Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 8 2016 10 10 997 1003 Hee-Ju KWON Asia Contents Institute, Konkuk University, Seoul, Korea Ik-Rae CHO College of Education, Hankuk University of Foreign Studies, Seoul, Korea Hyo-Joo PARK College of Education, Hankuk University of Foreign Studies, Seoul, Korea Tae-Young KIM College of Education, Hankuk University of Foreign Studies, Seoul, Korea 2016 08 28 2016 08 28 Background: In this study, we examined the status of Korean women’s alcohol consumption and identified the physical changes they undergo according to the level of consumption. The results of this study may thus be used as raw data to effectively control women’ drinking habits. Methods: This study consists of a secondary analysis using data from female participants in the 6th Korea National Health and Nutrition Examination Survey, which was conducted by the Korea Centers for Disease Control and Prevention(2013-2014, V-2). In total, 863 women were finally selected to analyze their anthropometric data [height, body weight, body mass index (BMI), and waist circumference], blood parameters (total cholesterol, triglyceride, and feeding glucose), blood pressure profile (systolic/diastolic), and nutrients (carbohydrate, protein, lipid, and total energy intake). Results: Women’s alcohol consumption contributed significantly to an increase in body weight, body fat, and BMI as well as to an increase in total energy intake resulting from increased fat consumption. Further, the systolic blood pressure increased significantly when women were exposed to alcohol. Conclusion: The results of this study suggest that alcohol consumption in women is associated with a range of adverse health implications. Notably, an increase in drinking frequency significantly affects their body weight, blood parameters, and nutrients, thus posing substantial health risks to the women, including obesity. Therefore, the Korean government should help women curve their drinking habits through regular training and campaigns.     https://ijph.tums.ac.ir/index.php/ijph/article/view/7600 https://ijph.tums.ac.ir/index.php/ijph/article/download/7600/5493

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 8 2016 10 10 970 977 Maria Adriana BURGIO Unit of Obstetrics and Gynecology, ASST Cremona, Cremona, Italy Antonio Simone LAGANÀ Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood “G. Barresi”, University of Messina, Messina, Italy Angela SICILIA School of Midwifery, University of Messina, Messina, Italy Romana PROSPERI PORTA Dept. of Gynecology, Obstetrics and Urology, "Sapienza" University of Rome, Policlinico Umberto I, Rome, Italy Maria Grazia PORPORA Dept. of Gynecology, Obstetrics and Urology, "Sapienza" University of Rome, Policlinico Umberto I, Rome, Italy Helena BAN FRANGEŽ Dept. of Reproduction, University Medical Center Ljubljana, Ljubljana, Slovenia Giovanni DI VENTI Unit of Nursing and Midwifery Administration, A.O.U. “Gaetano Martino”, Messina, Italy Onofrio TRIOLO Unit of Nursing and Midwifery Administration, A.O.U. “Gaetano Martino”, Messina, Italy 2016 08 28 2016 08 28 Background: UNICEF (United Nations International Children's Emergency Fund) and WHO estimate that if all babies were breastfed for at least the first six months of their lives, the rate of morbidity and malnutrition would significantly decrease all over the world. In this view, these two organizations promoted a worldwide campaign for breastfeeding, creating the Baby Friendly Hospital Initiative (BFHI) that encourages good practices for the promotion of breastfeeding in hospitals. The aim of our study was to review the available evidence regarding the positive effects of breastfeeding, in order to suggest to most appropriate strategy to support it. Methods: The main databases including Scopus, PubMed, MEDLINE, Google scholar and Science Direct were researched to obtain the original papers related to breastfeeding education. The main terms used to literature search were "Breastfeeding education", Breastfeeding support", and “Breastfeeding healthcare policy”. The timeframe included the obtained articles was from 1980 to 2015. Results: Our analysis confirms that healthcare providers play a pivotal role in education and encouraging mothers to begin and continue breastfeeding. In this view, the adequate training of healthcare providers seems to be mandatory in order to support this practice. Moreover, adequate facilities are needed in order to promote and support breastfeeding. Conclusion: Considering the available evidence, breastfeeding should be supported among all the mothers. Based on the positive data emerging from the public awareness campaign in different Countries of the world, we strongly encourage an accurate training for doctors and midwives and the implementation of adequate facilities in order to support breastfeeding.   https://ijph.tums.ac.ir/index.php/ijph/article/view/7597 https://ijph.tums.ac.ir/index.php/ijph/article/download/7597/5490

