Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 43 4 2014 04 15 391 405 Sze Loon CHOW Anselm Su TING Tin Tin SU 2016 01 03 2016 01 03 This systematic review was conducted to develop a conceptual framework that addresses various factors associated with return to work among cancer survivors. Databases Medline, EMBASE, ProQuest, PubMed and ScienceDirect were systematically searched using medical subject headings [MeSH] for studies published in English from 1990 to 2013. Studies that described adult cancer patients’ self-reported data or patients’ point of view on factors associated with return to work or employment status following cancer diagnosis were included. Articles selection was conducted in three steps: selection based on title and abstract, retrieval of full text and additions of articles from reference lists and recommendations from experts. Disagreement in data extraction was solved by consultation of third reviewer. Out of twenty seven articles, breast cancer was the most studied type of cancer (30%) while colorectal cancer was studied independently in two articles (7.4%). Conceptual framework on return to work identifies factors under environmental, personal, work demand, work ability, health status and financial factors. Extensive search of scientific databases over last 24 years and the development of the conceptual framework are the strength of this review. Conceptual framework reveals the various factors including non-medical factors associated with return to work upon cancer diagnosis. It serves as a reminder to the policy makers to focus on modifiable factors as potential areas for intervention to assist cancer survivors return to work, especially those with little financial assistance and health insurance.    https://ijph.tums.ac.ir/index.php/ijph/article/view/5665 https://ijph.tums.ac.ir/index.php/ijph/article/download/5665/4569

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 43 4 2014 04 15 406 15 Daniel Badulescu Dept. of Economics, Faculty of Economic Sciences, University of Oradea , Oradea, Romania. Alina Badulescu Dept. of Economics, Faculty of Economic Sciences, University of Oradea , Oradea, Romania. 2015 10 15 Nowadays, medical tourism reports impressive growth in terms of number of persons, income and number of countries involved in cross-border flows. So this study was undertaken to clarify entrepreneurship opportunities and bio-ethics boundaries in medical tourism. For tourism entrepreneurs, these outgoing flows related to medical procedures and tourism become an opportunity that cannot be ignored, so a wide range of tourist services related to health care are provided on a private, entrepreneurial basis. However, social and economic boundaries are omnipresent (impaired health services in receiving (incoming) countries, the crisis of the health care systems in emitting (outgoing) countries, over-consumption of medical and tourism services), and, not least, ethical considerations. Transforming medical care in a market tool, reducing human attributes to the status of commodity that can be bought, sold or negotiated, seriously challenges contemporary bioethics principles. It is a significant entering in the area (which is essentially un-ethic) of market transactions, where libertarianism and consumer-oriented attitudes dominates the spectrum of rational choice. So tourism comes to provide an organized and comfortable framework for all these choices, but many issues still re-main controversial and may worsen if national health systems and national and international regulations would not identify their problems and would continue to leave medical tourism to market mechanisms. Market will efficiently allocate the resources, but not always in an ethical manner. https://ijph.tums.ac.ir/index.php/ijph/article/view/4116 https://ijph.tums.ac.ir/index.php/ijph/article/download/4116/3774

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 43 4 2014 04 15 416 22 Xiangyu Chen Dept. of Epidemiology and Health Statistics, School of Public Health, Medical College of Soochow University , Suzhou, China. Qiaoqiao DU Dept. of Epidemiology and Health Statistics, School of Public Health, Medical College of Soochow University , Suzhou, China. Zongda Jin Dept. of Epidemiology and Health Statistics, School of Public Health, Medical College of Soochow University , Suzhou, China. Tian Xu Dept. of Epidemiology and Health Statistics, School of Public Health, Medical College of Soochow University , Suzhou, China. Jiachen Shi Dept. of Epidemiology and Health Statistics, School of Public Health, Medical College of Soochow University , Suzhou, China. Ge Gao Dept. of Epidemiology and Health Statistics, School of Public Health, Medical College of Soochow University , Suzhou, China. 2015 10 15 Traditional survey methods may cause refusals to respond or untruthful replies when encounter the sensitive questions. The Randomized Response Technique (RRT) is designed to decrease social desirability bias and obtain reliable estimates. This study aimed to apply these new methods on the sensitive questions survey.Simmons model was applied in the survey of issues relevant to commercial sex among men who have sex with men (MSM) in Beijing, China. Stratified two-stage sampling and stratified random sampling were applied.During July to December 2010 in Beijing, the commercial sex proportion among MSM was 0.051(95% CI: 0.017, 0.085), its estimated variance was 3.01×10(-4). The last male condom use rate during commercial sex was 0.778(95% CI: 0.746, 0.810), its estimated variance was 2.6×10(-4).We have introduced new approaches for the sensitive question survey among MSM. The new approaches are proved to be reliable and valid. https://ijph.tums.ac.ir/index.php/ijph/article/view/4114 https://ijph.tums.ac.ir/index.php/ijph/article/download/4114/3772

