Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 44 2 2015 02 15 211 7 Neda Roshanravan Dept. of Biochemistry and Diet Therapy, Student Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran. Mohammad Alizadeh Tabriz Health Services Management Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Mehdi Hedayati Cellular and Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohammad Asghari-Jafarabadi Road Traffic Injury Prevention Research Center, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran. Naimeh Mesri Alamdari Dept. of Biochemistry and Diet Therapy, Student Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran. Farideh Anari Rohzende Health and Therapeutic Center 2, Shabestar, Iran. Ali Tarighat-Esfanjani Nutrition Research Center, Faculty of Nutrition, Tabriz University of Medical Science, Tabriz, Iran. 2015 10 14 Background: Hyperglycemia and gestational diabetes mellitus are complications of pregnancy. Both mothers and newborns are typically at increased risk for complications. This study sought to determine effect of zinc supplementation on serum glucose levels, insulin resistance, energy and macronutrients intakes in pregnant women with impaired glucose tolerance. Methods: In this clinical trial 44 pregnant women with impaired glucose tolerance, from December 2012 –April 2013 were randomly divided into zinc (n=22) and placebo (n=22) groups and recived 30mg/day zinc gluconate and (n=22), and placebo for eight consecutive weeks respectively. Dietary food intake was estimated from 3-days diet records. Serum levels of zinc, fasting blood sugar, and insulin were measured by conventional methods. Also homeostatic model assessment of insulin resistance was calculated. Results: Serumlevels of fasting blood sugar, insulin and homeostatic model assessment of insulin resistance slightly decreased in zinc group, but these changes were not statistically significant. Serum zinc levels (P =0.012), energy (P=0.037), protein (P=0.019) and fat (P=0.017) intakes increased statistically significant in the zinc group after intervention but not in the placebo group. Conclusion: Oral supplementation with zinc could be effective in increasing serum zinc levels and energy intake with no effects on fasting blood sugar, homeostatic model assessment of insulin resistance and insulin levels. https://ijph.tums.ac.ir/index.php/ijph/article/view/3693 https://ijph.tums.ac.ir/index.php/ijph/article/download/3693/3367