Iran University of Medical Sciences, Tehran, Iran Maryam HAFIZI Department of Foreign Languages, Shiraz Branch, Islamic Azad University, Shiraz, Iran 2019 03 01 2019 05 22 Background: Preterm birth is the most important in children under 5 yr mortality. In this study, we used the Global Burden of Disease Data (GBD) to evaluate the trend of preterm infant mortality rate for all countries from 1990 to 2017 and to assess the effect of development factors on this trend. Methods: The preterm infant mortality rate data from 196 countries of the world, from 1990 to 2017, were extracted from the GBD database. To study the trend of preterm infant mortality rate, a mixed-effects log-linear regression model was fitted separately for each IHME super-region. In the next step of data analysis, the development factor was included in the model to determine its effect on this trend for all countries under study. Results: The average rate mortality rate has declined about 2% per year throughout the world over the mentioned period. The highest and lowest decreasing trends were observed in high-income countries (about 4.0%) and Sub-Saharan Africa (about 1.0%), respectively. Including the effect of development factor in the mentioned model revealed that in 1990, the rate of preterm infant mortality in developed countries was 2.2 times of this rate in developing countries and this rate ratio has increased to 2.69 in year 2017. Conclusion: Although the preterm infant mortality rate were decreasing in all super regions, there is a remarkable gap in this rate between developing and developed countries yet. Therefore, preventative strategies are needed to reduce preterm birth and its burden, especially in the developing world. https://ijph.tums.ac.ir/index.php/ijph/article/view/16391 https://ijph.tums.ac.ir/index.php/ijph/article/download/16391/7137

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 376 383 EN Hossein JAFARI Department of Biology, Faculty of Basic Sciences, Imam Hossein Comprehensive University, Tehran, Iran Saeid TAMADONI JAHROMI Persian Gulf and Oman Sea Ecology Research Center, Iranian Fisheries Sciences Research Institute, Agricultural Research Education and Extension Organization (AREEO), Bandar Abbas, Iran Jamil ZARGAN Department of Biology, Faculty of Basic Sciences, Imam Hossein Comprehensive University, Tehran, Iran Ehsan ZAMANI Department of Biology, Faculty of Basic Sciences, Imam Hossein Comprehensive University, Tehran, Iran Reza RANJBAR Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran Hossein HONARI Department of Biology, Faculty of Basic Sciences, Imam Hossein Comprehensive University, Tehran, Iran 2018 09 30 2019 04 30 Background: Most jellyfish species are poisonous. Human victims of jellyfish sting each year are 120 million. Chironex fleckeri is a venomous box jellyfish that inflicts painful and potentially fatal stings to humans. The CfTX-1 is one of the antigenic proteins of venom that is suggested to stimulate the immune system for treatment and vaccine. This study aimed to clone and express the CfTX-1 antigen in E. coli and then to determine the synthesis of related antibody in the mice. Methods: The study was performed in the Persian Gulf and Oman Sea Ecology Research Center, Bandar Abbas, Iran in autumn 2016. The synthetic CfTX-1 gene in PUC57 plasmid was purchased from Nedaye Fan Company. The 723 bp fragment of N-CfTX-1 was amplified by PCR, PUC57 plasmid containing CfTX-1 with BamHI SalI restriction enzyme sites were subcloned in pET28a [+] expression vector and transformed into E. coli BL21 (DE3). The CfTX-1 gene expression was induced by IPTG. Then antibody produced from the mice serum were isolated and confirmed by ELISA. After protein purification, resulted antigen was injected to mice in 4 repeats and then evaluated the rate of antibody in mice serum. Mice were challenged by the Carybdea alata. Results: The 726 bp of N-CfTX-1 were cloned in a vector of expression pET28a [+] and confirmed by PCR, sequencing and enzymatic analysis. Moreover, the recombinant protein was confirmed by SDS-PAGE and Western blotting. Then the antibody was isolated from mice serum and confirmed by ELISA test. The results showed that immunized mice tolerated 50x LD50[1] of jellyfish venom. Conclusion: The CfTX-1 recombinant protein was able to protect the BALB/c mice against jellyfish venom. The produced protein can be used as a candidate for vaccine against jellyfish venom. https://ijph.tums.ac.ir/index.php/ijph/article/view/14854 https://ijph.tums.ac.ir/index.php/ijph/article/download/14854/7138