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 43 4 2014 04 15 423 31 Fethi Ben Abdallah 1. Laboratory of Genetic, Biodiversity and Valorization of Bio-ressources. Higher Institute of Biotechnology , Monastir, Tunisia . ; 2. Fermentation Unit, Pasteur Institute , Tunisia. Rihab Lagha 3. Laboratory of Analysis, Treatment and Valorization of Environment polluants and Product. Faculty of Pharmacy, Monastir , Tunisia. Khaled Said 1. Laboratory of Genetic, Biodiversity and Valorization of Bio-ressources. Higher Institute of Biotechnology , Monastir, Tunisia . Héla Kallel 2. Fermentation Unit, Pasteur Institute , Tunisia. Jawhar Gharbi 4. Sequencing and Genomic Analysis Unit. Higher Institute of Biotechnology , Monastir, Tunisia. 2015 10 15 The aim of this study was to evaluate the ability of 15 serotypes of Salmonella to form biofilm on polystyrene, polyvinyl chloride (PVC) and glass surfaces. .Initially slime production was assessed on CRA agar and hydrophobicity of 20 Salmonella strains isolated from poultry and human and two Salmonella enterica serovar Typhimurium references strains was achieved by microbial adhesion to n-hexadecane. In addition, biofilm formation on polystyrene, PVC and glass surfaces was also investigated by using MTT and XTT colorimetric assay. Further, distribution of Salmonella enterotoxin (stn), Salmonella Enteritidis fimbrial (sef) and plasmid encoded fimbrial (pef) genes among tested strains was achieved by PCR.Salmonella strains developed red and white colonies on CRA and they are considered as hydrophilic with affinity values to n-hexadecane ranged between 0.29% and 29.55%. Quantitative biofilm assays showed that bacteria are able to form biofilm on polystyrene with different degrees and 54.54% of strains produce a strong biofilm on glass. In addition, all the strains form only a moderate (54.54%) and weak (40.91%) biofilm on PVC. PCR detection showed that only S. Enteritidis harbour Sef gene, whereas Pef and stn genes were detected in S. Kentucky, S. Amsterdam, S. Hadar, S. Enteritidis and S. Typhimurium.Salmonella serotypes are able to form biofilm on hydrophobic and hydrophilic industrial surfaces. Biofilm formation of Salmonella on these surfaces has an increased potential to compromise food safety and potentiate public health risk. https://ijph.tums.ac.ir/index.php/ijph/article/view/4112 https://ijph.tums.ac.ir/index.php/ijph/article/download/4112/3770

