Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 46 5 2017 05 09 612 619 Ioana SCROBOTĂ Dept. of Cranio-Maxillofacial Surgery and Radiology, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj Napoca, Romania AND Dept. of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania AND Dept. of Radiobiology and Tumour Biology, ”Prof. Dr. I. Chiricuță” Oncology Institute, Cluj-Napoca, România Grigore BĂCIUȚ Dept. of Cranio-Maxillofacial Surgery and Radiology, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj Napoca, Romania Adriana Gabriela FILIP Dept. of Physiology, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania Bianca TODOR Dept. of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania Florin BLAGA Dept. of Industrial Engineering, Faculty of Managerial and Technological Engineering, University of Oradea, Oradea, Romania Mihaela Felicia BĂCIUȚ Dept. of Implantology and Maxillofacial Surgery, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj Napoca, Romania 2017 05 09 2017 05 09 Background: The mapping of the malignization mechanism is still incomplete, but oxidative stress is strongly correlated to carcinogenesis. In our research, using fuzzy logic, we aimed to estimate the oxidative stress related-cancerization risk of the oral potentially malignant disorders. Methods: Serum from 16 patients diagnosed (clinical and histopathological) with oral potentially malignant disorders (Dept. of Cranio-Maxillofacial Surgery and Radiology, ”Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj Napoca, Romania) was processed fluorometric for malondialdehyde and proton donors assays (Dept. of Physiology,”Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania). The values were used as inputs, they were associated linguistic terms using MIN-MAX method and 25 IF-THEN inference rules were generated to estimate the output value, the cancerization risk appreciated on a scale from 1 to 10 - IF malondialdehyde is very high and donors protons are very low THEN the cancer risk is reaching the maximum value (Dept. of Industrial Engineering, Faculty of Managerial and Technological Engineering, University of Oradea, Oradea, Romania) (2012-2014). Results: We estimated the cancerization risk of the oral potentially malignant disorders by implementing the multi-criteria decision support system based on serum malondialdehyde and proton donors' values. The risk was estimated as a concrete numerical value on a scale from 1 to 10 depending on the input numerical/linguistic value. Conclusion: The multi-criteria decision support system proposed by us, integrated into a more complex computerized decision support system, could be used as an important aid in oral cancer screening and establish future medical decision in oral potentially malignant disorders.     https://ijph.tums.ac.ir/index.php/ijph/article/view/9909 https://ijph.tums.ac.ir/index.php/ijph/article/download/9909/5705