Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 54 10 2025 10 31 2101 2113 Nik Asyraf Nik Azis National Population and Family Development Board (LPPKN), No 12B, Jalan Raja Laut, Chow Kit, 50350 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia Mohamed S. Zulfarina Department. of Pharmacology, Medical Faculty, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia Nurul ‘Izzah Ibrahim Department. of Pharmacology, Medical Faculty, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia Alia Syamim Zahari National Population and Family Development Board (LPPKN), No 12B, Jalan Raja Laut, Chow Kit, 50350 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia Aisyah Sulaiman National Population and Family Development Board (LPPKN), No 12B, Jalan Raja Laut, Chow Kit, 50350 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia Ng Xue Min National Population and Family Development Board (LPPKN), No 12B, Jalan Raja Laut, Chow Kit, 50350 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia Azura Abdullah National Population and Family Development Board (LPPKN), No 12B, Jalan Raja Laut, Chow Kit, 50350 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia Alina Ali National Population and Family Development Board (LPPKN), No 12B, Jalan Raja Laut, Chow Kit, 50350 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia Norhalili Mohamad Tamiri National Population and Family Development Board (LPPKN), No 12B, Jalan Raja Laut, Chow Kit, 50350 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia Isa Naina-Mohamed Department. of Pharmacology, Medical Faculty, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia 2025 01 22 2025 05 07 Background: We conducted a systematic review which aimed to assess acceptability of implanon used based on reported side effects, continuation rates and user satisfaction in Muslim-majority Asian countries. Methods: We followed PRISMA guideline and searched SCOPUS and Medline databases for original articles that dealt with implanon, conducted in Muslim-majority Asian countries and had either continuation rates or side effects or satisfaction rate. The risk of bias of the selected studies was assessed using ROBINS-I V2 Risk of Bias tool. Results: The literature search successfully identified 7 potentially relevant articles, whereby 5 of them met the inclusion criteria. 5 articles were retained in the final synthesis with 619 total participants. Implanon’s documented side effects such as menstrual irregularity and weight gain, is tolerable due to its high efficacy. Implanon has low discontinuation rates among users and has a high satisfaction rate. Conclusion: Implanon is widely accepted in Muslim-majority Asian countries with a positive impact on family planning. https://ijph.tums.ac.ir/index.php/ijph/article/view/37921 https://ijph.tums.ac.ir/index.php/ijph/article/download/37921/8670