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 43 4 2014 04 15 432 40 Hui Zhou 1. School of Public Health, Medical College of Soochow University , SuZhou, China ; 2. The Center for Disease Control and Prevention of Suzhou Industry Park , SuZhou, China. Chen Yang 3. Center for Disease Control of Xiangcheng District in Suzhou City, Suzhou , Jiangsu, China. Chen Dong 1. School of Public Health, Medical College of Soochow University , SuZhou, China. Zhirong Guo 1. School of Public Health, Medical College of Soochow University , SuZhou, China. Xiaoshu Hu 4. Health Bureau of JiangSu Province , NanJing, China. Yong Xu 1. School of Public Health, Medical College of Soochow University , SuZhou, China. Zhengyuan Zhou 5. Changshu Center for Disease Control and Prevention , ChangShu, China. 2015 10 15 The aim was to compare the predictive power for Type 2 Diabetes mellitus (T2DM) using dynamic change (Difference) of metabolic syndrome (MS), Difference of fasting plasma glucose (FPG), baseline MS and FPG in cohort study.Overall, 3461 subjects were recruited from Prevention of Multiple Metabolic disorders and MS in Jiangsu of China Study with 3.8 years follow-up. Cox proportional-hazards regression and receiver operating characteristic were used to evaluate the predictive power for T2DM using Difference MS, Difference of FPG, baseline MS and FPG.Adjusted relative risk (aRR 5.24, 95% CI 4.28-6.42) of Difference of FPG to T2DM was highest than other. Difference of FPG owns the largest AUC (0.89, P<0.05), the highest sensitivity (96.25%) and specificity (80.49%) demonstrating that Difference of FPG can provide strongest predictive information to T2DM, Difference of MS comes second. Between FPG related tools, sensitivity of Difference of FPG almost was twice than baseline FPG(96.25% vs. 54.38%) suggesting that using baseline FPG would missed found 46% T2DM patients. Among MS related indicators, sensitivity of Difference of MS almost was twice than baseline MS (sensitivity 66.25% vs. 39.38%) suggesting that using baseline would missed found 61% T2DM patients.Dynamic change of FPG had the highest predictive power for T2DM in Chinese than Dynamic Change of MS, baseline MS and FPG. https://ijph.tums.ac.ir/index.php/ijph/article/view/4110 https://ijph.tums.ac.ir/index.php/ijph/article/download/4110/3768

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 43 4 2014 04 15 441 52 Ruqaiya Hussain Human Genetics and Toxicology Tab, Section of Genetics, Department of Zoology, Aligarh Muslim University , Aligarh, Uttar Pradesh, India. Ahsana Shah Human Genetics and Toxicology Tab, Section of Genetics, Department of Zoology, Aligarh Muslim University , Aligarh, Uttar Pradesh, India. Mohammad Afzal Human Genetics and Toxicology Tab, Section of Genetics, Department of Zoology, Aligarh Muslim University , Aligarh, Uttar Pradesh, India. 2015 10 15 The ability to taste Phenylthiocarbamide (PTC), a bitter organic compound, described as a bimodal autosomal trait is widely used to know the heritable trait in both genetic and anthropological studies. The present study was carried out to analyze the prevalence of PTC taste sensitivity and to determine the gene frequencies among some Muslim populations of Uttar Pradesh, India. This study has some physiological relevance to highlight the adaptability of endogamous groups to behavioral traits in the same place.Unrelated, healthy individuals of both sexes (Male-403, Female-418) belonging to different populations of Uttar Pradesh, India were randomly selected with the age range of 16-45 years observed for phenylthiocarbamide to taste sensitivity. PTC tasting ability was measured by using a serial dilution method of Harris and Kalmus.The phenotypic frequency of tasters was higher as compared to non-tasters, and the same is statistically significant (χ(2)= 11.92, df = 5, P = 0.036). There were more females among tasters (67.94%) than males (64.76%). This observation was statistically significant (χ(2) = 14.79, df = 5, P = 0.011).The frequency of PTC tasters is greater than non-tasters and the females have lower non-taster pheno-types as compared to males. This type of study will provide background information about genetic structure of population and serves as useful interaction of genetics, food preferences and dietary patterns. https://ijph.tums.ac.ir/index.php/ijph/article/view/4108 https://ijph.tums.ac.ir/index.php/ijph/article/download/4108/3766

