Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 9 2016 10 10 1126 1135 Tianjie HAN Dept. of Hematology, Tai’an Central Hospital, Tai’an, Shandong, China Junshan LI Dept. of Gastroenterology, Tai’an Central Hospital, Tai’an, Shandong, China Ling WANG Dept. of Hematology, Tai’an Central Hospital, Tai’an, Shandong, China Hongzhi XU Dept. of Hematology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China 2016 09 27 2016 09 27 Background: Coffee is implicated in the susceptibility to several cancers. However, the association between coffee and lymphoma remains unclear. This meta-analysis aimed to assess quantitatively the association between coffee and the incidence of lymphoma. Methods: A literature search was performed for cohort and case-control studies published using PubMed, Cochrane, and EMBASE databases. Studies were included if they reported relative ratios (RR) and corresponding 95% confidence intervals (CIs) of lymphoma with respect to coffee consumption. Pooled relative risk (RR) and its 95% confidence interval (CI) were calculated. All P values are two tailed Results: Seven studies met the inclusion criteria, which included three cohort and four case-control studies. Compared with did not or seldom drink coffee per day, being no significantly association between coffee and risk of lymphoma (pooled RR: 1.05, 95%CI: 0.89-1.23). In the subgroup analysis, no significant association between coffee and lymphoma risk was detected not only in different study types (cohort studies RR: 1.29; 95% CI, 0.92-1.80; case control studies RR: 0.99; 95% CI, 0.82-1.99) but also in different regions (Europe RR: 1.21; 95% CI: 0.99-1.47; USA RR: 0.85; 95% CI, 0.62-1.15; Asia RR: 1.08, 95% CI: 0.84-1.40) and coffee consumption status (≥4cups/d 1.03, 95% CI: 0.69–1.56; ＜4cups/d RR: 1.06, 95% CI: 0.89- 1.26 ). The funnel plot revealed no evidence for publication bias. Conclusion: There was no sufficient evidence to support coffee consumption association with the risk of lymphoma. Further well-designed large-scaled cohort studies are needed to provide conclusions that are more definitive.     https://ijph.tums.ac.ir/index.php/ijph/article/view/7848 https://ijph.tums.ac.ir/index.php/ijph/article/download/7848/5547