Tehran University of Medical Sciences Iranian Journal of Public Health 2251-6085 54 3 2025 03 04 542 553 Seyyed Ghavam shafagh School of Medicine, Iran University of Medical Sciences, Tehran, Iran Eslam Moradi-Asl Arthropod-Borne Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, Iran Marieh Mirzagholipour Students Research Committee, School of Health, Ardabil University of Medical Sciences, Ardabil, Iran Ali Salehi Sahlabadi 1. Safety Promotion and Injury Prevention Research Center, Research Institute for Health Sciences and Environment, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2. Department of Occupational Health and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran Sayed Vahid Esmaeili Student Research Committee, Department of Occupational Health and Safety Engineering, School of Public Health and Safe-ty, Shahid Beheshti University of Medical Sciences, Tehran, Iran Chiman Karami 1. Arthropod-Borne Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, Iran 2. Department of Microbiology, Parasitology and Immunology, Ardabil University of Medical Sciences, Ardabil, Iran 2024 07 13 2024 11 11 Background: This study investigated the impact of climate variables on the prevalence of malaria, a climate-sensitive infectious disease. Methods: A systematic review was conducted on articles published from Mar 2000 to Aug 2023 in Persian and English languages. Overall, 10,731 articles were retrieved, and 58 studies were included in the analysis. Results: Climate variables such as temperature, rainfall, and humidity play a significant role in predicting malaria outbreaks, with inconsistencies observed in different regions, including Iran. The study highlights the need for tailored preventive. Conclusion: Strategies and interventions to address the impact of climate change on malaria transmission. Enhanced health system resilience is essential to combat the anticipated rise in malaria cases in the future. https://ijph.tums.ac.ir/index.php/ijph/article/view/36075 https://ijph.tums.ac.ir/index.php/ijph/article/download/36075/8493