Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 46 9 2017 09 03 1184 1192 Yeong Seon HONG Health and Welfare Graduate School, Sahmyook University, Nowon-Ku, Seoul, Republic of Korea Dong-Kyu LEE Dept. of Biological Sciences, School of Health & Environment, Kosin University, Wachi-ro Yeongdo-gu Busan, Republic of Korea Jin-Han YOON Korea Health Project Evaluation Research Institute, Sahmyook University, 26-21 Kongneung-dong, Nowon-gu, Seoul, Republic of Korea Aeree SOHN Dept. of Health Management, Sahmyook University, 26-21 Kongneung-dong, Nowon-gu, Seoul, Republic of Korea 2017 09 03 2017 09 03 Background: The aim of this study was to provide evidence for developing intervention and effective management for the prevention of malaria based on epidemiological analysis and assessment of Korean soldiers’ knowledge on malaria and malaria preventive behavior. Methods: The data were collected from 294 Korean soldiers nearby the demilitarized zone in Gyeonggi Province in 2016. Multiple regression analyses were applied for statistical analysis. Results: The level of education (β=.24, P<.001), educational experience on malaria (β=.21, P<.001) and ranks like corporal (β=.13, P<.05), and sergeant (β=.13, P<.05) were observed to be associated with the level of knowledge of malaria (F=9.62, =.12, P<.001). Knowledge of malaria (β=.25, P<.001) and malaria education experience (β=.22, P<.001) were the factors that influenced malaria prevention behavior and practice (F=12.45, =.18, P<.001). Conclusion: The level of knowledge and education experience was associated with malaria prevention practice. Therefore, malaria education is very important for the soldiers in nearby DMZ for prevention of malaria. The findings provide implications for the development of intervention programs focusing on increasing the levels of knowledge and practices related to malaria.     https://ijph.tums.ac.ir/index.php/ijph/article/view/10990 https://ijph.tums.ac.ir/index.php/ijph/article/download/10990/5676

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 46 9 2017 09 03 1156 1166 Jafar Sadegh TABRIZI Health Services Management, Tabriz Health Services Management Research Center, Dept. of Health Services Management, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran Faramarz POURASGHAR Road Traffic Injury Research Center, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran AND Dept. of Medical Informatics, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran Raana GHOLAMZADEH NIKJOO Iranian Center of Excellence in Health Management, Dept. of Health Services Management, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran 2017 09 03 2017 09 03 Background: After the establishment of Primary Health Care (PHC) program in Iran, health indicators have improved every year. This progress was so rapid that a number of shortcomings and weaknesses of the PHC program remained silent behind its successes. This study aimed to assess the status of Iran’s PHC system (strengths, weaknesses, opportunities and threats) in terms of health system’s control knobs. Methods: The search was conducted through two English `databases of Web of Knowledge and PubMed, two English publications of Science Direct and Springer and two Persian databases of Magiran and SID. Keywords were selected from MeSH and included primary health care, PHC and Iran in both Persian and English. No time limit was considered. Results: Iran's PHC system has numerous successes in dealing with health system’s control knobs; which largely part of that related to the health network implementation, the role of Behvarz, improvement of health indicators in rural areas and the elimination of urban-rural inequality, but there are some weaknesses, opportunities and threats in the Iranian PHC system as well. Conclusion: By considering socio-economic changes the current structure of PHC system needs to be reformed to coordinate with phenomenon of chronic diseases, accidents and aging. The current information system in PHC does not provide the required information for decision makers and policy makers so it needs to be transformed to the electronic system with unique electronic health file for individuals.   https://ijph.tums.ac.ir/index.php/ijph/article/view/10986 https://ijph.tums.ac.ir/index.php/ijph/article/download/10986/5672

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 46 9 2017 09 03 1292 1294 Eun-Ju CHOI Division of Sport Sciences, Konkuk University, Chungju-si, Korea Wi-Young SO Sports and Health Care Major, Korea National University of Transportation, Chungju-si, Korea Taikyeong Ted. JEONG Dept. of Computer Science and Engineering, Seoul Women’s University, Seoul, Korea 2017 09 03 2017 09 03 Effects of the CrossFit Exercise Data Analysis on Body  Composition and Blood Profiles https://ijph.tums.ac.ir/index.php/ijph/article/view/11003 https://ijph.tums.ac.ir/index.php/ijph/article/download/11003/5689