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 384 390 Mehdi BASAKHA 1. Department of Social Welfare Management, School of Education Sciences and Social Welfare, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran 2. Social Determinants of Health Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Neda SOLEIMANVANDIAZAR Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, Iran University of Medical Sciences, Tehran, Iran Fateh TAVANGAR Department of Social Welfare Management, School of Education Sciences and Social Welfare, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Shabnam DANESHI Student Research Committee, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran 2019 01 21 2019 06 03 Background: The human life value is among the most important challenges of the health economic evaluation. This limitation has reduced the feasibility of applying the cost-benefit method in evaluations of health interventions and policies. Using the human capital approach and discounted value of future earnings, the present study calculated the human capital of different age groups. Methods: The required data were obtained using “income and expenditures of Iranian households” data in 2015 from the Statistical Center of Iran, which included the information on 19380 urban households. Results: According to the calculation of human capital, the maximum value of a statistical life year in the high-income group was related to the age group of 30-34 yr old (223,286 US$ equals to 9378 million Iranian Rials). The lowest value in all three groups of high, medium and low income is related to the age group of 85 and older. In addition, the economic value of statistical life year for men has been calculated as higher than that of women, however, in older age groups, the human capital of both genders have been converging. Conclusion: The economic value of life for young people aged between 20 to 30 yr was higher than other demographic groups. The findings of the research help to provide a more accurate base for the cost-benefit analysis of health and social policies. Considering the economic value of the statistical life for different age groups may change policy priorities in areas related to health and life of human beings. https://ijph.tums.ac.ir/index.php/ijph/article/view/15996 https://ijph.tums.ac.ir/index.php/ijph/article/download/15996/7139

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 391 396 Mahsa RAHMANI SAMANI 1. School of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran 2. Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences and Metabolism, Shahid Beheshti University of Medical Sciences, Tehran, Iran Marjan ZARIF-YEGANEH Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences and Metabolism, Shahid Beheshti University of Medical Sciences, Tehran, Iran Atefeh MEHRABI 1. School of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran 2. Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences and Metabolism, Shahid Beheshti University of Medical Sciences, Tehran, Iran Amir Nader EMAMI RAZAVI Iran National Tumor Bank, Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran Sara SHEIKHOLESLAMI Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences and Metabolism, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mehdi HEDAYATI Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences and Metabolism, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2019 07 23 2020 01 21 Background: Medullary thyroid cancer (MTC) accounts for 5%–10% of all thyroid cancers, but causes 13% of all thyroid cancer related deaths. MicroRNAs (miRs) have key functions in the development and progression of MTC. Altered expression of some miRs has been reported in many human cancers, including Thyroid cancer. Therefore, we aimed to analyze the expression of miR-154, miR-183 and miR-127 in MTC tumor tissues. Methods: In this case-control study, 15 MTC Formalin-fixed, paraffin-embedded (FFPE) tissue samples and 15 adjacent normal thyroid FFPE tissues, as a control group, were collected from Taleghani, and Loghman Hakim Hospitals, Tehran, Iran since 2005 till 2015. After RNA extraction and cDNA synthesis, the expression of miR-127, miR-154 and miR-183 was measured by quantitative Real-Time Polymerase Chain Reaction (qRT-PCR). Results: Our data showed a significant increase in the expression of miR-127 in MTC samples in comparison with the control group (P<0.05). Although miR-154 and miR-183 expression levels had increase expression in MTC tumors, this change was not statistically significant. Conclusion: The miR-127 could be considered as a prognostic, diagnostic and therapeutic marker for the management of MTC, and it is proposed for further investigation to fully establish the role of this miRNA in MTC. https://ijph.tums.ac.ir/index.php/ijph/article/view/17877 https://ijph.tums.ac.ir/index.php/ijph/article/download/17877/7140

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 50 2 2021 02 01 397 406 EN Saman SARGAZI Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran Milad HEIDARI NIA 1. Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran 2. Department of Biology, Faculty of Science, Isfahan University, Isfahan, Iran Shekoufeh MIRINEJAD Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran Mahdiyeh MOUDI Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran Mahdiyeh JAFARI SHAHROUDI Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran Ramin SARAVANI 1. Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran 2. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran