Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 8 2016 10 10 986 996 Parvin MANSOURI Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran Alemeh KHADEMI Dept. of Iranian Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran Daryoush PAHLEVAN Research Center for Social Determinants of Health, Semnan University of Medical Sciences, Semnan, Iran Zahra MEMARIANI Dept. of Traditional Pharmacy, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran Jale ALIASL The Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran Laila SHIRBEIGI Dept. of Iranian Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran 2016 08 28 2016 08 28 Background: Hand Eczema (HE) is a dermatological disorder with frequent relapses and multiple causes such as atopic, allergic and irritant contact dermatitis. The management is complex because of the wide range of different pathogenesis. Efficacy of some of available treatments is not well established and it can affect patients’ quality of life significantly. Methods: Reports on HE such as diagnosis, pathophysiology, pharmacological and nonpharmacological therapy that described in medieval Iranian medicine, were gathered and analyzed from selected medical and pharmaceutical textbooks of Iranian Traditional Medicine (ITM). The search of databases such as PubMed, EMBASE/Excerpta Medica, Science direct, Scopus, Google scholar, Web of science, Sid, Iran medex, Irandoc, was performed to reconfirm the efficacy of ITM remedies in conventional medicine from 1980-Jan-1 to 2015-Dec-30. Results: According to their opinion, HE is highly associated with liver function. This disorder was categorized into two main types as wet and dry ones. Most Iranian textbook explained signs of HE, as excessive skin itching, redness, burning and dryness. Treatments recommended by Iranian scientists were lifestyle modification, dietary intervention and performing the rules of prevention as well as herbal therapy and special manipulations. Conclusion: Iranian practitioners believed that, six essential principles, diet therapy and medicinal plants have high impact on treatment of HE. These remedies based on Iranian scholar’s experiences might be useful for further studies to the management of HE.   https://ijph.tums.ac.ir/index.php/ijph/article/view/7599 https://ijph.tums.ac.ir/index.php/ijph/article/download/7599/5492