Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 53 8 2024 08 06 1898 1902 Ainura Manasovna Satarkulova Department of Fundamental Disciplines, International Higher School of Medicine, Bishkek, Kyrgyz Republic Kanykei Sadyrbekovna Keneshova Department of Fundamental Disciplines, International Higher School of Medicine, Bishkek, Kyrgyz Republic Shadiya Yusupdjanovna Aisaeva Integrated Research Center, International Higher School of Medicine, Bishkek, Kyrgyz Republic Asel Abdumomunovna Usenova Department of Special Surgical Disciplines, International Higher School of Medicine, Bishkek, Kyrgyz Republic Shirin Syrgakovna Bakirova Department of Fundamental Disciplines, International Higher School of Medicine, Bishkek, Kyrgyz Republic 2024 08 06 2024 08 06 Background: We aimed to evaluate the functional state of the population of the midlands and highlands of Alai region (Kyrgyzstan) on the basis of body mass index (BMI) and adaptation potential (AP). The characteris- tic of people with overweight and underweight are presented. A clean dependence of AP on BMI was revealed. Methods: In Alai region (Kyrgyzstan), 285 citizens of Gulcha village (1.540 m above sea level) and 312 citizens of Sary-Tash village (3.200 m above sea level) were examined in July-August 2023. Blood pressure (BP) was generally measured at rest in the seated position. The BMI and AP were calculated. Results: In the midlands and highlands BP correspond to the physiological norm. The AP scores in the mid- lands region for men was 2.32 points, for women - 2.38 points, but in highlands areas these values were slightly higher: for men – 2.52 points, for women – 2.42 points. The total BMI values for men in the midlands and highlands were 23.39 and 23.24 kg/m2 respectively, for women in the midlands this indicator became higher than normal (26.53 kg/m2), but in the highlands it corresponded to the norm (24.78 kg/m2). Conclusion: It is necessary to determine the value of AP, BMI and type of self-regulation of blood circulation when assessing the functional state of residents living in mountain areas. In the highlands overweight, which is one of the significant risk factors for health disorders, with tension of regulatory mechanisms can become a trigger for the development of cardiovascular diseases. https://ijph.tums.ac.ir/index.php/ijph/article/view/36294 https://ijph.tums.ac.ir/index.php/ijph/article/download/36294/8328