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 46 9 2017 09 03 1193 1203 Liubao GU Dept. of Statistics, School of Economics, Hebei University, Baoding, China Huihui FENG Dept. of Statistics, School of Economics, Hebei University, Baoding, China Jian JIN JIN Dept. of Statistics, School of Economics, Hebei University, Baoding, China 2017 09 03 2017 09 03 Background: Population aging has become increasingly serious in China. The demand for medical insurance of the elderly is increasing, and their health status and life satisfaction are becoming significant issues. This study investigates the effects of medical insurance on the health status and life satisfaction of the elderly. Methods: The national baseline survey data of the China Health and Retirement Longitudinal Survey in 2013 were adopted. The Ordered Probit Model was established. The effects of the medical insurance for urban employees, medical insurance for urban residents, and new rural cooperative medical insurance on the health status and life satisfaction of the elderly were investigated. Results: Medical insurance could facilitate the improvement of the health status and life satisfaction of the elderly. Accordingly, the health status and life satisfaction of the elderly who have medical insurance for urban residents improved significantly. The regression coefficients were 0.348 and 0.307. The corresponding regression coefficients of the medical insurance for urban employees were 0.189 and 0.236. The regression coefficients of the new rural cooperative medical insurance were 0.170 and 0.188. Conclusion: Medical insurance can significantly improve the health status and life satisfaction of the elderly. This development is of immense significance for the formulation of equal medical security. https://ijph.tums.ac.ir/index.php/ijph/article/view/10991 https://ijph.tums.ac.ir/index.php/ijph/article/download/10991/5677

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 46 9 2017 09 03 1167 1175 Sanaz JOULAI VEIJOUYE Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran AND Dept. of Biology, University Campus 2, University of Guilan, Rasht, Iran Abazar YARI Dept. of Anatomy, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran Fatemeh HEIDARI Dept. of Anatomy, School of Medicine, Qom University of Medical Sciences, Qom, Iran Nayereh SAJEDI Dept. of Anatomy, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Fatemeh GHOROGHI MOGHANI Dept. of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Maliheh NOBAKHT Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran AND Dept. of Anatomy, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran AND Anti-Microbial Resistance Research Center, Iran University of Medical Sciences, Tehran, Iran 2017 09 03 2017 09 03 Background: Hair follicle stem cells exist in different sites. Most of the hair follicle stem cells are reside in niche called bulge. Bulge region is located between the opening of sebaceous gland and the attachment site of the arrector pili muscle. Methods: Data were collected using databases and resources of PubMed, Web of Science, Science Direct, Scopus, MEDLINE and their references from the earliest available published to identify English observational studies on hair follicle bulge region. Results: Bulge stem cells are pluripotent with high proliferative capacity. Specific markers allow the bulge cells to be isolated from mouse or human hair follicle. Stem cells isolated from bulge region are label retaining and slow cycling hence these cells are defined as label-retaining cells. Bulge cell populations, due to their plasticity nature are able to differentiate into distinct linage and could contribute in tissue regeneration. Conclusion: The current review discuss about bulge stem cells characteristics and biology including their cycle, location, plasticity, specific markers and regenerative nature. Also the differences between mouse and human hair follicles are investigated.     https://ijph.tums.ac.ir/index.php/ijph/article/view/10987 https://ijph.tums.ac.ir/index.php/ijph/article/download/10987/5673

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 46 9 2017 09 03 1295 1296 Pavol BENO Dept. of Laboratory Medicine in Health Care, Faculty of Health Sciences and Social Work, Trnava University, Trnava, Slovak Republic Martin SAMOHYL Institute of Hygiene, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic 2017 09 03 2017 09 03 The Treated Drug Users in the Slovak Republic https://ijph.tums.ac.ir/index.php/ijph/article/view/11007 https://ijph.tums.ac.ir/index.php/ijph/article/download/11007/5693