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 43 4 2014 04 15 453 9 Farhad Babaei 1. Dept. of Virology, School of Public Health, Tehran University of Medical Sciences , Tehran, Iran. Seyed Ali Ahmadi 2. School of Medicine, Tehran University of Medical Sciences , Tehran, Iran. Ramin Abiri 3. Dept. of Microbiology, School of Medicine, Kermanshah University of Medical Sciences , Kermanshah, Iran. Farhad Rezaei 1. Dept. of Virology, School of Public Health, Tehran University of Medical Sciences , Tehran, Iran. Maryam Naseri 1. Dept. of Virology, School of Public Health, Tehran University of Medical Sciences , Tehran, Iran. Mahmoud Mahmoudi 4. Dept. of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences , Tehran, Iran. Rakhshande Nategh 1. Dept. of Virology, School of Public Health, Tehran University of Medical Sciences , Tehran, Iran. Talat Mokhtari Azad 1. Dept. of Virology, School of Public Health, Tehran University of Medical Sciences , Tehran, Iran. 2015 10 15 The TP53 gene is one of the most frequently mutated genes amongst human malignancies, particularly TP53 codon 72 polymorphism. Furthermore, an association between the TP53 codon 72 variants and prostate cancer has been reported in several studies. Although some studies have indicated an associaal attitude, physical stress, and psychological stress across the menstrual cycle. Methods: This study was conducted from Apr to Jun 2021 in the Gyeonggi Province of Korea. Women aged ≥20 yr were divided into premenstrual (n=17), menstrual (n=8), and postmenstrual periods (n=23). Menstrual symptoms and menstrual attitudes were assessed using questionnaires. Quantitative electroencephalography was used to assess the physical stress indices (left and right), and the psychological stress indices (left and right), with brainwave parameters quantified by frequency series power spectrum analysis. Data were compared using the non-parametric tests. Results: More menstrual symptoms were experienced in the menstrual period than in the premenstrual period (Z=2.16, P=.031). Menstrual attitudes did not significantly differ among menstrual periods (Z=1.20, P=.231). Physical stress indices were high (≥10 μV) throughout the menstrual cycle and there were significant differences among the three periods (left: χ2=4.00, P=.035, right: χ2=5.78, P=.046). Psychological stress indices were >1 μV during the premenstrual and menstrual periods. Conclusion: Women experience more severe and diverse menstrual symptoms in the menstrual period than in other periods. Objective investigations are needed to inform an effective approach for addressing negative menstruation-related experiences.  https://ijph.tums.ac.ir/index.php/ijph/article/view/30335 https://ijph.tums.ac.ir/index.php/ijph/article/download/30335/7954

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 6 2023 06 13 1170 1180 Wei Wei Department of Cardiothoracic Surgery, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai 519000, China Xuan Wei Department of Radiation Oncology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510520, China Xin Xie Department of Cardiothoracic Surgery, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai 519000, China 2022 12 02 2023 04 07 Background: Esophageal squamous cell carcinoma (ESCC), a widely known esophageal disease, severely affects people's health. Numerous investigations demonstrated that long non-coding RNAs (lncRNAs) performed key jobs inside a wide scope of organic cycles and stand out in malignant growth. Our study planned to investigate the roles and mechanisms of linc01614 in ESCC. Methods: A Total of 60 ESCC tissue samples including 30 patients with cisplatin sensitivity and 30 patients with cisplatin resistance, who received DDP-based treatment, were obtained from Zhuhai People's Hospital, Zhuhai City during 2021. These tissues were frozen and saved in a -80 ℃ ultra-low temperature freezer. We performed CCK-8, clone formation, flow cytometry assays to determine the effect of linc01614 on ESCC progression, and explored the specific mechanism of linc01614 in ESCC cell proliferation, apoptosis, and chemotherapy resistance. Results: linc01614 expression was upregulated in ESCC tissues and cells compared with non-tumor tissues and human normal esophageal epithelial cells (Het-1A). Knockdown of linc01614 repressed cell expansion, chemotherapy opposition, and advanced cell apoptosis in ESCC. Besides, linc01614 regulated the expression of miR-4775 as a competitive endogenous RNA (ceRNA). Conclusion: The linc01614/miR-4775 axis played an important role in ESCC progression and drug resistance, revealing that linc01614 is a promising target in ESCC treatment. https://ijph.tums.ac.ir/index.php/ijph/article/view/30529 https://ijph.tums.ac.ir/index.php/ijph/article/download/30529/7955

