Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 45 1 2016 02 13 20 26 Lei HE Dept. of Hepabiliary Surgery, PLA General Hospital, Beijing 100853, China Maohu LIN Dept. of Urological Surgery, the First Affiliated Hospital of PLA General Hospital, Beijing100051, China Wensheng FAN Dept. of Gynecology and Obstetrics, PLA General Hospital, Beijing100853,China Yunxi LIU Dept. of Nosocomial Infection and Disease Control, PLA General Hospital, Beijing100853,China Jijiang SUO Dept. of Nosocomial Infection and Disease Control, PLA General Hospital, Beijing100853,China Yubin XING Dept. of Nosocomial Infection and Disease Control, PLA General Hospital, Beijing100853,China Ning JIA Dept. of Nosocomial Infection and Disease Control, PLA General Hospital, Beijing100853,China 2016 01 27 2016 01 27 Background: During recent years, infection of Acinetobacter baumanii showed a rapid growth in hospitals and community. Toll-like receptors (TLRs) are the most important pattern recognition receptors, which play a critical role during recognizing invading pathogens by the natural immune system. Our objective was to determine the associations of TLRs polymorphisms with the susceptibility to A. baumanii infection in a Chinese population. Methods: We carried out a case-control study, genotyping 13 polymorphisms of TLR-2, TLR-4, TLR-5 and TLR-9 genes on 423 A. baumanii-infected patients and 385 exposed controls. Thirteen SNPs at the TLR-2 (rs3804099, rs7656411 and rs76112010), TLR-4 (rs1927914, rs10759932 and rs11536889), TLR-5 (rs1341987, rs1640827, rs1861172, rs2241097, rs5744174 and rs17163737) and TLR9 (rs187084) genes were analyzed. SNP genotyping was performed using an improved multiplex ligation detection reaction (iMLDR) technique. Results:  The SNP of TLR-9, rs187084, was related to A. baumanii-infection significantly under recessive model (G/G, to A/A + G/A, P = 0.0064, OR = 0.59, 95% CI = 0.40-0.86) after adjustment with age. Besides, the haplotype GCG of TLR-4 was significantly associated with A. baumanii infection (P = 0.027). Conclusion:  TLR-4 and TLR-9 may be related to the susceptibility to A. baumanii infection in a Chinese population.     https://ijph.tums.ac.ir/index.php/ijph/article/view/5840 https://ijph.tums.ac.ir/index.php/ijph/article/download/5840/5274