Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 11 2016 12 21 1465 1472 Somayeh SABOORI Dept. of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran AND Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran Mahmoud DJALALI Dept. of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran Esmaeil YOUSEFI RAD Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran Ebrahim Nematipour Dept. of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran Ali Akbar SABOOR-YARAGHI Dept. of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran Mohammad Hassan JAVANBAKHT Dept. of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran Mohammad Reza ESHRAGHIAN Dept. of Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Atena RAMEZANI Dept. of Basic Sciences and Nutrition, Cardiovascular Research Center, School of Public Health, Mazandaran University of Medical Sciences, Sari, Iran Fariba KOOHDANI Dept. of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran AND Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 2016 11 26 2016 11 26 Background: Omega 3 and vitamin E are two critical nutrients which include beneficial effects in coronary artery disease (CAD). The aim of this study was to assess the effects of omega 3 alone supplementation or in combination with vitamin E on serum glucose and lipid levels and insulin resistance in CAD patients. Methods: Participants of this clinical trial included 60 male patients with CAD who selected from Tehran Heart Center in Tehran, Iran in 2014. They received 4 g/day omega 3 plus 400 IU/day vitamin E (OE), 4 g/day omega 3 with vitamin E placebo (OP), or omega 3 and vitamin E placebo (PP) for two months. Serum glucose, lipids and insulin were assessed and HOMA-IR was calculated before and after the trial and effects of these nutrients on the highlighted parameters were compared within the study groups. Results: Serum glucose level increased significantly in OP group (P=0.004), but not in OE group. OE and OP groups showed a significant decrease in fasting serum TG (P=0.020 and P=0.001, respectively). Serum insulin and HOMA-IR decreased significantly in OE group (P=0.044 and P=0.039, respectively) but did not change significantly in OP group. Conclusion: Although, omega 3 supplementation may include adverse effects on serum glucose level, co-administration of omega 3 and vitamin E can beneficially decrease serum insulin and insulin resistance in CAD patients.     https://ijph.tums.ac.ir/index.php/ijph/article/view/8348 https://ijph.tums.ac.ir/index.php/ijph/article/download/8348/5363