Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 46 4 2017 04 26 500 505 Huifang ZHANG Hemodialysis Room, Yantaishan Hospital, Yantai, Shandong, China Chongting LIN Hemodialysis Room, Yantaishan Hospital, Yantai, Shandong, China Songbo YUAN Administrative Office, Binzhou Medical University, Yantai, Shandong, China Qinghua WANG School of Nursing, Binzhou Medical University, Yantai, Shandong, China Jiangcheng YANG Dept. of Nephrology, Haiyang Hospital of Traditional Chinese Medicine, Haiyang, Shandong, China 2017 04 26 2017 04 26 Background: We aimed to observe the effect of holistic nursing on patients undergoing hematodialysis for uremia who simultaneously were suffering from moderate to severe malnutrition. Methods: Eighty patients with uremia on maintenance hematodialysis with malnutrition between June 2014 and June 2015 from Yantaishan Hospital, Yantai, Shandong, China were included and equally and randomly were divided into the control group (n=43) and observation group (n=43). Routine nursing was used in the control group while holistic nursing was used in observation group (before, during and after dialysis) and the clinical effects in the two groups were compared after 3 months. Results: At follow-up visits, serum creatinine and urea nitrogen levels of the patients in the two groups were decreased, whereas hemoglobin and albumin levels were increased. In addition, these improvements were greater in the observation group and the differences were statistically significant (P<0.05). Furthermore, during follow-up visits, MQSGA and MIS scores of the two groups were lower and the scores of the observation group were lower than those in the control group were, and the differences were statistically significant (P<0.05). Conclusion: Holistic nursing is able to improve significantly malnutrition in patients with uremia on hematodialysis.   https://ijph.tums.ac.ir/index.php/ijph/article/view/9758 https://ijph.tums.ac.ir/index.php/ijph/article/download/9758/5629