Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 12 2016 12 27 1645 1651 Mehdi ASSMAR Dept. of Microbiology, Islamic Azad University, Lahijan, Iran Sara YEGANEH Dept. of Microbiology, Islamic Azad University, Lahijan, Iran Fariborz MANSOURGHANAEI Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Nour AMIRMOZAFARI Dept. of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran 2016 12 27 2016 12 27 Background: This study aimed to determine the role of tumor markers AFP, CA15-3, CA125, CA19-9 and CEA in patients with hepatitis B and C. Methods: This descriptive cross-sectional study was performed from Oct 2012 to Oct 2014. Serum samples of 129 patients with hepatitis B and C referred to Guilan Liver and Digestive Disease Research Center in Rasht, Iran were collected and checked for the existence of the listed tumor markers by ELISA. Results: No increase in serum levels of tumor marker CA19-9, CEA and CA15-3 were seen in patients with hepatitis (P>0.05). In patients with hepatitis B, increase in CA125 were observed (P=0.03). In hepatitis C patients, there was an increase in AFP levels (P=0.03). Conclusion: The levels of AFP and CA125 markers were high in hepatitis C and hepatitis B, respectively. However, the increased levels were not seen is malignancy. Due to the small sample size, further study is necessary to find the reasons of the increase. https://ijph.tums.ac.ir/index.php/ijph/article/view/8640 https://ijph.tums.ac.ir/index.php/ijph/article/download/8640/5483