Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 42 10 2013 10 15 1158 1166 Fatemeh Sadat Hoseini 1. Dept. of Anatomy, School of Medicine, Tehran University of Medical Sciences , Tehran, Iran. Mohammad Eslami 2. Dept. of Population, Family and School Health, Ministry of Health and Medical Education , Tehran, Iran. Mohammed Abbasi 3. Family Planning Office, Gilan University of Medical Sciences , Rasht, Iran. Fatemeh Noroozi Fashkhami 3. Family Planning Office, Gilan University of Medical Sciences , Rasht, Iran. Soheila Besharati 3. Family Planning Office, Gilan University of Medical Sciences , Rasht, Iran. 2015 10 15 We aimed to compare acceptability of Levonorgestrel with the Yuzpe regimen among Iranian women based on their side-effects and resulting changes in the amount and pattern of menses.Five hundred twenty nine participants aged 15-49 having regular menses and one act of unprotected intercourse within 72 h were included in the double-blind, controlled trial in 2006-2007 and randomly assigned into LNG (n=263) and HD (n=266) groups, receiving Levonorgestrel 0.75 mg given 12 h apart and ethinyl estradiol 100 μg plus 0.5 mg Levonorgestrel 0.5 mg repeated after 12 h, respectively.The participants receiving Levonorgestrel experienced significantly lower side-effects in the case of nausea, vomiting, and dizziness (P<0.05). The changes occurred in the amount and pattern of menses were the same for both groups (P>0.05). No significant difference was observed between the efficiencies of the treatments.Significantly lower side-effects of Levonorgestrel can be considered as greater acceptability and translated to higher efficiency. https://ijph.tums.ac.ir/index.php/ijph/article/view/4383 https://ijph.tums.ac.ir/index.php/ijph/article/download/4383/4032