Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 54 10 2025 10 31 2173 2189 Muhammad Thoriq School of Population Health, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia Wilda Rachmadina Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia Julian Swannjo Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia Fajrul Farhany Central for Health Policy and Management Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Jogjakarta, Indonesia Adrian Kus Department of Didactics and Medical Simulation, Medical University of Lublin, Lublin, Poland Agus Rachmanto Govtech Health, Peruri Digital Security, Jakarta, Indonesia . Sulistiawati Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia 2024 12 13 2025 04 06 Background: Telemedicine is increasingly vital in healthcare, offering remote consultations via message-based and video call-based platforms. These methods improve healthcare accessibility, particularly when in-person visits are limited. Telemedicine is increasingly vital in healthcare, offering remote consultations via message-based and video call-based platforms. These methods improve healthcare accessibility, particularly when in-person visits are limited. Methods: A systematic search was conducted in ScienceDirect, PubMed, and up to August 2024. Studies evaluating the accessibility and practicality of global telemedicine were evaluated. From initial 439 records, 19 studies were finally in this systematic review. Studies were reviewed thoroughly with quality appraisal using the Newcastle Ottawa Scale, in which those rated for high quality studies were included. Results: Most studies (74%) were from high-income countries, notably the United States (26%) and Denmark (11%). Observational studies dominated (95%), focusing on follow-up consultations (47%) and diagnostic services (32%), particularly in general care (32%), neurology (11%), and surgery (5%). Research peaked in 2022 (32%) during the COVID-19 pandemic. Common platforms included WhatsApp, AnyDesk, and QliqSOFT. Accessibility was the primary focus in 53% of studies, while 47% addressed feasibility. Challenges like technological barriers and privacy concerns were particularly noted in lower-income regions. Conclusion: Telemedicine has enhanced healthcare accessibility and demonstrated feasibility. However, technological limitations and remote consultation challenges persist, particularly in lower-income regions. Continued research is needed to optimize telemedicine and equitable access.  https://ijph.tums.ac.ir/index.php/ijph/article/view/37510 https://ijph.tums.ac.ir/index.php/ijph/article/download/37510/8676