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 46 9 2017 09 03 1204 1210 Phuong Kim TRUONG Faculty of Biology and Biotechnology, University of Sciences, Vietnam National University, Ho Chi Minh, Vietnam AND Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh, Vietnam Thuan Duc LAO Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh, Vietnam Thuy Ai Huyen LE Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh, Vietnam 2017 09 03 2017 09 03 Background: Human papillomavirus (HPV) infection has been considered as main cause of cervical cancer. Recently, aberrant DNA methylation at tumor suppressor genes (TSGs), leading to inactivation, has also been an early epigenetic event and cofactor in cervical carcinogenesis. This study was performed to evaluate an association between the hypermethylation of p16INK4α gene’s promoter and HPV exposure in non-invasive samples (liquid-based papanicolaous samples) in Vietnamese population. Methods: 109 liquid-based papanicolaous test samples were archived and admitted from the Medic Medical Center and Au Lac Clinic Laboratory, Vietnam, from 2011–2014. Methylation-Specific-PCR (MSP) was performed to analyze methylation status from the liquid-based papanicolaous test samples identified whether HPV/or non-HPV, high-risk/low-risk HPV infection. Results: An upward trend was observed concerning the p16INK4α hypermethylation frequency in high-risk HPV infection, counting for 55.6%, and the low methylation frequency in low-risk and non-HPV infected samples, counting for 22.9%, 8.0%, respectively. The significant correlation between candidate p16INK4α hypermethylation and HPV exposure was observed (P<0.0001). Moreover, the odds ratio (OR) and relative risk (RR) were found in statistical significant value. (OR=5.76, 95%CI: 2.36 – 14.04, P<0.01; RR=3.11, 95%CI: 1.75–5.53, P<0.01). Conclusion: Presence of p16INK4α hypermethylation was the specific characteristic of high-risk HPV infected samples in Vietnamese population. The OR and RR values showed that the strong correlation between p16INK4α hypermethylation and high-risk HPV infection, in which increased the risk of cervical cancer. The combination of p16INK4α hypermethylation and HPV detection based biomarker could be used in non-invasive samples obtained from high-risk cancer patients, offer significant practical advantages.     https://ijph.tums.ac.ir/index.php/ijph/article/view/10992 https://ijph.tums.ac.ir/index.php/ijph/article/download/10992/5678

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 46 9 2017 09 03 1176 1183 Maryam MOOSAVI Dept. of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran AND Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran 2017 09 03 2017 09 03 Background: From old times, the human kind has used clays, externally or internally, for maintaining body health or treating some diseases. Meanwhile there are few scientific articles reviewing the beneficial effects of clays on body function. Bentonite clay is one of the available clays in nature, used as traditional habits, and remedies in many cultures. Methods: These articles explored among 2500 scientific articles published in PubMed to sort the scientific works have been done on the effects of this clay on body function (it was about 100 articles). Results: Bentonite has a broad range of action on different parts of body. Conclusion: As traditional remedies seem to have a deep root in maintaining body health, it merits doing more research works on bentonite clay and its impacts on body function.     https://ijph.tums.ac.ir/index.php/ijph/article/view/10989 https://in locale="en_US">Dept. of Community Medicine, Liaquat National Hospital & Medical College, Karachi, Pakistan 2016 12 27 2016 12 27 Rotavirus Vaccine Demand in Pakistan https://ijph.tums.ac.ir/index.php/ijph/article/view/8642 https://ijph.tums.ac.ir/index.php/ijph/article/download/8642/5486

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 12 2016 12 27 1595 1603 Mei HA School of Nursing, Chongqing Medical and Pharmaceutical College, Chongqing 400020, PR China Xiaoling QIAN The Second Hospital of Lanzhou University, Lanzhou, PR China Hong YANG School of Nursing, Chongqing Medical and Pharmaceutical College, Chongqing 400020, PR China Jichun HUANG School of Nursing, Chongqing Medical and Pharmaceutical College, Chongqing 400020, PR China Changjiang LIU Key Lab of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing 400020, PR China 2016 12 27 2016 12 27 Background: The public’s cognition of stroke and responses to stroke symptoms are important to prevent complications and decrease the mortality when stroke occurs. The aim of study was to develop and validate the Chinese version of the Stroke Action Test (C-STAT) in a Chinese population. Methods: This study was rigorously implemented with the published guideline for the translation, adaptation and validation of instruments for the cross-cultural use in healthcare care research. A cross-sectional study was performed among 328 stroke patients and family members in the Department of Neurology in the Second Hospital of Lanzhou University, Gansu province, China in 2014. Results: The Chinese version of the instrument showed favorable content equivalence with the source version. Values of Cronbach’s alpha and test-retest reliability of the C-STAT were 0.88 and 0.86, respectively. Principal component analysis supported four-factor solutions of the C-STAT. Criterion-related validity showed that the C-STAT was a significant predictor of the 7-item stroke symptom scores (R = 0.77; t = 21.74, P< 0.001). Conclusion: The C-STAT is an intelligible and brief psychometrical tool to assess individuals’ knowledge of the appropriate responses to stroke symptoms in Chinese populations. It could also be used by health care providers to assess educational programs on stroke prevention.   https://ijph.tums.ac.ir/index.php/ijph/article/view/8651 https://ijph.tums.ac.ir/index.php/ijph/article/download/8651/5403