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 6 2023 06 13 1181 1189 Aleksandra Nikolic Clinic for Rheumatology, Allergology and Clinical Immunology, Clinical Centre Kragujevac, Kragujevac, Serbia Sonja Djuric Gentext Research group, University of Valencia, Valencia, Spain Vladimir Biocanin Faculty of Dentistry, University of Bussines Academy, Novi Sad, Serbia Katarina Djordjevic Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Marko Ravic Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Aleksandra Stojanovic Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Olivera Milovanovic Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Jasmina Skerlic Faculty of Technical Sciences, University of Pristina, Kosovska Mitrovica, Serbia Radisa Pavlovic Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Tamara Nikolic Turnic 1. Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia 2. N.A. Semashko Public Health and Healthcare Department, F.F. Erismann Institute of Public Health, I.M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russian Federation 2021 12 27 2022 05 07 Background: Elevated blood pressure (BP) is one of the leading causes for developing major cardiovascular events and still represents a major public health challenge worldwide. We aimed to provide data on predictors of poor adherence to medication in hypertensive patients in Serbia. Methods: Observational, analytical study was undertaken at a group of 388 patients who refilled their medications in the Pharmacy Institution, “Apoteka Kragujevac”, Kragujevac, Serbia between Jan and Mar 2019. Afterward, we conducted a case-control study to evaluate the influence of the variables associated with the adherence. We used a self-developed questionnaire and SF-36 to assess the influence of the quality of life on medication adherence. Results: Results revealed four independent predictors of non-adherence: increased number of medications, living in a city, forgetfulness of the dosing regimen and low energy. The odds of non-adherence were the highest among the participants living in the city and the low energy was the only factor inversely associated with the level of non-adherence. Conclusion: Many factors were associated with the non-adherence to medication. Further studies are needed to find the most appropriate protocol to promote adherence. The four risk factors (increased number of medications, living in a city, forgetfulness of the dosing regimen and low energy) are associated with non-adherence in adult hypertensive patients.   https://ijph.tums.ac.ir/index.php/ijph/article/view/27311 https://ijph.tums.ac.ir/index.php/ijph/article/download/27311/7956

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 6 2023 06 13 1190 1198 EN Chunjing Tu School of Teacher Education, Taizhou University, Taizhou, China Yuxuan Tu Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China Chongmin Jiang China Institute of Sport Science, Beijing, China Sanhua Zhang College of Education, Hangzhou Normal University, Hangzhou, China 2022 12 22 2023 04 25 Background: We aimed to establish the cut-off value of weight-for-height for preschool children in China, and to explore the influence of overweight and obesity on the physical performance of preschool children. Methods: Data from 31 provinces in China monitored in 2010 and 2014, the standard deviation unit curves of WFH were established by using GAMLSS (generalized additive model for location, scale, and shape) method preschool children in China, and then the cut-off values of normal weight, overweight and obesity were divided. The research group tested 5 physical performance indicators of 5154 preschool children from April 2018 to June 2019 in Beijing and Zhejiang in China. We then compared physical performance differences between the normal-weight group and the overweight-obesity group. Results: A smooth and effective standard deviation unit curve of WFH was established. The overweight and obesity of Chinese preschool children were at a high level. Being overweight and obese reduced preschool children's relative strength, speed, sensitivity, coordination, and balance ability, but did not reduce preschool children's flexibility. In general, the physical performance of preschool children in the normal weight group was better than that in the overweight and obesity group. Conclusion: It is suggested to use the WFH criteria in this study to evaluate overweight and obesity in Chinese preschool children, and strengthen physical activity and take in energy substances properly of preschool children, to control the spread of overweight and obesity， to improve physical performance level.   https://ijph.tums.ac.ir/index.php/ijph/article/view/30742 https://ijph.tums.ac.ir/index.php/ijph/article/download/30742/7957

