Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 42 1 2013 01 15 79 85 Sharareh Seifi Medical Oncology Department, National Research Institute of TB and Lung Disease, Masih Daneshvari Hospital, Tehran, Iran. Iraj Asvadi Kermani Roya Dolatkhah Atabak Asvadi Kermani Ebrahim Sakhinia Mohammad Asgarzadeh Saeed Dastgiri Ayoub Ebrahimi Arezou Asghari Haggi Mahsa Nadri Touraj Asvadi Kermani 2015 10 15 Human papilloma virus causes benign and malignant abnormalities in different part of the body. The link between high risk types of HPV and some anogenital and aerodigestive tract cancer is well established. Oral HPV infection plays a role in developing oropharyngeal squamous cell carcinoma. We studied the prevalence of oral HPV in healthy individuals and its relative risk factors.Saliva samples of 114 healthy subjects were collected for HPV DNA analysis. Volunteers completed questionnaires and signed a written consent. For data analysis descriptive statistic, chi square test and odds ratio was used.The frequency of oral HPV in healthy individuals was 6.1 %(seven participant).The most frequent type was HPV-18 in five of them. HPV-6 and HPV-66 each was detected in one case. Relation of oral HPV positivity to demographic features and risk factors was not statistically significant.The prevalence of oral HPV infection in our community is the same as many other communities of developing countries, stressing that HPV-18 were the dominant type. https://ijph.tums.ac.ir/index.php/ijph/article/view/4774 https://ijph.tums.ac.ir/index.php/ijph/article/download/4774/4412