Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 43 10 2014 10 15 1417 23 Kobra Shiasi Arani 1. Research Center for Biochemistry and Nutrition in Metabolic Disorders, Kashan University of Medical Sciences , Kashan, Iran. Abbas Taghavi Ardakani 2. Dept. of Pediatrics, Kashan University of Medical Sciences , Kashan, Iran. Razieh Moazami Goudarzi 2. Dept. of Pediatrics, Kashan University of Medical Sciences , Kashan, Iran. Hamid Reza Talari 3. Dept. of Radiology, Kashan University of Medical Sciences , Kashan, Iran. Kamran Hami 3. Dept. of Radiology, Kashan University of Medical Sciences , Kashan, Iran. Hossein Akbari 4. Trauma Research Center, Kashan University of Medical Sciences , Kashan, Iran. Nima Akbari 4. Trauma Research Center, Kashan University of Medical Sciences , Kashan, Iran. 2015 10 15 We evaluated the effect of vitamin E and metformin on fatty liver disease in obese children.This interventional study has been done on 119 children with Non-alcoholic fatty liver disease (based on sonography results). Patients were divided into four treatment groups; they received metformin 1gr daily (age< 12 years), metformin 1.5 gr daily (age> 12 years), vitamin E 800 U daily and vitamin E 400 U daily. Liver sonography was performed for patients for two periods of two months. This trial was registered in Iranian Registry of Clinical Trials (IRCT), No.IRCT2013021012421N1.The study group comprised 119 individuals (62 females, 57 males). The mean age was 10± 3.19 yr. There was no significant difference in terms of sex and BMI between the groups. Overall liver sonography showed normal liver in 66 patients (55.46%), 66.63% after two months and 33.37% after four months. After two months, the most therapeutic response observed in the group which received vitamin E 800 u daily (48.1%) and the least therapeutic response was in the group which received vitamin E 400 u daily (14.3%). After four months, the greater response was seen in vitamin E 400 u daily group (45.8%) and the least response in the metformin 1 gram daily group (19%).In comparison with metformin, vitamin E is more influential in remission; however both are efficient in treatment of fatty liver. Vitamin E 400 u daily responses better in four-month treatment. https://ijph.tums.ac.ir/index.php/ijph/article/view/3870 https://ijph.tums.ac.ir/index.php/ijph/article/download/3870/3533