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 6 2023 06 13 1199 1206 EN Aasma Munawwar Department of Zoology, Government College, University Faisalabad, Faisalabad, Pakistan Amna Sajjad Department of Zoology, Government College, University Faisalabad, Faisalabad, Pakistan Shahla Faisal Department of Statistics, Government College University, Faisalabad, Pakistan Azhar Rasul Department of Zoology, Government College, University Faisalabad, Faisalabad, Pakistan Aneeqa Zarbab Department of Zoology, Government College, University Faisalabad, Faisalabad, Pakistan Afshan Ashraf Government College University Faisalabad Afshan Bibi Department of Zoology, Government College, University Faisalabad, Faisalabad, Pakistan Adnan Ahmad Department of Zoology, Government College, University Faisalabad, Faisalabad, Pakistan Salma Siddique Institute of Industrial Biotechnology, GCU Lahore, Lahore, Pakistan 2021 11 20 2022 04 30 Background: Breast cancer is the most common malignancy among women worldwide. We aimed to know the past trends of age-specific breast cancer incidence rates in Faisalabad city. Methods: A retrospective study was designed at Allied Hospital Faisalabad (AHF), Pakistan from 2014-2018. Overall, 12742 cancer patients presented throughout these years, out of which 3390 were breast cancer cases. Descriptive statistics were computed and the results were presented as counts and percentage for categorical variables. Means and standard errors were computed for the continuous variables. For testing the association among categorical variables, a chi-square test of independence was used and the p-values less than 0.05 are reported as significant. Results: 84.70% patients were diagnosed with invasive breast carcinoma and 15.30% were all other types reported in the Allied Hospital Faisalabad. The incidence of breast cancer was outrageous in the 40-49 year-old age group (1021 patients, 30.12%) and the mean age is 45 in all years. An increase of 34.86% was observed from 2014 to 2018. The comprehensive four-year data (2015 to 2018) were further analyzed for histology, surgery, staging and grading pattern as 2014 files data was insufficient to discuss. The stage III and grade III were most common throughout the years from 2015 to 2018 with 33.9% and 55.71% respectively. Conclusion: Breast cancer is diagnosed more commonly in women than in any other type of cancers in Faisalabad city. There is a need to upgrade the existing hospital facilities to make the women diagnose the cancer at an earlier stage. https://ijph.tums.ac.ir/index.php/ijph/article/view/26951 https://ijph.tums.ac.ir/index.php/ijph/article/download/26951/7958

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 6 2023 06 13 1207 1214 Jing Liu Department of Pediatric Comprehensive Internal Medicine, Three Gorges Hospital Affiliated to Chongqing University，Chongqing, 404100, China Hongying Nie Department of Pediatrics, Wushan County People's Hospital, Chongqing, 404700, China Fan Rao Department of Pediatric Comprehensive Internal Medicine, Three Gorges Hospital Affiliated to Chongqing University，Chongqing, 404100, China 2023 01 19 2023 04 07  Background: We aimed to assess the effect of life-cycle management on the satisfaction and health outcomes of children with chronic diseases and their parents, as well as the career benefits of healthcare workers. Methods: Participants were children with chronic diseases who received long-term treatment at the Three Gorges Hospital Affiliated to Chongqing University from January 2021 to November 2022. From the first admission, compare the children's disease onset, satisfaction and professional benefits of medical staff among "Medical and Nursing Integration" + "Internet plus"-based life cycle management group (n = 221, the experimental group), the routine management group (n = 53, the control group 1) and the "Medical and Nursing Integration" group (n = 67, control group 2). Results: The overall satisfaction of children in the experimental group (100 %) was higher than that in the control group 1 (98.11%) and control group 2 (98.51%). The times of second admission and third admission of patients in the experimental group were significantly lower than those in control group 1 were (both P<0.001) and control group 2 (both P<0.01). Nurses' sense of professional benefit, professional identity, and doctor's satisfaction with nurses in the experimental group were significantly higher than those in control group 1 (P<0.05, P<0.01, P<0.001) and control group 2 (all P<0.05). Conclusion: The application of "Medical and Nursing Integration" + "Internet plus"-based life cycle management in chronic disease nursing management can effectively improve the management on pediatric chronic diseases.   https://ijph.tums.ac.ir/index.php/ijph/article/view/30972 https://ijph.tums.ac.ir/index.php/ijph/article/download/30972/7959