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 8 2016 10 10 1080 1082 Majid AKRAMI Dept. of Surgery, Shiraz University of Medical Sciences, Shiraz, Iran Mohammad Reza SASANI Medical Imaging Research Center, Dept. of Radiology, Shiraz University of Medical Sciences, Shiraz, Iran 2016 08 28 2016 08 28 Nutritional status is very important especially in older adults because of its effects on quality of life. Phytobezoar, for instance, that can lead to small bowel obstruction has risk factors such as excessive consumption of foods with high fiber content and inadequate chewing. These factors are related to dietary habits. Furthermore, aging process and some of related physiologic changes can predispose one to phytobezoar formation. We describe a 61-yr-old man presented to the Emergency Department of Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran, in 2015 with small bowel obstruction due to phytobezoar following large amount of pomegranate seeds intake a few days before admission as an example of increased morbidity relating to unusual dietary habit.     https://ijph.tums.ac.ir/index.php/ijph/article/view/7610 https://ijph.tums.ac.ir/index.php/ijph/article/download/7610/5518

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 8 2016 10 10 1083 1084 Brunah de Oliveira BUCHE Dept. of Dentistry, Universidade Positivo, Curitiba, Brazil Bruno GUSSO Dept. of Dentistry, Universidade Positivo, Curitiba, Brazil Fernanda Mara de Paiva BERTOLI Dept. of Dentistry, Universidade Positivo, Curitiba, Brazil Juliana Feltrin de SOUZA Dept. of Dentistry, Universidade Federal do Paraná, Curitiba, Brazil Ana Tereza Bittencourt GUIMARÃES Dept. of Biological Sciences, Universidade do Oeste do Paraná, Cascavel, Brazil João Armando BRANCHER Dept. of Dentistry, Universidade Positivo, Curitiba, Brazil 2016 08 28 2016 08 28 Estimation of the Salivary Iron in Children with Dental Caries: A Pilot Study https://ijph.tums.ac.ir/index.php/ijph/article/view/7611 https://ijph.tums.ac.ir/index.php/ijph/article/download/7611/5521

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 8 2016 10 10 1074 1079 Ionel BOSTAN The Stefan Cel Mare University of Suceava, Doctoral School of Economics, Suceava, Romania 2016 08 28 2016 08 28 Background: The present paper focuses on approaching the context and the actual manner of applying a method, known to be efficient and with a solid scientific background, on the institutional level of healthcare in Romania. Methods: The analyses and correlations developed by the author have taken into account the latest editions of the journals and publications of these institutions, such as statistical papers, standards, procedural guidebooks, reports. Most of the data (easily identifiable in the electronic environment) have been selected to enable the subsequent further investigation. Results: The payments made in 2012 for the audited NHP1-4, have increased by 82 282.66 thousand € (39.2%) as compared to 2010, and by 50578.22 thousand € (20.9%) as compared to 2011. The amounts paid for NHP1-4 have had an ascending trend starting with 2010, but, during 2010-2012, as the contribution of the Ministry of Health from the state budget has decreased from 152590.66 thousand € to 95328.22 thousand €, CNAS’s funding from the FNUASS resources has increased by 2.4 times. Conclusion: Following the analysis conducted on the NHP1-4, the findings based on representative samples are: (i) the specific legal standards related to the development of the NHP1-4, did not provide all the mechanisms that would ensure the certain procurement of medication and medical supplies as needed and did not ensure the efficient use of the allocated funds; (ii) clear discontinuities have been identified in the funding of NHP1-4, etc.     https://ijph.tums.ac.ir/index.php/ijph/article/view/7609 https://ijph.tums.ac.ir/index.php/ijph/article/download/7609/5517

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 8 2016 10 10 1004 1011 Wenxin XU Institute of Physical Education and Sport Science, Fujian Normal University, Fuzhou, Fujian, 350007, China Jiwei YAO Physical Education Institute, Hunan University of Science and Technology, Fuzhou, Fujian, 350007, China Longfei CHEN The First Affiliated Hospital, Fujian Medical University, Xiangtan, Hunan, 411201, China 2016 08 28 2016 08 28 Background: Chronic cor pulmonale (CCP) is a disease of increasing frequency in Chinese people and profoundly influences their health. CCP is often accompanied by anxiety and other psychological problems, and patients may show signs of motor function decline. However, little attention has been paid to the impact of CCP-related psychological problems on motor function. Methods: Patients with CCP receiving in- or outpatient treatment in the Respiratory Department of Xiangya Hospital of Central South University and the Second Xiangya Hospital of Central South University in Hunan Province between January and July 2015 were investigated. A total of 167 questionnaires were distributed, with 160 valid questionnaires ultimately collected from 95 male and 65 female participants of mean age (± standard deviation) of 68.2 ± 12.3 yr. Self-Rating Anxiety Scale (SAS) scoring was adopted to evaluate anxiety in the participants, and heart rate, blood pressure, breathing rate, 6-minute walk test and Borg index score were combined to detect the exercise capability of the participants. Results: Anxiety was present in 48.8% of patients. Heart rate, systolic blood pressure, breathing rate and the Borg score of CCP patients with anxiety were higher than in CCP patients without anxiety (P < 0.05), while mean walking distance was shorter (P < 0.05). Conclusion: The rate of anxiety in patients with CCP is relatively high. Anxiety reduces motor function in CCP patients; therefore, in the process of treating patients with CCP, effort should be made to engage simultaneously patients in psychotherapy.     https://ijph.tums.ac.ir/index.php/ijph/article/view/7601 https://ijph.tums.ac.ir/index.php/ijph/article/download/7601/5494

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 8 2016 10 10 978 985 Zahra CHERAGHI Dept. of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Amin DOOSTI-IRANI Dept. of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Sima NEDJAT Knowledge Utilization Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Parvin CHERAGHI Dept. of Health Education and Promotion, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran Saharnaz NEDJAT Dept. of Epidemiology and Biostatistics, School of Public Health, Knowledge Utilization Research Center, Tehran University of Medical Sciences, Tehran, Iran 2016 08 28 2016 08 28  Background: Due to the increase in the elderly population in different societies, their primary needs, physical and mental health, and quality of life, is important. This study aimed to estimate the overall mean score of the QOL based on the Qol-Brief questionnaire in the elderly population of Iran. Methods: The international and national databases, including; Medline, Scopus, Science Direct, MagIran, and SID were searched up to Feb 2015. All studies, addressed the quality of life among the healthy Iranian elderly population using WHO-QOL-BRIEF questionnaire, were included. The random effect model was used for data analysis and the results were reported with a 95% confidence. Results: Out of 2150 studies, seven studies involved 1366 elderly participants were included in the meta-analysis. The pooled mean score of total QOL was 60.1±4.6. The pooled mean score of quality of life for physical health was 55.13 [51.03, 59.22], for environmental was 51.80 [45.50, 58.10], for psychological was 56.68 [53.29, 60.08] and for the social relationship was 57.82 [55.79, 59.86]. The men had a better status and in two health domains, including; physical and psychological health. Conclusion: The results of this study stress the necessity of attention to the quality of life in the domains of physical health (especially in women), and environmental health in the elderly population.     https://ijph.tums.ac.ir/index.php/ijph/article/view/7598 https://ijph.tums.ac.ir/index.php/ijph/article/download/7598/5491

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 8 2016 10 10 350 356 Phuong Kim TRUONG Dept. of Molecular and Environmental Biotechnology, Faculty of Biology and Biotechnology, University of Science, Vietnam AND National University, Ho Chi Minh, VietnamDept. of Pharmaceutical and Medical Biotechnology, Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh, Vietnam Thuan Duc LAO Dept. of Pharmaceutical and Medical Biotechnology, Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh, Vietnam Thuy Ai Huyen LE Dept. of Pharmaceutical and Medical Biotechnology, Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh, Vietnam 2018 03 04 2018 03 04  Background: The infection of human papillomavirus (HPV) has been considered as the common cause of cervical cancer, which is the leading cause of cancer death in women, in Vietnam. Recently, hypermethylation at tumor suppressor genes (TSGs) has been also demonstrated to be an early epigenetic event and cofactor in human cancer, including cancer of cervix. This study evaluated the frequency of DcR1 gene promoter hypermethylation status as well as whether did or not an association between patterns of DNA hypermethylation and high-risk HPV infection, led to risk of cervical cancer. Methods: Methylation-Specific-PCR (MSP) was performed to analyze hypermethylation status from 109 liquid-based Papanicolaou test samples, archived and admitted from the Medic Medical Center and Au Lac Clinic Laboratory, Vietnam, from 2011–2014, a kind of non-invasive samples identified whether HPV/or non-HPV, high-risk/low-risk HPV infection. Results: DcR1 promoter was differentially methylated in 50% cases of high-risk HPV genotype 16 and 18 infected samples. In contrast, a low frequency of hypermethylated DcR1 promoter was found in low risk HPV genotype infected sample (16.0%), and non-HPV infected sample (14.6%). A trend toward positive association was found between hypermethylation of DcR1 gene and HPV exposure was observed (P=0.0005). Moreover, the odds ratio (OR) and relative risk (RR) were found in statistical significant value (OR=5.63 (95%CI = 2.25 - 14.07, P<0.01), RR=3.31 (95%CI = 1.75 - 6.26, P<0.01)). Conclusion: The hypermethylation of DcR1 gene promoter is a significant characteristic of high-risk HPV infected samples in Vietnamese cervical patients. The OR and RR values showed that the strong correlation between DcR1 hypermethylation and high-risk HPV infection, in which increased the risk of cervical cancer. The combination of DcR1 hypermethylation and HPV detection based biomarker could be used in non-invasive samples obtained from high-risk cancer patients, offer significant practical advantages.     https://ijph.tums.ac.ir/index.php/ijph/article/view/12681 https://ijph.tums.ac.ir/index.php/ijph/article/download/12681/5920

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 47 3 2018 03 04 455 457 Raziyeh KARAMI ESHKAFTAKI Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran Effat FARROKHI Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran Fatemeh HEYBATI GOJANI Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran Najmeh SALEHI VANANI Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran Maryam KARAMI ESHKAFTAKI Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran Ezzatollah MEMARZADEH Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran Morteza HASHEMZADEH CHALESHTORI Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran 2018 03 04 2018 03 04 No Abstract### https://ijph.tums.ac.ir/index.php/ijph/article/view/12699 https://ijph.tums.ac.ir/index.php/ijph/article/download/12699/5936

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 47 3 2018 03 04 357 366 Yat YEN School of Public Affairs, University of Science and Technology of China, Hefei, China AND Dept. of Social Work, National Institute of Social Affairs, Phnom Penh, Cambodia Yumin SHI School of Public Affairs, University of Science and Technology of China, Hefei, China Bunly SOEUNG Faculty of Social Sciences, Svay Rieng University, Svay Rieng, Cambodia Rathny SUY School of Public Affairs, University of Science and Technology of China, Hefei, China Muhammad Tayyab SOHAIL School of Public Administration, China University of Geosciences (Wuhan), Wuhan, Hubei, China 2018 03 04 2018 03 04 Background: We examined the current prevalence of substance abuse and sexual behaviors among junior high school students and the relationships between substance abuse, sexual behaviors, and victimization using multiple mediations. Methods: Overall, 1703 junior high school students from the 2013 Cambodia Global School-based Health Survey were selected for the study. The descriptive statistics were performed in IBM SPSS to determine the prevalence of substance abuse, sexual behaviors, and victimization. The Process Macro was installed in Regression of the SPSS to test the hypotheses and mediations. Results: The majority of students who used alcohol (15.4%), drugs (3.05%), and had sexual intercourse (12.45%), were male aged 14-15, and in grade 7. These students were very vulnerable to many risky behaviors, including bullying (22.20%), physical attacks (20.96%) and fights (14.50%), unintentional accidents (21.32%), and suicidal attempts (5.05%). All three hypotheses were significantly supported. Of the potential mediators examined, drug use is the most important mediator. Conclusion: The substance abuse and reproductive health are national problems, but abusive behaviors among students are of particular concern. Explicit policies and awareness programs of such problems at the high school level need to be made and called for public participation, particularly the school authorities and parents.   https://ijph.tums.ac.ir/index.php/ijph/article/view/12682 https://ijph.tums.ac.ir/index.php/ijph/article/download/12682/5921

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 47 3 2018 03 04 458 459 Mahtab KARAMI Health Information Management Research Center, Dept. of Health Information Technology and Management, School of Allied-Medical Sciences, Kashan University of Medical Sciences, Kashan, Iran Ali HOSSEINI SHAHMIRZADI Primary Healthcare System, SART Distract PHC Center, Mazandaran University of Medical Sciences, Sari, ‎Iran 2018 03 04 2018 03 04 No Abstract### https://ijph.tums.ac.ir/index.php/ijph/article/view/12700 https://ijph.tums.ac.ir/index.php/ijph/article/download/12700/5942

