Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 44 2 2015 02 15 282 4 Jiana Shi Dept. of Pharmacy, Tongde Hospital of Zhejiang Province, Hangzhou, China AND Dept. of Pharmacology, Toxicology and Biochemical Pharmaceutics, Zhejiang University, Hangzhou, China. Xiaojun Wang Dept. of Pharmacy, Tongde Hospital of Zhejiang Province, Hangzhou, China. Yin Ying Dept. of Pharmacy, Tongde Hospital of Zhejiang Province, Hangzhou, China. Lin Xu Dept. of Cardiovascular Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, China. Danyan Zhu Dept. of Pharmacology, Toxicology and Biochemical Pharmaceutics, Zhejiang University, Hangzhou, China. 2015 10 14 Mirtazapine is a new antidepressant that can increase noradrenergic and serotonergic neurotransmission. It is also a postsynaptic antagonist of 5-HT2 and 5-HT3. In addition, it has only a weak affinity for 5-HT1 receptors and has very weak muscarinic anticholinergic and histamine (H1) antagonist properties. We report a case of hypertensive urgency that ensued after a patient took a single low dose of mirtazapine. https://ijph.tums.ac.ir/index.php/ijph/article/view/3672 https://ijph.tums.ac.ir/index.php/ijph/article/download/3672/3346