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 6 2023 06 13 1215 1224 Draginja Vuksanovic Stankovic Department of Civil Law, Faculty of Law, University of Montenegro, Podgorica, Montenegro Nemanja Radojevic 1. Harvard School of Public Health, Massachusetts, United States 2. Clinical Center of Montenegro, Faculty of Medicine, University of Montenegro, Podgorica, Montenegro Batric Vukcevic Clinical Center of Montenegro, Faculty of Medicine, University of Montenegro, Podgorica, Montenegro Andrea Jovovic Clinical Center of Montenegro, Faculty of Medicine, University of Montenegro, Podgorica, Montenegro SV Subramanian Harvard School of Public Health, Massachusetts, United States 2023 03 27 2023 06 13 Background: Domestic violence is defined as the combined pattern of physical, psychological, economic and/or sexual violence against a family member. Intimate partner violence is the most common form. We aimed to present the basic characteristics of the Montenegrin families and family members affected by domestic violence, with the intent to inform the global mosaic of differences related to cultural specificities. Methods: A cross-sectional study was performed using 323 cases judicially processed and officially judged according to Criminal Act from 2015-2017 in Montenegro. Socioeconomic characteristic were investigated followed by analysis of many variables. Results: Demographic characteristics, socio-economic status, and other characteristics of the perpetrators and the victims, as well as characteristics of violent act with posible risk factors, are presented. The results of case-control analyisis of intimate-partner relationships are given, too. Conclusion: A typical example of domestic violence in Montenegro shows an intimate couple with a violent male and a victimized female partner, living in a rented residence in the suburbs, with both partners in the fourth decade of their lives. The most frequent income level was poor, with half of the batterers and nearly three quarters of the victims unsatisfied with their marriage. The increased presence of such factors (both modifiable and unmodifiable) in the partiarchical families suffering from domestic violence should spark interest in public health and government authorities regarding domestic violence screening adapted for patriarchical societies. https://ijph.tums.ac.ir/index.php/ijph/article/view/31574 https://ijph.tums.ac.ir/index.php/ijph/article/download/31574/7961

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 6 2023 06 13 1225 1237 EN Xiao Xiao Urology Department, Chongqing University Fuling Hospital, Chongqing, 408000, PR China Junxiong Peng Urology Department, Chongqing University Fuling Hospital, Chongqing, 408000, PR China Yong Chen Urology Department, Chongqing University Fuling Hospital, Chongqing, 408000, PR China Xingshan Lu Urology Department, Chongqing University Fuling Hospital, Chongqing, 408000, PR China Wei Sun Urology Department, Chongqing University Fuling Hospital, Chongqing, 408000, PR China Weizhong Xiao Urology Department, Chongqing University Fuling Hospital, Chongqing, 408000, PR China Mengjuan Yuan Urology Department, Chongqing University Fuling Hospital, Chongqing, 408000, PR China Xiaolan Huang Urology Department, Chongqing University Fuling Hospital, Chongqing, 408000, PR China 2022 03 02 2022 05 19 Background: Bladder cancer (BCa) is one of the most common urinary tract malignancies. Our study aimed to provide promising biomarkers for BCa screening and prognosis. Methods: BCa samples were obtained from Gene Expression Omnibus (GEO) datasets. Differentially expressed genes (DEGs) were analysed by GO/KEGG analysis. Univariate Cox hazard analysis and Kaplan Meier Curve clarified the relevance of DEGs and survival. Receiver operating characteristic (ROC) curve showed the discrimination ability of DEGs in BCa patient outcome prediction. RT-PCR was used to validate gene expression. Results: Overall, 61 common up regulated and 170 common down-regulated genes in BCa were obtained. DEGs were mainly enriched in proliferation and metastasis processes. CDC20, COL14A1, SPARCL1, TMOD1, RHOJ, FXYD6 and MFAP4 had clinical relevance to survival with high accuracy. CDC20, SPARCL1 and TMOD1 are promising biomarkers of BCa. CDC20, SPARCL1 and TMOD1 are involved in cancer immune infiltration. Conclusion: CDC20, SPARCL1 and TMOD1 are promising biomarkers of bladder cancer. In addition, CDC20, SPARCL1 and TMOD1 are involved in cancer immune infiltration, which provides new targets in immune therapy in bladder cancer. https://ijph.tums.ac.ir/index.php/ijph/article/view/28039 https://ijph.tums.ac.ir/index.php/ijph/article/download/28039/7962