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 47 3 2018 03 04 367 372 Jian ZHANG Dept. of Obstetrical, Binzhou Central Hospital, Binzhou, Shandong, China Ning LI Dept. of Obstetrical, Binzhou Central Hospital, Binzhou, Shandong, China Wenling GUO Dept. of Obstetrical, Binzhou Central Hospital, Binzhou, Shandong, China Chuanyan MA Dept. of Obstetrical, Binzhou Central Hospital, Binzhou, Shandong, China Guangcheng ZHAO Dept. of Imaging, Binzhou Central Hospital, Binzhou, Shandong, China 2018 03 04 2018 03 04 Background: We aimed to explore the diagnostic value of urinary microalbumin (mALB) level in postpartum acute kidney injury. Methods: A total of 127 maternity patients were selected from December 2013 to January in 2016 in Binzhou Central Hospital, Binzhou, Shandong, China and divided into two groups: the kidney injury and normal kidney group. The dynamic changes and diagnostic value of urine microprotein in postpartum acute kidney injury were analyzed. Results: The postpartum mean arterial pressure of maternity patients in the kidney injury group was 104.3 ± 11.6 mmHg, which was significantly higher than that of the normal kidney group (P<0.05). The mean age of the kidney injury group was 32.3 ± 11.6 years, which was significantly higher than that of the normal kidney group (P=0.006). In the kidney injury group, the postpartum glomerular filtration rate (GFR) was 78.4 ± 11.5 mL/min, which was significantly lower than the normal group (P=0.001), and urinary microalbumin was 2.87 ± 1.24 mg/mmol·Cr. The difference was statistically significant (P=0.002). mALB/GFR, Cr, urinary mALB, and GFR were the independent risk factors of postpartum acute kidney injury. The area under the ROC curve for mALB/GFR was 0.759, whereas the area under the ROC curve for Cr was 0.681, which was smaller (P = 0.042). The area under the ROC curve of mALB was 0.785 (P=0.027), which was close to the area under the ROC curve of mALB/GFR. Conclusion: Urinary mALB test is noninvasive and has high diagnostic value for postpartum kidney injury.     https://ijph.tums.ac.ir/index.php/ijph/article/view/12683 https://ijph.tums.ac.ir/index.php/ijph/article/download/12683/5922

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 47 3 2018 03 04 460 461 Forouzan ROSTAMI Dept. of Nursing, Faculty of Nursing and Midwifery, Chalous Branch, Islamic Azad University, Chalous, Iran Syed Tajuddin SYED HASSAN Dept. of Medicine, Nursing Unit, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia Farideh YAGHMAEI Dept. of Nursing, Faculty of Nursing and Midwifery, Zanjan Branch, Islamic Azad University, Zanjan, Iran 2018 03 04 2018 03 04 No Abstract### https://ijph.tums.ac.ir/index.php/ijph/article/view/12702 https://ijph.tums.ac.ir/index.php/ijph/article/download/12702/5939

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 47 3 2018 03 04 373 381 Chunyu YANG Faculty of Architecture and Urban Planning, Chongqing University, Chongqing, China Zhiyuan ZHANG Faculty of Architecture and Urban Planning, Chongqing University, Chongqing, China Juntao MA Faculty of Architecture and Urban Planning, Chongqing University, Chongqing, China Ting CHEN Faculty of Architecture and Urban Planning, Chongqing University, Chongqing, China 2018 03 04 2018 03 04  Background: The increasing worldwide incidence of depression causes massive economic losses to the country and society. Insufficient sun exposure aggravates depressive symptoms in patients with depression. Preventive light replenishment is provided to patients with depression and the potential population. In addition, we studied the applicable spectrum, which is crucial in the prevention of depression. Methods: Forty depressed male rats were randomly divided into five groups of 8 rats each: depressive model, microwave sulfur lamp, halogen lamp, fluorescent lamp, and LED lamp groups. Rats in the illuminated groups were exposed to light for 45 days for 2 h daily. Eight healthy rats were selected for the control group. The body weight and general behaviors of rats were recorded. After the experiment, peripheral blood was collected from the tail vein, and the concentrations of MT, 5-HT, NA, and BDNF in serum were detected by ELISA. Results: After the model was established, the body weight of rats in the depressive model group increased slowly. Compared with those of the control group, the results of the three behavioral tests were significantly different (P<0.05); the contents of MT, 5-HT, NA, and BDNF were relatively low (P<0.05). In addition, depression characteristics were significant. Rats regained their pleasant sensation after microwave sulfur lamp intervention. Compared with the rats in the depressive model group, the levels of MT, 5-HT, NA, and BDNF increased sharply. Conclusion: The spectral energy distribution of microwave sulfur lamp is similar to the solar spectrum, which can alleviate depressive symptoms in depressed rats.     https://ijph.tums.ac.ir/index.php/ijph/article/view/12684 https://ijph.tums.ac.ir/index.php/ijph/article/download/12684/5923