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 12 2016 12 27 1558 1567 Joanna KRUK Dept. of Prevention and Occupational Therapy, Faculty of Physical Culture and Health Promotion, University of Szczecin, Szcze-cin, Poland Hassan ABOUL-ENEIN Dept. of Pharmaceutical and Medicinal Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Center, Dokki, Giza, Egypt 2016 12 27 2016 12 27 Background: Prostate cancer (PCa) is the second most common malignancy in men worldwide. The purpose of this study was to provide a brief synthesis the current knowledge for the effects of physical activity (PA) and nutrition on PCa risk. Methods: A systematic review of English languages reviews, meta-analysis, and original articles published from 2009 to 2015 extracted from the following websites: MEDLINE, Web of Science, Health Source, Science Direct, and their references. Results: The review of the literature led to the selection of 12 review or meta-analysis studies and 15 lately published observational studies. Most of studies reported relationship of recreational and occupational PA and vegetables, fruits, vitamins, red/processed meats, and fats consumption with risk of PCa. Decreased risk for PCa associated with exercise was reported in seven of the ten articles on this topic. The inverse association of vegetables and/or fruit intake with PCa risk was reported in eight of 13 papers. The effect of meat/fat intake on PCa was estimated in four articles finding increased risk. There was heterogeneity between studies, and findings are inconsistent. Conclusion: Physical activity does not significantly reduce the risk of PCa; however, vigorous exercise may reduce the risk of aggressive tumor. Besides, there is a lack of definitive evidence supporting the preventive role of diet against PCa. Due to many other benefits of regular moderate-vigorous PA and a diet high in vegetables and fruits and low in red/processed meats and fats, these lifestyle patterns may be recommended.     https://ijph.tums.ac.ir/index.php/ijph/article/view/8630 https://ijph.tums.ac.ir/index.php/ijph/article/download/8630/5399

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 12 2016 12 27 1660 1661 Hua ZHANG Dept. of Medical Insurance, School of Public Health, Southeast University, Nanjing, Jiangsu, China Mingdong HUO Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu, China Jianqian CHAO Dept. of Medical Insurance, School of Public Health, Southeast University, Nanjing, Jiangsu, China Pei LIU Dept. of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing, Jiangsu, China 2016 12 27 2016 12 27 Willing to Pay for Antiviral Treatment of Hepa¬titis B Patients https://ijph.tums.ac.ir/index.php/ijph/article/view/8643 https://ijph.tums.ac.ir/index.php/ijph/article/download/8643/5487

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 12 2016 12 27 1604 1609 Min LI Dept. of Thoracic Surgery, Xuzhou Central Hospital Affiliated to Southeast University, Jiangsu, Xuzou 221009, People’s Republic of China Miao ZHANG Dept. of Thoracic Surgery, Xuzhou Central Hospital Affiliated to Southeast University, Jiangsu, Xuzou 221009, People’s Republic of China Heng WANG Dept. of Thoracic Surgery, Xuzhou Central Hospital Affiliated to Southeast University, Jiangsu, Xuzou 221009, People’s Republic of China Xuefeng PAN Dept. of Thoracic Surgery, Xuzhou Central Hospital Affiliated to Southeast University, Jiangsu, Xuzou 221009, People’s Republic of China Wenbin WU Dept. of Thoracic Surgery, Xuzhou Central Hospital Affiliated to Southeast University, Jiangsu, Xuzou 221009, People’s Republic of China Qi ZHANG Dept. of Thoracic Surgery, Xuzhou Central Hospital Affiliated to Southeast University, Jiangsu, Xuzou 221009, People’s Republic of China Yun LIU Dept. of Thoracic Surgery, Xuzhou Central Hospital Affiliated to Southeast University, Jiangsu, Xuzou 221009, People’s Republic of China Hui ZHANG Dept. of Thoracic Surgery, Xuzhou Central Hospital Affiliated to Southeast University, Jiangsu, Xuzou 221009, People’s Republic of China 2016 12 27 2016 12 27 Background: The objective of the present study was to explore the efficacy of internet-based intervention on quality of life of patients with chronic post-surgical pain (CPSP).   Methods: A retrospective analysis was performed on 81 patients diagnosed with CPSP after radical resection for lung cancer between January 2013 and July 2014.  They were enrolled either as part of the conventional care group which included 40 cases or the internet-based pain intervention group which included 41 cases. The patients in the conventional care group were treated weekly in the outpatient clinic, while patients in internet-based group were treated via smartphone or the internet.  The 36-Item Short Form Health Survey (SF-36) was utilized to assess the quality of life of patients who were suffering from CPSP, 1 month and 3 months after therapy. Results: The patients in the internet-based pain intervention group demonstrated similar health-related qualities of life and overall satisfaction rates compared with the conventional care group (P>0.05). Conclusion: Internet-based pain management is a suitable option to improve the quality of life of patients with CPSP after radical resection for lung cancer.   https://ijph.tums.ac.ir/index.php/ijph/article/view/8634 https://ijph.tums.ac.ir/index.php/ijph/article/download/8634/5404