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 6 2023 06 13 1238 1247 Jagoda Gavrilovic 1. Department of Infectious Diseases, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia 2. Clinic for Infectious Diseases, University Clinical Centre Kragujevac, Kragujevac, Serbia Marija Kovacevic Department of Anatomy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia Dragana Ignjatovic Ristic 1. Department of Psychiatry, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia 2. Clinic of Psychiatry, University Clinical Centre Kragujevac, Kragujevac, Serbia Marija Peulic Center of Medical Oncology, University Clinical Centre Kragujevac, Kragujevac, Serbia Aleksandar Gavrilovic 1. Department of Neurology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia 2. Clinic of Neurology, University Clinical Centre Kragujevac, Kragujevac, Serbia 2022 11 02 2023 04 25 Background: We aimed to determine the level of hope in breast cancer patients along with the influence of sociodemographic characteristics on the expressed level of hope. Methods: A descriptive cross-sectional study was conducted on the sample size of 72 female patients with breast cancer diagnosis. The study was conducted at the University Clinical Center of Kragujevac, Serbia from November 2020 until March 2022. Data were collected from the patients in a form of the Sociodemographic Variables Questionnaire (Q-SV). The Herth Hope Index (HHI) was used in assessing the level of hope. Results: The value of the total HHI score was ranging from 14 to 48, whereas the mean value of the HHI score was 40.00±5.92. The significantly higher level of hope was reported in female patients who: searched the Internet for gathering information on their disease (39.24±6.23; P=0.047), were religious (38.77±6.13; P=0.003), believed in God (38.45±5.51; P=0.004), had no formal medical education (38.44±5.75; P=0.036) and after therapy (38.76±6.49; P=0.022). Conclusion: Hope is an existential internal resource possibly affecting the manner in which female patients perceive their own health state and future as well. A better understanding of the meaning of hope during treatment can be of great value in supporting cancer patients.   https://ijph.tums.ac.ir/index.php/ijph/article/view/30292 https://ijph.tums.ac.ir/index.php/ijph/article/download/30292/7963

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 6 2023 06 13 1248 1258 Huilan Bao The Endocrinology Department, the People’s Hospital, Jinhua, 321000, China 2023 03 20 2023 06 13 Background: Message framing is a low-cost and effective intervention method to improve diabetics’ health behaviors. The study aimed to investigate the impacts of positive and negative message framing interventions on the self-management activities and self-efficacy of patients with type 2 diabetes mellitus (T2DM). Method: Overall, 102 T2DM patients from Jinhua People’s Hospital of China were recruited and divided into three groups: positive and negative message framing intervention groups and a control group. A 12-week experiment was implemented on the first two groups. Then, the differences of the patients’ self-management activities and self-efficacies were analyzed between the experimental and control groups. Finally, the mediating effect of self-efficacy between two types of message framing interventions and patients’ self-management activities was investigated. Results: Both positive and negative message framing interventions could significantly improve the T2DM patients’ self-management activities in diet, blood glucose testing, foot care, and medication taking (P<0.05), meanwhile significantly improving their self-efficacies along the nutrition, physical exercise and weight, medical treatment, blood sugar, and feet check (P<0.05). Results of the difference analysis for both within-group and inter-group showed that, compared with the positive messaging framing intervention, the negative one had more significant effects on enhancing the patients’ self-management activities and self-efficacy. Self-efficacy had only a mediating effect between negative messaging framing intervention and self-management activities (β = 0.94, 95% CI: 0.0934 – 0.456). Conclusion: Negative messaging framing intervention could better enrich T2DM patients’ diabetes knowledge through offering threatening information, thereby enhancing their self-efficacies, and ultimately improve their self-management activities. https://ijph.tums.ac.ir/index.php/ijph/article/view/31523 https://ijph.tums.ac.ir/index.php/ijph/article/download/31523/7964

Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 52 6 2023 06 13 1259 1268 Hasti Masihay-Akbar Research Center for Social Determinants of Health, R