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 47 3 2018 03 04 462 463 Ahmad KALATEH SADATI Abbas Rahimi FOROUSHANI Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Iran 2019 06 27 No Abstract#### https://ijph.tums.ac.ir/index.php/ijph/article/view/17604 https://ijph.tums.ac.ir/index.php/ijph/article/download/17604/6460

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 7 2019 07 01 1278 1283 Dong YANG Department of Paediatrics, Xuzhou Central Hospital, Xuzhou 221000, P.R. China Bin ZHOU Department of Paediatrics, Xuzhou Central Hospital, Xuzhou 221000, P.R. China Bao JIN Department of Paediatrics, Xuzhou Central Hospital, Xuzhou 221000, P.R. China Xiao LIU Department of Paediatrics, Xuzhou Central Hospital, Xuzhou 221000, P.R. China Yun WANG Department of Paediatrics, Xuzhou Central Hospital, Xuzhou 221000, P.R. China 2019 06 27 Background: To investigate the effect of caffeine citrate on the integrated brain electroencephalogram (EEG) of apnea and low birth weight infants. Methods: Overall, 212 infants with apnea and low birth weight admitted to Xuzhou Central Hospital from June 2016 to June 2018 were enrolled. The infants were divided into control group and observation group according to the random number table method, 106 cases in each group. Infants in control group were treated with aminophylline, and infants in the observation group were given caffeine citrate. All children were continuously tested by digital amplitude integrated brain function monitor. The amplitude-integrated electroencephalogram (aEEG) was used to detect sleep arousal cycle (Cy), graphic continuity (Co), lower edge amplitude value (LB) scores, aEEG continuous voltage and periodic occurrence rate, narrowband voltage and bandwidth. Results: After treatment, scores of Cy, Co and LB increased in both groups, and the scores were significantly higher in observation group than in control group (P=0.029, 0.017, 0.047). After treatment, continuous voltage positive rate, sleep-wake cycle occurrence rate, and narrow-band lower boundary voltage increased in both groups, and the values were significantly higher in observation group than in control group (P=0.011, 0.042). After treatment, aEEG detection bandwidth and the upper boundary voltage of the narrow band decreased in both groups, and the values were significantly lower in observation group than in control group (P=0.007, 0.020, 0.032). Conclusion: Citrate caffeine can alleviate the brain development of low-weight infants with apnea, improve brain electrical activity and promote brain function and maturity.   https://ijph.tums.ac.ir/index.php/ijph/article/view/17587 https://ijph.tums.ac.ir/index.php/ijph/article/download/17587/6444

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 7 2019 07 01 1387 1389 Touraj MIANDOABI Department of Parasitology and Mycology, Shahid Beheshti University of Medical Sciences, Tehran, Iran Fariborz BAHRAMI Department of Immunology, Pasteur Institute of Iran, Tehran, Iran Vahideh MOEIN VAZIRI Department of Parasitology and Mycology, Shahid Beheshti University of Medical Sciences, Tehran, Iran Soheila AJDARY Department of Immunology, Pasteur Institute of Iran, Tehran, Iran 2019 06 27 No Abstract#### https://ijph.tums.ac.ir/index.php/ijph/article/view/17605 https://ijph.tums.ac.ir/index.php/ijph/article/download/17605/6461

