Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 54 4 2025 04 02 795 800 Kee Leng Chua Staff Health Clinic and Wellness Centre, National University Hospital, Singapore 119074, Singapore Hwang Ching Chan Epidemiology Unit, National University Hospital, Singapore 119074, Singapore Jyoti Somani Epidemiology Unit, National University Hospital, Singapore 119074, Singapore See Ming Lim Staff Health Clinic and Wellness Centre, National University Hospital, Singapore 119074, Singapore 2024 09 04 2024 12 15 Background: We investigated trends in acute respiratory illnesses and influenza activity in Singapore throughout the COVID-19 pandemic. Methods: Publicly available data from the Ministry of Health, Singapore was used to estimate the number of daily acute respiratory illnesses (ARI) and influenza cases between 2019 and Jun 2023. Overseas travel activity was obtained from the Department of Statistics, Singapore. Trends in ARI and influenza activity during different phases of the COVID-19 pandemic with changes in key public health measures were compared. Results: Pre-pandemic influenza activity exhibited seasonal peaks in Jan and Jul, with daily estimated cases exceeding 40 during these periods. During the early pandemic, influenza cases declined sharply to close to zero and remained at these levels until mid-2022, even after public health measures were eased. ARI cases followed a similar initial decline but gradually returned to pre-pandemic levels by 2023, with peaks occurring outside the usual seasonal pattern. These trends corresponded with phases of public health measures, including mask-wearing and travel restrictions. Conclusion: Several hypotheses for these contrasting trends were explored, including increased public health awareness, higher influenza vaccination rates, and potential virus-virus interactions.   https://ijph.tums.ac.ir/index.php/ijph/article/view/36539 https://ijph.tums.ac.ir/index.php/ijph/article/download/36539/8520