Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 4 2016 04 27 460 468 Jai PRAKASH Dept. Physiology, King George’s Medical University, Lucknow, India Dept. of Pediatrics, King George’s Medical University, Lucknow, India Balraj MITTAL Dept. of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India Shally AWASTHI Dept. of Pediatrics, King George’s Medical University, Lucknow, India Neena SRIVASTAVA Dept. Physiology, King George’s Medical University, Lucknow, India 2016 04 27 2016 04 27 Background: Obesity associated with type 2 diabetes, and hypertension increased mortality and morbidity. Glutamate decarboxylase 2 (GAD2) gene is associated with obesity and it regulate food intake and insulin level. We investigated the association of GAD-2gene −243A>G (rs2236418) and +61450C>A (rs992990) polymorphisms with obesity and related phenotypes. Methods: Insulin, glucose and lipid levels were estimated using standard protocols. All subjects were genotyped (PCR-RFLP) method. Results: The −243A>G polymorphism of the GAD-2 gene was significantly associated with higher risk of obesity (P<0.05). Conclusion: GAD-2 gene polymorphisms influence obesity and related phenotype in complex manner, probably by regulating the food intake, insulin and body weight.     https://ijph.tums.ac.ir/index.php/ijph/article/view/6576 https://ijph.tums.ac.ir/index.php/ijph/article/download/6576/5360