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 7 2019 07 01 1284 1291 Zlatko ZIMET National Institute of Public Health, Ljubljana, Slovenia Marjan BILBAN Department of Public Health, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia Joško OSREDKAR Institute of Clinical Chemistry and Biochemistry, University Medical Center Ljubljana, Ljubljana, Slovenia Borut POLJŠAK Laboratory of Oxidative Stress Research, Faculty of Health Sciences, University of Ljubljana, Ljubljana, Slovenia Teja FABJAN Institute of Clinical Chemistry and Biochemistry, University Medical Center Ljubljana, Ljubljana, Slovenia Kristina SUHADOLC Institute of Clinical Chemistry and Biochemistry, University Medical Center Ljubljana, Ljubljana, Slovenia 2019 06 27 Background: We aimed to investigate the polluted working environment triggers oxidative stress and alter enzymatic antioxidant activity by a short-term interval. Methods: The experimental study, performed in 2014, involved 94 workers from the Velenje Coalmine in Slovenia, arranged into three groups according to a number of consecutive working days in a mineshaft, supported by a control group. Levels of the antioxidant enzymes (GPx, CAT, SOD) together with TAC (the combined effect of all antioxidants) and 8-isoprostane (a biological marker of oxidative stress/damage) were measured in human plasma. Results: Workers occupationally exposed for three consecutive working days had significantly increased 8-isoprostane biomarker, a parameter of oxidative stress (P<0.001). The antioxidant levels of TAC (P<0.001), CAT (P<0.001) and SOD (P<0.001) were all significantly decreased compared to a control group. Conclusion: Workers in polluted working environment had significantly increased oxidative stress and altered antioxidant activity already on a third consecutive working day.   https://ijph.tums.ac.ir/index.php/ijph/article/view/17588 https://ijph.tums.ac.ir/index.php/ijph/article/download/17588/6445

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 7 2019 07 01 1390 1391 Parya BABAN ZADEH Department of Microbiology, Faculty of Pharmaceutical Sciences, North Islamic Azad University, Tehran, Iran Azad KHALEDI Department of Microbiology and Immunology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran Davoud ESMAEILI Department of Microbiology and Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran AND Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran 2019 06 27 No Abstract#### https://ijph.tums.ac.ir/index.php/ijph/article/view/17606 https://ijph.tums.ac.ir/index.php/ijph/article/download/17606/6462

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 7 2019 07 01 1292 1300 Hui WANG Department of Immunology, Qiqihar Medical University, Qiqihar 161000, P.R. China Shuhua LI Department of Traditional Chinese Medicine, The First Hospital of Qiqihar, Qiqihar 161000, P.R. China Houzhong LI Department of Pharmacology, Mudanjiang Medical University, Mudanjiang 157011, P.R. China Fengxia DU Department of Pathogen Biology, Qiqihar Medical University, Qiqihar 161000, P.R. China Jie GUAN Department of Immunology, Qiqihar Medical University, Qiqihar 161000, P.R. China Yanmin WU Department of Immunology, Qiqihar Medical University, Qiqihar 161000, P.R. China 2019 06 27 Background: We aimed to investigate the effect of probiotic VSL#3 on NF-κB and TNF-α in rats with colitis and the correlation with TLR4-NF-κB signal pathway. Methods: Sixty Sprague Dawley (SD) rats were divided into the control, model and therapy groups (n=20) according to the random number table. Rats in the model and therapy groups were modeled for colitis, and rats in the therapy group were intragastrically administered with probiotic VSL#3. The expression of TLR4 and NF-κB protein, and the levels of NF-κB, TLR4, and TNF-α mRNA in the colon tissue were detected. The concentration of TNF-α in the serum after modeling but before intragastric administration (T0), 3d (T1) and 7d after intragastric administration (T2) was detected. Results: The expression of TLR4 and NF-κB p65 protein, and the levels of TLR4, NF-κB, and TNF-α mRAN in the therapy group decreased (P < 0.001). At T0, T1, and T2, the concentration of TNF-α in the model and control groups increased (P < 0.001). TLR4 and NF-κB in the therapy group were positively correlated with TNF-α mRAN (P < 0.050).Conclusion: In conclusion, probiotic VSL#3 inhibits the expression of NF-κB and TNF-α in rats with colitis through TLR4-NF-κB signal pathway, so it is expected to be a first choice drug for the treatment of colitis. Conclusion: In conclusion, probiotic VSL#3 inhibits the expression of NF-κB and TNF-α in rats with colitis through TLR4-NF-κB signal pathway, so it is expected to be a first choice drug for the treatment of colitis.   https://ijph.tums.ac.ir/index.php/ijph/article/view/17589 https://ijph.tums.ac.ir/index.php/ijph/article/download/17589/6446