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 12 2016 12 27 1568 1576 Somaye YOSAEE Dept. of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran AND Ewaz School of Health, Larestan School of Medical Sciences, Larestan, Iran Sepideh SOLTANI Dept. of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran Eghbal SEKHAVATI Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Shima JAZAYERI Dept. of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran AND Research Center for Prevention of Cardiovascular Disease, Iran University of Medical Sciences, Tehran, Iran 2016 12 27 2016 12 27 Background: Heart disease is one of the most common chronic disease and leading cause of morbidity and mortality worldwide. Adropin, a newly identified protein, is important for energy homeostasis and maintaining insulin sensitivity, and has been referred to as a novel regulator of endothelial cells. Endothelial dysfunction is a key early event in atherogenesis and onset of HD. Therefore, this review gives a systematic overview of studies investigating plasma adropin level in patient with heart disease. Methods: Data carried out in PubMed, Scopus, Web of Science, Embase, Google scholar and MEDLINE, from the earliest available online indexing year through 2015. The search restricted to studies conducted in humans. The keyword search was adropin to apply in title, abstract and keywords. References lists of all original published articles were scanned to find additional eligible studies. Results: Heart failure (HF), coronary atherosclerosis acute myocardial infarction and Cardiac Syndrome X (CSX) were type of heart disease acknowledged in this study. Majority of evidences introduced low adropin as an independent risk factor of heart disease. In a case-control study, the plasma level of adropin increased with the severity of HF. Conclusion: Adropinmay be a potential serum biomarker for early diagnosis of HD.   https://ijph.tums.ac.ir/index.php/ijph/article/view/8631 https://ijph.tums.ac.ir/index.php/ijph/article/download/8631/5400

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 12 2016 12 27 1662 1664 Mahtab KARAMI Dept. of Health Information Technology and Management, School of Allied Medical Sciences, Kashan University of Medical Sciences, Kashan, Iran Nasrin HAFIZI Dept. of Health Information Technology and Management, School of Allied Medical Sciences, Kashan University of Medical Sciences, Kashan, Iran 2016 12 27 2016 12 27 E-game in Healthcare: As an E-intervention to Promote Public Health https://ijph.tums.ac.ir/index.php/ijph/article/view/8644 https://ijph.tums.ac.ir/index.php/ijph/article/download/8644/5488

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 12 2016 12 27 1610 1617 Davoud AFSHAR Dept. of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mohammad Reza POURMAND Dept. of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran AND Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran Mahmood JEDDI-TEHRANI Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran Ali Akbar SABOOR YARAGHI Dept. of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mohammad AZARSA Dept. of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Fazel SHOKRI Dept. of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2016 12 27 2016 12 27 Background: Choline-binding proteins (CBPs) are a group of surface-exposed proteins, which play crucial and physiological roles in Streptococcus pneumoniae. The novel member of CBPs, choline-binding protein M (CbpM) may have binding activity to plasma proteins. This study aimed to clone and express CbpM and demonstrate its interaction with plasma proteins and patients’ sera. Methods: The total length of cbpM gene was cloned in pET21a vector and expressed in BL21 expression host. Verification of recombinant protein was evaluated by Western blot using anti-His tag monoclonal antibody. Binding ability of the recombinant protein to plasma proteins and the interaction with patients’ sera were assessed by Western blot and ELISA methods. Results: The cbpM gene was successfully cloned into pET21a and expressed in BL21 host. Binding activity to fibronectin and fibrinogen and antibody reaction of CbpM to patients’ sera was demonstrated by Western blot and ELISA methods, respectively. Conclusion: CbpM is one of the pneumococcal surface-exposed proteins, which mediates pneumococcal binding to fibronectin and fibrinogen proteins.   https://ijph.tums.ac.ir/index.php/ijph/article/view/8636 https://ijph.tums.ac.ir/index.php/ijph/article/download/8636/5479

