Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 11 2016 12 21 1420 1426 You LI Dept. of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China Jian QIN Dept. of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China Xiao WEI Dept. of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China Guiyun LIANG Dept. of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China Liwei SHI Dept. of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China Meiyu JIANG Dept. of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China Tianlong XIA Dept. of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China Xue LIANG Dept. of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China Min HE Dept. of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China Zhiyong ZHANG Dept. of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China 2016 11 26 2016 11 26 Background: We aimed to identify the role of SIRT6 gene polymorphism rs350846 in human longevity. Methods: SIRT6 C/G genotypes were determined using Taqman SNP Genotyping Assays in 169 long-lived inhabitants (LG group aged 90-110 yr), 158 healthy internal controls (internal control group; aged 26-82 yr) and 176 healthy external controls (external control group; aged 20-82 yr) without a family history of exceptional longevity. Statistical analysis was conducted using SPSS 16.0. Results: BMI and TG level were lower in the longevity than in the two control groups, while serum LDL-c and HDL-c and SBP and DBP levels in long-lived individuals were higher than in the two control groups (P<0.01). The waist circumference was obviously different (P=0.001) among the three groups, with the maximum observed in the external group. No statistically significant differences of the gender FBG and TC were seen in long-lived individuals than in the two control groups. Significant genotype differences existed among the different groups except for the longevity and internal control group. The frequency of the minor allele-C was 0.319. The minor allele frequency of rs350846 in SIRT6 was much higher in the external control than in the other groups. BMI, SBP and HDL-c displayed significant effect on longevity. Conclusion: The C allele of rs350846 in SIRT6 gene, CC and CG genotypes as well as BMI, systolic pressure and HDL-c are associated with longevity. Further studies are needed to validate our results.   https://ijph.tums.ac.ir/index.php/ijph/article/view/8343 https://ijph.tums.ac.ir/index.php/ijph/article/download/8343/5355