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 7 2019 07 01 1392 1394 Fatemeh EGHBALIAN Research Institute for Islamic and Complementary Medicine, School of Iranian Traditional Medicine, Iran University of Medical Sciences, Tehran, Iran Hoorieh MOHAMMADI KENARI Research Institute for Islamic and Complementary Medicine, School of Iranian Traditional Medicine, Iran University of Medical Sciences, Tehran, Iran Gholamreza KORDAFSHARI Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Mehrdad KARIMI Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Akramosadat ATYABI Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Laila SHIRBEIGI Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran 2019 06 27 No Abstract#### https://ijph.tums.ac.ir/index.php/ijph/article/view/17607 https://ijph.tums.ac.ir/index.php/ijph/article/download/17607/6463

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 7 2019 07 01 1301 1309 Seyed-Farzad MOHAMMADI Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran Cyrus ALINIA Department of Public Health, Urmia University of Medical Sciences, Urmia, Iran Ebrahim GHADERI Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran Alireza LASHAY Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran Mahmoud JABBARVAND Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran Elham ASHRAFI Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran Naser NOURMOHAMMADI Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran Saeid SHAHRAZ Tufts Medical Center, Institute for Clinical Research and Health Policy Studies, Boston, Massachusetts, USA 2019 06 27 Background: Due to lack of information about ophthalmic economics in Iran, health policy makers unable to distribute resources optimally in terms of efficiency and equity. Therefore, we estimated the total and eye care utilization, out-of-pocket expenditures, and its association with social determinants of health in Iran in 2015. Methods: A multi-stage population-based, cross-sectional study in a random sample aged 50 yr or older in Kurdistan Province, Northwest Iran was used. The utilization rate of eye and general health care and related out-of-pocket expenditures was estimated during the recent last six months. To find the association between social factors and care out-of-pocket expenditures, we used a Heckman two-step regression model. Results: About 81% and 37% of participants were utilized the health and ophthalmic services, respectively. Statistically significant lower ophthalmic utilization rates were observed among men, middle-aged population, illiterate participants, rural residents, daily-paid workers, and the poorest participants. The average of vision and total health-related out-of-pocket expenditures among those used these services have estimated as US$43.7 (SE: 2.6) and US$439.9 (SE: 22.8), respectively. The highest (US$ 396.6) and lowest (US$ 10.4) ophthalmic out-of-pocket costs were related to patients with Glaucoma and Central Nervous System abnormalities, respectively. Multivariate analyses confirmed an unequal probability of having the ophthalmic out-of-pocket expenditures among different subgroups especially in favor of females, older, and those with more severe visual impairment. Conclusion: Ophthalmic disorders reconstituted about 10% of all health services OOP expenditures on average among individuals older than 50 yr.     https://ijph.tums.ac.ir/index.php/ijph/article/view/17590 https://ijph.tums.ac.ir/index.php/ijph/article/download/17590/6447

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48 7 2019 07 01 1310 1316 Farnaz SAFAVIFAR Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Farshid SAADAT Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran Seyedeh Zohreh JALALI Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran Mohammad Reza KHORAMIZADEH Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran AND Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 2019 06 27 Background: Curcumin and resveratrol are two polyphenolic compounds extensively investigated for their medicinal effects on inflammatory signaling. However, there is a paucity of information on the Adenosine-3’, 5’-cyclic monophosphate (cAMP) kinetics following administration of curcumin and resveratrol in biological systems. In this study, kinetic modulation of cAMP as a target detection messenger in pro-inflammatory pathways was assessed by co-administration of curcumin and resveratrol using a cellular sensor model. Methods: To evaluate their putative activity, curcumin and resveratrol compounds were administered alone or in combination on the media culture of cAMP EPAC (exchange protein directly activated by cAMP) bioluminescence resonance energy transfer (BRET) biosensor. The study was performed at the following two centers at Tehran University of Medical Sciences (TUMS):  1- Biotechnology Research Center, and, 2- Endocrinology and Metabolism Research Institute (EMRI) in 2017. Time course kinetic of cAMP response signals were plotted. Forskolin and IBMX were used to stabilize the cAMP signals. Results: When we treated HEK-293T biosensor cells at 10uM concentration, curcumin and resveratrol upregulated cAMP signaling. Co-administration of resveratrol and curcumin revealed an augmented cAMP level, as compared to treatments with the compounds alone. Conclusion: Co-administration of curcumin and resveratrol leverage cAMP kinetic response in a time-course manner. The presented methodology can be readily adopted for drug development and novel biopharmaceutical functional analyses.     https://ijph.tums.ac.ir/index.php/ijph/article/view/17591 https://ijph.tums.ac.ir/index.php/ijph/article/download/17591/6448

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 48