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 12 2016 12 27 1665 1666 Jannan GHAPANCHI Dept. of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran Fahimeh REZAZADEH Dept. of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran Erfan FAKHRAEE School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran Aisa ZAMANI 3.Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran 2016 12 27 2016 12 27 Prevalence of Xerostomia in Patients Referred to Shiraz Dental School, Shiraz, Iran during 2006-2013 https://ijph.tums.ac.ir/index.php/ijph/article/view/8645 https://ijph.tums.ac.ir/index.php/ijph/article/download/8645/5489

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 12 2016 12 27 1618 1624 Maryam Beigom MOBASHERI Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran AND Dept. of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Reza SHIRKOOHI Dept. of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Mohammad Hossein MODARRESSI Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran AND Dept. of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran 2016 12 27 2016 12 27 Background: Breast cancer is the most frequent cancer in women. Cancer/Testis antigens are immunogenic proteins ectopically expressed in human neoplasms. Synaptonemal complex protein 3 (SYCP3) belongs to cancer/testis genes family involved in meiotic events and spermatogenesis. The aim of this study was to express analysis of SYCP3 in breast cancer and validate it as a breast cancer biomarker. Methods: Expression of SYCP3 transcripts in 47 breast tumors, 6 breast cancer cell lines (MCF7, SKBR3, T47D, BT474, MDA-MB-231 and MDA-MB 468), 5 normal breast and 2 testis tissues was studied by Real Time RT-PCR reaction. The reference genes phosphoglucomutase 1 and hypoxanthine guanine phosphoribosyl transferase were used as reactions normalizers. The software tool REST 2009 was applied for statistical analysis of the data. The research was conducted from Apr 2014 to August 2015 in Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Results: All of the studied breast cancer cell lines showed very high levels of SYCP3 overexpression in comparison to normal breast (P=0.001) and even to normal testis (P=0.001), except for MCF7 cell line. Breast tumors showed moderately increasing in transcript changes in comparison to normal breast. Conclusion: SYCP3 is a known testis-specific gene, but interestingly five out of six studied breast cancer of cell lines showed higher expression levels of SYCP3 in comparison to normal testis and normal breast tissues. SYCP3 has critical role in cell division with known interaction with the tumor suppressor genes, BRCA1 and BRCA2, which are critical genes in breast cancer.   https://ijph.tums.ac.ir/index.php/ijph/article/view/8637 https://ijph.tums.ac.ir/index.php/ijph/article/download/8637/5480

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 12 2016 12 27 1667 1668 Shahram SAVAD Dept. of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Sepideh HAMZEHLOU Dept. of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Jila GHAFFOURIAN ABADI Dept. of Obstetrics and Gynecology, Kamali Hospital, Alborz University of Medical Sciences, Karaj, Iran Mohammad Hossein MODARRESSI Dept. of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Shahab NOORIAN Dept. of Pediatric Endocrinology and Metabolism, Bahonar Hospital, Alborz University of Medical Sciences, Karaj, Iran 2016 12 27 2016 12 27 Dizygotic Twins Concordant for Down Syndrome: Implication for Establishing a National Birth Defect Registry in Iran https://ijph.tums.ac.ir/index.php/ijph/article/view/8646 https://ijph.tums.ac.ir/index.php/ijph/article/download/8646/5495

https://ijph.tums.ac.ir/index.php/ijph/article/view/11767 https://ijph.tums.ac.ir/index.php/ijph/article/download/11767/5849

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 46 12 2017 11 29 1752 1753 Erfan AYUBI Dept. of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran AND Dept. of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Ali HOSSEINI Dept. of Geography and Urban Planning, University of Tehran, Tehran, Iran Kamyar MANSORI Social Determinants of Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran Salman KHAZAEI Dept. of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran 2017 11 29 2017 11 29 Province Disparity on Female Breast Cancer in Iran https://ijph.tums.ac.ir/index.php/ijph/article/view/11781 https://ijph.tums.ac.ir/index.php/ijph/article/download/11781/5862

