Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 3 2016 03 15 322 328 Ensieh LOTFALI Dept. of Medical Mycology and Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Parivash KORDBACHEH Dept. of Medical Mycology and Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Hossein MIRHENDI Dept. of Medical Mycology and Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Farideh ZAINI Dept. of Medical Mycology and Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Ali GHAJARI Dept. of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Rasoul MOHAMMADI Dept. of Medical, Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Fatemeh NOORBAKHSH Dept. of Biology, Faculty of Science, Islamic Azad University, Varamin-Pishva, Iran Maryam MO­AZENI Invasive Fungi Research Center, Dept. of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Aliakbar FALLAHI Dept. of Microbiology & Parasitology & Immunology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Sassan REZAIE Dept. of Medical Mycology and Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2016 03 15 2016 03 15 Background: Candida parapsilosis is an emergent agent of invasive fungal infections. This yeast is one of the five most widespread yeasts concerned in invasive candidiasis. C. parapsilosis stands out as the second most common yeast species isolated from patients with bloodstream infections especially in neonates with catheter. Recently several reports suggested that its reduced susceptibility to azoles and polyene might become a cause for clinical concern, although C. parapsilosis is not believed to be intensely prone to the development of antifungal resistance. Methods: In the present report, One hundred and twenty clinical isolates of C. parapsilosis complex were identified and differentiated by using PCR-RFLP analysis. The isolates were then analyzed to determine their susceptibility profile to fluconazole (FLU), itraconazole (ITC) and amphotericin B. The minimum inhibitory concentration (MIC) results were analyzed according to the standard CLSI guide. Results: All of isolates were identified as C. parapsilosis. No C. metapsilosis and C. orthopsilosis strains were found. Evaluation of the antifungal susceptibility profile showed that only three (2.5%) C. parapsilosis were resistant to fluconazole, three (2.5%) C. parapsilosis were resistant to itraconazole and two (1.7%) C. parapsilosis were amphotericin B resistant. Conclusion: Profiles in clinical isolates of C. parapsilosis can provide important information for the control of antifungal resistance as well as distribution and susceptibility profiles in populations.   https://ijph.tums.ac.ir/index.php/ijph/article/view/6264 https://ijph.tums.ac.ir/index.php/ijph/article/download/6264/5325