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 46 12 2017 11 29 1697 1703 Masoomeh GHADERIPOUR Dept. of Medical Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Khadijeh KHANALIHA Dept. of Medical Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mehdi MOHEBALI Dept. of Medical Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran AND Center for Research of Endemic Parasites of Iran (CREPI), Tehran University of Medical Sciences, Tehran, Iran Saeedeh SHOJAEE Dept. of Medical Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Maryam BARKHORI Dept. of Medical Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Hamed MIRJALALI Dept. of Medical Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mostafa REZAEIAN Dept. of Medical Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran AND Center for Research of Endemic Parasites of Iran (CREPI), Tehran University of Medical Sciences, Tehran, Iran 2017 11 29 2017 11 29 Background: Microsporidia have been reported as the cause of opportunistic infections in immunocompromised patients in Iran and other countries. There is no data on prevalence of intestinal microsporidia in healthy population of Iran. This study aimed to provide preliminary data on the present status of microsporidia infection in the local healthy population in Jiroft, Kerman Province from southeastern Iran in 2013-2014. Methods: Fresh stool samples were randomly collected from 418 residents in rural 209 (50%) and urban 209 (50%) areas of Jiroft. All of the collected samples were concentrated with conventional formalin-ether, stained with Ryan blue. Microscopic examination was performed with high magnification on each sample separately for the demonstration of microsporidia spores. Results: Microsporidial spores were identified in 41 out of 418 (9.8%) samples including 16.41(39%) from rural areas and 25.41(61%) from urban areas. In general, there was no significant difference between sex, age, job, education, and contact with soil and livestock, water supply, gastrointestinal disorders and microsporidia infection among general population in Jiroft. Conclusion: Intestinal microsporidia infection without clinical manifestations is prevalent in general population resident in southeastern Iran. Appropriate molecular methods are needed for microsporidia species identification.   https://ijph.tums.ac.ir/index.php/ijph/article/view/11768 https://ijph.tums.ac.ir/index.php/ijph/article/download/11768/5850

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 46 12 2017 11 29 1704 1711 Imen CHATTI Laboratory of Human Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached Hospital, Sousse, Tunisia Jean-Baptiste WOILLARD U850 INSERM, University of Limoges, CHU Limoges, FHU SUPORT, Limoges, France Amira MILI Laboratory of Human Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached Hospital, Sousse, Tunisia Isabelle CREVEAUX Laboratoire de Biochimie Médicale, Faculté de Médecine, Clermont-Ferrand, France Ilhem BEN CHARFEDDINE Laboratory of Human Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached Hospital, Sousse, Tunisia Jihène FEKI Service d’ Oncologie Médicale et Service de Chirurgie Générale, CHU Habib Bourguiba, Université de Sfax, Sfax, Tunisia Sarah LANGLAIS Laboratoire de Biochimie Médicale, Faculté de Médecine, Clermont-Ferrand, France Leila BEN FATMA Dept. of Medical Oncology, CHU Farhat Hached, Sousse, Tunisia Ali SAAD Laboratory of Human Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached Hospital, Sousse, Tunisia Moez GRIBAA Laboratory of Human Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached Hospital, Sousse, Tunisia Frédéric LIBERT Laboratoire de Pharmacologie et Toxicologie, CHU G. Montpied, Clermont-Ferrand, France Inserm, U1107 NEURO-DOL, Clermont Université, 63001 Clermont-Ferrand, France 2017 11 29 2017 11 29 Background: Pain and its opioid treatments are complex measurable traits. Responses to morphine in terms of pain control is likely to be determined by many factors, including the underlying pain sensitivity of the patient, along with nature and extent of the painful process, concomitant medications, genetic and other clinical and environmental factors. This study investigated genetic polymorphisms implicated in the inter-individual pain response variability to opioid treatment in the Tunisian population. Methods: This prospective association study investigated seven variations in the OPRM1, OPRK1 and COMT gene, which encode Mu and KAPPA opioid receptors, and Catechol-O-methyltransferase enzyme respectively, in a cohort of 129 Tunisian cancer pain patients under oral morphine treatment. Genotyping was performed by simple probe probes on Light Cyler for rs17174629, rs1799972, rs1799971, rs1051659, rs1051660 and rs4680 and by PCR assay for the indel in the promoter region of OPRK1 (rs35566036). A statistical associations study between dose (continuous), dose escalation (yes/no) and SNP or haplotypes were investigated using linear multiple regressions and logistic regressions respectively adjusted on metastases and pain covariates in the R software. Results: We detected significant association of the rs1051660 adjusted on metastasis and pain (P=0.02), no other association has been detected between the 7 polymorphisms screened and the dose of morphine needed for pain relief. Conclusion: This can be explained by the strong genetic heterogeneity in the cosmopolitan areas where our patients were recruited for this study, compared to more homegenous population recruited in other studies.     https://ijph.tums.ac.ir/index.php/ijph/article/view/11769 https://ijph.tums.ac.ir/index.php/ijph/article/download/11769/5851

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 46 12 2017 11 29 1712 1719 Ali ROSTAMI Dept. of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Hooshang KHAZAN Dept. of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Bahram KAZEMI Dept. of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran AND Dept. of Biotechnology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Eshrat Beigom KIA Dept. of Medical Parasitology & Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mojgan BANDEPOUR Dept. of Biotechnology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Niloofar TAGHIPOUR Dept. of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Gholamreza MOWLAVI Dept. of Medical Parasitology & Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2017 11 29 2017 11 29 Background: Trichinellosis is an important and neglected foodborne zoonotic infectious disease in worldwide. The most human outbreaks in recent years have been related to consumption of wild boar meat. This cross-sectional study determined the prevalence of Trichinella spp. infections in hunted wild boars in northern Iran. Methods: Thirty-five hunted wild boars were subjected in this study in 2015. All samples were examined by conventional artificial digestion method to detect of muscle larvae. Genomic DNA was extracted by phenol-chloroform method from isolated larvae. To identify the Trichinella species, a PCR-based method was applied using the internal transcribed spacer 2 (ITS2) and mitochondrial small-subunit ribosomal RNA (rRNA) gene sequences. Results: The overall prevalence of Trichinella spp. infection was 5.7% (2/35, 95%CI= 0-13.4). The mean larval burdens in two positive samples were 0.05 and 6 larvae per gr tissue muscle, respectively. The PCR reaction, using specific primers, yielded two 367 bp and 195 bp bands on agarose gel for ITS 2 and rrnS, respectively. Conclusion: There is a hidden burden of Trichinella spp. infection in wild boar population in Iran. Moreover, T. britovi is the prevalent species circulating in wild boars of Iran. Therefore, education of the hunters and other consumers should be performed about the risk of consumption of raw or undercooked meat and meat products from wild boars.     https://ijph.tums.ac.ir/index.php/ijph/article/view/11770 https://ijph.tums.ac.ir/index.php/ijph/article/download/11770/5852

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 46 12 2017 11 29 1720 1725 Mahmood NEKOEI MOGHADAM Health Services Management Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran Mohammadreza AMIRESMAILI Medical Informatics Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran Reza GOUDARZI Research Center for Modeling in Health, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran Saeed AMINI Health Services Management, EDC, Arak University of Medical Sciences, Arak, Iran Sajad KHOSRAVI Dept. of Health Services Management, School of Public Health, Bam University of Medical Sciences, Bam, Iran 2017 11 29 2017 11 29 Background: Reduction of inappropriate use of health services can decrease health care costs without harming the quality of services. This study aimed to investigate inappropriate admission and hospitalization at Afzalipour Hospital of Kerman, Iran. Methods: Inappropriate admission and hospitalization were assessed via a cross-sectional study on 400 patients in Kerman Afzalipour Hospital, Kerman, Iran in 2015. The Iranian version of the Appropriateness Assessment Protocol was used for data collection. Chi-square tests and logistic regression were used to analyze the data. Results: The rate of inappropriate admissions and hospitalization were 7.6% and 9% respectively. There was no significant relationship between inappropriate admissions and any of the studied variables; however, there was a significant relationship between inappropriate hospitalization and age, length of stay and hospital departments. Conclusion: If standard measures of admission and hospitalization execute correctly, unnecessary hospitalization rate can be reduced, so more patients can be treated and cost and workload of hospital personnel can be moderated.     https://ijph.tums.ac.ir/index.php/ijph/article/view/11771 https://ijph.tums.ac.ir/index.php/ijph/article/download/11771/5853

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085